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  1. Book ; Online ; E-Book: Flow chemistry in drug discovery

    Alcazar, Jesus / Hoz, Antonio de la / Díaz-Ortiz, Angel

    (Topics in Medicinal Chemistry ; Volume 38)

    2021  

    Abstract: This book reviews the challenges and opportunities posed by flow chemistry in drug discovery, and offers a handy reference tool for medicinal chemists interested in the synthesis of biologically active compounds. Prepared by expert contributors, the ... ...

    Author's details Jesus Alcazar, Antonio de la Hoz and Angel Díaz-Ortiz, editors
    Series title Topics in Medicinal Chemistry ; Volume 38
    Abstract This book reviews the challenges and opportunities posed by flow chemistry in drug discovery, and offers a handy reference tool for medicinal chemists interested in the synthesis of biologically active compounds. Prepared by expert contributors, the respective chapters cover not only fundamental methodologies and reactions, such as the application of catalysis, especially biocatalysis and organocatalysis; and non-conventional activation techniques, from photochemistry to electrochemistry; but also the development of new process windows, processes and reactions in drug synthesis. Particular attention is given to automatization and library synthesis, which are of great importance in the pharmaceutical industry. Readers will also find coverage on selected topics of general interest, such as how flow chemistry is contributing to drug discovery R&D in developing countries, and the green character of this enabling technology, for example in the production of raw materials for the pharmaceutical industry from waste. Given its scope, the book appeals to medicinal chemistry researchers working in academia and industry alike, as well as professionals involved in scale-up and drug development.
    MeSH term(s) Technology, Pharmaceutical. ; Drug Discovery. ; Chemistry/instrumentation.
    Keywords Drug development ; Flow chemistry ; Pharmaceutical chemistry
    Subject code 615.19
    Language English
    Size 1 online resource (479 pages) :, illustrations
    Publisher Springer Nature Switzerland AG
    Publishing place Cham, Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-85592-9 ; 9783030855918 ; 3030855910 ; 978-3-030-85592-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Flow Chemistry in Drug Discovery

    Alcazar, Jesus / Díaz-Ortiz, Angel / de la Hoz, Antonio

    (Topics in Medicinal Chemistry)

    2021  

    Author's details Antonio de la Hoz is professor in Organic Chemistry in the University of Castilla-La Mancha. He obtained his Ph. D. from the Universidad Complutense in Madrid in 1986. After his postdoctoral research in 1987 with Prof. Mikael Begtrup at the Danmarks Tekniske Høskole, he joined the Faculty of Chemistry of the Universidad de Castilla-La Mancha in Ciudad Real in 1988. In 1993, he worked under the supervision Prof. André Loupy in the Université de Paris-Sud in Microwave Assisted Organic Chemistry. Prof. de la Hoz has authored over 220 scientific publications and he has been a foundation member of the Spanish Green Chemistry Network. His current research interests focus on Green methodologies, microwave activation, mechanochemistry, flow methodologies and solvent-free reactions, and the applications of heterocyclic compounds in material and supramolecular chemistry. Ángel Díaz-Ortiz Ángel Díaz-Ortiz obtained his PhD in Chemistry from the Complutense University of Madrid (Spain) in 1988
    Series title Topics in Medicinal Chemistry
    Keywords Synthesis of Bioactive Compounds ; Automated synthesis ; Asymmetric catalysis in flow ; Photochemistry in flow ; Electrochemistry in flow ; Organocatalysis ; Biocatalysis ; Flash Chemistry in microsystems ; Sustainable and Green Chemistry ; Drug Discovery ; Flow Chemistry
    Language English
    Size 508 p.
    Edition 1
    Publisher Springer International Publishing
    Document type Book
    Note PDA Manuell_13
    Format 160 x 241 x 33
    ISBN 9783030855918 ; 3030855910
    Database PDA

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  3. Article ; Online: The open data revolution: Enhancing healthcare in intensive care units.

    Muñoz-Lezcano, Sergio / de la Fuente, Carmen / Estella, Ángel / Amaya-Villar, Rosario / Puppo-Moreno, Antonio M / Armengol-de la Hoz, Miguel Ángel / Garnacho-Montero, José

    Medicina intensiva

    2024  

    Language English
    Publishing date 2024-04-05
    Publishing country Spain
    Document type Journal Article
    ISSN 2173-5727
    ISSN (online) 2173-5727
    DOI 10.1016/j.medine.2024.03.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Donor-Acceptor-Donor 1

    Tardío, Carlos / Álvarez Conde, Javier / Rodríguez, Ana María / Prieto, Pilar / Hoz, Antonio de la / Cabanillas-González, Juan / Torres-Moya, Iván

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 12

    Abstract: A new series of donor-acceptor-donor (D-A-D) structures derived from arylethynyl ... ...

    Abstract A new series of donor-acceptor-donor (D-A-D) structures derived from arylethynyl 1
    Language English
    Publishing date 2023-06-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28124631
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  5. Article: The mechanism of the reaction of hydrazines with α,β-unsaturated carbonyl compounds to afford hydrazones and 2-pyrazolines (4,5-dihydro-1H-pyrazoles): Experimental and theoretical results

    Hoz, Antonio de la / Alkorta, Ibon / Elguero, José

    Tetrahedron. 2021 Sept. 24, v. 97

    2021  

    Abstract: The reaction of hydrazines with α,β-unsaturated carbonyl compounds to afford 2-pyrazolines was studied using a dissymmetric chalcone (phenyl/p-tolyl) and three hydrazines, hydrazine itself, phenylhydrazine and thiosemicarbazide. Several products were ... ...

    Abstract The reaction of hydrazines with α,β-unsaturated carbonyl compounds to afford 2-pyrazolines was studied using a dissymmetric chalcone (phenyl/p-tolyl) and three hydrazines, hydrazine itself, phenylhydrazine and thiosemicarbazide. Several products were identified, and some reaction paths established thanks to the evolution of ¹H and ¹³C NMR spectra with time. Theoretical calculations on energies and chemical shifts were of paramount importance to ascertain the structure of some products. For important steps, the transition states were calculated while IRCs proved necessary to find some unexpected intermediates.
    Keywords chalcone ; hydrazine ; hydrazones
    Language English
    Dates of publication 2021-0924
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204285-x
    ISSN 1464-5416 ; 0040-4020 ; 0563-2064
    ISSN (online) 1464-5416
    ISSN 0040-4020 ; 0563-2064
    DOI 10.1016/j.tet.2021.132413
    Database NAL-Catalogue (AGRICOLA)

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    Zs.B 1076: Show issues Location:
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  6. Article ; Online: Peptidyl nitroalkene inhibitors of main protease rationalized by computational and crystallographic investigations as antivirals against SARS-CoV-2.

    Medrano, Francisco J / de la Hoz-Rodríguez, Sergio / Martí, Sergio / Arafet, Kemel / Schirmeister, Tanja / Hammerschmidt, Stefan J / Müller, Christin / González-Martínez, Águeda / Santillana, Elena / Ziebuhr, John / Romero, Antonio / Zimmer, Collin / Weldert, Annabelle / Zimmermann, Robert / Lodola, Alessio / Świderek, Katarzyna / Moliner, Vicent / González, Florenci V

    Communications chemistry

    2024  Volume 7, Issue 1, Page(s) 15

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic continues to represent a global public health issue. The viral main protease ( ... ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic continues to represent a global public health issue. The viral main protease (M
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2929562-2
    ISSN 2399-3669 ; 2399-3669
    ISSN (online) 2399-3669
    ISSN 2399-3669
    DOI 10.1038/s42004-024-01104-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Fully Automated Flow Protocol for C(sp

    Pijper, Brenda / Martín, Raúl / Huertas-Alonso, Alberto J / Linares, Maria Lourdes / López, Enol / Llaveria, Josep / Díaz-Ortiz, Ángel / Dixon, Darren J / de la Hoz, Antonio / Alcázar, Jesús

    Organic letters

    2023  Volume 26, Issue 14, Page(s) 2724–2728

    Abstract: Herein, we present a novel C( ... ...

    Abstract Herein, we present a novel C(sp
    Language English
    Publishing date 2023-05-23
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c01390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Donor–Acceptor–Donor 1 H -Benzo[ d ]imidazole Derivatives as Optical Waveguides

    Carlos Tardío / Javier Álvarez Conde / Ana María Rodríguez / Pilar Prieto / Antonio de la Hoz / Juan Cabanillas-González / Iván Torres-Moya

    Molecules, Vol 28, Iss 4631, p

    2023  Volume 4631

    Abstract: A new series of donor–acceptor–donor (D–A–D) structures derived from arylethynyl 1 H -benzo[ d ]imidazole was synthesized and processed into single crystals with the goal of testing such crystals’ ability to act as optical waveguides. Some crystals ... ...

    Abstract A new series of donor–acceptor–donor (D–A–D) structures derived from arylethynyl 1 H -benzo[ d ]imidazole was synthesized and processed into single crystals with the goal of testing such crystals’ ability to act as optical waveguides. Some crystals displayed luminescence in the 550–600 nm range and optical waveguiding behavior with optical loss coefficients around 10 −2 dB/μm, which indicated a notable light transport. The crystalline structure, confirmed by X-ray diffraction, contains internal channels that are important for light propagation, as we previously reported. The combination of a 1D assembly, a single crystal structure, and notable light emission properties with low losses from self-absorption made 1 H -benzo[ d ]imidazole derivatives appealing compounds for optical waveguide applications.
    Keywords optical waveguide ; 1 H -benzo[ d ]imidazole ; donor-acceptor-donor systems ; Organic chemistry ; QD241-441
    Subject code 535
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Predictors of mechanical ventilation and mortality in critically ill patients with COVID-19 pneumonia.

    Muñoz Lezcano, Sergio / Armengol de la Hoz, Miguel Ángel / Corbi, Alberto / López, Fernando / García, Miguel Sánchez / Reiz, Antonio Nuñez / González, Tomás Fariña / Zlatkov, Viktor Yordanov

    Medicina intensiva

    2023  Volume 48, Issue 1, Page(s) 3–13

    Abstract: Objective: To determine if potential predictors for invasive mechanical ventilation (IMV) are also determinants for mortality in COVID-19-associated acute respiratory distress syndrome (C-ARDS).: Design: Single center highly detailed longitudinal ... ...

    Abstract Objective: To determine if potential predictors for invasive mechanical ventilation (IMV) are also determinants for mortality in COVID-19-associated acute respiratory distress syndrome (C-ARDS).
    Design: Single center highly detailed longitudinal observational study.
    Setting: Tertiary hospital ICU: two first COVID-19 pandemic waves, Madrid, Spain.
    Patients or participants: 280 patients with C-ARDS, not requiring IMV on admission.
    Interventions: None.
    Main variables of interest: Target: endotracheal intubation and IMV, mortality.
    Predictors: demographics, hourly evolution of oxygenation, clinical data, and laboratory results.
    Results: The time between symptom onset and ICU admission, the APACHE II score, the ROX index, and procalcitonin levels in blood were potential predictors related to both IMV and mortality. The ROX index was the most significant predictor associated with IMV, while APACHE II, LDH, and DaysSympICU were the most with mortality.
    Conclusions: According to the results of the analysis, there are significant predictors linked with IMV and mortality in C-ARDS patients, including the time between symptom onset and ICU admission, the severity of the COVID-19 waves, and several clinical and laboratory measures. These findings may help clinicians to better identify patients at risk for IMV and mortality and improve their management.
    MeSH term(s) Humans ; Respiration, Artificial ; COVID-19/therapy ; Critical Illness ; Pandemics ; Pneumonia ; Respiratory Distress Syndrome
    Language English
    Publishing date 2023-07-25
    Publishing country Spain
    Document type Observational Study ; Journal Article
    ISSN 2173-5727
    ISSN (online) 2173-5727
    DOI 10.1016/j.medine.2023.07.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: ST-elevation myocardial infarction (STEMI) secondary to splenic rupture after colonoscopy.

    Requena de Torre, José / de la Hoz García, Celia / Navarro Guillamón, Laura / Vaserott Vargas, Francisco Javier / Robles-Musso Castillo, Emilio / Martínez Amate, Eva María / Ariza Fernández, José Luis / Cárdenas Cruz, Antonio

    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

    2022  Volume 114, Issue 4, Page(s) 246–247

    Abstract: We have read with interest the recently published case on splenic rupture after colonoscopy. Although this complication is being observed more frequently, in the case presented here, the particularity lies in the myocardial ischemia caused as a ... ...

    Abstract We have read with interest the recently published case on splenic rupture after colonoscopy. Although this complication is being observed more frequently, in the case presented here, the particularity lies in the myocardial ischemia caused as a consequence of stasis at coronary level, determining a situation of extreme gravity, a diagnostic challenge and a therapeutic emergency.
    MeSH term(s) Colonoscopy/adverse effects ; Coronary Artery Disease/complications ; Humans ; ST Elevation Myocardial Infarction/complications ; ST Elevation Myocardial Infarction/therapy ; Splenic Rupture/complications ; Splenic Rupture/etiology
    Language English
    Publishing date 2022-01-19
    Publishing country Spain
    Document type Letter
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2022.8541/2021
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    Zs.B 199: Show issues Location:
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