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  1. Article ; Online: Occlusive Cytomegalovirus Panuveitis following Intravitreal Dexamethasone Implant.

    Kim, Hyun Jun / Brill, Daniel / Giuliari, Gian Paolo

    Retinal cases & brief reports

    2023  

    Abstract: Purpose: To report a case of unilateral cytomegalovirus (CMV) panuveitis with occlusive vasculitis following injection of intravitreal dexamethasone implant in a patient with type 2 diabetes mellitus.: Methods: Observational case report.: Results: ...

    Abstract Purpose: To report a case of unilateral cytomegalovirus (CMV) panuveitis with occlusive vasculitis following injection of intravitreal dexamethasone implant in a patient with type 2 diabetes mellitus.
    Methods: Observational case report.
    Results: A 60-year-old immunocompetent male with well-controlled type 2 diabetes mellitus was treated with intravitreal dexamethasone implant for recurrent uveitis that was responsive to steroids. 3 months after implantation, patient develops panuveitis with occlusive vasculitis. Anterior chamber tap confirms diagnosis of cytomegalovirus retinitis. Intravitreal foscarnet and oral valganciclovir led to quiescent disease.
    Conclusions: Patients treated with local immunosuppressants should be monitored carefully to assess treatment response and complications, even in the absence of frank immunodeficiency. Quantitative viral PCR can be an effective way to monitor treatment response to antiviral therapy.
    Language English
    Publishing date 2023-01-31
    Publishing country United States
    Document type Journal Article
    ISSN 1937-1578
    ISSN (online) 1937-1578
    DOI 10.1097/ICB.0000000000001407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation.

    Stoffer, John N / Slingsby, Taylor J / Giuliari, Gian Paolo

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2021  Volume 57, Issue 1, Page(s) e21–e22

    MeSH term(s) Angiogenesis Inhibitors/adverse effects ; Bevacizumab/adverse effects ; Endophthalmitis/diagnosis ; Endophthalmitis/drug therapy ; Endophthalmitis/etiology ; Eye Infections, Bacterial/diagnosis ; Eye Infections, Bacterial/drug therapy ; Eye Infections, Bacterial/etiology ; Humans ; Intravitreal Injections ; Lactobacillus acidophilus ; Lenses, Intraocular ; Retrospective Studies
    Chemical Substances Angiogenesis Inhibitors ; Bevacizumab (2S9ZZM9Q9V)
    Language English
    Publishing date 2021-06-27
    Publishing country England
    Document type Letter
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.1016/j.jcjo.2021.06.002
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    Zs.A 588: Show issues Location:
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  3. Article ; Online: Migratory orbital inflammation in rheumatoid arthritis.

    Sorab, Priya / Hura, Arjan S / Ortiz, Alexander / Giuliari, Gian Paolo

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2021  Volume 57, Issue 4, Page(s) e145–e146

    MeSH term(s) Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/diagnosis ; Humans ; Inflammation
    Language English
    Publishing date 2021-12-23
    Publishing country England
    Document type Letter
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.1016/j.jcjo.2021.11.012
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  4. Article ; Online: Proliferative vitreoretinopathy: current and emerging treatments.

    Sadaka, Ama / Giuliari, Gian Paolo

    Clinical ophthalmology (Auckland, N.Z.)

    2012  Volume 6, Page(s) 1325–1333

    Abstract: Proliferative vitreoretinopathy is a disease process that follows the proliferation of ectopic cell sheets in the vitreous and/or periretinal area, causing periretinal membrane formation and traction, in patients with rhegmatogenous retinal detachments. ... ...

    Abstract Proliferative vitreoretinopathy is a disease process that follows the proliferation of ectopic cell sheets in the vitreous and/or periretinal area, causing periretinal membrane formation and traction, in patients with rhegmatogenous retinal detachments. Currently, vitreous surgery is the standard treatment; however, the results aren't satisfactory given the vision loss that ensues and that redetachment is relatively common. It is becoming clearer that there exists an interplay between various cytokines/growth factors, matrix proteins, and the different cell types that drive the undesirable formation of periretinal membranes. This fundamental understanding is aiding in identifying different adjunct agents that can block the cellular events intrinsic to proliferative vitreoretinopathy. In this review, we describe the current understanding on the pathogenesis and discuss how the fundamental understanding of the biochemical/molecular events is instrumental in developing the novel treatment strategies that are also highlighted.
    Language English
    Publishing date 2012-08-14
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2415713-2
    ISSN 1177-5483 ; 1177-5483
    ISSN (online) 1177-5483
    ISSN 1177-5483
    DOI 10.2147/OPTH.S27896
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  5. Article ; Online: Uveal metastatic disease: current and new treatment options (review).

    Giuliari, Gian Paolo / Sadaka, Ama

    Oncology reports

    2012  Volume 27, Issue 3, Page(s) 603–607

    Abstract: Choroidal metastasis represents the most common form of intraocular malignancies. It may occur in up to 10% of patients with systemic metastasis with almost half of the patients developing central nervous system disease. The most common primary sites of ... ...

    Abstract Choroidal metastasis represents the most common form of intraocular malignancies. It may occur in up to 10% of patients with systemic metastasis with almost half of the patients developing central nervous system disease. The most common primary sites of ocular metastasis are breast cancer in women and lung cancer in men. In most cases, these lesions tend to be asymptomatic and are not evaluated by an ophthalmologist. The diagnosis is generally made by the history of present or prior malignancies and an ophthalmological examination with slit-lamp biomicroscopy and indirect ophthalmoscopy. As with other malignancies, management may vary with each patient. Small tumors, that do not compromise the vision and that have responded previously to systemic treatment, may be closely observed. For larger lesions and for symptomatic ones, external beam radiation offers an excellent alternative to save the eye and stabilize vision. Bevacizumab (Avastin), a potent monoclonal antibody that has also been employed for the treatment of ocular vaso-proliferative diseases, has been used in the treatment of choroidal metastasis and has shown promising results.
    MeSH term(s) Humans ; Uveal Neoplasms/secondary ; Uveal Neoplasms/therapy
    Language English
    Publishing date 2012-03
    Publishing country Greece
    Document type Journal Article ; Review
    ZDB-ID 1222484-4
    ISSN 1791-2431 ; 1021-335X
    ISSN (online) 1791-2431
    ISSN 1021-335X
    DOI 10.3892/or.2011.1563
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  6. Article ; Online: Images in clinical medicine. Intravitreal triamcinolone for diabetic macular edema.

    Giuliari, GianPaolo

    The New England journal of medicine

    2010  Volume 363, Issue 24, Page(s) 2351

    MeSH term(s) Crystallization ; Diabetic Retinopathy/drug therapy ; Diabetic Retinopathy/pathology ; Glucocorticoids/therapeutic use ; Humans ; Macular Edema/drug therapy ; Macular Edema/pathology ; Male ; Middle Aged ; Retina/pathology ; Tomography, Optical Coherence ; Triamcinolone/therapeutic use
    Chemical Substances Glucocorticoids ; Triamcinolone (1ZK20VI6TY)
    Language English
    Publishing date 2010-12-09
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMicm1003140
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    Ua VI Zs.34: Show issues Location:
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  7. Article ; Online: Biologic agents in experimental autoimmune uveitis.

    Giuliari, Gian Paolo / Sadaka, Ama / Hinkle, David M

    International ophthalmology

    2013  Volume 34, Issue 1, Page(s) 145–156

    Abstract: Experimental uveitis models were developed in an effort to elucidate the pathogenesis of human uveitis. The therapeutic effects of numerous anti-inflammatory agents including corticosteroids and immunomodulatory agents including biologic response ... ...

    Abstract Experimental uveitis models were developed in an effort to elucidate the pathogenesis of human uveitis. The therapeutic effects of numerous anti-inflammatory agents including corticosteroids and immunomodulatory agents including biologic response modifiers have been investigated in both experimental and human uveitis. Monoclonal antibodies to tumor necrosis factor alpha and anti-interleukins, among others, demonstrate efficacy and are employed in the treatment of uveitis refractory to conventional immunomodulatory agents.
    MeSH term(s) Animals ; Antibodies, Monoclonal/therapeutic use ; Autoimmune Diseases/drug therapy ; Biological Factors/therapeutic use ; Disease Models, Animal ; Humans ; Immunoconjugates/therapeutic use ; Immunosuppressive Agents/therapeutic use ; Immunotherapy ; Interleukins/immunology ; Models, Biological ; Molecular Targeted Therapy/methods ; Tumor Necrosis Factor-alpha/immunology ; Uveitis/drug therapy ; Uveitis/immunology
    Chemical Substances Antibodies, Monoclonal ; Biological Factors ; Immunoconjugates ; Immunosuppressive Agents ; Interleukins ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2013-03-14
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 800087-6
    ISSN 1573-2630 ; 0165-5701
    ISSN (online) 1573-2630
    ISSN 0165-5701
    DOI 10.1007/s10792-013-9756-0
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    Zs.A 1479: Show issues Location:
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  8. Article ; Online: Amelanotic choroidal melanoma.

    Giuliari, Gian Paolo / Connor, Allan / Simpson, E Rand

    Lancet (London, England)

    2011  Volume 377, Issue 9768, Page(s) 848

    MeSH term(s) Adult ; Choroid Neoplasms/diagnosis ; Female ; Fluorescein Angiography ; Humans ; Melanoma/diagnosis ; Ophthalmoscopy ; Uveal Neoplasms/diagnosis
    Language English
    Publishing date 2011-03-05
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(10)60815-X
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    Zs.MG 94: Show issues

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  9. Article: The new face of age-related macular degeneration.

    Giuliari, Gian Paolo / Ciardella, Antonio P

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2007  Volume 42, Issue 4, Page(s) 629–630

    MeSH term(s) Angiogenesis Inhibitors/therapeutic use ; Choroidal Neovascularization/drug therapy ; Choroidal Neovascularization/etiology ; Humans ; Macular Degeneration/complications ; Macular Degeneration/drug therapy ; Vascular Endothelial Growth Factor A/antagonists & inhibitors
    Chemical Substances Angiogenesis Inhibitors ; VEGFA protein, human ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2007-08
    Publishing country England
    Document type Letter
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.3129/can j ophthalmol.i07-086
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  10. Article: Acute myeloid leukemia presenting as unilateral proptosis.

    Giuliari, Gian Paolo / Cortez, María Angélica

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2007  Volume 42, Issue 1, Page(s) 150–151

    MeSH term(s) Acute Disease ; Child ; Exophthalmos/diagnostic imaging ; Exophthalmos/etiology ; Exophthalmos/pathology ; Fatal Outcome ; Humans ; Leukemia, Myeloid/complications ; Leukemia, Myeloid/diagnostic imaging ; Leukemia, Myeloid/pathology ; Leukemic Infiltration ; Male ; Tomography, X-Ray Computed
    Language English
    Publishing date 2007-02
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.3129/can j ophthalmol.06-113
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