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  1. Article ; Online: Parasitism as a lifestyle: Ultimate intimacy between Apicomplexan protozoans and metazoan hosts.

    Tardieux, Isabelle

    Biology of the cell

    2021  Volume 113, Issue 3, Page(s) 131–132

    Abstract: Editorial: The Apicomplexa parasite Toxoplasma gondii glides on substrate with a helical path and releases material that forms a trail behind. The helical microtubules (green) periodically compress and relax, acting as spring force by coupling with the ... ...

    Abstract Editorial: The Apicomplexa parasite Toxoplasma gondii glides on substrate with a helical path and releases material that forms a trail behind. The helical microtubules (green) periodically compress and relax, acting as spring force by coupling with the myosin motor (red).
    MeSH term(s) Animals ; Apicomplexa/immunology ; Apicomplexa/parasitology ; Host-Parasite Interactions/immunology ; Humans ; Protozoan Infections/immunology ; Protozoan Infections/parasitology ; Protozoan Proteins/immunology
    Chemical Substances Protozoan Proteins
    Language English
    Publishing date 2021-01-25
    Publishing country England
    Document type Editorial
    ZDB-ID 245745-3
    ISSN 1768-322X ; 0399-0311 ; 0248-4900
    ISSN (online) 1768-322X
    ISSN 0399-0311 ; 0248-4900
    DOI 10.1111/boc.202000128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Fostering innovation to solve the biomechanics of microbe-host interactions: Focus on the adhesive forces underlying Apicomplexa parasite biology.

    Vigetti, Luis / Tardieux, Isabelle

    Biology of the cell

    2023  Volume 115, Issue 10, Page(s) e202300016

    Abstract: The protozoa, Toxoplasma gondii and Plasmodium spp., are preeminent members of the Apicomplexa parasitic phylum in large part due to their public health and economic impact. Hence, they serve as model unicellular eukaryotes with which to explore the ... ...

    Abstract The protozoa, Toxoplasma gondii and Plasmodium spp., are preeminent members of the Apicomplexa parasitic phylum in large part due to their public health and economic impact. Hence, they serve as model unicellular eukaryotes with which to explore the repertoire of molecular and cellular strategies that specific developmental morphotypes deploy to timely adjust to their host(s) in order to perpetuate. In particular, host tissue- and cell-invasive morphotypes termed zoites alternate extracellular and intracellular lifestyles, thereby sensing and reacting to a wealth of host-derived biomechanical cues over their partnership. In the recent years, biophysical tools especially related to real time force measurement have been introduced, teaching us how creative are these microbes to shape a unique motility system that powers fast gliding through a variety of extracellular matrices, across cellular barriers, in vascular systems or into host cells. Equally performant was this toolkit to start illuminating how parasites manipulate their hosting cell adhesive and rheological properties to their advantage. In this review, besides highlighting major discoveries along the way, we discuss the most promising development, synergy, and multimodal integration in active noninvasive force microscopy methods. These should in the near future unlock current limitations and allow capturing, from molecules to tissues, the many biomechanical and biophysical interplays over the dynamic host and microbe partnership.
    MeSH term(s) Animals ; Parasites ; Biomechanical Phenomena ; Host-Parasite Interactions ; Toxoplasma ; Biology
    Language English
    Publishing date 2023-07-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 245745-3
    ISSN 1768-322X ; 0399-0311 ; 0248-4900
    ISSN (online) 1768-322X
    ISSN 0399-0311 ; 0248-4900
    DOI 10.1111/boc.202300016
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  3. Article ; Online: Lumière sur le « twist » final du parasite Toxoplasma pour envahir sa cellule hôte nourricière.

    Tardieux, Isabelle

    Medecine sciences : M/S

    2019  Volume 35, Issue 2, Page(s) 109–112

    Title translation Illuminating the last twist of the Toxoplasma parasite to invade a host-feeding cell.
    MeSH term(s) Animals ; Green Fluorescent Proteins/chemistry ; Green Fluorescent Proteins/metabolism ; Host-Parasite Interactions/physiology ; Humans ; Molecular Imaging/trends ; Parasites/pathogenicity ; Single-Cell Analysis/methods ; Single-Cell Analysis/trends ; Toxoplasma/pathogenicity ; Toxoplasma/physiology ; Tumor Cells, Cultured
    Chemical Substances Green Fluorescent Proteins (147336-22-9)
    Language French
    Publishing date 2019-02-18
    Publishing country France
    Document type News
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2019013
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  4. Article ; Online: Actin Nanobodies Uncover the Mystery of Actin Filament Dynamics in Toxoplasma gondii.

    Tardieux, Isabelle

    Trends in parasitology

    2017  Volume 33, Issue 8, Page(s) 579–581

    Abstract: While the intracellular parasite Toxoplasma relies on a divergent actomyosin motor to support unique speeds in directional movement, the dynamics and architecture of parasite actin filaments remain a much-discussed issue. Using actin chromobodies, Periz ... ...

    Abstract While the intracellular parasite Toxoplasma relies on a divergent actomyosin motor to support unique speeds in directional movement, the dynamics and architecture of parasite actin filaments remain a much-discussed issue. Using actin chromobodies, Periz et al. started to unveil how networks of dynamic F-actin connect Toxoplasma progeny and expand in the replicative vacuole.
    MeSH term(s) Actin Cytoskeleton/metabolism ; Actins/chemistry ; Actins/metabolism ; Animals ; Single-Domain Antibodies/metabolism ; Toxoplasma/metabolism ; Vacuoles/metabolism
    Chemical Substances Actins ; Single-Domain Antibodies
    Language English
    Publishing date 2017
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2017.06.007
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  5. Article: Actin Nanobodies Uncover the Mystery of Actin Filament Dynamics in Toxoplasma gondii

    Tardieux, Isabelle

    Trends in parasitology. 2017 Aug., v. 33, no. 8

    2017  

    Abstract: While the intracellular parasite Toxoplasma relies on a divergent actomyosin motor to support unique speeds in directional movement, the dynamics and architecture of parasite actin filaments remain a much-discussed issue. Using actin chromobodies, Periz ... ...

    Abstract While the intracellular parasite Toxoplasma relies on a divergent actomyosin motor to support unique speeds in directional movement, the dynamics and architecture of parasite actin filaments remain a much-discussed issue. Using actin chromobodies, Periz et al. started to unveil how networks of dynamic F-actin connect Toxoplasma progeny and expand in the replicative vacuole.
    Keywords actin ; microfilaments ; parasites ; progeny ; Toxoplasma gondii ; vacuoles
    Language English
    Dates of publication 2017-08
    Size p. 579-581.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2017.06.007
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Phenotyping Toxoplasma Invasive Skills by Fast Live Cell Imaging.

    Pavlou, Georgios / Tardieux, Isabelle

    Methods in molecular biology (Clifton, N.J.)

    2019  Volume 2071, Page(s) 209–220

    Abstract: Host cell invasion by Toxoplasma gondii/T. gondii tachyzoites is an obligate but complex multistep process occurring in second-scale. To capture the dynamic nature of the whole entry process requires fast and high-resolution live cell imaging. Recent ... ...

    Abstract Host cell invasion by Toxoplasma gondii/T. gondii tachyzoites is an obligate but complex multistep process occurring in second-scale. To capture the dynamic nature of the whole entry process requires fast and high-resolution live cell imaging. Recent advances in T. gondii/host cell genome editing and in quantitative live cell imaging-image acquisition and processing included-provide a systematic way to accurately phenotype T. gondii tachyzoite invasive behaviour and to highlight any variation or default from a standard scenario. Therefore, applying these combined strategies allows gaining deeper insights into the complex mechanisms underlying host cell invasion.
    MeSH term(s) Animals ; Hepatocytes/metabolism ; Host-Parasite Interactions ; Toxoplasma/pathogenicity
    Language English
    Publishing date 2019-11-22
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-9857-9_12
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  7. Article ; Online: Editorial overview.

    Tardieux, Isabelle

    Current opinion in microbiology

    2011  Volume 14, Issue 4, Page(s) 412–413

    MeSH term(s) Animals ; Apicomplexa/immunology ; Apicomplexa/pathogenicity ; Culicidae/immunology ; Culicidae/parasitology ; Host-Parasite Interactions ; Humans ; Mammals ; Protozoan Infections/immunology ; Protozoan Infections/parasitology
    Language English
    Publishing date 2011-08
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1418474-6
    ISSN 1879-0364 ; 1369-5274
    ISSN (online) 1879-0364
    ISSN 1369-5274
    DOI 10.1016/j.mib.2011.07.020
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  8. Article ; Online: Intracellular protozoan parasites: living probes of the host cell surface molecular repertoire.

    Pavlou, Georgios / Milon, Geneviève / Tardieux, Isabelle

    Current opinion in microbiology

    2019  Volume 52, Page(s) 116–123

    Abstract: Intracellular protozoans co-evolved with their mammalian host cells a range of strategies to cope with the composite and dynamic cell surface features they encounter during migration and infection. Therefore, these single-celled eukaryotic parasites ... ...

    Abstract Intracellular protozoans co-evolved with their mammalian host cells a range of strategies to cope with the composite and dynamic cell surface features they encounter during migration and infection. Therefore, these single-celled eukaryotic parasites represent a fascinating source of living probes for precisely capturing the dynamic coupling between the membrane and contractile cortex components of the cell surface. Such biomechanical changes drive a constant re-sculpting of the host cell surface, enabling rapid adjustments that contribute to cellular homeostasis. As emphasized in this review, through the design of specific molecular devices and stratagems to interfere with the biomechanics of the mammalian cell surface these parasitic microbes escape from dangerous or unfavourable microenvironments by breaching host cell membranes, directing the membrane repair machinery to wounded membrane areas, or minimizing membrane assault using discretion and speed when invading host cells for sustained residence.
    MeSH term(s) Animals ; Apicomplexa/genetics ; Apicomplexa/pathogenicity ; Cell Membrane/parasitology ; Cell Membrane/pathology ; Cytoplasm/parasitology ; Host-Parasite Interactions ; Humans ; Kinetoplastida/genetics ; Kinetoplastida/pathogenicity ; Leishmania/genetics ; Leishmania/pathogenicity ; Plasmodium/genetics ; Plasmodium/pathogenicity ; Protozoan Infections ; Toxoplasma/genetics ; Toxoplasma/pathogenicity ; Trypanosoma/genetics ; Trypanosoma/pathogenicity
    Language English
    Publishing date 2019-07-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Video-Audio Media
    ZDB-ID 1418474-6
    ISSN 1879-0364 ; 1369-5274
    ISSN (online) 1879-0364
    ISSN 1369-5274
    DOI 10.1016/j.mib.2019.06.007
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  9. Article ; Online: The BCC7 Protein Contributes to the

    Vigetti, Luis / Labouré, Tatiana / Roumégous, Chloé / Cannella, Dominique / Touquet, Bastien / Mayer, Claudine / Couté, Yohann / Frénal, Karine / Tardieux, Isabelle / Renesto, Patricia

    International journal of molecular sciences

    2022  Volume 23, Issue 11

    Abstract: ... T. ... ...

    Abstract T. gondii
    MeSH term(s) Cell Division ; Myosins/metabolism ; Proteomics ; Protozoan Proteins/genetics ; Protozoan Proteins/metabolism ; Toxoplasma/metabolism
    Chemical Substances Protozoan Proteins ; Myosins (EC 3.6.4.1)
    Language English
    Publishing date 2022-05-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23115995
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  10. Article ; Online: Reassessing the mechanics of parasite motility and host-cell invasion.

    Tardieux, Isabelle / Baum, Jake

    The Journal of cell biology

    2016  Volume 214, Issue 5, Page(s) 507–515

    Abstract: The capacity to migrate is fundamental to multicellular and single-celled life. Apicomplexan parasites, an ancient protozoan clade that includes malaria parasites (Plasmodium) and Toxoplasma, achieve remarkable speeds of directional cell movement. This ... ...

    Abstract The capacity to migrate is fundamental to multicellular and single-celled life. Apicomplexan parasites, an ancient protozoan clade that includes malaria parasites (Plasmodium) and Toxoplasma, achieve remarkable speeds of directional cell movement. This rapidity is achieved via a divergent actomyosin motor system, housed within a narrow compartment that lies underneath the length of the parasite plasma membrane. How this motor functions at a mechanistic level during motility and host cell invasion is a matter of debate. Here, we integrate old and new insights toward refining the current model for the function of this motor with the aim of revitalizing interest in the mechanics of how these deadly pathogens move.
    MeSH term(s) Animals ; Cell Adhesion ; Cell Movement ; Cell Shape ; Host-Parasite Interactions ; Humans ; Models, Biological ; Parasites/cytology
    Language English
    Publishing date 2016-08-26
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.201605100
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