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  1. Article ; Online: Micronutrients and bioactive substances: Their potential roles in combating COVID-19.

    Keflie, Tibebeselassie Seyoum / Biesalski, Hans Konrad

    Nutrition (Burbank, Los Angeles County, Calif.)

    2020  Volume 84, Page(s) 111103

    Abstract: Objectives: The coronavirus disease 2019 (COVID-19) pandemic is seriously threatening public health and setting off huge economic crises across the world. In the absence of specific drugs for COVID-19, there is an urgent need to look for alternative ... ...

    Abstract Objectives: The coronavirus disease 2019 (COVID-19) pandemic is seriously threatening public health and setting off huge economic crises across the world. In the absence of specific drugs for COVID-19, there is an urgent need to look for alternative approaches. Therefore, the aim of this paper was to review the roles of micronutrients and bioactive substances as potential alternative approaches in combating COVID-19.
    Methods: This review was based on the literature identified using electronic searches in different databases.
    Results: Vitamins (A, B, C, D, and E), minerals (selenium and zinc), and bioactive substances from curcumin, echinacea, propolis, garlic, soybean, green tea, and other polyphenols were identified as having potential roles in interfering with spike glycoproteins, angiotensin converting enzyme 2, and transmembrane protease serine 2 at the entry site, and inhibiting activities of papain-like protease, 3 chymotrypsin-like protease, and RNA-dependent RNA polymerase in the replication cycle of severe acute respiratory syndrome coronavirus 2. Having immunomodulating, antiinflammatory, antioxidant, and antiviral properties, such micronutrients and bioactive substances are consequently promising alterative nutritional approaches to combat COVID-19.
    Conclusions: The roles of micronutrients and bioactive substances in the fight against COVID-19 are exciting areas of research. This review may suggest directions for further study.
    MeSH term(s) COVID-19/virology ; Humans ; Micronutrients/pharmacology ; Phytochemicals/pharmacology ; SARS-CoV-2 ; COVID-19 Drug Treatment
    Chemical Substances Micronutrients ; Phytochemicals
    Language English
    Publishing date 2020-12-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639259-3
    ISSN 1873-1244 ; 0899-9007
    ISSN (online) 1873-1244
    ISSN 0899-9007
    DOI 10.1016/j.nut.2020.111103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online ; Thesis: Nutrition and tuberculosis in Ethiopia

    Keflie, Tibebeselassie Seyoum [Verfasser] / Biesalski, Hans Konrad [Akademischer Betreuer]

    the role of vitamin D2 derived from sun exposed oyster mushroom on the treatment outcomes of tuberculosis

    2020  

    Author's details Tibebeselassie Seyoum Keflie ; Betreuer: Hans Konrad Biesalski
    Keywords Naturwissenschaften ; Science
    Subject code sg500
    Language English
    Publisher Kommunikations-, Informations- und Medienzentrum der Universität Hohenheim
    Publishing place Hohenheim
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  3. Article: Impact of the natural resource of UVB on the content of vitamin D

    Keflie, Tibebeselassie Seyoum / Nölle, Nils / Lambert, Christine / Nohr, Donatus / Biesalski, Hans Konrad

    Saudi journal of biological sciences

    2018  Volume 26, Issue 7, Page(s) 1724–1730

    Abstract: Vitamin D deficiency is a pandemic problem. Non-animal source of vitamin D is obtained from edible mushrooms. Oyster mushroom ( ...

    Abstract Vitamin D deficiency is a pandemic problem. Non-animal source of vitamin D is obtained from edible mushrooms. Oyster mushroom (
    Language English
    Publishing date 2018-08-01
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 2515206-3
    ISSN 2213-7106 ; 1319-562X
    ISSN (online) 2213-7106
    ISSN 1319-562X
    DOI 10.1016/j.sjbs.2018.07.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Microscopic examination and smear negative pulmonary tuberculosis in Ethiopia

    Tibebeselassie Seyoum Keflie / Gobena Ameni

    The Pan African Medical Journal, Vol 19, Iss

    2014  Volume 162

    Abstract: BACKGROUND: tuberculosis causes illness among millions of people each year and ranks as the second leading cause of death from infectious disease worldwide. The aim of this study was to investigate the detection rate of microscopic examination and ... ...

    Abstract BACKGROUND: tuberculosis causes illness among millions of people each year and ranks as the second leading cause of death from infectious disease worldwide. The aim of this study was to investigate the detection rate of microscopic examination and estimate risk of transmission of TB by smear negative pulmonary TB patients. METHODS: a cross-sectional study and retrospective data analysis on TB were undertaken in Northwest Shewa, Ethiopia. Microscopic examination, bacterial culture and PCR were performed. The statistical analysis was made by using STATA software version 10. RESULTS: a total of 92 suspected TB cases was included in the study. Of these, 27.17% (25/92) were positive for microscopic examination and 51% (47/92) for culture. The sensitivity and specificity of microscopic examination with 95% CI were 48.94% (34.08% to 63.93%) and 95.56% (84.82 to 99.33%), respectively. The positive and negative predictive values were 92% (73.93% to 98.78%) and 64.18% (51.53% to 75.53%), respectively. Of 8150 pulmonary TB cases in the retrospective study, 58.9% was smear negative. The proportion of TB-HIV co-infection was 28.66% (96/335). CONCLUSION: the sensitivity of microscopic examination was 48.94% which was very low. The poor sensitivity of this test together with the advent of HIV/AIDS elevated the prevalence of smear negative pulmonary TB. This in turn increased the risk of TB transmission.
    Keywords microscopic examination ; smear negative pulmonary tb ; sensitivity ; specificity ; Medicine ; R
    Subject code 610 ; 630
    Language English
    Publishing date 2014-10-01T00:00:00Z
    Publisher The Pan African Medical Journal
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Impact of the natural resource of UVB on the content of vitamin D2 in oyster mushroom (Pleurotus ostreatus) under subtropical settings

    Tibebeselassie Seyoum Keflie / Nils Nölle / Christine Lambert / Donatus Nohr / Hans Konrad Biesalski

    Saudi Journal of Biological Sciences, Vol 26, Iss 7, Pp 1724-

    2019  Volume 1730

    Abstract: Vitamin D deficiency is a pandemic problem. Non-animal source of vitamin D is obtained from edible mushrooms. Oyster mushroom (Pleurotus ostreatus) was sliced into the size of 1 cm3, 4 cm3 and 9 cm3, and treated with the sun as a natural resource of UVB ... ...

    Abstract Vitamin D deficiency is a pandemic problem. Non-animal source of vitamin D is obtained from edible mushrooms. Oyster mushroom (Pleurotus ostreatus) was sliced into the size of 1 cm3, 4 cm3 and 9 cm3, and treated with the sun as a natural resource of UVB under subtropical settings in Ethiopia. The content of vitamin D was measured by using high-performance liquid chromatography (HPLC). After sun treatment, there was a significant increment in the content of vitamin D2 from nil to 67.4 ± 28.0 µg/g dry weight (DW). Based on the results of the overall pairwise comparisons, 1 cm3 size of slice group had the highest content of vitamin D2. Duration of sun exposure, sizes of mushroom slices and moisture content were identified as determining factors for vitamin D2 synthesis. Exposing slices of oyster mushroom to the sunlight for <30 min provides the amount that satisfies the current recommended dietary allowance (RDA) of vitamin D without any visible change in color and texture. Thus, sun treatment of oyster mushroom is an effective and economically cheap strategy in the fight against vitamin D deficiency. Keywords: Sun-treatment, Vitamin D2, Oyster mushroom, Subtropics
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2019-11-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Vitamin A and zinc deficiencies among tuberculosis patients in Ethiopia.

    Keflie, Tibebeselassie Seyoum / Samuel, Aregash / Woldegiorgis, Ashagrie Zewdu / Mihret, Adane / Abebe, Markos / Biesalski, Hans Konrad

    Journal of clinical tuberculosis and other mycobacterial diseases

    2018  Volume 12, Page(s) 27–33

    Abstract: Background: The link between tuberculosis (TB) and malnutrition has long been recognized. Vitamin A and zinc deficiencies may reduce the host defenses and increase the risk for diseases.: Objective: The aim of the present study was to estimate the ... ...

    Abstract Background: The link between tuberculosis (TB) and malnutrition has long been recognized. Vitamin A and zinc deficiencies may reduce the host defenses and increase the risk for diseases.
    Objective: The aim of the present study was to estimate the difference in vitamin A and zinc deficiencies together with dietary intakes among pulmonary TB patients and controls.
    Materials and methods: A case-control study design was employed to undertake this study in North Shewa, Ethiopia. Sputum smear examination, high-performance liquid chromatography (HPLC), flame atomic absorption spectrometry (FAAS), and enzyme-linked immunosorbent assay (ELISA) were used to analyse acid fast bacilli (AFB), vitamin A, zinc, and C-reactive protein (CRP), respectively. Dietary intake was assessed using a 24-h recall questionnaire. Mann-Whitney U test, Kruskal-Wallis test, Chi-square, odds ratio (OR), Spearman correlation, and multinomial logistic regression model were computed for data analyses.
    Results: In this study, 62 TB cases and 59 controls were included. The proportions of vitamin A deficiency among TB cases and controls were 56.4% and 39.0%, respectively. All TB cases and 92.5% controls were zinc deficient. The odds of TB cases with deficiencies of vitamin A and zinc was 2.3 (95% CI: 1.1 to 4.8)times more likely as compared to the controls. More than 80% of all participants had below average fulfilment of energy and vitamin A intakes.
    Conclusion: Vitamin A and zinc deficiencies are severe problems among TB patients. Moreover, undernutrition determines the development of TB. Therefore, the management programs of TB need to address the problems of vitamin A and zinc deficiencies together with protein-energy malnutrition.
    Language English
    Publishing date 2018-06-14
    Publishing country England
    Document type Journal Article
    ISSN 2405-5794
    ISSN (online) 2405-5794
    DOI 10.1016/j.jctube.2018.05.002
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  7. Article: Vitamin D deficiencies among tuberculosis patients in Africa: A systematic review

    Keflie, Tibebeselassie Seyoum / Christine Lambert / Donatus Nohr / Hans Konrad Biesalski / Nils Nölle

    Nutrition. 2015 Oct., v. 31, no. 10

    2015  

    Abstract: The aim of this study was to explore the existence of vitamin D deficiency (VDD) in tuberculosis (TB) patients living in Africa and to identify its predictor variables. PRISMA guidelines and checklists were used. The sources of the data were Medline/ ... ...

    Abstract The aim of this study was to explore the existence of vitamin D deficiency (VDD) in tuberculosis (TB) patients living in Africa and to identify its predictor variables. PRISMA guidelines and checklists were used. The sources of the data were Medline/PubMed, Web of Science, Scopus, and Google Scholar databases. We identified 23 articles, of which 15 reported the status of vitamin D in TB with TB. The definition of serum vitamin D status was summarized as severe, deficient, and insufficient when the concentration of 25-hydroxyvitamin (OH)-D ≤25, ≤50, and ≤75 nmol/L, respectively. The reports showed that up to 88.9% and 96.3% of patients with TB tested by radioimmunoassay had VDD and vitamin D insufficiency, respectively. Statistically significant variables such as lack of sun exposure, inadequate dietary intake, season, clothing, comorbidities, low body mass index, age, skin pigmentation, use of antiretroviral therapy and anti-TB drugs, and socioeconomic status were identified as the main predictor variables of vitamin D status. VDD and vitamin D insufficiency were highly prevalent in TB patients in Africa. Further case–control studies are warranted to clarify the cause–effect relationship between vitamin D and TB and thereby, design valuable strategies to manage VDD among TB patients in Africa.
    Keywords antiretroviral agents ; blood serum ; body mass index ; case-control studies ; comorbidity ; databases ; drugs ; food intake ; guidelines ; patients ; pigmentation ; radioimmunoassays ; socioeconomic status ; systematic review ; therapeutics ; tuberculosis ; vitamin D ; vitamin D deficiency ; vitamin status ; Africa
    Language English
    Dates of publication 2015-10
    Size p. 1204-1212.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 639259-3
    ISSN 1873-1244 ; 0899-9007
    ISSN (online) 1873-1244
    ISSN 0899-9007
    DOI 10.1016/j.nut.2015.05.003
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4802: Show issues

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  8. Article ; Online: Vitamin D deficiencies among tuberculosis patients in Africa: A systematic review.

    Keflie, Tibebeselassie Seyoum / Nölle, Nils / Lambert, Christine / Nohr, Donatus / Biesalski, Hans Konrad

    Nutrition (Burbank, Los Angeles County, Calif.)

    2015  Volume 31, Issue 10, Page(s) 1204–1212

    Abstract: The aim of this study was to explore the existence of vitamin D deficiency (VDD) in tuberculosis (TB) patients living in Africa and to identify its predictor variables. PRISMA guidelines and checklists were used. The sources of the data were Medline/ ... ...

    Abstract The aim of this study was to explore the existence of vitamin D deficiency (VDD) in tuberculosis (TB) patients living in Africa and to identify its predictor variables. PRISMA guidelines and checklists were used. The sources of the data were Medline/PubMed, Web of Science, Scopus, and Google Scholar databases. We identified 23 articles, of which 15 reported the status of vitamin D in TB with TB. The definition of serum vitamin D status was summarized as severe, deficient, and insufficient when the concentration of 25-hydroxyvitamin (OH)-D ≤25, ≤50, and ≤75 nmol/L, respectively. The reports showed that up to 88.9% and 96.3% of patients with TB tested by radioimmunoassay had VDD and vitamin D insufficiency, respectively. Statistically significant variables such as lack of sun exposure, inadequate dietary intake, season, clothing, comorbidities, low body mass index, age, skin pigmentation, use of antiretroviral therapy and anti-TB drugs, and socioeconomic status were identified as the main predictor variables of vitamin D status. VDD and vitamin D insufficiency were highly prevalent in TB patients in Africa. Further case-control studies are warranted to clarify the cause-effect relationship between vitamin D and TB and thereby, design valuable strategies to manage VDD among TB patients in Africa.
    MeSH term(s) Adolescent ; Adult ; Africa/epidemiology ; Child ; Female ; Humans ; Male ; Middle Aged ; Nutritional Status ; Prevalence ; Risk Factors ; Tuberculosis, Pulmonary/blood ; Tuberculosis, Pulmonary/complications ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/epidemiology ; Young Adult
    Chemical Substances Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
    Language English
    Publishing date 2015-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 639259-3
    ISSN 1873-1244 ; 0899-9007
    ISSN (online) 1873-1244
    ISSN 0899-9007
    DOI 10.1016/j.nut.2015.05.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    ab Jg. 2022: Lesesaal (EG)

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