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  1. Article: Microthrombotic Complications of COVID-19 Are Likely Due to Embolism of Circulating Endothelial Derived Ultralarge von Willebrand Factor (eULVWF) Decorated-Platelet Strings.

    Varatharajah, N / Rajah, Suganthi

    Federal practitioner : for the health care professionals of the VA, DoD, and PHS

    2020  Volume 37, Issue 6, Page(s) 258–259

    Language English
    Publishing date 2020-05-01
    Publishing country United States
    Document type Journal Article
    ISSN 1078-4497
    ISSN 1078-4497
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Microthrombotic Complications of COVID-19 Are Likely Due to Embolism of Circulating Endothelial Derived Ultralarge Von Willebrand Factor (eULVWF) Decorated-Platelet Strings.

    Varatharajah, N / Rajah, Suganthi

    Federal practitioner : for the health care professionals of the VA, DoD, and PHS

    2020  Volume 37, Issue 6, Page(s) e1–e2

    Keywords covid19
    Language English
    Publishing date 2020-05-15
    Publishing country United States
    Document type Journal Article
    ISSN 1078-4497
    ISSN 1078-4497
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Microthrombotic Complications of COVID-19 Are Likely Due to Embolism of Circulating Endothelial Derived Ultralarge Von Willebrand Factor (eULVWF) Decorated-Platelet Strings

    Varatharajah, N. / Rajah, Suganthi

    Fed Pract

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #522429
    Database COVID19

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  4. Book ; Online: Tensor Decomposition of Large-scale Clinical EEGs Reveals Interpretable Patterns of Brain Physiology

    Gupta, Teja / Wagh, Neeraj / Rawal, Samarth / Berry, Brent / Worrell, Gregory / Varatharajah, Yogatheesan

    2022  

    Abstract: Identifying abnormal patterns in electroencephalography (EEG) remains the cornerstone of diagnosing several neurological diseases. The current clinical EEG review process relies heavily on expert visual review, which is unscalable and error-prone. In an ... ...

    Abstract Identifying abnormal patterns in electroencephalography (EEG) remains the cornerstone of diagnosing several neurological diseases. The current clinical EEG review process relies heavily on expert visual review, which is unscalable and error-prone. In an effort to augment the expert review process, there is a significant interest in mining population-level EEG patterns using unsupervised approaches. Current approaches rely either on two-dimensional decompositions (e.g., principal and independent component analyses) or deep representation learning (e.g., auto-encoders, self-supervision). However, most approaches do not leverage the natural multi-dimensional structure of EEGs and lack interpretability. In this study, we propose a tensor decomposition approach using the canonical polyadic decomposition to discover a parsimonious set of population-level EEG patterns, retaining the natural multi-dimensional structure of EEGs (time x space x frequency). We then validate their clinical value using a cohort of patients including varying stages of cognitive impairment. Our results show that the discovered patterns reflect physiologically meaningful features and accurately classify the stages of cognitive impairment (healthy vs mild cognitive impairment vs Alzheimer's dementia) with substantially fewer features compared to classical and deep learning-based baselines. We conclude that the decomposition of population-level EEG tensors recovers expert-interpretable EEG patterns that can aid in the study of smaller specialized clinical cohorts.

    Comment: 4 pages, 3 Figures, 2 Tables; Accepted at IEEE NER 2023
    Keywords Electrical Engineering and Systems Science - Signal Processing ; Computer Science - Machine Learning ; Statistics - Applications
    Subject code 616
    Publishing date 2022-11-24
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Looking for a face in the crowd: fixation-related potentials in an eye-movement visual search task.

    Kaunitz, Lisandro N / Kamienkowski, Juan E / Varatharajah, Alexander / Sigman, Mariano / Quiroga, Rodrigo Quian / Ison, Matias J

    NeuroImage

    2014  Volume 89, Page(s) 297–305

    Abstract: Despite the compelling contribution of the study of event related potentials (ERPs) and eye movements to cognitive neuroscience, these two approaches have largely evolved independently. We designed an eye-movement visual search paradigm that allowed us ... ...

    Abstract Despite the compelling contribution of the study of event related potentials (ERPs) and eye movements to cognitive neuroscience, these two approaches have largely evolved independently. We designed an eye-movement visual search paradigm that allowed us to concurrently record EEG and eye movements while subjects were asked to find a hidden target face in a crowded scene with distractor faces. Fixation event-related potentials (fERPs) to target and distractor stimuli showed the emergence of robust sensory components associated with the perception of stimuli and cognitive components associated with the detection of target faces. We compared those components with the ones obtained in a control task at fixation: qualitative similarities as well as differences in terms of scalp topography and latency emerged between the two. By using single trial analyses, fixations to target and distractors could be decoded from the EEG signals above chance level in 11 out of 12 subjects. Our results show that EEG signatures related to cognitive behavior develop across spatially unconstrained exploration of natural scenes and provide a first step towards understanding the mechanisms of target detection during natural search.
    MeSH term(s) Adult ; Brain/physiology ; Electroencephalography ; Evoked Potentials, Visual ; Face ; Female ; Fixation, Ocular/physiology ; Humans ; Male ; Photic Stimulation ; Saccades/physiology ; Visual Perception/physiology ; Young Adult
    Language English
    Publishing date 2014-04-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1147767-2
    ISSN 1095-9572 ; 1053-8119
    ISSN (online) 1095-9572
    ISSN 1053-8119
    DOI 10.1016/j.neuroimage.2013.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Which method of distal pancreatectomy is cost-effective among open, laparoscopic, or robotic surgery?

    Rodriguez, Maylis / Memeo, Riccardo / Leon, Piera / Panaro, Fabrizio / Tzedakis, Stylianos / Perotto, Ornella / Varatharajah, Sharmini / de'Angelis, Nicola / Riva, Pietro / Mutter, Didier / Navarro, Francis / Marescaux, Jacques / Pessaux, Patrick

    Hepatobiliary surgery and nutrition

    2018  Volume 7, Issue 5, Page(s) 345–352

    Abstract: Background: The aim of this study was to analyze the clinical and economic impact of robotic distal pancreatectomy, laparoscopic distal pancreatectomy, and open distal pancreatectomy.: Methods: All consecutive patients who underwent distal pancreatic ...

    Abstract Background: The aim of this study was to analyze the clinical and economic impact of robotic distal pancreatectomy, laparoscopic distal pancreatectomy, and open distal pancreatectomy.
    Methods: All consecutive patients who underwent distal pancreatic resection for benign and malignant diseases between January 2012 and December 2015 were prospectively included. Cost analysis was performed; all charges from patient admission to discharge were considered.
    Results: There were 21 robotic (RDP), 25 laparoscopic (LDP), and 43 open (ODP) procedures. Operative time was longer in the RDP group (RDP =345 minutes, LDP =306 min, ODP =251 min, P=0.01). Blood loss was higher in the ODP group (RDP =192 mL, LDP =356 mL, ODP =573 mL, P=0.0002). Spleen preservation was more frequent in the RDP group (RDP =66.6%, LDP =61.9%, ODP =9.3%, P=0.001). The rate of patients with Clavien-Dindo > grade III was higher in the ODP group (RDP =0%, LDP =12%, ODP =23%, P=0.01), especially for non-surgical complications, which were more frequent in the ODP group (RDP =9.5%, LDP =24%, ODP =41.8%, P=0.02). Length of hospital stay was increased in the ODP group (ODP =19 days, LDP =13 days, RDP =11 days, P=0.007). The total cost of the procedure, including the surgical procedure and postoperative course was higher in the ODP group (ODP =30,929 Euros, LDP =22,150 Euros, RDP =21,219 Euros, P=0.02).
    Conclusions: Cost-effective results of RDP seem to be similar to LDP with some better short-term outcomes.
    Language English
    Publishing date 2018-10-03
    Publishing country China (Republic : 1949- )
    Document type Journal Article
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn.2018.09.03
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Management and outcomes of adolescent and young adult sarcoma patients: results from the French nationwide database NETSARC.

    Kubicek, Pierre / Cesne, Axel Le / Lervat, Cyril / Toulmonde, Maud / Chevreau, Christine / Duffaud, Florence / Le Nail, Louis-Romée / Morelle, Magali / Gaspar, Nathalie / Vérité, Cécile / Castex, Marie-Pierre / Penel, Nicolas / Saada, Esma / Causeret, Sylvain / Bertucci, François / Perrin, Christophe / Bompas, Emmanuelle / Orbach, Daniel / Laurence, Valérie /
    Piperno-Neumann, Sophie / Anract, Philippe / Rios, Maria / Gentet, Jean-Claude / Mascard, Éric / Pannier, Stéphanie / Blouin, Pascale / Carrère, Sébastien / Chaigneau, Loïc / Soibinet-Oudot, Pauline / Corradini, Nadège / Boudou-Rouquette, Pascaline / Ruzic, Jean-Christophe / Lebrun-Ly, Valérie / Dubray-Longeras, Pascale / Varatharajah, Sharmini / Lebbe, Céleste / Ropars, Mickaël / Kurtz, Jean-Emmanuel / Guillemet, Cécile / Lotz, Jean-Pierre / Berchoud, Juliane / Cherrier, Grégory / Ducimetière, Françoise / Chemin, Claire / Italiano, Antoine / Honoré, Charles / Desandes, Emmanuel / Blay, Jean-Yves / Gouin, François / Marec-Bérard, Perrine

    BMC cancer

    2023  Volume 23, Issue 1, Page(s) 69

    Abstract: Background: The initial management of patients with sarcoma is a critical issue. We used the nationwide French National Cancer Institute-funded prospective sarcoma database NETSARC to report the management and oncologic outcomes in adolescents and young ...

    Abstract Background: The initial management of patients with sarcoma is a critical issue. We used the nationwide French National Cancer Institute-funded prospective sarcoma database NETSARC to report the management and oncologic outcomes in adolescents and young adults (AYAs) patients with sarcoma at the national level.
    Patients and methods: NETSARC database gathers regularly monitored and updated data from patients with sarcoma. NETSARC was queried for patients (15-30 years) with sarcoma diagnosed from 2010 to 2017 for whom tumor resection had been performed. We reported management, locoregional recurrence-free survival (LRFS), progression-free survival (PFS), and overall survival (OS) in AYA treated in French reference sarcoma centers (RSC) and outside RSC (non-RSC) and conducted multivariable survival analyses adjusted for classical prognostic factors.
    Results: Among 3,227 patients aged 15-30 years with sarcoma diagnosed between 2010 and 2017, the study included 2,227 patients with surgery data available, among whom 1,290 AYAs had been operated in RSC, and 937 AYAs in non-RSC. Significant differences in compliance to guidelines were observed including pre-treatment biopsy (RSC: 85.9%; non-RSC 48.1%), pre-treatment imaging (RSC: 86.8%; non-RSC: 56.5%) and R0 margins (RSC 57.6%; non-RSC: 20.2%) (p < 0.001). 3y-OS rates were 81.1% (95%CI 78.3-83.6) in AYA in RSC and 82.7% (95%CI 79.4-85.5) in AYA in non-RSC, respectively. Whereas no significant differences in OS was observed in AYAs treated in RSC and in non-RSC, LRFS and PFS were improved in AYAs treated in RSC compared to AYAs treated in non-RSC (Hazard Ratios (HR): 0.58 and 0.83, respectively).
    Conclusions: This study highlights the importance for AYA patients with sarcoma to be managed in national sarcoma reference centers involving multidisciplinary medical teams with paediatric and adult oncologists.
    MeSH term(s) Humans ; Adolescent ; Young Adult ; Child ; Prospective Studies ; Sarcoma/diagnosis ; Sarcoma/surgery ; Soft Tissue Neoplasms/surgery ; Databases, Factual ; Progression-Free Survival
    Language English
    Publishing date 2023-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-023-10556-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Determinants of the access to remote specialised services provided by national sarcoma reference centres.

    Fayet, Yohan / Tétreau, Raphaël / Honoré, Charles / Le Nail, Louis-Romée / Dalban, Cécile / Gouin, François / Causeret, Sylvain / Piperno-Neumann, Sophie / Mathoulin-Pelissier, Simone / Karanian, Marie / Italiano, Antoine / Chaigneau, Loïc / Gantzer, Justine / Bertucci, François / Ropars, Mickael / Saada-Bouzid, Esma / Cordoba, Abel / Ruzic, Jean-Christophe / Varatharajah, Sharmini /
    Ducimetière, Françoise / Chabaud, Sylvie / Dubray-Longeras, Pascale / Fiorenza, Fabrice / De Percin, Sixtine / Lebbé, Céleste / Soibinet, Pauline / Michelin, Paul / Rios, Maria / Farsi, Fadila / Penel, Nicolas / Bompas, Emmanuelle / Duffaud, Florence / Chevreau, Christine / Le Cesne, Axel / Blay, Jean-Yves / Le Loarer, François / Ray-Coquard, Isabelle

    BMC cancer

    2021  Volume 21, Issue 1, Page(s) 631

    Abstract: ... were analysed. The IGéAS cohort (n = 20,590) includes all patients living in France with first sarcoma ...

    Abstract Background: Spatial inequalities in cancer management have been evidenced by studies reporting lower quality of care or/and lower survival for patients living in remote or socially deprived areas. NETSARC+ is a national reference network implemented to improve the outcome of sarcoma patients in France since 2010, providing remote access to specialized diagnosis and Multidisciplinary Tumour Board (MTB). The IGéAS research program aims to assess the potential of this innovative organization, with remote management of cancers including rare tumours, to go through geographical barriers usually impeding the optimal management of cancer patients.
    Methods: Using the nationwide NETSARC+ databases, the individual, clinical and geographical determinants of the access to sarcoma-specialized diagnosis and MTB were analysed. The IGéAS cohort (n = 20,590) includes all patients living in France with first sarcoma diagnosis between 2011 and 2014. Early access was defined as specialised review performed before 30 days of sampling and as first sarcoma MTB discussion performed before the first surgery.
    Results: Some clinical populations are at highest risk of initial management without access to sarcoma specialized services, such as patients with non-GIST visceral sarcoma for diagnosis [OR 1.96, 95% CI 1.78 to 2.15] and MTB discussion [OR 3.56, 95% CI 3.16 to 4.01]. Social deprivation of the municipality is not associated with early access on NETSARC+ remote services. The quintile of patients furthest away from reference centres have lower chances of early access to specialized diagnosis [OR 1.18, 95% CI 1.06 to 1.31] and MTB discussion [OR 1.24, 95% CI 1.10 to 1.40] but this influence of the distance is slight in comparison with clinical factors and previous studies on the access to cancer-specialized facilities.
    Conclusions: In the context of national organization driven by reference network, distance to reference centres slightly alters the early access to sarcoma specialized services and social deprivation has no impact on it. The reference networks' organization, designed to improve the access to specialized services and the quality of cancer management, can be considered as an interesting device to reduce social and spatial inequalities in cancer management. The potential of this organization must be confirmed by further studies, including survival analysis.
    MeSH term(s) Adolescent ; Adult ; Aged ; Databases, Factual/statistics & numerical data ; Female ; France ; Health Services Accessibility/organization & administration ; Health Services Accessibility/statistics & numerical data ; Healthcare Disparities/organization & administration ; Healthcare Disparities/statistics & numerical data ; Humans ; Male ; Medical Oncology/organization & administration ; Medical Oncology/statistics & numerical data ; Middle Aged ; Patient Care Team/organization & administration ; Patient Care Team/statistics & numerical data ; Quality of Health Care ; Remote Consultation/organization & administration ; Remote Consultation/statistics & numerical data ; Sarcoma/diagnosis ; Sarcoma/therapy ; Young Adult
    Language English
    Publishing date 2021-05-29
    Publishing country England
    Document type Journal Article
    ISSN 1471-2407
    ISSN (online) 1471-2407
    DOI 10.1186/s12885-021-08393-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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