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  1. Article ; Online: Reconstituting the dynamic steady states of actin networks in vitro.

    Théry, Manuel / Blanchoin, Laurent

    Nature cell biology

    2024  Volume 26, Issue 4, Page(s) 494–497

    MeSH term(s) Actins ; Actin Cytoskeleton
    Chemical Substances Actins
    Language English
    Publishing date 2024-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1474722-4
    ISSN 1476-4679 ; 1465-7392
    ISSN (online) 1476-4679
    ISSN 1465-7392
    DOI 10.1038/s41556-024-01379-x
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  2. Article ; Online: Visualization and Quantification of Microtubule Self-Repair.

    Gaillard, Jérémie / Blanchoin, Laurent / Théry, Manuel / Schaedel, Laura

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2430, Page(s) 279–289

    Abstract: Since its discovery, several decades ago, microtubule dynamic instability has been the subject of countless studies that demonstrate its impact on cellular behavior in health and disease. Recent studies reveal a new dimension of microtubule dynamics. ... ...

    Abstract Since its discovery, several decades ago, microtubule dynamic instability has been the subject of countless studies that demonstrate its impact on cellular behavior in health and disease. Recent studies reveal a new dimension of microtubule dynamics. Microtubules are not only dynamic at their tips but also exhibit loss and incorporation of tubulin subunits along their lattice far from the tips. Although this phenomenon has been observed to occur under various conditions in vitro as well as in cells, many questions remain regarding the regulation of lattice dynamics and their contribution to overall microtubule network organization and function. Compared to microtubule tip dynamics, the dynamics of tubulin incorporation along the lattice are more challenging to investigate as they are hidden in classical experimental setups, which is likely the reason they were overlooked for a long time. In this chapter, we present a strategy to visualize and quantify the incorporation of tubulin subunits into the microtubule lattice in vitro. The proposed method does not require specialized equipment and can thus be carried out readily in most research laboratories.
    MeSH term(s) Microtubules/metabolism ; Tubulin/metabolism
    Chemical Substances Tubulin
    Language English
    Publishing date 2022-04-27
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1983-4_18
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  3. Article ; Online: Microtubule self-repair.

    Théry, Manuel / Blanchoin, Laurent

    Current opinion in cell biology

    2020  Volume 68, Page(s) 144–154

    Abstract: The stochastic switching between microtubule growth and shrinkage is a fascinating and unique process in the regulation of the cytoskeleton. To understand it, almost all attention has been focused on the microtubule ends. However, recent research has ... ...

    Abstract The stochastic switching between microtubule growth and shrinkage is a fascinating and unique process in the regulation of the cytoskeleton. To understand it, almost all attention has been focused on the microtubule ends. However, recent research has revived the idea that tubulin dimers can also be exchanged in protofilaments along the microtubule shaft, thus repairing the microtubule and protecting it from disassembly. Here, we review the research describing this phenomenon, the mechanisms regulating the removal and insertion of tubulin dimers, as well as the potential implications for key functions of the microtubule network, such as intracellular transport and cell polarization.
    MeSH term(s) Animals ; Biomechanical Phenomena ; Cell Physiological Phenomena ; Cytoskeleton/chemistry ; Cytoskeleton/physiology ; Humans ; Microtubules/chemistry ; Microtubules/physiology ; Tubulin/chemistry ; Tubulin/physiology
    Chemical Substances Tubulin
    Language English
    Publishing date 2020-11-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1026381-0
    ISSN 1879-0410 ; 0955-0674
    ISSN (online) 1879-0410
    ISSN 0955-0674
    DOI 10.1016/j.ceb.2020.10.012
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  4. Article ; Online: Working in the real and the imaginary.

    Théry, Manuel

    Molecular biology of the cell

    2014  Volume 25, Issue 21, Page(s) 3248–3250

    Abstract: The science we practice is shaped by our interactions with people; the enthusiastic teachers, the fascinating mentors, the inspiring colleagues, and the inquisitive students. The science we enjoy takes us into areas we couldn't have anticipated. From ... ...

    Abstract The science we practice is shaped by our interactions with people; the enthusiastic teachers, the fascinating mentors, the inspiring colleagues, and the inquisitive students. The science we enjoy takes us into areas we couldn't have anticipated. From time to time, we come back to reality and try to find ways to share our new explorations with our friends and relatives and to convert our insights into collective progress. What could be a better job?
    MeSH term(s) Cell Biology/instrumentation ; Cell Biology/trends ; Cytological Techniques ; Research Design ; Research Personnel
    Language English
    Publishing date 2014-10-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1098979-1
    ISSN 1939-4586 ; 1059-1524
    ISSN (online) 1939-4586
    ISSN 1059-1524
    DOI 10.1091/mbc.E14-05-1021
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  5. Article ; Online: Actin-microtubule dynamic composite forms responsive active matter with memory.

    Kučera, Ondřej / Gaillard, Jérémie / Guérin, Christophe / Théry, Manuel / Blanchoin, Laurent

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 31, Page(s) e2209522119

    Abstract: Active cytoskeletal materials in vitro demonstrate self-organizing properties similar to those observed in their counterparts in cells. However, the search to emulate phenomena observed in living matter has fallen short of producing a cytoskeletal ... ...

    Abstract Active cytoskeletal materials in vitro demonstrate self-organizing properties similar to those observed in their counterparts in cells. However, the search to emulate phenomena observed in living matter has fallen short of producing a cytoskeletal network that would be structurally stable yet possess adaptive plasticity. Here, we address this challenge by combining cytoskeletal polymers in a composite where self-assembling microtubules and actin filaments collectively self-organize due to the activity of microtubule-percolating molecular motors. We demonstrate that microtubules spatially organize actin filaments that in turn guide microtubules. The two networks align in an ordered fashion using this feedback loop. In this composite, actin filaments can act as structural memory and, depending on the concentration of the components, microtubules either write this memory or get guided by it. The system is sensitive to external stimuli, suggesting possible autoregulatory behavior in changing mechanochemical environments. We thus establish an artificial active actin-microtubule composite as a system demonstrating architectural stability and plasticity.
    MeSH term(s) Actin Cytoskeleton/chemistry ; Actin Cytoskeleton/metabolism ; Actins/chemistry ; Actins/metabolism ; Microtubules/metabolism ; Protein Stability
    Chemical Substances Actins
    Language English
    Publishing date 2022-07-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2209522119
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  6. Article ; Online: Cellular stretch reveals superelastic powers.

    Théry, Manuel / Asnacios, Atef

    Nature

    2018  Volume 563, Issue 7730, Page(s) 192–194

    MeSH term(s) Elasticity ; Epithelium ; Histone Deacetylase Inhibitors
    Chemical Substances Histone Deacetylase Inhibitors
    Language English
    Publishing date 2018-10-29
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-018-07172-9
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    Zs.MO 244: Show issues

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  7. Article ; Online: Editorial overview: Cell architecture: Integrating physics and chemistry in emergent cellular properties.

    Ivaska, Johanna / Théry, Manuel

    Current opinion in cell biology

    2018  Volume 56, Page(s) iii–iv

    Language English
    Publishing date 2018-12-21
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1026381-0
    ISSN 1879-0410 ; 0955-0674
    ISSN (online) 1879-0410
    ISSN 0955-0674
    DOI 10.1016/j.ceb.2018.12.003
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  8. Article ; Online: Golgi mechanics controls lipid metabolism.

    Théry, Manuel / Pende, Mario

    Nature cell biology

    2018  Volume 21, Issue 3, Page(s) 301–302

    MeSH term(s) Cues ; Extracellular Matrix ; Golgi Apparatus ; Lipid Metabolism ; Organic Chemicals ; Sterol Regulatory Element Binding Protein 1
    Chemical Substances Organic Chemicals ; Sterol Regulatory Element Binding Protein 1 ; lipine
    Language English
    Publishing date 2018-11-25
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1474722-4
    ISSN 1476-4679 ; 1465-7392
    ISSN (online) 1476-4679
    ISSN 1465-7392
    DOI 10.1038/s41556-019-0289-2
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  9. Article ; Online: A new perspective on microtubule dynamics: destruction by molecular motors and self-repair.

    Triclin, Sarah / Inoue, Daisuke / Gaillard, Jérémie / Blanchoin, Laurent / Théry, Manuel

    Comptes rendus biologies

    2021  Volume 344, Issue 3, Page(s) 297–310

    Abstract: Microtubules are dynamic polymers, permanently assembling and disassembling, that serve as tracks for intra-cellular transport by molecular motors. We recently found that the low energy of tubulin dimer interactions allows for spontaneous loss of tubulin ...

    Abstract Microtubules are dynamic polymers, permanently assembling and disassembling, that serve as tracks for intra-cellular transport by molecular motors. We recently found that the low energy of tubulin dimer interactions allows for spontaneous loss of tubulin dimers from the microtubule lattice [1]. This raised the possibility that the mechanical work produced by molecular motors as they move on microtubules can break dimer interactions and trigger microtubule disassembly. In a recent study, we tested this hypothesis by studying the interplay between microtubules and moving molecular motors in vitro [2]. Our results show that molecular motors can remove tubulin dimers from the lattice and rapidly destroy microtubules. We also found that dimer removal by motors was compensated by the insertion of free tubulin dimers into the microtubule lattice. This self-repair mechanism allows microtubules to survive the damage induced by molecular motors as they move along their tracks. Our study reveals the existence of coupling between the motion of molecular motors and the renewal of the microtubule lattice.
    MeSH term(s) Microtubules ; Tubulin
    Chemical Substances Tubulin
    Language English
    Publishing date 2021-11-15
    Publishing country France
    Document type Journal Article
    ZDB-ID 2072863-3
    ISSN 1768-3238 ; 1631-0691
    ISSN (online) 1768-3238
    ISSN 1631-0691
    DOI 10.5802/crbiol.59
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  10. Article ; Online: Actin Architecture Steers Microtubules in Active Cytoskeletal Composite.

    Kučera, Ondřej / Gaillard, Jérémie / Guérin, Christophe / Utzschneider, Clothilde / Théry, Manuel / Blanchoin, Laurent

    Nano letters

    2022  Volume 22, Issue 21, Page(s) 8584–8591

    Abstract: Motility assays use surface-immobilized molecular motors to propel cytoskeletal filaments. They have been widely used to characterize motor properties and their impact on cytoskeletal self-organization. Moreover, the motility assays are a promising class ...

    Abstract Motility assays use surface-immobilized molecular motors to propel cytoskeletal filaments. They have been widely used to characterize motor properties and their impact on cytoskeletal self-organization. Moreover, the motility assays are a promising class of bioinspired active tools for nanotechnological applications. While these assays involve controlling the filament direction and speed, either as a sensory readout or a functional feature, designing a subtle control embedded in the assay is an ongoing challenge. Here, we investigate the interaction between gliding microtubules and networks of actin filaments. We demonstrate that the microtubule's behavior depends on the actin architecture. Both unbranched and branched actin decelerate microtubule gliding; however, an unbranched actin network provides additional guidance and effectively steers the microtubules. This effect, which resembles the recognition of cortical actin by microtubules, is a conceptually new means of controlling the filament gliding with potential application in the design of active materials and cytoskeletal nanodevices.
    MeSH term(s) Actins ; Microtubules ; Cytoskeleton ; Actin Cytoskeleton ; Nanotechnology
    Chemical Substances Actins
    Language English
    Publishing date 2022-10-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.2c03117
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