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  1. Article ; Online: Running Variability in Marathon-Evaluation of the Pacing Variables.

    Cuk, Ivan / Markovic, Srdjan / Weiss, Katja / Knechtle, Beat

    Medicina (Kaunas, Lithuania)

    2024  Volume 60, Issue 2

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Male ; Humans ; Female ; Middle Aged ; Physical Endurance ; Marathon Running ; Reproducibility of Results ; Running ; Time Factors ; Athletic Performance
    Language English
    Publishing date 2024-01-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina60020218
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
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  2. Article: A New Method for Pore Pressure Prediction on Malfunctioning Cells Using Artificial Neural Networks

    Markovic, Milica / Brankovic, Jelena Markovic / Stosovic, Miona Andrejevic / Zivkovic, Srdjan / Brankovic, Bojan

    Water resources management. 2021 Feb., v. 35, no. 3

    2021  

    Abstract: Embankment rockfill dams are the most common dam construction types used in the world today. One third of all embankment dam failures are caused by dam slope instability. The dam is stable when the slopes are stable. Slope safety of the dam is assessed ... ...

    Abstract Embankment rockfill dams are the most common dam construction types used in the world today. One third of all embankment dam failures are caused by dam slope instability. The dam is stable when the slopes are stable. Slope safety of the dam is assessed through pore and total pressure data analysis registered on pressure measurement cells installed in the dam. During the service life of a dam, one or more cells may malfunction after years of operation. Cell replacement implies economically unjustified high costs and is usually technically impossible and high risk. In this paper, the problem of a malfunctioning cell with a small available dataset is analysed. A new method for pore pressure prediction on malfunctioning cells has been developed using several successive artificial neural networks (ANNs) to obtain high accuracy of the predicted values. The results show that these predicted values are more precise than values we could have obtained using only one artificial neural network for prediction.
    Keywords administrative management ; data collection ; durability ; neural networks ; prediction ; risk ; water
    Language English
    Dates of publication 2021-02
    Size p. 979-992.
    Publishing place Springer Netherlands
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 59924-4
    ISSN 1573-1650 ; 0920-4741
    ISSN (online) 1573-1650
    ISSN 0920-4741
    DOI 10.1007/s11269-021-02763-0
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 6155: Show issues

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  3. Article: Infliximab Rescue in Acute Severe Ulcerative Colitis Complicated by Clostridium Difficile Infection: A Case Series.

    Markovic, Srdjan / Jankovic, Marijana / Kalaba, Ana / Zogovic, Branimir / Sreckovic, Slobodan S

    Cureus

    2021  Volume 13, Issue 10, Page(s) e19019

    Abstract: Relapses in inflammatory bowel disease (IBD) complicated ... ...

    Abstract Relapses in inflammatory bowel disease (IBD) complicated by
    Language English
    Publishing date 2021-10-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.19019
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  4. Article ; Online: The Effect of COVID-19 Resurgence on Morbidity and Mortality in Patients With IBD on Biologic Therapy.

    Markovic, Srdjan / Ivanovski, Tamara Knezevic / Zogovic, Branimir / Kalaba, Ana / Zaric, Dusan / Svorcan, Petar

    Inflammatory bowel diseases

    2021  Volume 27, Issue 8, Page(s) e90

    MeSH term(s) Biological Therapy ; COVID-19 ; Humans ; Inflammatory Bowel Diseases/drug therapy ; Morbidity ; SARS-CoV-2
    Language English
    Publishing date 2021-03-10
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1340971-2
    ISSN 1536-4844 ; 1078-0998
    ISSN (online) 1536-4844
    ISSN 1078-0998
    DOI 10.1093/ibd/izab048
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4530: Show issues Location:
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  5. Article ; Online: Structural Transitions of Papain-like Cysteine Proteases: Implications for Sensor Development.

    Marković, Srdjan / Andrejević, Natalija S / Milošević, Jelica / Polović, Natalija Đ

    Biomimetics (Basel, Switzerland)

    2023  Volume 8, Issue 3

    Abstract: The significant role of papain-like cysteine proteases, including papain, cathepsin L and SARS-CoV-2 PLpro, in biomedicine and biotechnology makes them interesting model systems for sensor development. These enzymes have a free thiol group that is ... ...

    Abstract The significant role of papain-like cysteine proteases, including papain, cathepsin L and SARS-CoV-2 PLpro, in biomedicine and biotechnology makes them interesting model systems for sensor development. These enzymes have a free thiol group that is suitable for many sensor designs including strong binding to gold nanoparticles or low-molecular-weight inhibitors. Focusing on the importance of the preservation of native protein structure for inhibitor-binding and molecular-imprinting, which has been applied in some efficient examples of sensor development, the aim of this work was to examine the effects of the free-thiol-group's reversible blocking on papain denaturation that is the basis of its activity loss and aggregation. To utilize biophysical methods common in protein structural transitions characterization, such as fluorimetry and high-resolution infrared spectroscopy, low-molecular-weight electrophilic thiol blocking reagent S-Methyl methanethiosulfonate (MMTS) was used in solution. MMTS binding led to a two-fold increase in 8-Anilinonaphthalene-1-sulfonic acid fluorescence, indicating increased hydrophobic residue exposure. A more in-depth analysis showed significant transitions on the secondary structure level upon MMTS binding, mostly characterized by the lowered content of α-helices and unordered structures (either for approximately one third), and the increase in aggregation-specific β-sheets (from 25 to 52%) in a dose-dependant manner. The recovery of this inhibited protein showed that reversibility of inhibition is accompanied by reversibility of protein denaturation. Nevertheless, a 100-fold molar excess of the inhibitor led to the incomplete recovery of proteolytic activity, which can be explained by irreversible denaturation. The structural stability of the C-terminal β-sheet rich domain of the papain-like cysteine protease family opens up an interesting possibility to use its foldamers as a strategy for sensor development and other multiple potential applications that rely on the great commercial value of papain-like cysteine proteases.
    Language English
    Publishing date 2023-07-01
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2313-7673
    ISSN (online) 2313-7673
    DOI 10.3390/biomimetics8030281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The cell phone in the twenty-first century: Risk for addiction or ingestion? Case report and review of the literature.

    Dragasevic, Sanja / Lalosevic, Milica Stojkovic / Toncev, Ljubisa / Milovanovic, Tamara / Markovic, Aleksandra Pavlovic / Djuranovic, Srdjan / Popovic, Dragan

    World journal of emergency medicine

    2021  Volume 12, Issue 4, Page(s) 335–336

    Language English
    Publishing date 2021-09-01
    Publishing country China
    Document type Journal Article
    ZDB-ID 2753264-1
    ISSN 1920-8642
    ISSN 1920-8642
    DOI 10.5847/wjem.j.1920-8642.2021.04.017
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  7. Article ; Online: Biological Therapy for Inflammatory Bowel Disease During the COVID-19 Pandemic: Experiences From a Tertiary IBD Service.

    Markovic, Srdjan / Ivanovski, Tamara Knezevic / Zogovic, Branimir / Cvetkovic, Mirjana / Svorcan, Petar

    Inflammatory bowel diseases

    2020  Volume 26, Issue 12, Page(s) e152

    MeSH term(s) Adult ; Biological Products/therapeutic use ; COVID-19/epidemiology ; Delivery of Health Care ; Humans ; Inflammatory Bowel Diseases/therapy ; Middle Aged ; Pandemics ; Serbia ; Young Adult
    Chemical Substances Biological Products
    Keywords covid19
    Language English
    Publishing date 2020-10-12
    Publishing country England
    Document type Letter
    ZDB-ID 1340971-2
    ISSN 1536-4844 ; 1078-0998
    ISSN (online) 1536-4844
    ISSN 1078-0998
    DOI 10.1093/ibd/izaa274
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4530: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: The Predictive Value of Risk Factors and Prognostic Scores in Hospitalized COVID-19 Patients.

    Brajkovic, Milica / Vukcevic, Miodrag / Nikolic, Sofija / Dukic, Marija / Brankovic, Marija / Sekulic, Ana / Popadic, Viseslav / Stjepanovic, Mihailo / Radojevic, Aleksandra / Markovic-Denic, Ljiljana / Rajovic, Nina / Milic, Natasa / Tanasilovic, Srdjan / Todorovic, Zoran / Zdravkovic, Marija

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 16

    Abstract: Introduction: Risk stratification in patients with COVID-19 is a challenging task. Early warning scores (EWSs) are commonly used tools in the initial assessment of critical patients. However, their utility in patients with COVID-19 is still undetermined. ...

    Abstract Introduction: Risk stratification in patients with COVID-19 is a challenging task. Early warning scores (EWSs) are commonly used tools in the initial assessment of critical patients. However, their utility in patients with COVID-19 is still undetermined.
    Aim: This study aimed to discover the most valuable predictive model among existing EWSs for ICU admissions and mortality in COVID-19 patients.
    Materials and methods: This was a single-center cohort study that included 3608 COVID-19 patients admitted to the University Clinical Hospital Center Bezanijska Kosa, Belgrade, Serbia, between 23 June 2020, and 14 April 2021. Various demographic, laboratory, and clinical data were collected to calculate several EWSs and determine their efficacy. For all 3608 patients, five EWSs were calculated (MEWS, NEWS, NEWS2, REMS, and qSOFA). Model discrimination performance was tested using sensitivity, specificity, and positive and negative predictive values. C statistic, representing the area under the receiver operating characteristic (ROC) curve, was used for the overall assessment of the predictive model.
    Results: Among the evaluated prediction scores for 3068 patients with COVID-19, REMS demonstrated the highest diagnostic performance with the sensitivity, PPV, specificity, and NPV of 72.1%, 20.6%, 74.9%, and 96.8%, respectively. In the multivariate logistic regression analysis, aside from REMS, age (
    Conclusions: Among all evaluated EWSs to predict mortality and ICU admission in COVID-19 patients, the REMS score demonstrated the highest efficacy.
    Language English
    Publishing date 2023-08-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13162653
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  9. Article: SMAD4 Gene Analysis in Patients with Early Onset Colorectal Cancer: A Pilot Study

    Nikolic, Aleksandra / Despotovic, Jovana / Babic, Tamara / Antic, Jadranka / Markovic, Srdjan / Krivokapic, Zoran / Radojkovic, Dragica

    Cytology and genetics. 2022 June, v. 56, no. 3

    2022  

    Abstract: In colorectal cancer (CRC), inactivation of SMAD4 occurs early in the disease development and SMAD4 represents one of key driver genes in progression and metastasis. Loss of SMAD4 protein expression is a relatively common feature of sporadic colorectal ... ...

    Abstract In colorectal cancer (CRC), inactivation of SMAD4 occurs early in the disease development and SMAD4 represents one of key driver genes in progression and metastasis. Loss of SMAD4 protein expression is a relatively common feature of sporadic colorectal cancers, and it was observed to be even more frequent in tumors of patients with early onset disease and also more frequent in microsatellite stable tumors. Pathogenic variants in the SMAD4 gene are usually missense or nonsense mutations, and they are more frequent in the C-terminal domain. The aim of this study was to perform genetic analysis of SMAD4 C-terminal domain in colorectal cancer patients with early onset disease and microsatellite stable tumors. This pilot study was conducted with a purpose of investigating if such genetic screening strategy would be useful for diagnostic purposes in this specific subgroup of CRC patients. The study was conducted in a selected set of DNA samples extracted from the tumors of CRC patients who had less than 50 years at the time of diagnosis. Genetic analysis of C-terminal domain has encompassed analysis of exons 9, 10, 11 and 12 of the SMAD4 gene by PCR and direct DNA sequencing. Among the twenty analyzed tumor DNAs, one sample was found to harbor a SMAD4 variant: NC_000018.9:g.48591918C > T; (NM005359.5: c.1081C > T; Arg361Cys). The variant was discovered in exon 9, affecting the codon 361, which represents a mutational hot spot within the SMAD4 gene. This variant was discovered in homozygous state in the tumor of a 47 yr old female with T3 stage carcinoma of the right colon. Considering the incidence and functional consequences of SMAD4 exon 9 variants, the screening of this region could be a useful low cost strategy for the genetic analysis of colorectal tumors from patients with early onset disease, as well as for susceptibility testing.
    Keywords DNA ; amino acid sequences ; carcinoma ; cell biology ; colon ; colorectal neoplasms ; exons ; females ; genetic analysis ; homozygosity ; metastasis ; microsatellite repeats ; protein synthesis
    Language English
    Dates of publication 2022-06
    Size p. 273-276.
    Publishing place Pleiades Publishing
    Document type Article
    ZDB-ID 390717-x
    ISSN 1934-9440 ; 0095-4527
    ISSN (online) 1934-9440
    ISSN 0095-4527
    DOI 10.3103/S0095452722030082
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    In stock of ZB MED Bonn / Germany

    Z 2982: Show issues

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  10. Article ; Online: Tree species flammability based on plant traits: A synthesis.

    Popović, Zorica / Bojović, Srdjan / Marković, Milena / Cerdà, Artemi

    The Science of the total environment

    2021  Volume 800, Page(s) 149625

    Abstract: The occurrence of large and recurring forest fires has long been associated with fire-prone environments, but this perception has been shifted rapidly in recent decades as Earths' landscapes have become increasingly threatened by severe and unpredictable ...

    Abstract The occurrence of large and recurring forest fires has long been associated with fire-prone environments, but this perception has been shifted rapidly in recent decades as Earths' landscapes have become increasingly threatened by severe and unpredictable fires as a result of climate changes. In this regard, the flammability of trees is a topic of great interest for ecology, management, and the development of sustainable restoration and rehabilitation plans. Tree species differ in regard to flammability, and many plant functional traits contribute to flammability at species, community and vegetation level. The relationship between plant traits and flammability at species level is important for a broader understanding of the vegetation-fire dynamic at the local and landscape scales. This review summarizes the current state of knowledge regarding the impact of individual plant traits of tree species on flammability components. By keywords-based searching of academic databases, 85 research papers were collected and analyzed. The literature synthesis shows: i) main issues addressed in studies on plant trait-based tree flammability, ii) general research output and biogeographic regions studied, iii) inventory of tree taxa investigated, iv) relationships between plant traits and flammability components, v) the most relevant plant traits that determine the flammability-related differences between species.
    MeSH term(s) Ecosystem ; Fires ; Phenotype ; Plants ; Trees ; Wildfires
    Language English
    Publishing date 2021-08-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2021.149625
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
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