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  1. Article ; Online: Editorial: Community series in new insights in sepsis pathogenesis and renal dysfunction: immune mechanisms and novel management strategies: volume II.

    Honore, Patrick M / Stasi, Alexandra / Cantaluppi, Vincenzo

    Frontiers in immunology

    2023  Volume 14, Page(s) 1322571

    MeSH term(s) Humans ; Neutrophils ; Sepsis/therapy ; Kidney Diseases/etiology ; Kidney Diseases/therapy
    Language English
    Publishing date 2023-10-27
    Publishing country Switzerland
    Document type Editorial ; Comment
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1322571
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  2. Article: Editorial: COVID-19 Related Kidney Disease: From Epidemiology to Clinical Management.

    Fiorentino, Marco / Cantaluppi, Vincenzo / Mehta, Ravindra L

    Frontiers in medicine

    2022  Volume 9, Page(s) 956409

    Language English
    Publishing date 2022-06-28
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.956409
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  3. Article ; Online: Pharmacotherapy considerations in patients who develop acute kidney injury during anti-cancer therapy.

    Parodi, Emanuele / Rossi, Maura / Bottiglieri, Achille / Ladetto, Marco / Merlotti, Guido / Cantaluppi, Vincenzo / Quaglia, Marco

    Expert opinion on pharmacotherapy

    2024  , Page(s) 1–16

    Abstract: Introduction: Acute kidney injury (AKI) frequently develops in patients receiving cancer therapy and requires a wide differential diagnosis due to possible role of unique cancer and drug-related factors, in addition to common pre- and post-renal causes. ...

    Abstract Introduction: Acute kidney injury (AKI) frequently develops in patients receiving cancer therapy and requires a wide differential diagnosis due to possible role of unique cancer and drug-related factors, in addition to common pre- and post-renal causes. Rapid development of new molecular targeted anti-cancer drugs and immunotherapies has opened unprecedented possibilities of treatment at the price of an increased spectrum of renal side effects.
    Areas covered: The present review aims at providing a state-of-the-art picture of AKI in cancer patient (PubMed and Embase libraries were searched from inception to January 2024), with a focus on differential diagnosis and management of diverse clinical settings. Reports of parenchymal AKI due to glomerular, microvascular, tubular and interstitial damage have been constantly increasing. Complex electrolyte and acid-base disorders can coexist. The role of renal biopsy and possible therapeutic approaches are also discussed.
    Expert opinion: Onconephrology has become an important subspecialty of clinical nephrology, requiring constantly updated skills and a high degree of interdisciplinary integration to tackle diagnostic challenges and even therapeutic and ethical dilemmas. Integrated onconephrological guidelines and availability of biomarkers may provide new tools for management of this unique type of patients in the near future.
    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2024.2346268
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5130: Show issues Location:
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  4. Article ; Online: Role of the CD40-CD40 Ligand Pathway in Cardiovascular Events, Neurological Alterations, and Other Clinical Complications of Chronic Hemodialysis Patients: Protective Role of Adsorptive Membranes.

    Marengo, Marita / Migliori, Massimiliano / Merlotti, Guido / Fabbrini, Paolo / Panichi, Vincenzo / Cantaluppi, Vincenzo

    Blood purification

    2023  , Page(s) 1–16

    Abstract: Despite the recent advances in dialysis technology, mortality rate of chronic uremic patients still remains excessively high: of note, in comparison to age- and sex-matched healthy controls, this frail population shows a higher incidence of infections, ... ...

    Abstract Despite the recent advances in dialysis technology, mortality rate of chronic uremic patients still remains excessively high: of note, in comparison to age- and sex-matched healthy controls, this frail population shows a higher incidence of infections, cancer, cognitive decline, and, in particular, major adverse cardiovascular events (MACE) that represent nowadays the first cause of mortality. Several traditional and nontraditional factors contribute to this increased risk for MACE and accelerated cellular senescence: among these, inflammation has been shown to play a key role. The costimulatory pathway CD40-CD40 Ligand (CD40L) is harmfully activated during inflammation and uremia-associated clinical complications: in particular, the soluble form of CD40L (sCD40L) can bind to the CD40 receptor triggering a cascade of detrimental pathways in immune and nonimmune cells. In this narrative review, we summarize the current concepts of the biological role of the CD40-CD40L pathway in uremia-associated organ dysfunction, focusing on the above-described main causes of mortality. Moreover, we discuss the interaction of the CD40-CD40L pathway with extracellular vesicles, microparticles recently identified as new uremic toxins. The biological effects of sCD40L in MACE, cognitive decline, infections, and cancer will be also briefly commented. Last, based on recent studies and ongoing clinical trials, we herein describe the modulatory activity of adsorptive dialysis membranes in polymethylmethacrylate on CD40-CD40L detrimental activation.
    Language English
    Publishing date 2023-06-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 605548-5
    ISSN 1421-9735 ; 0253-5068
    ISSN (online) 1421-9735
    ISSN 0253-5068
    DOI 10.1159/000530808
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    Zs.A 1872: Show issues Location:
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  5. Article ; Online: Editorial

    Marco Fiorentino / Vincenzo Cantaluppi / Ravindra L. Mehta

    Frontiers in Medicine, Vol

    COVID-19 Related Kidney Disease: From Epidemiology to Clinical Management

    2022  Volume 9

    Keywords COVID-19 ; kidney disease ; dialysis ; acute kidney injury ; vaccination ; kidney transplant ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
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  6. Article ; Online: Extracellular Vesicles Released from Stem Cells as a New Therapeutic Strategy for Primary and Secondary Glomerulonephritis.

    Quaglia, Marco / Merlotti, Guido / Fornara, Laura / Colombatto, Andrea / Cantaluppi, Vincenzo

    International journal of molecular sciences

    2022  Volume 23, Issue 10

    Abstract: Current treatment of primary and secondary glomerulopathies is hampered by many limits and a significant proportion of these disorders still evolves towards end-stage renal disease. A possible answer to this unmet challenge could be represented by ... ...

    Abstract Current treatment of primary and secondary glomerulopathies is hampered by many limits and a significant proportion of these disorders still evolves towards end-stage renal disease. A possible answer to this unmet challenge could be represented by therapies with stem cells, which include a variety of progenitor cell types derived from embryonic or adult tissues. Stem cell self-renewal and multi-lineage differentiation ability explain their potential to protect and regenerate injured cells, including kidney tubular cells, podocytes and endothelial cells. In addition, a broad spectrum of anti-inflammatory and immunomodulatory actions appears to interfere with the pathogenic mechanisms of glomerulonephritis. Of note, mesenchymal stromal cells have been particularly investigated as therapy for Lupus Nephritis and Diabetic Nephropathy, whereas initial evidence suggest their beneficial effects in primary glomerulopathies such as IgA nephritis. Extracellular vesicles mediate a complex intercellular communication network, shuttling proteins, nucleic acids and other bioactive molecules from origin to target cells to modulate their functions. Stem cell-derived extracellular vesicles recapitulate beneficial cytoprotective, reparative and immunomodulatory properties of parental cells and are increasingly recognized as a cell-free alternative to stem cell-based therapies for different diseases including glomerulonephritis, also considering the low risk for potential adverse effects such as maldifferentiation and tumorigenesis. We herein summarize the renoprotective potential of therapies with stem cells and extracellular vesicles derived from progenitor cells in glomerulonephritis, with a focus on their different mechanisms of actions. Technological progress and growing knowledge are paving the way for wider clinical application of regenerative medicine to primary and secondary glomerulonephritis: this multi-level, pleiotropic therapy may open new scenarios overcoming the limits and side effects of traditional treatments, although the promising results of experimental models need to be confirmed in the clinical setting.
    MeSH term(s) Endothelial Cells ; Extracellular Vesicles/metabolism ; Glomerulonephritis/metabolism ; Glomerulonephritis/therapy ; Humans ; Regenerative Medicine/methods ; Stem Cells/metabolism
    Language English
    Publishing date 2022-05-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23105760
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  7. Article ; Online: Renal Injury During Preclampsia: Role of Extracellular Vesicles.

    Pagani, Fabiola / Cantaluppi, Vincenzo

    Nephron

    2019  Volume 143, Issue 3, Page(s) 197–201

    Abstract: Preeclampsia (PE) represents an important cause of acute kidney injury during pregnancy with a high rate of both maternal and fetal morbidity and mortality. The presence of endothelial dysfunction is the main cause of PE development; however, the ... ...

    Abstract Preeclampsia (PE) represents an important cause of acute kidney injury during pregnancy with a high rate of both maternal and fetal morbidity and mortality. The presence of endothelial dysfunction is the main cause of PE development; however, the pathogenic mechanisms are not still fully elucidated. A plethora of harmful mediators are released in response to endothelial damage: these circulating molecules (soluble fms-like tyrosine kinase 1, endothelin-1) can exert antiangiogenic and vasoconstrictive effects on distant organs including the kidney. In this scenario, extracellular vesicles (EVs), microparticles released by different types of activated cells and involved in intercellular communication, are produced both in normal pregnancy and PE. The aim of this review is to summarize the modern concepts of PE-associated kidney damage and the potential role of EV in these detrimental mechanisms.
    MeSH term(s) Acute Kidney Injury/etiology ; Acute Kidney Injury/pathology ; Acute Kidney Injury/therapy ; Adult ; Extracellular Vesicles/pathology ; Female ; Humans ; Pre-Eclampsia/pathology ; Pre-Eclampsia/therapy ; Pregnancy
    Language English
    Publishing date 2019-08-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 207121-6
    ISSN 2235-3186 ; 1423-0186 ; 1660-8151 ; 0028-2766
    ISSN (online) 2235-3186 ; 1423-0186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000502456
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 169: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: Regenerative Role of Stem Cell-Derived Extracellular Vesicles in Acute Kidney Injury.

    Medica, Davide / Dellepiane, Sergio / Cantaluppi, Vincenzo

    Nephron

    2020  Volume 144, Issue 12, Page(s) 638–643

    Abstract: Acute kidney injury (AKI) is a frequent complication of hospital admission and worsens short- and long-term patients' prognosis. Currently, AKI treatment remains supportive and no therapy has proven significant benefit in clinical trials. Stem cells (SCs) ...

    Abstract Acute kidney injury (AKI) is a frequent complication of hospital admission and worsens short- and long-term patients' prognosis. Currently, AKI treatment remains supportive and no therapy has proven significant benefit in clinical trials. Stem cells (SCs) are a promising therapeutic option, but their translation to the clinical setting is limited by the risk of rejection or aberrant differentiation. Numerous studies have shown how SC effects are mediated by paracrine factors such as extracellular vesicles (EVs). In this review, we describe the preclinical evidence about EV efficacy in acute tubular and glomerular injury and the recently generated clinical data.
    MeSH term(s) Acute Kidney Injury/pathology ; Extracellular Vesicles/pathology ; Humans ; Kidney Glomerulus/pathology ; Regenerative Medicine ; Stem Cells/cytology
    Language English
    Publishing date 2020-10-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 207121-6
    ISSN 2235-3186 ; 1423-0186 ; 1660-8151 ; 0028-2766
    ISSN (online) 2235-3186 ; 1423-0186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000511347
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 169: Show issues Location:
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  9. Article ; Online: Extracellular Vesicles Released from Stem Cells as a New Therapeutic Strategy for Primary and Secondary Glomerulonephritis

    Marco Quaglia / Guido Merlotti / Laura Fornara / Andrea Colombatto / Vincenzo Cantaluppi

    International Journal of Molecular Sciences, Vol 23, Iss 5760, p

    2022  Volume 5760

    Abstract: Current treatment of primary and secondary glomerulopathies is hampered by many limits and a significant proportion of these disorders still evolves towards end-stage renal disease. A possible answer to this unmet challenge could be represented by ... ...

    Abstract Current treatment of primary and secondary glomerulopathies is hampered by many limits and a significant proportion of these disorders still evolves towards end-stage renal disease. A possible answer to this unmet challenge could be represented by therapies with stem cells, which include a variety of progenitor cell types derived from embryonic or adult tissues. Stem cell self-renewal and multi-lineage differentiation ability explain their potential to protect and regenerate injured cells, including kidney tubular cells, podocytes and endothelial cells. In addition, a broad spectrum of anti-inflammatory and immunomodulatory actions appears to interfere with the pathogenic mechanisms of glomerulonephritis. Of note, mesenchymal stromal cells have been particularly investigated as therapy for Lupus Nephritis and Diabetic Nephropathy, whereas initial evidence suggest their beneficial effects in primary glomerulopathies such as IgA nephritis. Extracellular vesicles mediate a complex intercellular communication network, shuttling proteins, nucleic acids and other bioactive molecules from origin to target cells to modulate their functions. Stem cell-derived extracellular vesicles recapitulate beneficial cytoprotective, reparative and immunomodulatory properties of parental cells and are increasingly recognized as a cell-free alternative to stem cell-based therapies for different diseases including glomerulonephritis, also considering the low risk for potential adverse effects such as maldifferentiation and tumorigenesis. We herein summarize the renoprotective potential of therapies with stem cells and extracellular vesicles derived from progenitor cells in glomerulonephritis, with a focus on their different mechanisms of actions. Technological progress and growing knowledge are paving the way for wider clinical application of regenerative medicine to primary and secondary glomerulonephritis: this multi-level, pleiotropic therapy may open new scenarios overcoming the limits and side effects of traditional treatments, ...
    Keywords glomerulonephritis ; focal and segmental glomerulosclerosis ; IgA glomerulonephritis ; vasculitis ; lupus nephritis ; diabetic nephropathy ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 571
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Update on current and potential application of extracellular vesicles in kidney transplantation.

    Abinti, Matteo / Favi, Evaldo / Alfieri, Carlo Maria / Zanoni, Francesca / Armelloni, Silvia / Ferraresso, Mariano / Cantaluppi, Vincenzo / Castellano, Giuseppe

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2023  Volume 23, Issue 11, Page(s) 1673–1693

    Abstract: Kidney transplantation (KT) is the best treatment for end-stage kidney disease. However, early diagnosis of graft injury remains challenging, mainly because of the lack of accurate and noninvasive diagnostic techniques. Improving graft outcomes is ... ...

    Abstract Kidney transplantation (KT) is the best treatment for end-stage kidney disease. However, early diagnosis of graft injury remains challenging, mainly because of the lack of accurate and noninvasive diagnostic techniques. Improving graft outcomes is equally demanding, as is the development of innovative therapies. Many research efforts are focusing on extracellular vesicles, cellular particles free in each body fluid that have shown promising results as precise markers of damage and potential therapeutic targets in many diseases, including the renal field. In fact, through their receptors and cargo, they act in damage response and immune modulation. In transplantation, they may be used to determine organ quality and aging, the presence of delayed graft function, rejection, and many other transplant-related pathologies. Moreover, their low immunogenicity and safe profile make them ideal for drug delivery and the development of therapies to improve KT outcomes. In this review, we summarize current evidence about extracellular vesicles in KT, starting with their characteristics and major laboratory techniques for isolation and characterization. Then, we discuss their use as potential markers of damage and as therapeutic targets, discussing their promising use in clinical practice as a form of liquid biopsy.
    MeSH term(s) Humans ; Kidney Transplantation/adverse effects ; Kidney ; Kidney Failure, Chronic/surgery ; Extracellular Vesicles ; Graft Rejection/diagnosis ; Graft Rejection/etiology ; Graft Rejection/prevention & control
    Language English
    Publishing date 2023-07-28
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1016/j.ajt.2023.07.010
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