LIVIVO - Search results -

Search results

Result 1 - 10 of total 194

Search options

Article: Examining the effects of national initiatives to improve the physical health of people with psychosis in England: secondary analysis of data from the National Clinical Audit of Psychosis.

Williams, Ryan / Natkulasingam, Sagana / Tooke, Beatrice / Webster, Ella / Quirk, Alan / Gupta, Veenu / French, Paul / Smith, Jo / Crawford, Mike J

BJPsych bulletin

2021 Volume 46, Issue 3, Page(s) 140–147

Abstract: Aims and methods: To examine whether national initiatives have led to improvements in the physical health of people with psychosis. Secondary analysis of a national audit of services for people with psychosis. Proportions of patients in 'good health' ... ...

Abstract	Aims and methods: To examine whether national initiatives have led to improvements in the physical health of people with psychosis. Secondary analysis of a national audit of services for people with psychosis. Proportions of patients in 'good health' according to seven measures, and one composite measure derived from national standards, were compared between multiple rounds of data collection. Results: The proportion of patients in overall 'good health' under the care of 'Early Intervention in Psychosis' teams increased from 2014-2019, particularly for measures of smoking, alcohol and substance use. There was no overall change in the proportion of patients in overall 'good health' under the care of 'Community Mental Health Teams' from 2011-2017. However, there were improvements in alcohol use, blood glucose and lipid levels. Clinical implications: There have been modest improvements in the health of people with psychosis over the last nine years. Continuing efforts are required to translate these improvements into reductions in premature mortality.
Language	English
Publishing date	2021-02-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2816886-0
ISSN	2056-4708 ; 2056-4694
ISSN (online)	2056-4708
ISSN	2056-4694
DOI	10.1192/bjb.2021.38
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: The making of a new medical school.

Tooke, J E

Hospital medicine (London, England : 1998)

2001 Volume 62, Issue 11, Page(s) 660–661

MeSH term(s)	Curriculum ; Education, Medical, Undergraduate/organization & administration ; England ; Humans ; Schools, Medical/organization & administration ; Schools, Medical/supply & distribution
Language	English
Publishing date	2001-11
Publishing country	England
Document type	Editorial
ZDB-ID	604229-6
ISSN	1462-3935 ; 0007-1064
ISSN	1462-3935 ; 0007-1064
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 651: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.A 1515: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Multiple skin lesions on a background of hypergammaglobulinaemia.

Schauer, A / Wood, B A / Tan, E / Tai, A / McLean-Tooke, A / Crawford, J / Harvey, N T

Clinical and experimental dermatology

2018 Volume 44, Issue 7, Page(s) 787–790

MeSH term(s)	Asia, Southeastern/ethnology ; C-Reactive Protein/analysis ; Diagnosis, Differential ; Humans ; Hypergammaglobulinemia/blood ; Male ; Plasma Cells/pathology ; Plasmacytoma/ethnology ; Plasmacytoma/pathology ; Skin Diseases/pathology
Chemical Substances	C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2018-11-25
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	195504-4
ISSN	1365-2230 ; 0307-6938
ISSN (online)	1365-2230
ISSN	0307-6938
DOI	10.1111/ced.13837
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1278: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Possible pathophysiological mechanisms for diabetic angiopathy in type 2 diabetes.

Tooke, J E

Journal of diabetes and its complications

2000 Volume 14, Issue 4, Page(s) 197–200

Abstract: The expression of large and small vessel disease in type 2 diabetes differs from that observed in type 1, with a higher prevalence of atherosclerosis and hypertension, maculopathy rather than proliferative retinopathy, and nephropathy of a more complex ... ...

Abstract	The expression of large and small vessel disease in type 2 diabetes differs from that observed in type 1, with a higher prevalence of atherosclerosis and hypertension, maculopathy rather than proliferative retinopathy, and nephropathy of a more complex nature. Such differences are mirrored by differences in vascular pathophysiology with an early impairment of microvascular vasodilatory reserve being a prominent feature. The defect appears to be endothelium dependent and in conjunction with evidence of endothelium activation suggests that the endothelium plays a crucial role in the pathogenesis of vascular disease in type 2 diabetes and may even be an intrinsic feature or common antecedent of the insulin resistance syndrome. Several cellular mechanisms may be proposed linking insulin resistance and endothelial dysfunction including (i) abnormalities of common signal transduction mechanisms, (ii) alterations in cell membrane fluidity altering the expression and/or presentation of a wide range of receptors, or (iii) changes in oxidative stress. It is intuitively unlikely that the alteration of a single signal transduction mechanism could be a common cause, particularly as aspects of endothelial dysfunction implicate different mechanisms. Accordingly, changes in oxidative stress, either stemming from glucose-mediated increased free-radical generation and/or reduction of antioxidant capacity, are strong contender mechanisms. Not only may increased oxidative stress result in the quenching of nitric oxide, neutralizing its many protective functions, but it may also damage DNA, protein structure, and membrane properties. Elucidating the links between oxidative stress, endothelial function, and insulin resistance has important implications for the prevention of diabetic angiopathy and perhaps for the prevention of diabetes itself.
MeSH term(s)	Diabetes Mellitus, Type 2/physiopathology ; Diabetic Angiopathies/physiopathology ; Endothelium, Vascular/physiopathology ; Humans ; Insulin Resistance ; Microcirculation/physiopathology ; Oxidative Stress ; Vasodilation
Language	English
Publishing date	2000-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1105840-7
ISSN	1056-8727
ISSN	1056-8727
DOI	10.1016/s1056-8727(00)00083-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2225: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: What is the mechanism of microalbuminuria in diabetes: a role for the glomerular endothelium?

Satchell, S C / Tooke, J E

Diabetologia

2008 Volume 51, Issue 5, Page(s) 714–725

Abstract: Microalbuminuria is an important risk factor for cardiovascular disease and progressive renal impairment. This holds true in the general population and particularly in those with diabetes, in whom it is common and marks out those likely to develop ... ...

Abstract	Microalbuminuria is an important risk factor for cardiovascular disease and progressive renal impairment. This holds true in the general population and particularly in those with diabetes, in whom it is common and marks out those likely to develop macrovascular disease and progressive renal impairment. Understanding the pathophysiological mechanisms through which microalbuminuria occurs holds the key to designing therapies to arrest its development and prevent these later manifestations. Microalbuminuria arises from the increased passage of albumin through the glomerular filtration barrier. This requires ultrastructural changes rather than alterations in glomerular pressure or filtration rate alone. Compromise of selective glomerular permeability can be confirmed in early diabetic nephropathy but does not correlate well with reported glomerular structural changes. The loss of systemic endothelial glycocalyx--a protein-rich surface layer on the endothelium--in diabetes suggests that damage to this layer represents this missing link. The epidemiology of microalbuminuria reveals a close association with systemic endothelial dysfunction and with vascular disease, also implicating glomerular endothelial dysfunction in microalbuminuria. Our understanding of the metabolic and hormonal sequelae of hyperglycaemia is increasing, and we consider these in the context of damage to the glomerular filtration barrier. Reactive oxygen species, inflammatory cytokines and growth factors are key players in this respect. Taken together with the above observations and the presence of generalised endothelial dysfunction, these considerations lead to the conclusion that glomerular endothelial dysfunction, and in particular damage to its glycocalyx, represents the most likely initiating step in diabetic microalbuminuria.
MeSH term(s)	Albuminuria/pathology ; Albuminuria/physiopathology ; Diabetes Mellitus, Type 1/pathology ; Diabetes Mellitus, Type 1/physiopathology ; Diabetes Mellitus, Type 2/pathology ; Diabetes Mellitus, Type 2/physiopathology ; Diabetic Angiopathies/pathology ; Diabetic Nephropathies/pathology ; Diabetic Nephropathies/physiopathology ; Endothelial Cells/pathology ; Endothelial Cells/physiology ; Glomerular Filtration Rate ; Humans ; Hypoglycemia/pathology ; Hypoglycemia/physiopathology ; Kidney Glomerulus/pathology ; Kidney Glomerulus/physiopathology ; Risk Factors ; Serum Albumin/metabolism
Chemical Substances	Serum Albumin
Language	English
Publishing date	2008-03-18
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1694-9
ISSN	1432-0428 ; 0012-186X
ISSN (online)	1432-0428
ISSN	0012-186X
DOI	10.1007/s00125-008-0961-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 279: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Allosteric communication in class A β-lactamases occurs via cooperative coupling of loop dynamics.

Galdadas, Ioannis / Qu, Shen / Oliveira, Ana Sofia F / Olehnovics, Edgar / Mack, Andrew R / Mojica, Maria F / Agarwal, Pratul K / Tooke, Catherine L / Gervasio, Francesco Luigi / Spencer, James / Bonomo, Robert A / Mulholland, Adrian J / Haider, Shozeb

eLife

2021 Volume 10

Abstract: Understanding allostery in enzymes and tools to identify it offer promising alternative strategies to inhibitor development. Through a combination of equilibrium and nonequilibrium molecular dynamics simulations, we identify allosteric effects and ... ...

Abstract	Understanding allostery in enzymes and tools to identify it offer promising alternative strategies to inhibitor development. Through a combination of equilibrium and nonequilibrium molecular dynamics simulations, we identify allosteric effects and communication pathways in two prototypical class A β-lactamases, TEM-1 and KPC-2, which are important determinants of antibiotic resistance. The nonequilibrium simulations reveal pathways of communication operating over distances of 30 Å or more. Propagation of the signal occurs through cooperative coupling of loop dynamics. Notably, 50% or more of clinically relevant amino acid substitutions map onto the identified signal transduction pathways. This suggests that clinically important variation may affect, or be driven by, differences in allosteric behavior, providing a mechanism by which amino acid substitutions may affect the relationship between spectrum of activity, catalytic turnover, and potential allosteric behavior in this clinically important enzyme family. Simulations of the type presented here will help in identifying and analyzing such differences.
MeSH term(s)	Amino Acid Substitution ; Drug Resistance, Bacterial ; Molecular Dynamics Simulation ; Protein Conformation ; beta-Lactamases/chemistry
Chemical Substances	beta-Lactamases (EC 3.5.2.6)
Language	English
Publishing date	2021-03-23
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.66567
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: A Novel Targeted Amplicon Next-Generation Sequencing Gene Panel for the Diagnosis of Common Variable Immunodeficiency Has a High Diagnostic Yield: Results from the Perth CVID Cohort Study.

Kermode, William / De Santis, Dianne / Truong, Linh / Della Mina, Erika / Salman, Sam / Thompson, Grace / Nolan, David / Loh, Richard / Mallon, Dominic / Mclean-Tooke, Andrew / John, Mina / Tangye, Stuart G / O'Sullivan, Michael / D'Orsogna, Lloyd J

The Journal of molecular diagnostics : JMD

2022 Volume 24, Issue 6, Page(s) 586–599

Abstract: With the advent of next-generation sequencing (NGS), monogenic forms of common variable immunodeficiency (CVID) have been increasingly described. Our study aimed to identify disease-causing variants in a Western Australian CVID cohort using a novel ... ...

Abstract	With the advent of next-generation sequencing (NGS), monogenic forms of common variable immunodeficiency (CVID) have been increasingly described. Our study aimed to identify disease-causing variants in a Western Australian CVID cohort using a novel targeted NGS panel. Targeted amplicon NGS was performed on 22 unrelated subjects who met the formal European Society for Immunodeficiencies-Pan-American Group for Immunodeficiency diagnostic criteria for CVID and had at least one of the following additional criteria: disease onset at age <18 years, autoimmunity, low memory B lymphocytes, family history, and/or history of lymphoproliferation. Candidate variants were assessed by in silico predictions of deleteriousness, comparison to the literature, and classified according to the American College of Medical Genetics and Genomics-Association for Molecular Pathology criteria. All detected genetic variants were verified independently by an external laboratory, and additional functional studies were performed if required. Pathogenic or likely pathogenic variants were detected in 6 of 22 (27%) patients. Monoallelic variants of uncertain significance were also identified in a further 4 of 22 patients (18%). Pathogenic variants, likely pathogenic variants, or variants of uncertain significance were found in TNFRSF13B, TNFRSF13C, ICOS, AICDA, IL21R, NFKB2, and CD40LG, including novel variants and variants with unexpected inheritance pattern. Targeted amplicon NGS is an effective tool to identify monogenic disease-causing variants in CVID, and is comparable or superior to other NGS methods. Moreover, targeted amplicon NGS identified patients who may benefit from targeted therapeutic strategies and had important implications for family members.
MeSH term(s)	Adolescent ; Australia ; Cohort Studies ; Common Variable Immunodeficiency/diagnosis ; Common Variable Immunodeficiency/genetics ; High-Throughput Nucleotide Sequencing ; Humans ; Mutation
Language	English
Publishing date	2022-05-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2000060-1
ISSN	1943-7811 ; 1525-1578
ISSN (online)	1943-7811
ISSN	1525-1578
DOI	10.1016/j.jmoldx.2022.02.007
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5146: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Microvasculature in diabetes.

Tooke, J E

Cardiovascular research

1996 Volume 32, Issue 4, Page(s) 764–771

MeSH term(s)	Diabetes Mellitus/physiopathology ; Diabetic Angiopathies/physiopathology ; Endothelium, Vascular/physiopathology ; Humans ; Microcirculation/physiopathology
Language	English
Publishing date	1996-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	80340-6
ISSN	1755-3245 ; 0008-6363
ISSN (online)	1755-3245
ISSN	0008-6363
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 565: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Endothelium: the main actor or choreographer in the remodelling of the retinal microvasculature in diabetes?

Tooke, J E

Diabetologia

1996 Volume 39, Issue 6, Page(s) 745–746

MeSH term(s)	Diabetic Retinopathy/etiology ; Diabetic Retinopathy/physiopathology ; Endothelium, Vascular/physiology ; Humans ; Microcirculation ; Retinal Vessels/anatomy & histology ; Retinal Vessels/physiology
Language	English
Publishing date	1996-06
Publishing country	Germany
Document type	Comment ; Journal Article
ZDB-ID	1694-9
ISSN	1432-0428 ; 0012-186X
ISSN (online)	1432-0428
ISSN	0012-186X
DOI	10.1007/bf00418549
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 279: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Demonstration of the role of cell wall homeostasis in

Proceedings of the National Academy of Sciences of the United States of America

2021 Volume 118, Issue 44

Abstract: Bacterial cell wall peptidoglycan is essential, maintaining both cellular integrity and morphology, in the face of internal turgor pressure. Peptidoglycan synthesis is important, as it is targeted by cell wall antibiotics, including methicillin and ... ...

Abstract	Bacterial cell wall peptidoglycan is essential, maintaining both cellular integrity and morphology, in the face of internal turgor pressure. Peptidoglycan synthesis is important, as it is targeted by cell wall antibiotics, including methicillin and vancomycin. Here, we have used the major human pathogen
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents/metabolism ; Anti-Infective Agents/pharmacology ; Bacterial Proteins/metabolism ; Cell Wall/metabolism ; Cell Wall/physiology ; Homeostasis ; Methicillin/pharmacology ; N-Acetylmuramoyl-L-alanine Amidase/metabolism ; Peptidoglycan/metabolism ; Staphylococcal Infections/microbiology ; Staphylococcus aureus/growth & development ; Staphylococcus aureus/metabolism ; Teichoic Acids/metabolism ; Vancomycin/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Anti-Infective Agents ; Bacterial Proteins ; Peptidoglycan ; Teichoic Acids ; Vancomycin (6Q205EH1VU) ; N-Acetylmuramoyl-L-alanine Amidase (EC 3.5.1.28) ; Methicillin (Q91FH1328A)
Language	English
Publishing date	2021-10-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2106022118
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1148: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito