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Article ; Online: The Landscape of Secondary Genetic Rearrangements in Pediatric Patients with B-Cell Acute Lymphoblastic Leukemia with t(12;21).

Kaczmarska, Agnieszka / Derebas, Justyna / Pinkosz, Michalina / Niedźwiecki, Maciej / Lejman, Monika

2023 Volume 12, Issue 3

Abstract: The most frequent chromosomal rearrangement in childhood B-cell acute lymphoblastic leukemia (B-ALL) is translocation t(12;21)(p13;q22). It results in the fusion of ... ...

Abstract	The most frequent chromosomal rearrangement in childhood B-cell acute lymphoblastic leukemia (B-ALL) is translocation t(12;21)(p13;q22). It results in the fusion of the
MeSH term(s)	Child ; Humans ; Core Binding Factor Alpha 2 Subunit/genetics ; Core Binding Factor Alpha 2 Subunit/metabolism ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Chromosome Aberrations ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Translocation, Genetic ; Burkitt Lymphoma
Chemical Substances	Core Binding Factor Alpha 2 Subunit ; Oncogene Proteins, Fusion
Language	English
Publishing date	2023-01-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12030357
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Thrushes (Aves: Passeriformes) as indicators of microplastic pollution in terrestrial environments.

Deoniziak, Krzysztof / Cichowska, Aleksandra / Niedźwiecki, Sławomir / Pol, Wojciech

The Science of the total environment

2022 Volume 853, Page(s) 158621

Abstract: Microplastic pollution is one of the leading global conservation issues. The aim of this study was to investigate the occurrence of microplastics in the gastrointestinal tracts of Common Blackbirds Turdus merula (N = 16) and Song Thrushes Turdus ... ...

Abstract	Microplastic pollution is one of the leading global conservation issues. The aim of this study was to investigate the occurrence of microplastics in the gastrointestinal tracts of Common Blackbirds Turdus merula (N = 16) and Song Thrushes Turdus philomelos (N = 18), songbirds with exceptionally terrestrial lifestyles and a wide distribution range. We searched for microplastics of over 100 μm in size and assessed whether their contamination differed regarding the age of the birds and the time of year. We used birds that had died as a result of collision with anthropogenic infrastructure, which were sampled during wildlife monitoring of anthropogenic infrastructures and citizen science projects in north-eastern Poland. We found that all the analysed individuals contained microplastic in their gastrointestinal tracts, which were classified as fibers, fragments, films and pellets. A total number of 1073 microplastics were observed, mostly consisting of fibers (84 %) and films (10 %) below 1 mm in size. The dominant colours of microplastics were transparent (75 %) and brown (14 %). The species average microplastic concentration was higher in Song Thrushes (40.1) than Common Blackbirds (21.9), however the difference was not statistically significant. Moreover, we found no seasonal or age-related differences in microplastic ingestion in either species. While our results show a ubiquity of microplastics in terrestrial environments, they also indicate that thrushes have the potential to be used as indicators of microplastic pollution in terrestrial ecosystems.
MeSH term(s)	Animals ; Microplastics ; Songbirds ; Plastics ; Passeriformes ; Ecosystem ; Environmental Monitoring ; Water Pollutants, Chemical/analysis
Chemical Substances	Microplastics ; Plastics ; Water Pollutants, Chemical
Language	English
Publishing date	2022-09-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.158621
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Article: Better Cardiorespiratory Fitness Defined as VO

Flotyńska, Justyna / Naskręt, Dariusz / Niedźwiecki, Paweł / Grzelka-Woźniak, Agata / Pypeć, Aleksandra / Kaczmarek, Anita / Cieluch, Aleksandra / Zozulińska-Ziółkiewicz, Dorota / Uruska, Aleksandra

Clinical medicine insights. Endocrinology and diabetes

2024 Volume 17, Page(s) 11795514241244872

Abstract: Introduction: An essential process affecting the course of type 1 diabetes (DM1) is the appearance and duration of clinical remission. One of the most important factors promoting the occurrence of remission is physical activity, due to increased ... ...

Abstract	Introduction: An essential process affecting the course of type 1 diabetes (DM1) is the appearance and duration of clinical remission. One of the most important factors promoting the occurrence of remission is physical activity, due to increased activity of antioxidants, reduces insulin resistance and improves glucose transport. Maximal oxygen capacity (VO Methods: The pCR was assessed by the following mathematical formula: A1c (%) + [4 × insulin dose (U/kg/d)]. The result ⩽9 indicates pCR. VO Results: The study group consisted of 32 adults with DM1. People with pCR were proved to have higher VO Conclusion: The higher VO
Language	English
Publishing date	2024-04-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2628990-8
ISSN	1179-5514
ISSN	1179-5514
DOI	10.1177/11795514241244872
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Article: (Pseudo) "Exclusive" Contracts: An Insidious Business Practice that Selectively Damages IR.

Niedzwiecki, Gerald A

Seminars in interventional radiology

2019 Volume 36, Issue 1, Page(s) 43–45

Abstract: Contracting is an important part of running the business of private practice interventional radiology. A basic knowledge of contracting is vital for the practicing interventionalist to best position him or herself to excel in private practice. Exclusive ... ...

Abstract	Contracting is an important part of running the business of private practice interventional radiology. A basic knowledge of contracting is vital for the practicing interventionalist to best position him or herself to excel in private practice. Exclusive contracts are common in interventional, diagnostic, and radiology practices. Such contracts, however, may significantly limit the practice of individual interventional radiologists and impede the growth of interventional procedures in communities at large. This article outlines the role of exclusive contracts in interventional practices, and describes the limitations of such contracts.
Language	English
Publishing date	2019-03-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	848341-3
ISSN	1098-8963 ; 0739-9529
ISSN (online)	1098-8963
ISSN	0739-9529
DOI	10.1055/s-0039-1679947
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Article ; Online: Land Cover Changes Utilising Landsat Satellite Imageries for the Kumasi Metropolis and Its Adjoining Municipalities in Ghana (1986-2022).

Frimpong, Bernard Fosu / Koranteng, Addo / Atta-Darkwa, Thomas / Junior, Opoku Fosu / Zawiła-Niedźwiecki, Tomasz

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 5

Abstract: Forest loss, unbridled urbanisation, and the loss of arable lands have become contentious issues for the sustainable management of land. Landsat satellite images for 1986, 2003, 2013, and 2022, covering the Kumasi Metropolitan Assembly and its adjoining ... ...

Abstract	Forest loss, unbridled urbanisation, and the loss of arable lands have become contentious issues for the sustainable management of land. Landsat satellite images for 1986, 2003, 2013, and 2022, covering the Kumasi Metropolitan Assembly and its adjoining municipalities, were used to analyse the Land Use Land Cover (LULC) changes. The machine learning algorithm, Support Vector Machine (SVM), was used for the satellite image classification that led to the generation of the LULC maps. The Normalised Difference Vegetation Index (NDVI) and Normalised Difference Built-up Index (NDBI) were analysed to assess the correlations between the indices. The image overlays of the forest and urban extents and the calculation of the annual deforestation rates were evaluated. The study revealed decreasing trends in forestlands, increased urban/built-up areas (similar to the image overlays), and a decline in agricultural lands. However, there was a negative relationship between the NDVI and NDBI. The results corroborate the pressing need for the assessment of LULC utilising satellite sensors. This paper contributes to the existing outlines for evolving land design for the promotion of sustainable land use.
Language	English
Publishing date	2023-02-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23052644
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Article ; Online: Ultrasound-Guided Blocks for Spine Surgery: Part 1-Cervix.

Adamczyk, Kamil / Koszela, Kamil / Zaczyński, Artur / Niedźwiecki, Marcin / Brzozowska-Mańkowska, Sybilla / Gasik, Robert

International journal of environmental research and public health

2023 Volume 20, Issue 3

Abstract: Postoperative pain is common following spine surgery, particularly complex procedures. The main anesthetic efforts are focused on applying multimodal analgesia beforehand, and regional anesthesia is a critical component of it. The purpose of this study ... ...

Abstract	Postoperative pain is common following spine surgery, particularly complex procedures. The main anesthetic efforts are focused on applying multimodal analgesia beforehand, and regional anesthesia is a critical component of it. The purpose of this study is to examine the existing techniques for regional anesthesia in cervical spine surgery and to determine their effect and safety on pain reduction and postoperative patient's recovery. The electronic databases were searched for all literature pertaining to cervical nerve block procedures. The following peripheral, cervical nerve blocks were selected and described: paravertebral block, cervical plexus clock, paraspinal interfascial plane blocks such as multifidus cervicis, retrolaminar, inter-semispinal and interfacial, as well as erector spinae plane block and stellate ganglion block. Clinicians should choose more superficial techniques in the cervical region, as they have been shown to be comparably effective and less hazardous compared to paravertebral blocks.
MeSH term(s)	Female ; Humans ; Cervix Uteri ; Nerve Block/methods ; Pain Management/methods ; Anesthesia, Conduction ; Ultrasonography, Interventional
Language	English
Publishing date	2023-01-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20032098
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Article ; Online: The Search for Suitable Habitats for Endangered Species at Their Historical Sites-Conditions for the Success of

Arciszewski, Michał / Pogorzelec, Magdalena / Bronowicka-Mielniczuk, Urszula / Niedźwiecki, Michał / Parzymies, Marzena / Serafin, Artur

International journal of environmental research and public health

2023 Volume 20, Issue 2

Abstract: Restoring endangered plant species to their historical sites is not always possible due to constantly changing habitat conditions. The aim of this study was to test the effects of reintroduction of two relict willow species in eastern Poland. The ... ...

Abstract	Restoring endangered plant species to their historical sites is not always possible due to constantly changing habitat conditions. The aim of this study was to test the effects of reintroduction of two relict willow species in eastern Poland. The experiment consisted of planting 48 individuals of
MeSH term(s)	Humans ; Animals ; Endangered Species ; Salix ; Ecosystem ; Plants ; Biota
Language	English
Publishing date	2023-01-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20021133
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Article ; Online: Overview on Aneuploidy in Childhood B-Cell Acute Lymphoblastic Leukemia.

Panuciak, Kinga / Nowicka, Emilia / Mastalerczyk, Angelika / Zawitkowska, Joanna / Niedźwiecki, Maciej / Lejman, Monika

International journal of molecular sciences

2023 Volume 24, Issue 10

Abstract: Recent years have brought significant progress in the treatment of B-cell acute lymphoblastic leukemia (ALL). This was influenced by both the improved schemes of conventionally used therapy, as well as the development of new forms of treatment. As a ... ...

Abstract	Recent years have brought significant progress in the treatment of B-cell acute lymphoblastic leukemia (ALL). This was influenced by both the improved schemes of conventionally used therapy, as well as the development of new forms of treatment. As a consequence, 5-year survival rates have increased and now exceed 90% in pediatric patients. For this reason, it would seem that everything has already been explored in the context of ALL. However, delving into its pathogenesis at the molecular level shows that there are many variations that still need to be analyzed in more detail. One of them is aneuploidy, which is among the most common genetic changes in B-cell ALL. It includes both hyperdiploidy and hypodiploidy. Knowledge of the genetic background is important already at the time of diagnosis, because the first of these forms of aneuploidy is characterized by a good prognosis, in contrast to the second, which is in favor of an unfavorable course. In our work, we will focus on summarizing the current state of knowledge on aneuploidy, along with an indication of all the consequences that may be correlated with it in the context of the treatment of patients with B-cell ALL.
MeSH term(s)	Humans ; Child ; Aneuploidy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Burkitt Lymphoma
Language	English
Publishing date	2023-05-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24108764
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Article: Phytochemicals and micronutrients in suppressing infectivity caused by SARS-CoV-2 virions and seasonal coronavirus HCoV-229E in vivo.

Goc, Anna / Sumera, Waldemar / Rath, Matthias / Niedzwiecki, Aleksandra

European journal of microbiology & immunology

2023 Volume 13, Issue 1, Page(s) 6–14

Abstract: SARS-CoV-2 infection still poses health threats especially to older and immunocompromised individuals. New emerging variants of SARS-CoV-2, including Omicron and Arcturus, have been challenging the effectiveness of humoral immunity resulting from ... ...

Abstract	SARS-CoV-2 infection still poses health threats especially to older and immunocompromised individuals. New emerging variants of SARS-CoV-2, including Omicron and Arcturus, have been challenging the effectiveness of humoral immunity resulting from repeated vaccination and infection. With recent study implying a wave of new mutants in vaccinated people making them more susceptible to the newest variants and fueling a rapid viral evolution, there is a need for alternative or adjunct approaches against coronavirus infections other than vaccines. Our earlier work indicated that a specific combination of micronutrients and phytochemicals can inhibit key infection mechanisms shared by SARS-CoV-2 and its variants in vitro. Here we demonstrate in vivo that an intake of this micronutrient combination before and during infection of mice with engineered SARS-CoV-2 virions and HCoV-229E virus results in a significant decrease in viral load and level of spike protein in the lungs. This was accompanied by decreased inflammatory response, including TNFα, IL1β, ILα, and IL17. These and our earlier results confirm that by targeting multiple mechanisms simultaneously by a combination treatment we can effectively and safely challenge SARS-CoV-2 and HCoV-229E virus. If clinically confirmed, such an approach could complement already in-use preventive and therapeutic strategies against coronavirus infections.
Language	English
Publishing date	2023-05-31
Publishing country	Hungary
Document type	Journal Article
ZDB-ID	2652327-9
ISSN	2062-8633 ; 2062-509X
ISSN (online)	2062-8633
ISSN	2062-509X
DOI	10.1556/1886.2023.00010
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Article: Inhibitory effect of theaflavin-3,3'-digallate can involve its binding to the "stem" domain of α-hemolysin of Staphylococcus aureus.

Goc, Anna / Sumera, Waldemar / Rath, Matthias / Niedzwiecki, Aleksandra

European journal of microbiology & immunology

2023 Volume 13, Issue 3, Page(s) 83–87

Abstract: Infections caused by Staphylococcus aureus are currently a worldwide threat affecting millions of individuals. The pathogenicity of S. aureus is associated with numerous virulence factors, including cell surface proteins, polysaccharides, and secreted ... ...

Abstract	Infections caused by Staphylococcus aureus are currently a worldwide threat affecting millions of individuals. The pathogenicity of S. aureus is associated with numerous virulence factors, including cell surface proteins, polysaccharides, and secreted toxins. The pore-forming α-hemolysin, known as α-toxin, is produced by nearly all virulent strains of S. aureus and is implicated in several diseases including skin and soft tissue infections, atopic dermatitis, and pneumonia. There are currently no vaccines available for the prevention of S. aureus infections and the efficacy of available antibiotics has been fading. In this study we examined the mode of antihemolytic activity of theaflavin-3,3'-digallate against α-hemolysin of methicillin-resistant S. aureus by molecular docking using AutoDock Vina as the molecular docking tool. The theaflavin-3,3'-digallate docked the molecular sequence of the Hla (PDB ID:7ahl). The scores of the top 10 binding modes obtained were between -9.0 and -8.5 kcal mol-1, and the best binding mode was -9.0 kcal mol-1. Direct binding sites of theaflavin-3,3'-digallate to the "stem" domain of Hla were revealed which primarily targeted of the residues Met113, Thr117, Asn139. The disclosure of this potential binding mode warrants further clinical evaluation of theaflavin-3,3'-digallate as an anti-hemolytic compound in order to practically validate our results.
Language	English
Publishing date	2023-10-18
Publishing country	Hungary
Document type	Journal Article
ZDB-ID	2652327-9
ISSN	2062-8633 ; 2062-509X
ISSN (online)	2062-8633
ISSN	2062-509X
DOI	10.1556/1886.2023.00032
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