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Article: Coumarin-piperazine derivatives as biologically active compounds.

Ostrowska, Kinga

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

2019 Volume 28, Issue 2, Page(s) 220–232

Abstract: A number of psychiatric disorders, including anxiety, schizophrenia, Parkinson's disease, depression and others CNS diseases are known to induce defects in the function of neural pathways sustained by the neurotransmitters, like dopamine and serotonin. ...

Abstract	A number of psychiatric disorders, including anxiety, schizophrenia, Parkinson's disease, depression and others CNS diseases are known to induce defects in the function of neural pathways sustained by the neurotransmitters, like dopamine and serotonin.
Language	English
Publishing date	2019-12-07
Publishing country	Saudi Arabia
Document type	Journal Article ; Review
ZDB-ID	1378024-4
ISSN	1319-0164
ISSN	1319-0164
DOI	10.1016/j.jsps.2019.11.025
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Article ; Online: Cell dehydration of intergeneric hybrid induces subgenome-related specific responses.

Hura, Tomasz / Hura, Katarzyna / Dziurka, Kinga / Ostrowska, Agnieszka / Urban, Karolina

Physiologia plantarum

2023 Volume 175, Issue 1, Page(s) e13855

Abstract: The aim was to identify subgenome-related specific responses in two types of triticale, that is, of the wheat-dominated genome (WDG) and rye-dominated genome (RDG), to water stress induced in the early phase (tillering) of plant growth. Higher activity ... ...

Abstract	The aim was to identify subgenome-related specific responses in two types of triticale, that is, of the wheat-dominated genome (WDG) and rye-dominated genome (RDG), to water stress induced in the early phase (tillering) of plant growth. Higher activity of the primary metabolism of carbohydrates is a feature of the WDG type, while the dominance of the rye genome is associated with a higher activity of the secondary metabolism of phenolic compounds in the RDG type. The study analyzed carbohydrates and key enzymes of their synthesis, free phenolic compounds and carbohydrate-related components of the cell wall, monolignols, and shikimic acid (ShA), which is a key link between the primary and secondary metabolism of phenolic compounds. Under water stress, dominance of the wheat genome in the WDG type was manifested by an increased accumulation of the large subunit of Rubisco and sucrose phosphate synthase and a higher content of raffinose and stachyose compared with the RDG type. In dehydrated RDG plants, higher activity of L-phenylalanine ammonia lyase (PAL) and L-tyrosine ammonia lyase (TAL), as well as a higher level of ShA, free and cell wall-bound p-hydroxybenzoic acid, free homovanillic acid, free sinapic acid, and cell wall-bound syringic acid can be considered biochemical indicators of the dominance of the rye genome.
MeSH term(s)	Dehydration ; Phenylalanine Ammonia-Lyase/genetics ; Carbohydrates ; Plants/metabolism ; Phenols/metabolism
Chemical Substances	Phenylalanine Ammonia-Lyase (EC 4.3.1.24) ; Carbohydrates ; Phenols
Language	English
Publishing date	2023-01-17
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	2020837-6
ISSN	1399-3054 ; 0031-9317
ISSN (online)	1399-3054
ISSN	0031-9317
DOI	10.1111/ppl.13855
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Article ; Online: New Piperazine Derivatives of 6-Acetyl-7-hydroxy-4-methylcoumarin as 5-HT

Ostrowska, Kinga / Leśniak, Anna / Gryczka, Weronika / Dobrzycki, Łukasz / Bujalska-Zadrożny, Magdalena / Trzaskowski, Bartosz

International journal of molecular sciences

2023 Volume 24, Issue 3

Abstract: A series of 15 new derivatives of 6-acetyl-7-hydroxy-4-methylcoumarin containing a piperazine group were designed with the help of computational methods and were synthesized to study their affinity for the serotonin 5- ... ...

Abstract	A series of 15 new derivatives of 6-acetyl-7-hydroxy-4-methylcoumarin containing a piperazine group were designed with the help of computational methods and were synthesized to study their affinity for the serotonin 5-HT
MeSH term(s)	Serotonin ; Receptor, Serotonin, 5-HT1A ; Receptors, Serotonin ; Receptors, Serotonin, 5-HT1 ; Heterocyclic Compounds ; Piperazines/pharmacology ; Receptor, Serotonin, 5-HT2A
Chemical Substances	Serotonin (333DO1RDJY) ; Receptor, Serotonin, 5-HT1A (112692-38-3) ; 7-hydroxy-4-methylcoumarin ; Receptors, Serotonin ; Receptors, Serotonin, 5-HT1 ; Heterocyclic Compounds ; Piperazines ; Receptor, Serotonin, 5-HT2A
Language	English
Publishing date	2023-02-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24032779
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Article ; Online: Raman spectroscopy can recognize the KMT2A rearrangement as a distinct subtype of leukemia.

Leszczenko, Patrycja / Nowakowska, Anna M / Jakubowska, Justyna / Pastorczak, Agata / Zabczynska, Marta / Mlynarski, Wojciech / Baranska, Malgorzata / Ostrowska, Kinga / Majzner, Katarzyna

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2024 Volume 314, Page(s) 124173

Abstract: Acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) are the two most common hematologic malignancies, challenging to treat and associated with high recurrence and mortality rates. This work aims to identify specific Raman biomarkers of ... ...

Abstract	Acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) are the two most common hematologic malignancies, challenging to treat and associated with high recurrence and mortality rates. This work aims to identify specific Raman biomarkers of ALL cells with the KMT2A gene rearrangement (KMT2A-r), representing a highly aggressive subtype of childhood leukemia with a poor prognosis. The proposed approach combines the sensitivity and specificity of Raman spectroscopy with machine learning and allows us to distinguish not only myelo- and lymphoblasts but also discriminate B-cell precursor (BCP) ALL with KMT2A-r from other blasts of BCP-ALL. We have found that KMT2A-r ALL cells fixed with 0.5% glutaraldehyde exhibit a unique spectroscopic profile that enables us to identify this subtype from other leukemias and normal cells. Therefore, a rapid and label-free method was developed to identify ALL blasts with KMT2A-r based on the ratio of the two Raman bands assigned to phenylalanine - 1040 and 1008 cm
MeSH term(s)	Humans ; Myeloid-Lymphoid Leukemia Protein/genetics ; Spectrum Analysis, Raman ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/pathology ; Biomarkers ; Hematopoietic Stem Cells
Chemical Substances	Myeloid-Lymphoid Leukemia Protein (149025-06-9) ; Biomarkers
Language	English
Publishing date	2024-03-18
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2024.124173
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Article ; Online: Teaching "Biochemistry with Elements of Chemistry" in the COVID-19 pandemic.

Dudzik, Paulina / Bentke-Imiolek, Anna / Kocemba-Pilarczyk, Kinga A / Ostrowska, Barbara

Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology

2023 Volume 51, Issue 3, Page(s) 316–324

Abstract: The purpose of the presented article is to evaluate the students' perception of the online teaching educational model as a part of the "Biochemistry with Elements of Chemistry" course conducted during the COVID-19 pandemic at the Faculty of Medicine of ... ...

Abstract	The purpose of the presented article is to evaluate the students' perception of the online teaching educational model as a part of the "Biochemistry with Elements of Chemistry" course conducted during the COVID-19 pandemic at the Faculty of Medicine of the Jagiellonian University Medical College. The first part of the article reflects upon the pandemic impact on the transition from the in-person (standard format) to a complete remote learning format. The next part is based on the responses of the students to a questionnaire and presents an analysis of the students' preferences and perceptions regarding synchronous and asynchronous teaching methods. Students answered questions about the advantages and disadvantages of distance learning programs. They indicated the most suitable learning mode in terms of gaining knowledge and enhancing their motivation to learn. They listed factors that facilitated remote learning as well as those which made it difficult and posed a challenge to adjust to the new system, in all types of classes, that is, lectures, seminars, and laboratories. The last part of this paper presents the results of the students' performance in the pandemic-enforced system and compares them with the results from the previous class of students from the past year, when teaching was conducted mainly in the standard format. The conclusions from the given analysis may enable beneficial changes for the "Biochemistry with Elements of Chemistry" course for remote teaching in the future. It may also provide valuable insights for such types of courses conducted at other Universities and promote deliberations to continuously improve learning outcomes.
MeSH term(s)	Humans ; Pandemics ; COVID-19/epidemiology ; Students ; Learning ; Faculty
Language	English
Publishing date	2023-01-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2039717-3
ISSN	1539-3429 ; 1470-8175
ISSN (online)	1539-3429
ISSN	1470-8175
DOI	10.1002/bmb.21712
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Article ; Online: New Piperazine Derivatives of 6-Acetyl-7-hydroxy-4-methylcoumarin as 5-HT 1A Receptor Agents

Kinga Ostrowska / Anna Leśniak / Weronika Gryczka / Łukasz Dobrzycki / Magdalena Bujalska-Zadrożny / Bartosz Trzaskowski

International Journal of Molecular Sciences, Vol 24, Iss 2779, p

2023 Volume 2779

Abstract	A series of 15 new derivatives of 6-acetyl-7-hydroxy-4-methylcoumarin containing a piperazine group were designed with the help of computational methods and were synthesized to study their affinity for the serotonin 5-HT 1A and 5-HT 2A receptors. Among them, 6-acetyl-7-{4-[4-(3-bromophenyl)piperazin-1-yl]butoxy}-4-methylchromen-2-one ( 4 ) and 6-acetyl-7-{4-[4-(2-chlorophenyl)piperazin-1-yl]butoxy}-4-methylchromen-2-one ( 7 ) exhibited excellent activity for 5-HT 1A receptors with Ki values 0.78 (0.4–1.4) nM and 0.57 (0.2–1.3) nM, respectively, comparable to the Ki values of 8-OH-DPAT (0.25 (0.097–0.66) nM). The equilibrium dissociation constant values of the tested compounds showed differential intrinsic activities of the agonist and antagonist modes.
Keywords	6-acetyl-7-hydroxy-4-methylcoumarin ; piperazine ; serotonin receptors ; CNS activity ; crystal structure ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Raman classification of selected subtypes of acute lymphoblastic leukemia (ALL).

Adamczyk, Adriana / Nowakowska, Anna M / Jakubowska, Justyna / Zabczynska, Marta / Bartoszek, Maja / Kashyrskaya, Sviatlana / Fatla, Agnieszka / Stawoski, Kacper / Siakala, Kacper / Pastorczak, Agata / Ostrowska, Kinga / Mlynarski, Wojciech / Majzner, Katarzyna / Baranska, Malgorzata

The Analyst

2024 Volume 149, Issue 2, Page(s) 571–581

Abstract: B-cell precursor acute lymphoblastic leukemia (BCP-ALL) with chromosome translocations ... ...

Abstract	B-cell precursor acute lymphoblastic leukemia (BCP-ALL) with chromosome translocations like
MeSH term(s)	Humans ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Spectrum Analysis, Raman/methods
Language	English
Publishing date	2024-01-15
Publishing country	England
Document type	Journal Article
ZDB-ID	210747-8
ISSN	1364-5528 ; 0003-2654
ISSN (online)	1364-5528
ISSN	0003-2654
DOI	10.1039/d3an01708g
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Article ; Online: Cell dehydration of intergeneric hybrid induces subgenome‐related specific responses

Hura, Tomasz / Hura, Katarzyna / Dziurka, Kinga / Ostrowska, Agnieszka / Urban, Karolina

Physiologia Plantarum. 2023 Jan., v. 175, no. 1 p.e13855-

2023

Abstract: The aim was to identify subgenome‐related specific responses in two types of triticale, that is, of the wheat‐dominated genome (WDG) and rye‐dominated genome (RDG), to water stress induced in the early phase (tillering) of plant growth. Higher activity ... ...

Abstract	The aim was to identify subgenome‐related specific responses in two types of triticale, that is, of the wheat‐dominated genome (WDG) and rye‐dominated genome (RDG), to water stress induced in the early phase (tillering) of plant growth. Higher activity of the primary metabolism of carbohydrates is a feature of the WDG type, while the dominance of the rye genome is associated with a higher activity of the secondary metabolism of phenolic compounds in the RDG type. The study analyzed carbohydrates and key enzymes of their synthesis, free phenolic compounds and carbohydrate‐related components of the cell wall, monolignols, and shikimic acid (ShA), which is a key link between the primary and secondary metabolism of phenolic compounds. Under water stress, dominance of the wheat genome in the WDG type was manifested by an increased accumulation of the large subunit of Rubisco and sucrose phosphate synthase and a higher content of raffinose and stachyose compared with the RDG type. In dehydrated RDG plants, higher activity of L‐phenylalanine ammonia lyase (PAL) and L‐tyrosine ammonia lyase (TAL), as well as a higher level of ShA, free and cell wall‐bound p‐hydroxybenzoic acid, free homovanillic acid, free sinapic acid, and cell wall‐bound syringic acid can be considered biochemical indicators of the dominance of the rye genome.
Keywords	4-hydroxybenzoic acid ; cell walls ; genome ; homovanillic acid ; hybrids ; metabolism ; phenylalanine ammonia-lyase ; plant growth ; raffinose ; ribulose-bisphosphate carboxylase ; rye ; shikimic acid ; sinapic acid ; stachyose ; sucrose-phosphate synthase ; syringic acid ; tillering ; triticale ; tyrosine ammonia-lyase ; water stress ; wheat
Language	English
Dates of publication	2023-01
Publishing place	Blackwell Publishing Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2020837-6
ISSN	1399-3054 ; 0031-9317
ISSN (online)	1399-3054
ISSN	0031-9317
DOI	10.1111/ppl.13855
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Article ; Online: Synthesis, Biological Activity, ADME and Molecular Docking Studies of Novel Ursolic Acid Derivatives as Potent Anticancer Agents.

Michalak, Olga / Cybulski, Marcin / Szymanowski, Wojciech / Gornowicz, Agnieszka / Kubiszewski, Marek / Ostrowska, Kinga / Krzeczyński, Piotr / Bielawski, Krzysztof / Trzaskowski, Bartosz / Bielawska, Anna

International journal of molecular sciences

2023 Volume 24, Issue 10

Abstract: A series of new ursolic acid (UA) derivatives substituted with various amino acids (AAs) or dipeptides (DP) at the C-3 position of the steroid skeleton was designed and synthesized. The compounds were obtained by the esterification of UA with the ... ...

Abstract	A series of new ursolic acid (UA) derivatives substituted with various amino acids (AAs) or dipeptides (DP) at the C-3 position of the steroid skeleton was designed and synthesized. The compounds were obtained by the esterification of UA with the corresponding AAs. The cytotoxic activity of the synthesized conjugates was determined using the hormone-dependent breast cancer cell line MCF-7 and the triple-negative breast cancer cell line MDA. Three derivatives (
MeSH term(s)	Cell Line, Tumor ; Structure-Activity Relationship ; Molecular Docking Simulation ; Cell Proliferation ; Drug Screening Assays, Antitumor ; Antineoplastic Agents/chemistry ; Molecular Structure ; Ursolic Acid
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2023-05-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24108875
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Article ; Online: Separate or combined effects of soil compaction and/or drought on gas exchange, chlorophyll fluorescence and physiological traits of maize (Zea mays L.) hybrids

Grzesiak, Maciej T. / Maksymowicz, Anna / Hura, Katarzyna / Dziurka, Kinga / Ostrowska, Agnieszka / Grzesiak, Stanisław

Journal of Agronomy and Crop Science. 2023 Oct., v. 209, no. 5 p.689-704

2023

Abstract: In the natural environment, plants are subjected to simultaneous or sequential presence of various abiotic and/or biotic stresses, including soil compaction and soil drought. The effects of these stresses tested separately are relatively well understood, ...

Abstract	In the natural environment, plants are subjected to simultaneous or sequential presence of various abiotic and/or biotic stresses, including soil compaction and soil drought. The effects of these stresses tested separately are relatively well understood, but still little is known about their simultaneous effects on plants. Our research involved four single hybrids of maize differing in their degree of susceptibility to soil compaction and drought. We investigated the effects of low and high soil compaction under optimal irrigation (LI, HI) and under three‐week long soil drought (LD, HD), on the gas exchange (Pn, E, gS, Ci) and chlorophyll fluorescence parameters (F₀, Fₘ, Fᵥ, Fᵥ/Fₘ), total leaf area (LA), leaf greening (SPAD), leaf water deficit (WD), leaf water potential (ψ) and membrane injury (MI). The plants experiencing high soil compaction (HI) showed a decrease in all parameters of gas exchange (Pn, E, gS, Ci), leaf area (LA), leaf greening (SPAD) and the maximal quantum efficiency of PSII (Fᵥ/Fₘ) in comparison with plants growing in non‐compacted soil (LI). An increase was observed in the other fluorescence parameters, i.e., F₀, Fₘ and Fᵥ and leaf WD, ψ and MI in HI vs. LI variants. In the plants exposed to drought (LD, HD), the changes in the measured traits were greater, especially for the sensitive hybrids P‐8400 and NS‐3023, than for the plants from LI treatment. A significant interaction between the degree of stress susceptibility and relative trait change was observed for practically all of the measured features. Moreover, in the short recovery period after the end of drought, the measured traits in LD and HD plants did not fully return to the control level, especially in the case of the sensitive hybrids (P‐8400 NS‐3023). The physiological reaction of maize hybrids to soil compaction and/or soil drought indicated the genetically determined variability of tolerance to those stresses. Significant correlation between RTC and stress susceptibility indexes (S‐SI) provided suitable criteria for the hybrid selection. Also, our results showed the plasticity and capability of maize hybrids to respond to environmental conditions.
Keywords	Zea mays ; agronomy ; chlorophyll ; corn ; drought ; fluorescence ; gas exchange ; hybrids ; irrigation ; leaf area ; leaf water potential ; leaves ; photosystem II ; soil ; soil compaction
Language	English
Dates of publication	2023-10
Size	p. 689-704.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	635552-3
ISSN	0931-2250
ISSN	0931-2250
DOI	10.1111/jac.12648
Database	NAL-Catalogue (AGRICOLA)

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