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Article: Associations of phase angle with platelet-activating factor metabolism and related dietary factors in healthy volunteers.

Detopoulou, Paraskevi / Fragopoulou, Elizabeth / Nomikos, Tzortzis / Antonopoulou, Smaragdi

2023 Volume 10, Page(s) 1237086

Abstract: Introduction: Phase angle (PA) is derived from bioelectrical impedance analysis (BIA). It reflects cell membrane function and decreases in disease. It is affected by inflammation, oxidative stress, and diet. Platelet-activating factor (PAF) is a potent ... ...

Abstract	Introduction: Phase angle (PA) is derived from bioelectrical impedance analysis (BIA). It reflects cell membrane function and decreases in disease. It is affected by inflammation, oxidative stress, and diet. Platelet-activating factor (PAF) is a potent inflammatory lipid mediator. Its levels, along with the activity of its metabolic enzymes, including CDP-choline:1-alkyl-2-acetyl- Methods: In healthy subjects, PAF, its metabolic enzyme activity, and erythrocyte fatty acids were measured, while desaturases were estimated. Food-frequency questionnaires and recalls were used, and food groups, macronutrient intake, MedDietScore, and DAC were assessed. Lifestyle and biochemical variables were collected. DXA and BIA measurements were performed. Results: Lp-PLA Conclusion: PA is associated with PAF levels and Lp-PLA
Language	English
Publishing date	2023-11-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2023.1237086
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Article: Is food compass score useful for menu planning in the hospital setting?

Detopoulou, Paraskevi / Panoutsopoulos, George I / Kalonarchi, Garifallia / Papamikos, Vassilios

Nutrition and health

2022 , Page(s) 2601060221138369

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-11-09
Publishing country	England
Document type	Journal Article
ZDB-ID	603215-1
ISSN	2047-945X ; 0260-1060
ISSN (online)	2047-945X
ISSN	0260-1060
DOI	10.1177/02601060221138369
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Article: COVID-19 and Nutrition: Summary of Official Recommendations.

Detopoulou, Paraskevi / Tsouma, Christina / Papamikos, Vassilios

Topics in clinical nutrition

2022 Volume 37, Issue 3, Page(s) 187–202

Abstract: Medical nutrition therapy may have a key role in the COVID-19 pandemic. Given the spread of misinformation, the present review organizes and summarizes nutrition recommendations regarding COVID-19, serving as a reference guide for health professionals. ... ...

Abstract	Medical nutrition therapy may have a key role in the COVID-19 pandemic. Given the spread of misinformation, the present review organizes and summarizes nutrition recommendations regarding COVID-19, serving as a reference guide for health professionals. Nineteen official recommendations were included of international, US, Asian, European, Canadian, and Australian origin on (i) lactation, (ii) nutrition during quarantine, (iii) nutrition in high-risk groups, (iv) nutrition for recovery at home, and (v) nutrition in hospital. Breastfeeding is encouraged, and the role of hydration and the adoption of a healthy diet during quarantine are emphasized. Older people and/or people with comorbidities should be checked for malnutrition and follow a healthy diet. For patients recovering at home, hydration, protein, and energy intake should be ensured. For hospitalized patients, early feeding with a priority on enteral route is recommended.
Language	English
Publishing date	2022-06-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	639204-0
ISSN	1550-5146 ; 0883-5691
ISSN (online)	1550-5146
ISSN	0883-5691
DOI	10.1097/TIN.0000000000000286
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Article ; Online: Cancer, Phase Angle and Sarcopenia: The Role of Diet in Connection with Lung Cancer Prognosis.

Detopoulou, Paraskevi / Voulgaridou, Gavriela / Papadopoulou, Sousana

Lung

2022 Volume 200, Issue 3, Page(s) 347–379

Abstract: Lung cancer is the most common cause of cancer death and is associated with malnutrition and sarcopenia. The detection of sarcopenia and conduction of simple body composition measurements, such as the phase angle (PhA) deriving from bioelectrical ... ...

Abstract	Lung cancer is the most common cause of cancer death and is associated with malnutrition and sarcopenia. The detection of sarcopenia and conduction of simple body composition measurements, such as the phase angle (PhA) deriving from bioelectrical impedance analysis (BIA), can help to early identify, monitor, prevent and treat malnutrition. The present review aims to clarify the relationship between PhA and sarcopenia with the pathophysiology, clinical outcomes, and therapeutic aspects of lung cancer. PhA and sarcopenia are connected to lung cancer prognosis through various mechanisms including inflammation and oxidative stress, although more research is needed to identify the critical thresholds for increased mortality risk. Moreover, emphasis is given on the role of dietary interventions (oral nutritional supplementation, and dietary counseling) to manage sarcopenia and related variables in patients with lung cancer. Oral nutritional supplements and/or those containing n - 3 polyunsaturated fatty acids may have a positive effect on physical strength measures and muscle mass if administered at the beginning of chemotherapy. Data on sole dietary counseling or multimodal interventions are less promising so far. In the future, sophisticated body composition phenotypes deriving from the described methods along with artificial intelligence techniques could be used to design personalized nutrition interventions and timely treat these patients.
MeSH term(s)	Artificial Intelligence ; Diet ; Humans ; Lung Neoplasms/complications ; Malnutrition/diagnosis ; Malnutrition/etiology ; Prognosis ; Sarcopenia/diagnosis ; Sarcopenia/etiology ; Sarcopenia/therapy
Language	English
Publishing date	2022-05-26
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	6165-7
ISSN	1432-1750 ; 0341-2040
ISSN (online)	1432-1750
ISSN	0341-2040
DOI	10.1007/s00408-022-00536-z
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Article ; Online: Dietary acid load is associated with waist circumference in university students with low adherence to the Mediterranean diet: The potential role of ultra-processed foods

Detopoulou, Paraskevi / Dedes, Vassilios / Pylarinou, Ioanna / Syka, Dimitra / Tzirogiannis, Konstantinos / Panoutsopoulos, Georgios I.

European Society for Clinical Nutrition and Metabolism Clinical Nutrition ESPEN. 2023 Aug., v. 56 p.43-51

2023

Abstract: Dietary acid load (DAL), as expressed by potential renal acid load (PRAL) and net acid production (NEAP), is connected to cardiometabolic disorders and obesity. Mediterranean diet relates to lower, while western diets to higher DAL values. The present ... ...

Abstract	Dietary acid load (DAL), as expressed by potential renal acid load (PRAL) and net acid production (NEAP), is connected to cardiometabolic disorders and obesity. Mediterranean diet relates to lower, while western diets to higher DAL values. The present study aimed to assess the association of PRAL and NEAP with adiposity measures in young adults (19.61 ± 3.15 years, mean ± standard deviation) and explore the implication of Mediterranean diet adherence and ultra-processed foods (UPF) intake in this relation. 346 students (269 women) participated. Anthropometry was performed, and a food frequency questionnaire was administered. The MedDietScore was calculated, UPF consumption was calculated based on the NOVA classification and PRAL/NEAP was estimated from published equations. Waist Circumference (WC) was transformed to WC⁻¹ (1/WC) in order to achieve normality and run linear regression models. In subjects with MedDietScore ≤ 28.00, PRAL and NEAP were negatively associated with 1/WC (B = −1.594 × 10-5± 8 × 10–6, p = 0.044 for PRAL and B = −2.84 × 10-5 ± 1 × 10–5, p = 0.048 for NEAP). Moreover, in this subgroup, subjects with medium to high UPF intake i.e., in the 2nd or 3rd tertile of UPF intake representing more than 34.16% of energy, PRAL (2nd tertile B = −0.00007, SE = 0.00003, p = 0.018; 3rd tertile B = −0.00002, SE = 0.00001, p = 0.024) and NEAP (2nd tertile B = −0.00004, SE = 0.00002, p = 0.040; 3rd tertile B = −0.00007, SE = 0.00004, p = 0.055) were connected to central obesity. In similar models, PRAL and NEAP were not significant predictors of BMI. The DAL may be related to central obesity, especially in individuals with worse dietary quality, as reflected by lower adherence to the Mediterranean diet, and high intake of UPF. Nutrition guidance aiming at the reduction of DAL may be useful in the reduction of central obesity in these subgroups.
Keywords	Mediterranean diet ; adiposity ; clinical nutrition ; energy ; food frequency questionnaires ; food quality ; obesity ; regression analysis ; standard deviation ; waist circumference ; Dietary acid load ; Ultra-processed foods ; NOVA
Language	English
Dates of publication	2023-08
Size	p. 43-51.
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ISSN	2405-4577
DOI	10.1016/j.clnesp.2023.05.005
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Relation of Minimally Processed Foods and Ultra-Processed Foods with the Mediterranean Diet Score, Time-Related Meal Patterns and Waist Circumference: Results from a Cross-Sectional Study in University Students.

Detopoulou, Paraskevi / Dedes, Vassilios / Syka, Dimitra / Tzirogiannis, Konstantinos / Panoutsopoulos, Georgios I

International journal of environmental research and public health

2023 Volume 20, Issue 4

Abstract: Ultra-processed foods are associated with chronic diseases, cardiometabolic factors and obesity. According to the NOVA system, foods are classified into four categories (from 1 = unprocessed to 4 = ultra-processed foods). The purpose of the present study ...

Abstract	Ultra-processed foods are associated with chronic diseases, cardiometabolic factors and obesity. According to the NOVA system, foods are classified into four categories (from 1 = unprocessed to 4 = ultra-processed foods). The purpose of the present study was to assess the consumption of minimally processed foods (MPF) and ultra-processed foods (UPF) in university students and their relationship with obesity, Mediterranean diet adherence and meal patterns. In total, 346 students (269 women) of the University of Peloponnese participated. A food frequency questionnaire was used, and the MedDietScore was calculated. The % energy contribution of MPF and UPF was calculated. The identification of meal patterns was performed via principal component analysis. Both multivariate regression and Spearman's correlations were used to measure the association of UPF/MPF consumption with anthropometric indices (body mass index, BMI and waist circumference, WC), Mediterranean diet adherence and early/late meal patterns. UPF and MPF provided 40.7 ± 13.6% and 44.3 ± 11.9% (mean ± standard deviation) of energy intake, respectively. In multi-adjusted linear regression models UPF consumption (% energy) was positively associated with WC in men but it was not related to BMI (total sample, men, women). UPF consumption was negatively related to the MedDietScore (Spearman rho = -0.214,
MeSH term(s)	Young Adult ; Humans ; Male ; Female ; Cross-Sectional Studies ; Food, Processed ; Diet ; Diet, Mediterranean ; Waist Circumference ; Universities ; Fast Foods ; Feeding Behavior ; Obesity ; Energy Intake ; Students ; Food Handling
Language	English
Publishing date	2023-02-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20042806
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Article ; Online: Food Compass Score and its association with inflammatory markers and homocysteine in cardiovascular disease-free adults: a cross-sectional analysis of the ATTICA epidemiological study.

Detopoulou, Paraskevi / Damigou, Evangelia / Antonopoulou, Smaragdi / Fragopoulou, Elizabeth / Chysohoou, Christina / Pitsavos, Christos / Panagiotakos, Demosthenes

European journal of clinical nutrition

2023 Volume 77, Issue 10, Page(s) 998–1004

Abstract: Background/objectives: Several nutrient profiling systems have been developed to assist in food choices and policy. Food Compass Score (FCS) is a novel holistic food score assessing 54 parameters. The aim was to assess the relation of FCS with ... ...

Abstract	Background/objectives: Several nutrient profiling systems have been developed to assist in food choices and policy. Food Compass Score (FCS) is a novel holistic food score assessing 54 parameters. The aim was to assess the relation of FCS with inflammatory and lipid markers in cardiovascular disease-free volunteers. Subjects/methods: Information from the ATTICA epidemiological study participants, with complete data on lipid, inflammatory markers and dietary intake were studied (n = 1018). C-reactive protein (CRP) and amyloid A were determined by immunonephelometry, fibrinogen by nephelometry, homocysteine by fluorometry, while tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), adiponectin and leptin were determined by ELISA in fasting blood samples. Dietary intake was assessed through a semi-quantitative validated food frequency questionnaire. Each food was assigned a FCS value from the published values and then individual's FCS values were calculated. Results: Mean FCS was 56 (standard deviation: 5.7) and it was similar in men and women. FCS was inversely correlated with age (r = -0.06, p = 0.03). In multiple linear regression models, FCS was inversely associated with CRP (-0.03, 0.01), TNF-a (-0.04, 0.01), amyloid A (-0.10, 0.04) and homocysteine (-0.09, 0.04) (b coefficients, standard errors, all p < 0.05) and was not associated with IL-6, fibrinogen, adiponectin, leptin, or lipids levels (all p > 0.05). Conclusions: The inverse correlations of the FCS with inflammatory markers suggest that a diet containing foods with high FCS might be protective against inflammation process. Our results support the usefulness of the FCS, but future studies should evaluate its relation to cardiovascular and other inflammation-related chronic diseases.
Language	English
Publishing date	2023-07-03
Publishing country	England
Document type	Journal Article
ZDB-ID	639358-5
ISSN	1476-5640 ; 0954-3007
ISSN (online)	1476-5640
ISSN	0954-3007
DOI	10.1038/s41430-023-01300-z
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Article ; Online: Dietary acid load is associated with waist circumference in university students with low adherence to the Mediterranean diet: The potential role of ultra-processed foods.

Detopoulou, Paraskevi / Dedes, Vassilios / Pylarinou, Ioanna / Syka, Dimitra / Tzirogiannis, Konstantinos / Panoutsopoulos, Georgios I

Clinical nutrition ESPEN

2023 Volume 56, Page(s) 43–51

Abstract: Background and aims: Dietary acid load (DAL), as expressed by potential renal acid load (PRAL) and net acid production (NEAP), is connected to cardiometabolic disorders and obesity. Mediterranean diet relates to lower, while western diets to higher DAL ... ...

Abstract	Background and aims: Dietary acid load (DAL), as expressed by potential renal acid load (PRAL) and net acid production (NEAP), is connected to cardiometabolic disorders and obesity. Mediterranean diet relates to lower, while western diets to higher DAL values. The present study aimed to assess the association of PRAL and NEAP with adiposity measures in young adults (19.61 ± 3.15 years, mean ± standard deviation) and explore the implication of Mediterranean diet adherence and ultra-processed foods (UPF) intake in this relation. Methods: 346 students (269 women) participated. Anthropometry was performed, and a food frequency questionnaire was administered. The MedDietScore was calculated, UPF consumption was calculated based on the NOVA classification and PRAL/NEAP was estimated from published equations. Waist Circumference (WC) was transformed to WC Results: In subjects with MedDietScore ≤ 28.00, PRAL and NEAP were negatively associated with 1/WC (B = -1.594 × 10-5± 8 × 10-6, p = 0.044 for PRAL and B = -2.84 × 10-5 ± 1 × 10-5, p = 0.048 for NEAP). Moreover, in this subgroup, subjects with medium to high UPF intake i.e., in the 2nd or 3rd tertile of UPF intake representing more than 34.16% of energy, PRAL (2nd tertile B = -0.00007, SE = 0.00003, p = 0.018; 3rd tertile B = -0.00002, SE = 0.00001, p = 0.024) and NEAP (2nd tertile B = -0.00004, SE = 0.00002, p = 0.040; 3rd tertile B = -0.00007, SE = 0.00004, p = 0.055) were connected to central obesity. In similar models, PRAL and NEAP were not significant predictors of BMI. Conclusion: The DAL may be related to central obesity, especially in individuals with worse dietary quality, as reflected by lower adherence to the Mediterranean diet, and high intake of UPF. Nutrition guidance aiming at the reduction of DAL may be useful in the reduction of central obesity in these subgroups.
MeSH term(s)	Young Adult ; Humans ; Female ; Diet, Mediterranean ; Food, Processed ; Obesity, Abdominal ; Waist Circumference ; Universities ; Obesity
Language	English
Publishing date	2023-05-09
Publishing country	England
Document type	Journal Article
ISSN	2405-4577
ISSN (online)	2405-4577
DOI	10.1016/j.clnesp.2023.05.005
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Article ; Online: Micronutrients, Phytochemicals and Mediterranean Diet: A Potential Protective Role against COVID-19 through Modulation of PAF Actions and Metabolism.

Detopoulou, Paraskevi / Demopoulos, Constantinos A / Antonopoulou, Smaragdi

Nutrients

2021 Volume 13, Issue 2

Abstract: The new coronavirus disease 2019 (COVID-19) pandemic is an emerging situation with high rates of morbidity and mortality, in the pathophysiology of which inflammation and thrombosis are implicated. The disease is directly connected to the nutritional ... ...

Abstract	The new coronavirus disease 2019 (COVID-19) pandemic is an emerging situation with high rates of morbidity and mortality, in the pathophysiology of which inflammation and thrombosis are implicated. The disease is directly connected to the nutritional status of patients and a well-balanced diet is recommended by official sources. Recently, the role of platelet activating factor (PAF) was suggested in the pathogenesis of COVID-19. In the present review several micronutrients (vitamin A, vitamin C, vitamin E, vitamin D, selenium, omega-3 fatty acids, and minerals), phytochemicals and Mediterranean diet compounds with potential anti-COVID activity are presented. We further underline that the well-known anti-inflammatory and anti-thrombotic actions of the investigated nutrients and/or holistic dietary schemes, such as the Mediterranean diet, are also mediated through PAF. In conclusion, there is no single food to prevent coronavirus Although the relationship between PAF and COVID-19 is not robust, a healthy diet containing PAF inhibitors may target both inflammation and thrombosis and prevent the deleterious effects of COVID-19. The next step is the experimental confirmation or not of the PAF-COVID-19 hypothesis.
MeSH term(s)	COVID-19/prevention & control ; Diet, Mediterranean ; Humans ; Micronutrients ; Phytochemicals/pharmacology ; Platelet Activating Factor/metabolism ; SARS-CoV-2
Chemical Substances	Micronutrients ; Phytochemicals ; Platelet Activating Factor
Language	English
Publishing date	2021-01-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13020462
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Article ; Online: Association of PAF and its Metabolic Enzymes with GGT and the Fatty Liver Index in Healthy Volunteers.

Detopoulou, Paraskevi / Nomikos, Tzortzis / Fragopoulou, Elizabeth / Antonopoulou, Smaragdi

Current vascular pharmacology

2021 Volume 19, Issue 6, Page(s) 663–672

Abstract: Background: Platelet-activating-factor (PAF) is a lipid inflammatory mediator implicated in liver disease. Its main biosynthetic enzymes are cytidine diphosphate (CDP)-choline: 1-alkyl-2-acetyl-sn-glycerol-cholinephosphotransferase (PAF-CPT) and acetyl- ... ...

Abstract	Background: Platelet-activating-factor (PAF) is a lipid inflammatory mediator implicated in liver disease. Its main biosynthetic enzymes are cytidine diphosphate (CDP)-choline: 1-alkyl-2-acetyl-sn-glycerol-cholinephosphotransferase (PAF-CPT) and acetyl-coenzyme A: lyso-PAF-acetyltransferases (Lyso-PAF-AT). At the same time, PAF acetylhydrolase (PAF-AH) and lipoprotein-associated phospholipase A2 (Lp-PLA Objective: To explore the relation of PAF metabolism with liver diseases and non-alcoholic fatty liver disease, as reflected by the fatty liver index (FLI). Methods: In 106 healthy volunteers, PAF concentration, the activity of its metabolic enzymes and gamma-glutamyl transferase (GGT) were measured in whole blood, leukocytes and serum, respectively and the FLI was calculated. Partial correlations and linear regression models were used. Results: In males, serum GGT activity was positively correlated with abdominal fat (as assessed by analysis of a manually defined region of interest in dual-energy X-ray absorptiometry), triacylglycerols, bound-PAF and Lp-PLA Conclusion: Bound-PAF and Lp-PLA
MeSH term(s)	Fatty Liver/enzymology ; Female ; Healthy Volunteers ; Humans ; Male ; Platelet Activating Factor/metabolism ; gamma-Glutamyltransferase/metabolism
Chemical Substances	Platelet Activating Factor ; gamma-Glutamyltransferase (EC 2.3.2.2)
Language	English
Publishing date	2021-06-29
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2192362-0
ISSN	1875-6212 ; 1570-1611
ISSN (online)	1875-6212
ISSN	1570-1611
DOI	10.2174/1570161119666210628125239
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