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  1. Article ; Online: 'Not knowing something is normally a milestone on the way to knowledge'. An interview with Joan M. Braganza, DSc, FRCP, FRCPath, Reader Emeritus, University of Manchester, UK.

    Braganza, Joan M

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.

    2009  Volume 9, Issue 6, Page(s) 717–721

    Abstract: Dr. Joan Braganza, a world expert in the field of chronic pancreatitis, proposed a new template ... oxidative detoxification reactions via cytochromes P450. Dr. Braganza has gone on to show how pancreatic ... for new treatment modalities. In this interview, Dr. Braganza shares her life experience ...

    Abstract Dr. Joan Braganza, a world expert in the field of chronic pancreatitis, proposed a new template for its pathogenesis based on the role of free radical pathology, in particular the heightened but unmitigated oxidative detoxification reactions via cytochromes P450. Dr. Braganza has gone on to show how pancreatic damage in cystic fibrosis, acute pancreatitis and pancreatic cancer fit into the scheme, paving the way for new treatment modalities. In this interview, Dr. Braganza shares her life experience as an investigator and provides a perspective for young researchers entering the field of pancreatology.
    MeSH term(s) Antioxidants/therapeutic use ; Cystic Fibrosis/complications ; Cystic Fibrosis/diet therapy ; Cystic Fibrosis/metabolism ; Cytochrome P-450 Enzyme System/metabolism ; Humans ; Pancreatic Neoplasms/etiology ; Pancreatic Neoplasms/metabolism ; Pancreatitis, Chronic/diet therapy ; Pancreatitis, Chronic/metabolism ; Pancreatitis, Chronic/pathology ; Reactive Oxygen Species/adverse effects ; Reactive Oxygen Species/metabolism
    Chemical Substances Antioxidants ; Reactive Oxygen Species ; Cytochrome P-450 Enzyme System (9035-51-2)
    Language English
    Publishing date 2009
    Publishing country Switzerland
    Document type Interview
    ZDB-ID 2056680-3
    ISSN 1424-3911 ; 1424-3903
    ISSN (online) 1424-3911
    ISSN 1424-3903
    DOI 10.1159/000225371
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  2. Book ; Conference proceedings: New developments on the aetiogenesis of chronic pancreatitis

    Braganza, Joan M.

    implications for treatment and disease prophylaxis ; symposium ... World Congresses of Gastroenterology, Vienna, Austria, September 6 - 11, 1998 ; 9 tables

    (Digestion ; 59, Suppl. 4)

    1998  

    Event/congress World Congress of Gastroenterology (11, 1998, Wien)
    Author's details guest ed. Joan M. Braganza
    Series title Digestion ; 59, Suppl. 4
    Collection
    Keywords Chronische Bauchspeicheldrüsenentzündung ; Ätiologie
    Subject Krankheitsursache ; Krankheit ; Chronische Pankreatitis
    Language English
    Size 59 S. : Ill., graph. Darst.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book ; Conference proceedings
    HBZ-ID HT009519146
    ISBN 3-8055-6804-5 ; 978-3-8055-6804-3
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: Pancreatic extracts for painful chronic pancreatitis: micronutrient antioxidant therapy by proxy.

    Braganza, Joan M

    JOP : Journal of the pancreas

    2014  Volume 15, Issue 6, Page(s) 541–543

    Language English
    Publishing date 2014-11
    Publishing country Italy
    Document type Editorial
    ISSN 1590-8577
    ISSN (online) 1590-8577
    DOI 10.6092/1590-8577/2851
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  4. Book ; Conference proceedings: The pathogenesis of pancreatitis

    Braganza, Joan M.

    based on a symposium held on 15 November 1990 ... Manchester [during the annual meeting] of the Pancreatic Society of Great Britain and Ireland

    1991  

    Institution Symposium the Pathogenesis of Pancreatitis
    Pancreatic Society of Great Britain and Ireland
    Author's details ed. by Loan M. Braganza
    Keywords Pancreatitis / drug therapy / congresses ; Pancreatitis / etiology / congresses ; Pancreatitis / physiopathology / congresses ; Bauchspeicheldrüsenentzündung ; Pharmakotherapie ; Pathogenese
    Subject Pankreatitis ; Arzneimitteltherapie ; Arzneitherapie ; Medikamentöse Therapie
    Size X, 233 S. : Ill., graph. Darst.
    Publisher Manchester University Press
    Publishing place Manchester u.a.
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT003940479
    ISBN 0-7190-3480-9 ; 978-0-7190-3480-0
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1991 A 5412 order for loan Magazin

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  5. Article ; Online: Limitations of patient selection and other issues in chronic pancreatitis antioxidant trial.

    Braganza, Joan M

    Gastroenterology

    2013  Volume 144, Issue 3, Page(s) e17–8

    MeSH term(s) Antioxidants/therapeutic use ; Female ; Humans ; Male ; Pain/prevention & control ; Pancreatitis, Alcoholic/drug therapy ; Pancreatitis, Chronic/drug therapy
    Chemical Substances Antioxidants
    Language English
    Publishing date 2013-03
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2012.12.034
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    Zs.MO 572: Show issues

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  6. Article ; Online: Aligning quality improvement efforts and policy goals in a national integrated health system.

    Braganza, Melissa Z / Pearson, Elsa / Avila, Cecille Joan / Zlowe, Dave / Øvretveit, John / Kilbourne, Amy M

    Health services research

    2022  Volume 57 Suppl 1, Page(s) 9–19

    Abstract: Objective: To describe the design and impact of a systematic, enterprise-wide process for engaging US Department of Veterans Affairs (VA) leadership in prioritizing scarce implementation and evaluation resources.: Data sources: From 2017 to 2021, the ...

    Abstract Objective: To describe the design and impact of a systematic, enterprise-wide process for engaging US Department of Veterans Affairs (VA) leadership in prioritizing scarce implementation and evaluation resources.
    Data sources: From 2017 to 2021, the VA Quality Enhancement Research Initiative (QUERI) identified priorities from local, regional, and national leaders through qualitative discussions and a national survey and tracked impacts via reports generated from competitively funded initiatives addressing these priorities.
    Study design: Guided by the Learning Health System framework and QUERI Implementation Roadmap, QUERI engaged stakeholders to nominate and rank-order priorities, peer-reviewed and funded initiatives to scale up and spread evidence-based practices (EBPs) using theory-based implementation strategies, and evaluated the impact of these initiatives using the QUERI Impact Framework.
    Data collection/extraction methods: QUERI collected priority nominations through qualitative discussions and a web-based survey, and live voting was used to rank-order priorities. QUERI-funded teams regularly submitted progress reports describing the key activities, findings, and impacts of the quality improvement (QI) initiatives using a standardized form created in the VA Research Electronic Data Capture (REDCap).
    Principal findings: QUERI launched five QI initiatives to address priorities selected by VA leadership. In partnership with 28 health system leaders, these initiatives are implementing 10 EBPs across 53 sites, supporting 1055 VA employees in delivering evidence-based care. The success of these initiatives led to an expansion of QUERI's process to address 2021 VA leadership priorities: virtual care, health disparities, delayed or suppressed care due to COVID-19, employee burnout, long-term and home care options, and quality and cost of community care.
    Conclusions: QUERI, a unique program embedded in a national integrated health system, deployed a novel approach to inform policy making and enhance the real-world impact of research through prioritization of limited resources, rigorous peer-review, and assessment of impacts on the health system, employees, and Veterans.
    MeSH term(s) COVID-19 ; Delivery of Health Care, Integrated ; Goals ; Humans ; Policy ; Quality Improvement ; United States ; United States Department of Veterans Affairs
    Language English
    Publishing date 2022-03-04
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 410435-3
    ISSN 1475-6773 ; 0017-9124
    ISSN (online) 1475-6773
    ISSN 0017-9124
    DOI 10.1111/1475-6773.13944
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  7. Article ; Online: Mast cell control: likely modus operandi of panhaematin in experimental pancreatitis.

    Braganza, Joan M

    Gut

    2012  Volume 61, Issue 4, Page(s) 632; author reply 632–3

    MeSH term(s) Animals ; Female ; Hemin/therapeutic use ; Pancreatitis/drug therapy
    Chemical Substances Hemin (743LRP9S7N)
    Language English
    Publishing date 2012-04
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2011-300415
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  8. Article ; Online: Pancreatic Extracts for Painful Chronic Pancreatitis

    Joan M Braganza

    JOP Journal of the Pancreas, Vol 15, Iss 6, Pp 541-

    Micronutrient Antioxidant Therapy by Proxy

    2014  Volume 543

    Abstract: Pancreatic extracts have found their way into clinical practice to treat painful chronic pancreatitis, despite consensus from analysis of randomized controlled trials (RCT) that there is no clear evidence of benefit [1-3]. Proponents argue that success ... ...

    Abstract Pancreatic extracts have found their way into clinical practice to treat painful chronic pancreatitis, despite consensus from analysis of randomized controlled trials (RCT) that there is no clear evidence of benefit [1-3]. Proponents argue that success depends upon the use of non-enteric coated material to ensure delivery of proteases into the duodenum as in two RCT [4, 5], compared to several unsuccessful RCT using enteric coated preparations that deliver the enzymes further downstream [1-3]. It is posited that intraduodenal delivery ‘puts the pancreas to rest’ by dampening the feedback loop that otherwise leads, via high circulating levels of cholecystokinin - pancreozymin (CCK), to pain from pancreatic ductal hypertension. Clinicians are informed that patients with small-duct disease and mild to moderately impaired pancreatic secretory capacity will benefit, whereas those with advanced disease / steatorrhea will not. A proton pump inhibitor is advised, to safeguard the extracts in transit through the stomach. Treatment is advocated for four weeks in the first instance, to be continued for six months in responders, and indefinitely should pain resurface upon attempted withdrawal of treatment [6].
    Keywords Antioxidants ; Methionine ; Pancreatic Extracts ; Pancreatitis ; Chronic ; Selenium ; Zinc ; Medicine ; R ; Internal medicine ; RC31-1245 ; Specialties of internal medicine ; RC581-951 ; Diseases of the digestive system. Gastroenterology ; RC799-869
    Subject code 610
    Publishing date 2014-11-01T00:00:00Z
    Publisher E S Burioni Ricerche Bibliografiche
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Micronutrient Therapy for Chronic Pancreatitis

    Joan M Braganza

    JOP Journal of the Pancreas, Vol 14, Iss 4, Pp 304-

    Premises and Pitfalls

    2013  Volume 308

    Abstract: BDNF: brain-derived neurotrophic factor; CGRP: calcitonin gene-related peptide; CYP: cytochrome P450; CYP2E1: ethanol-inducible form of cytochrome P450; CYP1A: polycyclic aromatic hydrocarbon-inducible form of cytochrome P450; GSH: glutathione in its ... ...

    Abstract BDNF: brain-derived neurotrophic factor; CGRP: calcitonin gene-related peptide; CYP: cytochrome P450; CYP2E1: ethanol-inducible form of cytochrome P450; CYP1A: polycyclic aromatic hydrocarbon-inducible form of cytochrome P450; GSH: glutathione in its bioactive form; NGF: nerve growth factor; PAR-2: proteinase-activated receptor 2; ROS reactive oxygen species; RXS: reactive xenobiotic species; SP: substance P; TGF-beta: transforming growth factor beta; TRPV1: transient receptor potential vallinoid 1
    Keywords Antioxidants ; Mast Cells ; Nociceptors ; Medicine ; R ; Internal medicine ; RC31-1245 ; Specialties of internal medicine ; RC581-951 ; Diseases of the digestive system. Gastroenterology ; RC799-869
    Publishing date 2013-07-01T00:00:00Z
    Publisher E S Burioni Ricerche Bibliografiche
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Reply to "Folate Deficiency in Chronic Pancreatitis"

    Joan M Braganza

    JOP Journal of the Pancreas, Vol 11, Iss 4, Pp 413-

    2010  Volume 414

    Abstract: Dear Sir, We appreciate the comments of Rajesh et al. published in the present issue of JOP. J Pancreas (Online) [1] in respect of our review on ‘Micronutrient therapy for chronic pancreatitis’ [2] and thank you for the opportunity to respond. The ... ...

    Abstract Dear Sir, We appreciate the comments of Rajesh et al. published in the present issue of JOP. J Pancreas (Online) [1] in respect of our review on ‘Micronutrient therapy for chronic pancreatitis’ [2] and thank you for the opportunity to respond. The authors address two points in particular. i) Premorbid micronutrient insufficiency (especially of methionine and ascorbic acid) compromises the delivery of methyl and thiol moieties that facilitate exocytosis from acinar cells and leaves the exocrine pancreas vulnerable to other consequences of persistent electrophilic stress. These problems underlie chronic pancreatitis, such that micronutrient therapy affords first-line treatment and gives an opportunity for prophylaxis in individuals/communities at high risk of the disease
    Keywords Ascorbic Acid ; Cystic Fibrosis ; Folic Acid ; Homocysteine ; Methionine ; Pancreatitis ; Chronic ; Medicine ; R ; Internal medicine ; RC31-1245 ; Specialties of internal medicine ; RC581-951 ; Diseases of the digestive system. Gastroenterology ; RC799-869
    Subject code 610
    Publishing date 2010-07-01T00:00:00Z
    Publisher E S Burioni Ricerche Bibliografiche
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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