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  1. Article ; Online: Otoscopy-assisted intranasal cyst marsupialization for congenital dacryocystocele.

    Nakamura, Jutaro / Ohno, Tomoko / Inoue, Maki / Takeuchi, Masaki / Mizuki, Nobuhisa / Matsumura, Nozomi

    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

    2024  Volume 28, Issue 2, Page(s) 103859

    Abstract: We describe 3 infants with congenital dacryocystocele resistant to conservative treatment who were treated with a novel, simple intranasal cyst marsupialization (ICM) technique. Otoscopy-guided ICM was performed by an otolaryngologist in the manner of ... ...

    Abstract We describe 3 infants with congenital dacryocystocele resistant to conservative treatment who were treated with a novel, simple intranasal cyst marsupialization (ICM) technique. Otoscopy-guided ICM was performed by an otolaryngologist in the manner of otoscopic myringotomy for cases with nasal cyst distension. All 3 infants were treated successfully by a single surgical procedure under topical anesthesia in an office setting.
    MeSH term(s) Infant ; Humans ; Otoscopy ; Endoscopy/methods ; Lacrimal Duct Obstruction/congenital ; Cysts/surgery ; Cysts/congenital ; Dacryocystorhinostomy
    Language English
    Publishing date 2024-03-02
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1412476-2
    ISSN 1528-3933 ; 1091-8531
    ISSN (online) 1528-3933
    ISSN 1091-8531
    DOI 10.1016/j.jaapos.2024.103859
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  2. Article ; Online: Lacrimal sac massage for congenital nasolacrimal duct obstruction: a multicentre randomised controlled trial.

    Asano, Mizuki / Takeuchi, Masaki / Ohno, Tomoko / Nakamura, Jutaro / Mizuki, Nobuhisa / Matsumura, Nozomi

    The British journal of ophthalmology

    2024  

    Abstract: Aim: Congenital nasolacrimal duct obstruction (CNLDO) is the most common cause of epiphora and mucous discharge in the newborn. We conducted a multicentre randomised controlled trial to determine whether Crigler massage promotes the resolution of CNLDO ... ...

    Abstract Aim: Congenital nasolacrimal duct obstruction (CNLDO) is the most common cause of epiphora and mucous discharge in the newborn. We conducted a multicentre randomised controlled trial to determine whether Crigler massage promotes the resolution of CNLDO in infants under 1 year of age.
    Methods: A total of 102 infants aged 3-11 months with unilateral CNLDO were enrolled in the study. Patients were randomly assigned to the massage and non-massage groups (n=51/group). As an allocation adjustment factor, the patients were divided into age groups of 3-5, 6-8 and 9-11 months. In the massage group, the guardian performed 10 strokes two times per day for each day until resolution or 1 month. The primary endpoint was a comparison of the 1-month resolution rate in the massage and non-massage groups.
    Results: This study included 49 male and 53 female patients with a mean age of 6.4±2.4 months. Overall, in this study, the resolution rate was not significantly different between the massage and non-massage groups (31.4% and 33.3%, respectively). However, the resolution rate was higher in the massage group in the 3-5 months age group among the protocol-compliant patients after excluding those with insufficient massage frequency (the massage group, 68.8% and the non-massage group, 28.6%, p=0.022).
    Conclusions: There was no increase in the resolution rate after 1 month of lacrimal sac massage in patients 3-11 months old with unilateral CNLDO. However, in protocol-compliant younger age groups, Crigler massage may be effective.
    Trial registration number: UMIN Clinical Trial Registry (UMIN000032840; www.umin.ac.jp/).
    Language English
    Publishing date 2024-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 80078-8
    ISSN 1468-2079 ; 0007-1161
    ISSN (online) 1468-2079
    ISSN 0007-1161
    DOI 10.1136/bjo-2023-324595
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  3. Article ; Online: Comparing the effectiveness of two surgical techniques for treating lower lid epiblepharon in children: a randomized controlled trial.

    Takeuchi, Masaki / Matsumura, Nozomi / Ohno, Tomoko / Fujita, Takeshi / Asano, Mizuki / Mizuki, Nobuhisa

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 5857

    Abstract: A multicenter randomized controlled trial was conducted to compare the effectiveness of incisional and nonincisional surgical techniques for treating lower lid epiblepharon in children. The study included 89 eyes from 50 children aged 3-15 years (mean, 7. ...

    Abstract A multicenter randomized controlled trial was conducted to compare the effectiveness of incisional and nonincisional surgical techniques for treating lower lid epiblepharon in children. The study included 89 eyes from 50 children aged 3-15 years (mean, 7.5 ± 2.4 years) with moderate lower lid epiblepharon. Patients were randomly assigned to either incisional (modified Hotz procedure with lid margin splitting; 45 eyes of 25 patients) or nonincisional (44 eyes of 25 patients) surgery groups. Treatment outcomes and changes in astigmatism were evaluated 6 months after surgery. Incisional surgery provided a significantly higher percentage (77.8%) of well-corrected treatment results (P = 0.026; odds ratio, 2.88; 95% confidence interval, 1.07-8.22) than nonincisional surgery (55.4%). The mean change in astigmatism 6 months after surgery was - 0.24 ± 0.42 and - 0.01 ± 0.47 D in the incisional and nonincisional surgery groups, respectively. The improvement in astigmatism was significantly higher in the incisional surgery group than in the nonincisional surgery group (P = 0.008). The incisional surgical treatment for moderate epiblepharon in children resulted in a higher number of well-corrected patients, indicating an absence of both ciliary touch and superficial keratitis as well as statistically significant improvements in astigmatism correction.
    MeSH term(s) Humans ; Child ; Astigmatism ; Retrospective Studies ; Treatment Outcome ; Eyelashes ; Cornea ; Surgical Wound
    Language English
    Publishing date 2023-04-11
    Publishing country England
    Document type Randomized Controlled Trial ; Multicenter Study ; Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-32050-4
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  4. Article ; Online: Comparing the effectiveness of two surgical techniques for treating lower lid epiblepharon in children

    Masaki Takeuchi / Nozomi Matsumura / Tomoko Ohno / Takeshi Fujita / Mizuki Asano / Nobuhisa Mizuki

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    a randomized controlled trial

    2023  Volume 6

    Abstract: Abstract A multicenter randomized controlled trial was conducted to compare the effectiveness of incisional and nonincisional surgical techniques for treating lower lid epiblepharon in children. The study included 89 eyes from 50 children aged 3–15 years ...

    Abstract Abstract A multicenter randomized controlled trial was conducted to compare the effectiveness of incisional and nonincisional surgical techniques for treating lower lid epiblepharon in children. The study included 89 eyes from 50 children aged 3–15 years (mean, 7.5 ± 2.4 years) with moderate lower lid epiblepharon. Patients were randomly assigned to either incisional (modified Hotz procedure with lid margin splitting; 45 eyes of 25 patients) or nonincisional (44 eyes of 25 patients) surgery groups. Treatment outcomes and changes in astigmatism were evaluated 6 months after surgery. Incisional surgery provided a significantly higher percentage (77.8%) of well-corrected treatment results (P = 0.026; odds ratio, 2.88; 95% confidence interval, 1.07–8.22) than nonincisional surgery (55.4%). The mean change in astigmatism 6 months after surgery was − 0.24 ± 0.42 and − 0.01 ± 0.47 D in the incisional and nonincisional surgery groups, respectively. The improvement in astigmatism was significantly higher in the incisional surgery group than in the nonincisional surgery group (P = 0.008). The incisional surgical treatment for moderate epiblepharon in children resulted in a higher number of well-corrected patients, indicating an absence of both ciliary touch and superficial keratitis as well as statistically significant improvements in astigmatism correction.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616 ; 610
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Novel microsurgical precision grip and spring-handled instrument with a variable stabilizer.

    Matsumura, Nobuhisa

    Microsurgery

    2011  Volume 31, Issue 7, Page(s) 586–588

    MeSH term(s) Equipment Design ; Humans ; Microsurgery/instrumentation
    Language English
    Publishing date 2011-10
    Publishing country United States
    Document type Letter
    ZDB-ID 605524-2
    ISSN 1098-2752 ; 0738-1085
    ISSN (online) 1098-2752
    ISSN 0738-1085
    DOI 10.1002/micr.20933
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  6. Article ; Online: A newly designed ruler of a 0.1-mm scale on the tip of microsurgical instrument in supermicrosurgery.

    Matsumura, Nobuhisa

    Microsurgery

    2011  Volume 31, Issue 8, Page(s) 671–672

    MeSH term(s) Anastomosis, Surgical/instrumentation ; Anastomosis, Surgical/methods ; Equipment Design ; Equipment Safety ; Humans ; Microsurgery/instrumentation ; Microsurgery/methods ; Microvessels/surgery ; Surgical Instruments
    Language English
    Publishing date 2011-11
    Publishing country United States
    Document type Letter
    ZDB-ID 605524-2
    ISSN 1098-2752 ; 0738-1085
    ISSN (online) 1098-2752
    ISSN 0738-1085
    DOI 10.1002/micr.20948
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  7. Article ; Online: Dose reduction of docetaxel avoids the usage of pegfilgrastim in docetaxel plus ramucirumab therapy for recurrent nonsmall cell lung cancer.

    Hamai, Kosuke / Miyaka, Shinya / Tada, Shinpei / Fujita, Suguru / Hirakawa, Tetsu / Matsumura, Mirai / Ueno, Sayaka / Tanimoto, Takuya / Ishikawa, Nobuhisa

    Cancer reports (Hoboken, N.J.)

    2023  Volume 6, Issue 4, Page(s) e1793

    Abstract: Background: Pegfilgrastim is recommended in docetaxel plus ramucirumab (DTX + RAM) therapy for recurrent nonsmall cell lung cancer (NSCLC) because of the associated frequency of febrile neutropenia (FN). However, the FN occurs less frequently when the ... ...

    Abstract Background: Pegfilgrastim is recommended in docetaxel plus ramucirumab (DTX + RAM) therapy for recurrent nonsmall cell lung cancer (NSCLC) because of the associated frequency of febrile neutropenia (FN). However, the FN occurs less frequently when the dose of DTX is reduced because of other adverse events, such as appetite loss and oral mucositis.
    Methods and results: Twenty-two patients with recurrent NSCLC who received DTX + RAM therapy at the Hiroshima Prefectural Hospital. The cut-off value which is the most unlikely to cause FN without the combined use of pegfilgrastim was set using a receiver operating characteristic (ROC) curve. This was created according to the dose of DTX and the presence or absence of the onset of FN. We compared the incidence of FN when a DTX dose above and below the cut-off value was used. The ROC curve showed that 48 mg/m
    Conclusions: Pegfilgrastim can be discontinued when the dose of DTX is reduced to <48 mg/m
    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Docetaxel ; Drug Tapering ; Lung Neoplasms/drug therapy ; Ramucirumab
    Chemical Substances Docetaxel (15H5577CQD)
    Language English
    Publishing date 2023-02-02
    Publishing country United States
    Document type Journal Article
    ISSN 2573-8348
    ISSN (online) 2573-8348
    DOI 10.1002/cnr2.1793
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  8. Article ; Online: A new bayonet spring microsurgical instrument handle with a bar for microneurosurgery.

    Matsumura, Nobuhisa

    Surgical neurology international

    2012  Volume 3, Page(s) 152

    Abstract: Background: The bayonet-shaped spring surgical instrument is essential and perhaps the most important tool in microneurosurgery. It is needed to be handled gently, and so stable handling to the spring tension of the long instrument handle is necessary ... ...

    Abstract Background: The bayonet-shaped spring surgical instrument is essential and perhaps the most important tool in microneurosurgery. It is needed to be handled gently, and so stable handling to the spring tension of the long instrument handle is necessary for fine action in narrow and deep operative fields under an operating microscope.
    Methods: A bayonet spring microsurgical instrument handle with a bar as a stabilizer is presented for facilitating delicate microsurgical manipulations stably in microneurosurgery. The bar with the handle is a metric projection. The grip of this instrument is a modified writing grasp, which is composed of writing grasp and sandwiching a lateral-projected bar with handle between the medial side of the index finger and the lateral side of the middle finger. Then, this bar as a stabilizer of the instrument is suitable to fix it.
    Results: Microneurosurgical operations using this instrument system were performed. This was advantageous to stabilize the instrument in deep and narrow operative fields, to be sensitive to move its functional tips by fingertips, and to reduce unwanted movements under an operating microscope. This was disadvantageous to limit the rotational movement within fingers. There were no complications.
    Conclusion: This handle would provide a steady and balanced grip to ensure precise manipulation of the functional tips of the bayonet instrument for microneurosurgery. It may be useful particularly for the beginners or for the non-dominant hand of microsurgeons.
    Language English
    Publishing date 2012-12-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2567759-7
    ISSN 2152-7806 ; 2152-7806
    ISSN (online) 2152-7806
    ISSN 2152-7806
    DOI 10.4103/2152-7806.104746
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  9. Article ; Online: Probe-based confocal laser endomicroscopy for real-time evaluation of colorectal liver metastasis in resected surgical specimens.

    Takao, Mikiya / Kawaguchi, Yoshikuni / Matsumura, Masaru / Kazami, Yusuke / Tanimoto, Meguri / Abe, Satoru / Maki, Harufumi / Ishizawa, Takeaki / Arita, Junichi / Akamatsu, Nobuhisa / Kaneko, Junichi / Kokudo, Norihiro / Hasegawa, Kiyoshi

    Human cell

    2023  Volume 36, Issue 6, Page(s) 2066–2073

    Abstract: Probe-based confocal laser endomicroscopy (pCLE) enables real-time examination of tissue structure. This study investigated pCLE with or without fluorescein sodium for the intraoperative diagnosis of colorectal liver metastasis (CLM) and detection of ... ...

    Abstract Probe-based confocal laser endomicroscopy (pCLE) enables real-time examination of tissue structure. This study investigated pCLE with or without fluorescein sodium for the intraoperative diagnosis of colorectal liver metastasis (CLM) and detection of surgical margins. Thirty-four specimens of CLM and adjacent noncancerous tissue were obtained from 21 patients and examined by pCLE between May 2017 and March 2018. Images were obtained both without and with fluorescein sodium applied to the cut surface and compared with hematoxylin and eosin-stained tissue. Fluorescence intensity (FI) was measured by luminance-analysis software. Without external fluorophores, pCLE visualized 91.2% of CLM tissues as an irregular structure with low autofluorescence and 90.5% of noncancerous liver tissues as a regular structure with high autofluorescence. The median FI was significantly lower in cancer than in benign tissue in patients without chemotherapy [70.4 (51.6-110) vs. 48.3 (39.0-59.4), p = 0.002] and with chemotherapy [67.9 (54.6-89.2) vs. 48.6 (28.8-82.1), p < 0.001]. The border was clearly visible; pCLE with fluorescein sodium clearly showed their morphologies. In summary, our study demonstrated real-time pCLE distinguished CLM and noncancerous tissue by differences in structure and FI regardless of prehepatectomy chemotherapy. Fluorescein spray facilitated clear visualization of differences in the morphology.
    Language English
    Publishing date 2023-08-23
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1149134-6
    ISSN 1749-0774 ; 0914-7470
    ISSN (online) 1749-0774
    ISSN 0914-7470
    DOI 10.1007/s13577-023-00965-9
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    Zs.A 3676: Show issues Location:
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  10. Article ; Online: Need for a high-specificity test for confirming weakly positive result in an immunochromatographic SARS-CoV-2-specific antigen test: A case report.

    Tanimoto, Takuya / Matsumura, Mirai / Tada, Shinpei / Fujita, Suguru / Ueno, Sayaka / Hamai, Kosuke / Omoto, Takuji / Maeda, Hiroyuki / Nishisaka, Takashi / Ishikawa, Nobuhisa

    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

    2020  Volume 54, Issue 3, Page(s) 534–535

    MeSH term(s) Adult ; Antigens, Viral/immunology ; COVID-19/diagnosis ; COVID-19 Nucleic Acid Testing ; COVID-19 Serological Testing/methods ; Chromatography, Affinity/methods ; False Positive Reactions ; Humans ; Male ; Nasopharynx/virology ; RNA, Viral ; SARS-CoV-2/isolation & purification ; Saliva/virology ; Sensitivity and Specificity
    Chemical Substances Antigens, Viral ; RNA, Viral
    Language English
    Publishing date 2020-12-01
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 1497590-7
    ISSN 1995-9133 ; 1684-1182 ; 0253-2662
    ISSN (online) 1995-9133
    ISSN 1684-1182 ; 0253-2662
    DOI 10.1016/j.jmii.2020.11.004
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