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  1. Article ; Online: The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets.

    El, Kimberley / Douros, Jonathan D / Willard, Francis S / Novikoff, Aaron / Sargsyan, Ashot / Perez-Tilve, Diego / Wainscott, David B / Yang, Bin / Chen, Alex / Wothe, Donald / Coupland, Callum / Tschöp, Mattias H / Finan, Brian / D'Alessio, David A / Sloop, Kyle W / Müller, Timo D / Campbell, Jonathan E

    Nature metabolism

    2023  Volume 5, Issue 6, Page(s) 945–954

    Abstract: The incretins glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) mediate insulin responses that are proportionate to nutrient intake to facilitate glucose ... ...

    Abstract The incretins glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) mediate insulin responses that are proportionate to nutrient intake to facilitate glucose tolerance
    MeSH term(s) Gastric Inhibitory Polypeptide/pharmacology ; Humans ; Animals ; Mice ; Glucagon-Like Peptide Receptors/agonists ; Islets of Langerhans/drug effects ; Incretins/pharmacology ; Insulin/metabolism ; Hypoglycemic Agents/pharmacology ; Cells, Cultured
    Chemical Substances tirzepatide (OYN3CCI6QE) ; Gastric Inhibitory Polypeptide (59392-49-3) ; Glucagon-Like Peptide Receptors ; Incretins ; Insulin ; Hypoglycemic Agents
    Language English
    Publishing date 2023-06-05
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-023-00811-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Distinguishing substrate-specific phosphatases.

    NOVIKOFF, A B

    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

    2003  Volume 6, Issue 4, Page(s) 251–254

    MeSH term(s) Phosphoric Monoester Hydrolases/analysis
    Chemical Substances Phosphoric Monoester Hydrolases (EC 3.1.3.2)
    Language English
    Publishing date 2003-05-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218208-7
    ISSN 1551-5044 ; 0022-1554
    ISSN (online) 1551-5044
    ISSN 0022-1554
    DOI 10.1177/6.4.251
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  3. Article: The validity of histochemical phosphatase methods on the intracellular level.

    NOVIKOFF, A B

    Science (New York, N.Y.)

    2003  Volume 113, Issue 2934, Page(s) 320–325

    MeSH term(s) Biochemical Phenomena ; Cells ; Cytoplasm ; Diploidy ; Phosphoric Monoester Hydrolases
    Chemical Substances Phosphoric Monoester Hydrolases (EC 3.1.3.2)
    Language English
    Publishing date 2003-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.113.2934.320
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  4. Article: Electron microscopy: cytology of cell fractions.

    NOVIKOFF, A B

    Science (New York, N.Y.)

    2003  Volume 124, Issue 3229, Page(s) 969–972

    Abstract: ... The authors confirm the finding of Rouiller (18) and Novikoff et al. (7) of the dense bodies adjacent ...

    Abstract It should be evident from this brief account that electron microscopy of thin sections is an invaluable asset in the study of fractions isolated by differential centrifugation. I have tried to indicate how the integrity of particles, purity of fractions, and the existence of new particles can be established through its use. I have also suggested the desirability of a common terminology for all cytology -classic, electron-microscopic, and biochemical. Some have expressed the opinion that neutral terms such as alpha, beta, and gamma membranes (59) are more useful than ergastoplasm, Golgi apparatus, and so forth. As helpful as such neutral terms may be in describing intracellular structures, they do not appear to me to substitute for historically rooted cytological names. Note added in proof: Since this article went to press there has appeared an important article by G. E. Palade and P. Siekevitz (60). These authors consider that the vesicles without granules found in the microsome fraction were "probably derived from the smooth surfaced parts of the endoplasmic reticulum." The latter were found to be continuous with the granule-studded membranes; "the two varieties of profiles represent local differentiation within a common system." The authors confirm the finding of Rouiller (18) and Novikoff et al. (7) of the dense bodies adjacent to the bile canaliculi and describe their presence in the microsome fraction as a "minor component."
    MeSH term(s) Animals ; Cell Differentiation ; Cells ; Cytoplasm ; Electrons ; Endoplasmic Reticulum ; Golgi Apparatus ; Microscopy ; Microscopy, Electron
    Language English
    Publishing date 2003-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.124.3229.969
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  5. Article ; Online: TRPM7 kinase is required for insulin production and compensatory islet responses during obesity.

    Khajavi, Noushafarin / Beck, Andreas / Riçku, Klea / Beyerle, Philipp / Jacob, Katharina / Syamsul, Sabrina F / Belkacemi, Anouar / Reinach, Peter S / Schreier, Pascale Cf / Salah, Houssein / Popp, Tanja / Novikoff, Aaron / Breit, Andreas / Chubanov, Vladimir / Müller, Timo D / Zierler, Susanna / Gudermann, Thomas

    JCI insight

    2023  Volume 8, Issue 3

    Abstract: ... compensatory β cell responses because of mitigated protein kinase B (AKT)/ERK signaling. Collectively, our data ...

    Abstract Most overweight individuals do not develop diabetes due to compensatory islet responses to restore glucose homeostasis. Therefore, regulatory pathways that promote β cell compensation are potential targets for treatment of diabetes. The transient receptor potential cation channel subfamily M member 7 protein (TRPM7), harboring a cation channel and a serine/threonine kinase, has been implicated in controlling cell growth and proliferation. Here, we report that selective deletion of Trpm7 in β cells disrupted insulin secretion and led to progressive glucose intolerance. We indicate that the diminished insulinotropic response in β cell-specific Trpm7-knockout mice was caused by decreased insulin production because of impaired enzymatic activity of this protein. Accordingly, high-fat-fed mice with a genetic loss of TRPM7 kinase activity displayed a marked glucose intolerance accompanied by hyperglycemia. These detrimental glucoregulatory effects were engendered by reduced compensatory β cell responses because of mitigated protein kinase B (AKT)/ERK signaling. Collectively, our data identify TRPM7 kinase as a potentially novel regulator of insulin synthesis, β cell dynamics, and glucose homeostasis under obesogenic diet.
    MeSH term(s) Animals ; Mice ; Glucose ; Glucose Intolerance ; Insulin/metabolism ; Mice, Knockout ; Obesity ; Protein Serine-Threonine Kinases/metabolism ; TRPM Cation Channels/genetics ; TRPM Cation Channels/metabolism
    Chemical Substances Glucose (IY9XDZ35W2) ; Insulin ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; TRPM Cation Channels ; Trpm7 protein, mouse (EC 2.7.1.-)
    Language English
    Publishing date 2023-02-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.163397
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  6. Article: THE EXISTENCE OF A CYTOSTOME AND THE OCCURRENCE OF PINOCYTOSIS IN THE TRYPANOSOME, TRYPANOSOMA MEGA.

    Steinert, M / Novikoff, A B

    The Journal of biophysical and biochemical cytology

    2009  Volume 8, Issue 2, Page(s) 563–569

    Language English
    Publishing date 2009-10-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218153-8
    ISSN 0095-9901
    ISSN 0095-9901
    DOI 10.1083/jcb.8.2.563
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  7. Article: CYTOLOGICAL STUDIES ON TWO FUNCTIONAL HEPATOMAS : Interrelations of Endoplasmic Reticulum, Golgi Apparatus, and Lysosomes.

    Essner, E / Novikoff, A B

    The Journal of cell biology

    2009  Volume 15, Issue 2, Page(s) 289–312

    Abstract: The Reuber hepatoma H-35 and Morris hepatoma 5123 have been studied by electron microscopy and by cytochemical staining methods for a number of phosphatases. These studies emphasize the resemblances of the two tumors to rat liver, but they also indicate ... ...

    Abstract The Reuber hepatoma H-35 and Morris hepatoma 5123 have been studied by electron microscopy and by cytochemical staining methods for a number of phosphatases. These studies emphasize the resemblances of the two tumors to rat liver, but they also indicate distinctive features in each of the three tissues. Secretory product accumulates within the cisternae of the Golgi apparatus that dilate to form the Golgi vacuoles. The vacuoles apparently separate, and secretory material undergoes further condensation within them. These "secretory vacuoles" possess acid phosphatase activity and may thus be considered lysosomes. The membranes of the Golgi apparatus are without acid phosphatase activity but show high levels of thiaminepyrophosphatase activity. The endoplasmic reticulum also hydrolyzes thiaminepyrophosphate but at a lower rate; it hydrolyzes the diphosphates of uridine, guanosine, and inosine rapidly. These observations and the electron microscopic images are consistent with the view that the cytomembranes are in a dynamic state of flux, movement, and transformation in the living cell, and that smooth surfaced derivatives of the endoplasmic reticulum become refashioned into the Golgi membranes as the Golgi membranes are being refashioned into those that delimit secretory vacuoles. The variations encountered in the two hepatomas are described. The electron microscope literature dealing with the relations of the Golgi apparatus to secretory granules, on the one hand, and the endoplasmic reticulum, on the other, is reviewed briefly.
    Language English
    Publishing date 2009-10-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.15.2.289
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  8. Article: The proximal tubule cell in experimental hydronephrosis.

    NOVIKOFF, A B

    The Journal of biophysical and biochemical cytology

    2000  Volume 6, Issue 1, Page(s) 136–138

    MeSH term(s) Humans ; Hydronephrosis ; Kidney Tubules, Proximal
    Language English
    Publishing date 2000-12-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218153-8
    ISSN 0095-9901
    ISSN 0095-9901
    DOI 10.1083/jcb.6.1.136
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  9. Article: Biochemical studies on regenerating liver.

    NOVIKOFF, A B / POTTER, V R

    The Journal of biological chemistry

    2008  Volume 173, Issue 1, Page(s) 223–232

    MeSH term(s) Humans ; Liver Diseases ; Liver Regeneration
    Language English
    Publishing date 2008-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
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  10. Article: Preservation of the fine structure of isolated liver cell particulates with polyvinylpyrrollidone-sucrose.

    NOVIKOFF, A B

    The Journal of biophysical and biochemical cytology

    2000  Volume 2, Issue 4 Suppl, Page(s) 65–66

    MeSH term(s) Hepatocytes ; Histological Techniques ; Liver/anatomy & histology ; Povidone ; Preservation, Biological ; Sucrose/pharmacology
    Chemical Substances Sucrose (57-50-1) ; Povidone (FZ989GH94E)
    Language English
    Publishing date 2000-12-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218153-8
    ISSN 0095-9901
    ISSN 0095-9901
    DOI 10.1083/jcb.2.4.65
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