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  1. Article ; Online: Prevalence of serum MOG antibody and AQP4 antibody in optic neuritis after SARS-CoV-2 infection.

    Sun, Chuan-Bin

    Frontiers in immunology

    2023  Volume 14, Page(s) 1296518

    Abstract: Purpose: To evaluate the prevalence of serum myelin oligodendrocyte glycoprotein antibody (MOG-Ab) and aquaporin-4 antibody (AQP4-Ab) in optic neuritis (ON) patients after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by cell- ... ...

    Abstract Purpose: To evaluate the prevalence of serum myelin oligodendrocyte glycoprotein antibody (MOG-Ab) and aquaporin-4 antibody (AQP4-Ab) in optic neuritis (ON) patients after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by cell-based indirect immunofluorescence assay (CBA).
    Methods: In this prospective case series study, 35 patients clinically diagnosed as ON and laboratory-confirmed SARS-CoV-2 infection from 8 December 2022 to 8 February 2023 were included. All patients' clinical and laboratory data were collected and analyzed.
    Results: The mean age of the 35 patients (46 eyes) was 38.2 years (ranging from 6 to 69 years), and 17 cases were female patients. Thirty-three and two cases showed positive SARS-CoV-2 RNA test results before or shortly after ON onset, respectively. ON occurred unilaterally in 24 cases and bilaterally in 11 cases. Ophthalmic examination revealed swollen optic disc in 37 eyes, normal optic disc in 6 eyes, and temporally or wholly paled optic disc in 3 eyes. CBA revealed seropositive MOG-Ab in 10 cases and AQP4-Ab in 2 cases, respectively, of which 2 AQP4-Ab-seropositive cases and 1 MOG-Ab-seropositive case had a past medical history of ON. Most ON patients showed a rapid and dramatic response to pulse steroid therapy. The median of BCVA at the onset and at the last follow-up was 20/500 (ranging from light perception to 20/20) and 20/67 (ranging from counting fingers to 20/20), respectively.
    Conclusion: Serum MOG-Ab and AQP4-Ab were detected in 28.6% (10/35) and 5.7% (2/35) ON cases after SARS-CoV-2 infection. SARS-CoV-2 infection may trigger an onset or a relapse of ON, as well as the production of MOG-Ab.
    MeSH term(s) Humans ; Female ; Adult ; Male ; Prevalence ; RNA, Viral ; Aquaporin 4 ; Myelin-Oligodendrocyte Glycoprotein ; COVID-19 ; SARS-CoV-2 ; Optic Neuritis/epidemiology ; Optic Neuritis/etiology ; Optic Neuritis/diagnosis ; Autoantibodies
    Chemical Substances RNA, Viral ; Aquaporin 4 ; Myelin-Oligodendrocyte Glycoprotein ; Autoantibodies
    Language English
    Publishing date 2023-11-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1296518
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  2. Article ; Online: The Process Management of Graduation Design Based on Its Characteristics

    Sun Bin

    SHS Web of Conferences, Vol 123, p

    2021  Volume 01008

    Abstract: This paper sums up six features and three functions as the characteristics of graduation design, which is the last link of undergraduate education. And through the analysis of each link in the graduation design process, this paper gives an improvement ... ...

    Abstract This paper sums up six features and three functions as the characteristics of graduation design, which is the last link of undergraduate education. And through the analysis of each link in the graduation design process, this paper gives an improvement method for the graduation design based on these characteristics. Finally, an application example of this improvement in our university is given.
    Keywords Social Sciences ; H
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: CircROR1 upregulates CCNE1 expression to promote melanoma invasion and metastasis by recruiting KAT2A.

    Sun, Litong / Bin, Shizhen / Huang, Chenghui / Wang, Qi

    Experimental dermatology

    2024  Volume 33, Issue 4, Page(s) e15071

    Abstract: Circular RNAs (circRNAs) play important roles in cancer occurrence and progression. To explore and elucidate the clinical significance of specific circular RNA in melanoma and its potential molecular mechanism. CircROR1 expression in melanoma cells and ... ...

    Abstract Circular RNAs (circRNAs) play important roles in cancer occurrence and progression. To explore and elucidate the clinical significance of specific circular RNA in melanoma and its potential molecular mechanism. CircROR1 expression in melanoma cells and tissues was confirmed by qRT-PCR and ISH. qRT-PCR and Western blotting were performed to measure the levels of CCNE1, KAT2A, MMP9 and TIMP2. MTT, Transwell and wound healing assays were performed to evaluate cell proliferation, invasion and metastasis. A xenograft mouse model was established to further verify the CircROR1/CCNE1 axis in vivo. RNA pull-down and RIP assays were performed to detect the direct interaction KAT2A and CircROR1. A ChIP assay was used to investigate the enrichment of H3K9ac acetylation in the CCNE1 promoter. CircROR1 was significantly upregulated in metastatic melanoma cells and tissues, promoting proliferation, invasion and metastasis in vitro and tumour growth in vivo. CircROR1 overexpression increased CCNE1 and MMP9 protein expression and decreased TIMP2 protein expression. Functional rescue assays demonstrated that CircROR1 played a role in promoting malignant progression through CCNE1. CircROR1 specifically bound to the KAT2A protein without affecting its expression. CircROR1 overexpression increased the level of H3K9ac modification in the CCNE1 promoter region by recruiting KAT2A, thus upregulating CCNE1 expression. CircROR1 upregulates CCNE1 expression through KAT2A-mediated histone acetylation. Our research confirms the critical role of CircROR1 in melanoma invasion and metastasis, and CircROR1 could serve as a potential therapeutic target for melanoma treatment.
    MeSH term(s) Humans ; Animals ; Mice ; MicroRNAs/metabolism ; Matrix Metalloproteinase 9/genetics ; Matrix Metalloproteinase 9/metabolism ; Melanoma/metabolism ; Cell Line, Tumor ; RNA, Circular/genetics ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Cell Movement/genetics ; Oncogene Proteins/genetics ; Oncogene Proteins/metabolism ; Cyclin E/metabolism ; Histone Acetyltransferases/genetics ; Histone Acetyltransferases/metabolism
    Chemical Substances MicroRNAs ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; RNA, Circular ; CCNE1 protein, human ; Oncogene Proteins ; Cyclin E ; KAT2A protein, human (EC 2.3.1.48) ; Histone Acetyltransferases (EC 2.3.1.48)
    Language English
    Publishing date 2024-04-02
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1130936-2
    ISSN 1600-0625 ; 0906-6705
    ISSN (online) 1600-0625
    ISSN 0906-6705
    DOI 10.1111/exd.15071
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3508: Show issues Location:
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  4. Article ; Online: Free-Floating Cyst in the Vitreous.

    Sun, Chuan-Bin

    The New England journal of medicine

    2022  Volume 386, Issue 1, Page(s) e1

    MeSH term(s) Adolescent ; Cysts/diagnostic imaging ; Eye Diseases/diagnostic imaging ; Humans ; Iris/diagnostic imaging ; Iris Diseases/diagnostic imaging ; Male ; Ultrasonography ; Vitreous Body/diagnostic imaging ; Vitreous Body/pathology
    Language English
    Publishing date 2022-01-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMicm2112627
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  5. Article ; Online: The potential mechanism of iron overload-induced colonic inflammation.

    Sun, Shaopeng / Lv, Bin

    Ecotoxicology and environmental safety

    2024  Volume 277, Page(s) 116387

    MeSH term(s) Iron Overload ; Animals ; Colitis/chemically induced ; Inflammation/chemically induced ; Humans ; Colon/drug effects ; Colon/pathology ; Iron/toxicity
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2024-04-24
    Publishing country Netherlands
    Document type Journal Article ; Letter
    ZDB-ID 436536-7
    ISSN 1090-2414 ; 0147-6513
    ISSN (online) 1090-2414
    ISSN 0147-6513
    DOI 10.1016/j.ecoenv.2024.116387
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    Zs.A 1418: Show issues Location:
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  6. Article ; Online: The impacts of registration-and-fixation device positioning on the performance of implant placement assisted by dynamic computer-aided surgery: A randomized controlled trial.

    Wu, Bin-Zhang / Sun, Feng

    Clinical oral implants research

    2024  Volume 35, Issue 4, Page(s) 386–395

    Abstract: Objectives: To assess the efficacy of dynamic computer-aided surgery (dCAS) in replacing a single missing posterior tooth, we compare outcomes when using registration-and-fixation devices positioned anterior or posterior to the surgical site. ... ...

    Abstract Objectives: To assess the efficacy of dynamic computer-aided surgery (dCAS) in replacing a single missing posterior tooth, we compare outcomes when using registration-and-fixation devices positioned anterior or posterior to the surgical site. Registration is performed on either the anterior or opposite posterior teeth.
    Methods: Forty individuals needing posterior single-tooth implant placement were randomly assigned to anterior or posterior registration. Nine parameters were analyzed to detect the deviations between planned and actual implant placement, using Mann-Whitney and t-tests for nonnormally and normally distributed data, respectively.
    Results: The overall average angular deviation for this study was 2.08 ± 1.12°, with the respective average 3D platform and apex deviations of 0.77 ± 0.32 mm and 0.88 ± 0.32 mm. Angular deviation values for individuals in the anterior and posterior registration groups were 1.58°(IQR: 0.98°-2.38°) and 2.25°(IQR: 1.46°-3.43°), respectively (p = .165), with 3D platform deviations of 0.81 ± 0.29 mm and 0.74 ± 0.36 mm (p = .464), as well as 3D apex deviations of 0.89 ± 0.32 mm and 0.88 ± 0.33 mm (p = .986). No significant variations in absolute buccolingual (platform, p = .659; apex, p = .063), apicocoronal (platform, p = .671; apex, p = .649), or mesiodistal (platform, p = .134; apex, p = .355) deviations were observed at either analyzed levels.
    Conclusions: Both anterior and posterior registration approaches facilitate accurate dCAS-mediated implant placement for single missing posterior teeth. The device's placement (posterior-to or anterior-to the surgical site) did not affect the clinician's ability to achieve the planned implant location.
    MeSH term(s) Humans ; Dental Implantation, Endosseous ; Dental Implants ; Cone-Beam Computed Tomography ; Surgery, Computer-Assisted ; Tooth ; Computer-Aided Design ; Imaging, Three-Dimensional
    Chemical Substances Dental Implants
    Language English
    Publishing date 2024-01-29
    Publishing country Denmark
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1067626-0
    ISSN 1600-0501 ; 0905-7161
    ISSN (online) 1600-0501
    ISSN 0905-7161
    DOI 10.1111/clr.14237
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    Zs.A 3171: Show issues Location:
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  7. Article ; Online: The functional differentiation of brain–computer interfaces (BCIs) and its ethical implications

    Xiao-yu Sun / Bin Ye

    Humanities & Social Sciences Communications, Vol 10, Iss 1, Pp 1-

    2023  Volume 9

    Abstract: Abstract The growth of research and applications of brain–computer interfaces (BCIs) has spurred extensive discussion about their ethical implications. However, most existing research has primarily examined ethical issues related to BCIs from a general ... ...

    Abstract Abstract The growth of research and applications of brain–computer interfaces (BCIs) has spurred extensive discussion about their ethical implications. However, most existing research has primarily examined ethical issues related to BCIs from a general perspective, with little attention paid to the specific functions of the technology. This has resulted in a mismatch between governance and ethical issues, due to the lack of differentiation between write-in and read-out BCIs. By providing detailed descriptions of the functions and technical approaches of both write-in and read-out BCIs, we argue that ethical governance of BCIs should follow the principle of precise governance and develop refined governance strategies for different functional types of BCIs.
    Keywords History of scholarship and learning. The humanities ; AZ20-999 ; Social Sciences ; H
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Springer Nature
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Addressing musculoskeletal diseases by exploring the potentials of stem cells and plant-derived chemicals.

    Sun, Heng / Li, Bin

    Journal of orthopaedic translation

    2023  Volume 39, Page(s) A1–A2

    Language English
    Publishing date 2023-04-27
    Publishing country Singapore
    Document type Editorial
    ZDB-ID 2747531-1
    ISSN 2214-031X
    ISSN 2214-031X
    DOI 10.1016/j.jot.2023.04.004
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  9. Article ; Online: Commentary: Identification of cuproptosis hub genes contributing to the immune microenvironment in ulcerative colitis using bioinformatic analysis and experimental verification.

    Sun, Shaopeng / Lv, Bin

    Frontiers in immunology

    2023  Volume 14, Page(s) 1224127

    MeSH term(s) Humans ; Colitis, Ulcerative/genetics ; Colitis, Ulcerative/immunology ; Copper ; Apoptosis ; Computational Biology
    Chemical Substances Copper (789U1901C5)
    Language English
    Publishing date 2023-08-18
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1224127
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  10. Article: Detecting changes in the blood flow of the optic disk in patients with nonarteritic anterior ischemic optic neuropathy

    Xiao, Qing / Sun, Chuan-Bin

    Frontiers in neurology

    2023  Volume 14, Page(s) 1140770

    Abstract: Purpose: This study aimed to evaluate the changes in the blood flow of the optic disk in patients with nonarteritic anterior ischemic optic neuropathy (NAION) using optical coherence tomography-angiography (OCTA) and to investigate the relationship ... ...

    Abstract Purpose: This study aimed to evaluate the changes in the blood flow of the optic disk in patients with nonarteritic anterior ischemic optic neuropathy (NAION) using optical coherence tomography-angiography (OCTA) and to investigate the relationship among the changes in the blood flow of the optic disk, visual field defect, peripapillary retinal nerve fiber layer (RNFL), and macular ganglion cell complex (mGCC).
    Methods: This was a prospective observational case series study. A total of 89 patients (89 eyes) with NAION were included in this study. All patients underwent best corrected visual acuity (BCVA), slit-lamp and direct ophthalmoscopic examinations, color fundus photography, visual field test, and blood flow indicators of the radial peripapillary capillaries (RPC) including whole en face image vessel density (VD), peripapillary VD by OCTA, the peripapillary RNFL, and mGCC by spectral-domain optic coherence tomography (OCT). The changes of blood flow in the optic disk at ≤3, 4-8, 9-12, 13-24, and >24 weeks of the natural course of NAION were measured, and the relationship among the changes in the blood flow of the optic disk, visual field defect, peripapillary RNFL, and mGCC was also analyzed.
    Results: The mean age of 89 patients with NAION was 56.42 ± 6.81 years (ranging from 39 to 79). The initial RPC whole en face image VD was significantly reduced after acute NAION (≤3 weeks) (F = 45.598,
    Conclusion: Over the course of NAION, OCTA shows a tendency toward change in the retinal capillary plexus of the optic disk. OCTA is proved to be a practical and useful tool for observing papillary perfusion in NAION.
    Language English
    Publishing date 2023-03-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1140770
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