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Article: A case of bullous lesions in cutaneous T-cell lymphoma.

Xu, Suzanne / Weiss, Emma / Singh, Katelyn / Damsky, William / Girardi, Michael

2023 Volume 35, Page(s) 90–93

Language	English
Publishing date	2023-03-15
Publishing country	United States
Document type	Case Reports
ZDB-ID	2834220-3
ISSN	2352-5126
ISSN	2352-5126
DOI	10.1016/j.jdcr.2023.02.026
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Article ; Online: Overview and Clinical Applications of Artificial Intelligence and Machine Learning in Cardiac Anesthesiology.

Mathis, Michael / Steffner, Kirsten R / Subramanian, Harikesh / Gill, George P / Girardi, Natalia I / Bansal, Sagar / Bartels, Karsten / Khanna, Ashish K / Huang, Jiapeng

Journal of cardiothoracic and vascular anesthesia

2024 Volume 38, Issue 5, Page(s) 1211–1220

Abstract: Artificial intelligence- (AI) and machine learning (ML)-based applications are becoming increasingly pervasive in the healthcare setting. This has in turn challenged clinicians, hospital administrators, and health policymakers to understand such ... ...

Abstract	Artificial intelligence- (AI) and machine learning (ML)-based applications are becoming increasingly pervasive in the healthcare setting. This has in turn challenged clinicians, hospital administrators, and health policymakers to understand such technologies and develop frameworks for safe and sustained clinical implementation. Within cardiac anesthesiology, challenges and opportunities for AI/ML to support patient care are presented by the vast amounts of electronic health data, which are collected rapidly, interpreted, and acted upon within the periprocedural area. To address such challenges and opportunities, in this article, the authors review 3 recent applications relevant to cardiac anesthesiology, including depth of anesthesia monitoring, operating room resource optimization, and transthoracic/transesophageal echocardiography, as conceptual examples to explore strengths and limitations of AI/ML within healthcare, and characterize this evolving landscape. Through reviewing such applications, the authors introduce basic AI/ML concepts and methodologies, as well as practical considerations and ethical concerns for initiating and maintaining safe clinical implementation of AI/ML-based algorithms for cardiac anesthesia patient care.
MeSH term(s)	Humans ; Artificial Intelligence ; Anesthesiology ; Machine Learning ; Algorithms ; Heart
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1067317-9
ISSN	1532-8422 ; 1053-0770
ISSN (online)	1532-8422
ISSN	1053-0770
DOI	10.1053/j.jvca.2024.02.004
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Zs.A 2203: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Veliparib with carboplatin and paclitaxel in BRCA-mutated advanced breast cancer (BROCADE3): Final overall survival results from a randomized phase 3 trial.

Diéras, Véronique / Han, Hyo S / Wildiers, Hans / Friedlander, Michael / Ayoub, Jean-Pierre / Puhalla, Shannon L / Loirat, Delphine / Ratajczak, Christine / Adamu, Hephzibah / Girardi, Vincent / Arun, Banu K

European journal of cancer (Oxford, England : 1990)

2024 Volume 200, Page(s) 113580

Abstract: Background: In the BROCADE3 study, the addition of veliparib to carboplatin plus paclitaxel resulted in a significant improvement in progression-free survival (PFS) compared with placebo plus carboplatin and paclitaxel, in patients with germline BRCA1 ... ...

Abstract	Background: In the BROCADE3 study, the addition of veliparib to carboplatin plus paclitaxel resulted in a significant improvement in progression-free survival (PFS) compared with placebo plus carboplatin and paclitaxel, in patients with germline BRCA1 or BRCA2 (BRCA1/2)-mutated, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer. We now report final overall survival (OS) data. Methods: BROCADE3 is a randomized phase 3 study that enrolled patients with BRCA1/2-mutated, HER2-negative advanced breast cancer who received ≤ 2 prior lines of chemotherapy for metastatic disease. Patients were randomized 2:1 to carboplatin and paclitaxel, dosed with either veliparib or matching placebo. OS was a secondary endpoint. Results: In the intention-to-treat population (N = 509), 337 patients were randomized to receive veliparib and 172 to placebo. Median OS was 32.4 months vs 28.2 months (hazard ratio, 0.916; 95% CI, 0.736-1.140; P = .434). The updated safety data for veliparib are consistent with those reported in the primary analysis; the addition of veliparib was generally well tolerated. Conclusions: Final OS data indicate that the PFS improvement shown in the primary analysis did not translate into an OS benefit. The long survival times observed in both arms suggest that combination therapy with paclitaxel and carboplatin provides clinical benefit in the population of patients with BRCA1/2-mutated metastatic breast cancer.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Carboplatin ; Paclitaxel ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Benzimidazoles
Chemical Substances	Carboplatin (BG3F62OND5) ; Paclitaxel (P88XT4IS4D) ; BRCA1 protein, human ; BRCA1 Protein ; veliparib (01O4K0631N) ; BRCA2 protein, human ; BRCA2 Protein ; Benzimidazoles
Language	English
Publishing date	2024-01-28
Publishing country	England
Document type	Randomized Controlled Trial ; Clinical Trial, Phase III ; Journal Article
ZDB-ID	82061-1
ISSN	1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
ISSN (online)	1879-0852
ISSN	0277-5379 ; 0959-8049 ; 0964-1947
DOI	10.1016/j.ejca.2024.113580
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Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 583: Show issues

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Article ; Online: Occult HBV Infection in Patients Infected by HIV or HCV: Comparison between HBV-DNA and Two Assays for HBsAg.

Meschi, Silvia / Mizzoni, Klizia / Leoni, Bruno Daniele / Galli, Claudio / Garbuglia, Anna Rosa / Belladonna, Stefano / Girardi, Enrico / Maggi, Fabrizio / The Hbsagn Study Group

Viruses

2024 Volume 16, Issue 3

Abstract: We investigated the frequency and serological correlates of occult hepatitis B virus infection (OBI) and the potential impact of a highly sensitive assay for HBsAg in subjects infected by human immunodeficiency virus (HIV) or hepatitis C virus (HCV), who ...

Abstract	We investigated the frequency and serological correlates of occult hepatitis B virus infection (OBI) and the potential impact of a highly sensitive assay for HBsAg in subjects infected by human immunodeficiency virus (HIV) or hepatitis C virus (HCV), who are also at risk for hepatitis B virus (HBV) infection, often in an occult form. Samples from 499 patients with HIV, all HBsAg negative and anti-HBc positive, and 137 patients with HCV were tested for HBV-DNA, anti-HBc, anti-HBs, and HBsAg by a conventional and highly sensitive assay. HBV biomarkers were detected in 71.5% of HCV-RNA-positive, with a higher prevalence of cases positive only for anti-HBc in patients with HCV than in those with HIV. HBV-DNA was detectable in 0.6% of HIV-positive and 7.3% of HCV-RNA-positive patients. Among patients with HCV, four were positive for HBsAg and negative for HBV-DNA, bringing the rate of HBV-active infection in this group to 10.2%. Active HBV infection was not related to gender or specific patterns of HBV biomarkers but was higher in HCV patients coinfected by HIV compared to those infected only by HCV. Monitoring patients at high risk for HBV infection and reactivation may require testing for both HBV-DNA and HBsAg.
MeSH term(s)	Humans ; Hepatitis B virus/genetics ; Hepacivirus/genetics ; Hepatitis B Surface Antigens ; DNA, Viral ; HIV/genetics ; HIV Infections ; Hepatitis B/diagnosis ; Hepatitis B/epidemiology ; Hepatitis C/diagnosis ; Hepatitis C/epidemiology ; Hepatitis B, Chronic ; Hepatitis B Antibodies ; Prevalence ; Biomarkers ; RNA
Chemical Substances	Hepatitis B Surface Antigens ; DNA, Viral ; Hepatitis B Antibodies ; Biomarkers ; RNA (63231-63-0)
Language	English
Publishing date	2024-03-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v16030412
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Article ; Online: Six Month Interim Outcomes from SECURE: A Single arm, Multicenter, Prospective, Clinical Study on a Novel Minimally Invasive Posterior Sacroiliac Fusion Device.

Calodney, Aaron K / Azeem, Nomen / Buchanan, Patrick / Skaribas, Ioannis / Antony, Ajay / Kim, Christopher / Girardi, George / Vu, Chau / Bovinet, Christopher / Vogel, Rainer S / Li, Sean / Jassal, Naveep / Josephson, Youssef / Lubenow, Timothy R / Girardi, Nicholas / Pope, Jason E

Expert review of medical devices

2022 Volume 19, Issue 5, Page(s) 451–461

Abstract: Introduction: Sacroiliac joint disease is a prominent diagnosis across the world. A novel fixation technique employing a posterior approach, single point, bone allograft transfixation has proven to be helpful anecdotally. The purpose of this is study is ...

Abstract	Introduction: Sacroiliac joint disease is a prominent diagnosis across the world. A novel fixation technique employing a posterior approach, single point, bone allograft transfixation has proven to be helpful anecdotally. The purpose of this is study is to investigate prospectively the safety and efficacy of this approach. Methods: A multicenter, prospective, single arm study was performed after patient identification and treatment with the novel posterior fusion, single-point transfixation system and followed for 24 months. Target enrollment is 100 patients. Interim results on the first 69 consecutive patients at 6 months is presented. Primary endpoint at 6-month analysis was Pain Intensity reduction by visual analogue scale and functional improvement by Oswestry Disability Index. Adverse events were assessed for safety analysis. Results: In total, 69 patients were identified for this analysis. At 6 months, a mean improvement of 34.9 was identified by a reduction in VAS and functional improvement was demonstrated by a mean reduction in ODI of 17.7. There were three adverse events, all unrelated to the device. Conclusion: The posterior single point transfixation is safe and efficacious for the treatment of sacroiliac joint dysfunction with statistical improvements in pain and function.
MeSH term(s)	Humans ; Low Back Pain/diagnosis ; Low Back Pain/surgery ; Pain Measurement ; Prospective Studies ; Sacroiliac Joint/surgery ; Spinal Fusion/methods ; Treatment Outcome
Language	English
Publishing date	2022-07-18
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	2250857-0
ISSN	1745-2422 ; 1743-4440
ISSN (online)	1745-2422
ISSN	1743-4440
DOI	10.1080/17434440.2022.2090244
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Zs.A 6424: Show issues

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Article ; Online: Is Diastasis Recti Abdominis Associated With Low Back Pain? A Systematic Review.

Sokunbi, Gbolabo / Camino-Willhuber, Gaston / Paschal, Philip K / Olufade, Oluseun / Hussain, Farah S / Shue, Jennifer / Abjornson, Celeste / Zelenty, William D / Lebl, Darren R / Cammisa, Frank P / Girardi, Federico P / Hughes, Alexander P / Sama, Andrew A

World neurosurgery

2023 Volume 174, Page(s) 119–125

Abstract: Background: Low back pain (LBP) is a common cause of disability worldwide; multiple causes and risk factors have been proposed in the genesis of back pain. Some studies reported an association between diastasis recti abdominis (DRA), a surrogate for ... ...

Abstract	Background: Low back pain (LBP) is a common cause of disability worldwide; multiple causes and risk factors have been proposed in the genesis of back pain. Some studies reported an association between diastasis recti abdominis (DRA), a surrogate for decreased core strength muscle, and low back pain. We aimed to investigate the relationship between DRA and LBP through a systematic review. Methods: A systematic review of the literature of clinical studies in English literature was conducted. PubMed, Cochrane, and Embase databases were used to conduct the search up to January 2022. The strategy included the following keywords: "Lower Back Pain" AND "Diastasis Recti" OR "Rectus abdominis" OR "abdominal wall" OR "paraspinal musculature". Results: From 207 records initially found, 34 were suitable for full review. Thirteen studies were finally included in this review, with a total of 2,820 patients. Five studies found a positive association between DRA and LBP (5 of 13 = 38.5%) whereas 8 studies did not find any association between DRA and LBP (8 of 13 = 61.5%). Conclusions: Of the studies included in this systematic review, 61.5% did not find an association between DRA and LBP whereas a positive correlation was observed in 38.5% of studies included. Based on the quality of the studies included in our review, better studies are warranted to understand the association between DRA and LBP.
MeSH term(s)	Humans ; Rectus Abdominis ; Low Back Pain/epidemiology ; Low Back Pain/etiology ; Diastasis, Muscle/complications ; Abdominal Wall ; Muscle Strength
Language	English
Publishing date	2023-03-08
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2023.03.014
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Zs.A 1159: Show issues

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Article ; Online: Roadblocks and fast tracks: How RNA binding proteins affect the viral RNA journey in the cell.

Girardi, Erika / Pfeffer, Sebastien / Baumert, Thomas F / Majzoub, Karim

Seminars in cell & developmental biology

2020 Volume 111, Page(s) 86–100

Abstract: As obligate intracellular parasites with limited coding capacity, RNA viruses rely on host cells to complete their multiplication cycle. Viral RNAs (vRNAs) are central to infection. They carry all the necessary information for a virus to synthesize its ... ...

Abstract	As obligate intracellular parasites with limited coding capacity, RNA viruses rely on host cells to complete their multiplication cycle. Viral RNAs (vRNAs) are central to infection. They carry all the necessary information for a virus to synthesize its proteins, replicate and spread and could also play essential non-coding roles. Regardless of its origin or tropism, vRNA has by definition evolved in the presence of host RNA Binding Proteins (RBPs), which resulted in intricate and complicated interactions with these factors. While on one hand some host RBPs recognize vRNA as non-self and mobilize host antiviral defenses, vRNA must also co-opt other host RBPs to promote viral infection. Focusing on pathogenic RNA viruses, we will review important scenarios of RBP-vRNA interactions during which host RBPs recognize, modify or degrade vRNAs. We will then focus on how vRNA hijacks the largest ribonucleoprotein complex (RNP) in the cell, the ribosome, to selectively promote the synthesis of its proteins. We will finally reflect on how novel technologies are helping in deepening our understanding of vRNA-host RBPs interactions, which can be ultimately leveraged to combat everlasting viral threats.
MeSH term(s)	Eukaryotic Initiation Factors/genetics ; Eukaryotic Initiation Factors/immunology ; Gene Expression Regulation ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Humans ; Immunity, Innate/genetics ; Protein Binding ; Protein Biosynthesis ; RNA Viruses/genetics ; RNA Viruses/growth & development ; RNA Viruses/pathogenicity ; RNA, Messenger/genetics ; RNA, Messenger/immunology ; RNA, Viral/genetics ; RNA, Viral/immunology ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/immunology ; Ribosomes/genetics ; Ribosomes/metabolism ; Signal Transduction ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Virus Assembly/genetics ; Virus Diseases/genetics ; Virus Diseases/immunology ; Virus Diseases/pathology ; Virus Diseases/virology
Chemical Substances	Eukaryotic Initiation Factors ; RNA, Messenger ; RNA, Viral ; RNA-Binding Proteins ; Viral Proteins
Keywords	covid19
Language	English
Publishing date	2020-08-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1312473-0
ISSN	1096-3634 ; 1084-9521
ISSN (online)	1096-3634
ISSN	1084-9521
DOI	10.1016/j.semcdb.2020.08.006
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Zs.A 2918: Show issues

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Article ; Online: STS/AATS-Endorsed Rebuttal to 2023 ACC/AHA Chronic Coronary Disease Guideline: A Missed Opportunity to Present Accurate and Comprehensive Revascularization Recommendations.

Bakaeen, Faisal G / Ruel, Marc / Calhoon, John H / Girardi, Leonard N / Guyton, Robert / Hui, Dawn / Kelly, Rosemary F / MacGillivray, Thomas E / Malaisrie, S Christopher / Moon, Marc R / Sabik, Joseph F / Smith, Peter K / Svensson, Lars G / Szeto, Wilson Y

The Annals of thoracic surgery

2023 Volume 116, Issue 4, Page(s) 675–678

MeSH term(s)	Humans ; United States ; Myocardial Ischemia ; Coronary Artery Disease ; Heart Diseases ; American Heart Association
Language	English
Publishing date	2023-07-31
Publishing country	Netherlands
Document type	Editorial
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2023.02.007
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Article ; Online: STS/AATS-endorsed rebuttal to 2023 ACC/AHA Chronic Coronary Disease Guideline: A missed opportunity to present accurate and comprehensive revascularization recommendations.

The Journal of thoracic and cardiovascular surgery

2023 Volume 166, Issue 4, Page(s) 1115–1118

MeSH term(s)	Humans ; United States ; Myocardial Ischemia ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/surgery ; Heart Diseases ; American Heart Association
Language	English
Publishing date	2023-07-31
Publishing country	United States
Document type	Editorial
ZDB-ID	3104-5
ISSN	1097-685X ; 0022-5223
ISSN (online)	1097-685X
ISSN	0022-5223
DOI	10.1016/j.jtcvs.2023.03.001
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Article: Recovery of the autonomic nervous system following football training among division I collegiate football athletes: The influence of intensity and time.

Wittels, S Howard / Renaghan, Eric / Wishon, Michael Joseph / Wittels, Harrison L / Chong, Stephanie / Wittels, Eva Danielle / Hendricks, Stephanie / Hecocks, Dustin / Bellamy, Kyle / Girardi, Joe / Lee, Stephen / McDonald, Samantha / Feigenbaum, Luis A

Heliyon

2023 Volume 9, Issue 7, Page(s) e18125

Abstract: The autonomic nervous system (ANS) is profoundly affected by high intensity exercise. However, evidence is less clear on ANS recovery and function following prolonged bouts of high intensity exercise, especially in non-endurance athletes. Therefore, this ...

Abstract	The autonomic nervous system (ANS) is profoundly affected by high intensity exercise. However, evidence is less clear on ANS recovery and function following prolonged bouts of high intensity exercise, especially in non-endurance athletes. Therefore, this study aimed to investigate the relationships between duration and intensity of acute exercise training sessions and ANS recovery and function in Division I football athletes. Fifty, male football athletes were included in this study. Subjects participated in 135 days of exercise training sessions throughout the 25-week season and wore armband monitors (Warfighter Monitor, Tiger Tech Solutions) equipped with electrocardiography capabilities. Intensity was measured via heart rate (HR) during an 'active state', defined as HR ≥ 85 bpm. Further, data-driven intensity thresholds were used and included HR < 140 bpm, HR < 150 bpm, HR < 160 bpm, HR ≥ 140 bpm, HR ≥ 150 bpm and HR ≥ 160 bpm. Baseline HR and HR recovery were measured and represented ANS recovery and function 24h post-exercise. Linear regression models assessed the relationships between time spent at the identified intensity thresholds and ANS recovery and function 24h post-exercise. Statistical significance set at α < 0.05. Athletes participated in 128 training sessions, totaling 2735 data points analyzed. Subjects were predominantly non-Hispanic black (66.0%), aged 21.2 (±1.5) years and average body mass index of 29.2 (4.7) kg⋅(m
Language	English
Publishing date	2023-07-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e18125
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