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  1. Book ; Online ; E-Book: Malaria

    Mota, Maria M. / Rodríguez, Ana

    immune response to infection and vaccination

    2017  

    Author's details Maria M. Mota, Ana Rodriguez editors
    Keywords Malaria / immunology ; Malaria Vaccines / immunology
    Language English
    Size 1 Online-Ressource (vi, 278 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019391743
    ISBN 978-3-319-45210-4 ; 9783319452081 ; 3-319-45210-X ; 3319452088
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: The nutrient games - Plasmodium metabolism during hepatic development.

    Lahree, Aparajita / Mello-Vieira, João / Mota, Maria M

    Trends in parasitology

    2023  Volume 39, Issue 6, Page(s) 445–460

    Abstract: Malaria is a febrile illness caused by species of the protozoan parasite Plasmodium and is characterized by recursive infections of erythrocytes, leading to clinical symptoms and pathology. In mammals, Plasmodium parasites undergo a compulsory ... ...

    Abstract Malaria is a febrile illness caused by species of the protozoan parasite Plasmodium and is characterized by recursive infections of erythrocytes, leading to clinical symptoms and pathology. In mammals, Plasmodium parasites undergo a compulsory intrahepatic development stage before infecting erythrocytes. Liver-stage parasites have a metabolic configuration to facilitate the replication of several thousand daughter parasites. Their metabolism is of interest to identify cellular pathways essential for liver infection, to kill the parasite before onset of the disease. In this review, we summarize the current knowledge on nutrient acquisition and biosynthesis by liver-stage parasites mostly generated in murine malaria models, gaps in knowledge, and challenges to create a holistic view of the development and deficiencies in this field.
    MeSH term(s) Animals ; Mice ; Plasmodium/metabolism ; Liver/parasitology ; Malaria/parasitology ; Parasites/metabolism ; Erythrocytes/parasitology ; Protozoan Proteins/metabolism ; Mammals
    Chemical Substances Protozoan Proteins
    Language English
    Publishing date 2023-04-13
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2023.03.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The Impact of 8 Weeks of Combined Physical Exercise Training on SIRT3 and mTOR in Lymphocytes, and on Lipid Peroxidation.

    Soares, Jorge Pinto / Cardoso, Ricardo / Almeida, Vanessa / Pereira, Ana Fátima / Silva, Amélia M / Mota, Maria Paula

    Healthcare (Basel, Switzerland)

    2024  Volume 12, Issue 3

    Abstract: ... a vertical jump, 20 m velocity, ball throwing, and an aerobic capacity test. Lipid peroxidation (MDA) was ... training: 615.4 ± 45.3 m; post-training: 687.2 ± 34.6 m; t = -2.521; ...

    Abstract The sirtuins (SIRT) protein family and the mechanistic/mammalian target of rapamycin (mTOR) are intracellular molecules that have been involved in the regulation of several biological processes, as well as in various aging-related processes. This pilot study, in small scale, aimed to analyze the effects of an 8-week physical exercise program on SIRT3 and mTOR levels in lymphocytes, as well as on lipid peroxidation in middle aged and older men. A total of 9 participants aged between 56 and 73 years were enrolled in an 8-week physical exercise program comprising cardiovascular and high-intensity interval training. The program involved three sessions per week, each lasting 45-60 min, conducted on non-consecutive days. Tests were conducted before and after the experimental period (pre- and post-training). Assessments included a vertical jump, 20 m velocity, ball throwing, and an aerobic capacity test. Lipid peroxidation (MDA) was measured in plasma as an oxidative stress biomarker. Additionally, sirtuin 3 (SIRT3/β-actin) and mTOR (mTOR/β-actin) levels were measured in isolated lymphocytes extracted from venous blood. Following the exercise training period, our results demonstrated a significant improvement in aerobic capacity (pre-training: 615.4 ± 45.3 m; post-training: 687.2 ± 34.6 m; t = -2.521;
    Language English
    Publishing date 2024-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare12030350
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The reciprocal influence of the liver and blood stages of the malaria parasite's life cycle.

    Chora, Ângelo Ferreira / Mota, Maria M / Prudêncio, Miguel

    International journal for parasitology

    2022  Volume 52, Issue 11, Page(s) 711–715

    Abstract: While the liver and blood stages of the Plasmodium life cycle are commonly regarded as two separate fields of malaria research, several studies have pointed towards the existence of a bidirectional cross-talk, where one stage of mammalian infection may ... ...

    Abstract While the liver and blood stages of the Plasmodium life cycle are commonly regarded as two separate fields of malaria research, several studies have pointed towards the existence of a bidirectional cross-talk, where one stage of mammalian infection may impact the establishment and progression of the other. Despite the constraints in experimentally addressing concurrent liver and blood stage Plasmodium infections, animal models and clinical studies have unveiled a plethora of molecular interactions between the two. Here, we review the current knowledge on the reciprocal influence of hepatic and erythrocytic infection by malaria parasites, and discuss its impacts on immunity, pathology and vaccination against this deadly disease.
    MeSH term(s) Animals ; Parasites ; Plasmodium ; Malaria/parasitology ; Liver/parasitology ; Life Cycle Stages ; Mammals
    Language English
    Publishing date 2022-03-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 120518-3
    ISSN 1879-0135 ; 0020-7519
    ISSN (online) 1879-0135
    ISSN 0020-7519
    DOI 10.1016/j.ijpara.2022.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article: Enhancing the authenticity of animal by-products: harmonization of DNA extraction methods from novel ingredients.

    Filipa-Silva, Andreia / Castro, Raquel / Rebelo, Mariana / Mota, Maria J / Almeida, André / Valente, Luísa M P / Gomes, Sónia

    Frontiers in chemistry

    2024  Volume 12, Page(s) 1350433

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-02-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2024.1350433
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Role of acemannan and pectic polysaccharides in saline-water stress tolerance of Aloe vera (Aloe barbadensis Miller) plant.

    Comas-Serra, Francesca / Miró, José Luis / Umaña, Mónica M / Minjares-Fuentes, Rafael / Femenia, Antoni / Mota-Ituarte, María / Pedroza-Sandoval, Aurelio

    International journal of biological macromolecules

    2024  Volume 268, Issue Pt 1, Page(s) 131601

    Abstract: This study investigates the impact of water and salinity stress on Aloe vera, focusing on the role of Aloe vera polysaccharides in mitigating these stresses. Pectins and acemannan were the most affected polymers. Low soil moisture and high salinity (NaCl ...

    Abstract This study investigates the impact of water and salinity stress on Aloe vera, focusing on the role of Aloe vera polysaccharides in mitigating these stresses. Pectins and acemannan were the most affected polymers. Low soil moisture and high salinity (NaCl 80 mM) increased pectic substances, altering rhamnogalacturonan type I in Aloe vera gel. Aloe vera pectins maintained a consistent 60 % methyl-esterification regardless of conditions. Interestingly, acemannan content rose with salinity, particularly under low moisture, accompanied by 90 to 150 % acetylation increase. These changes improved the functionality of Aloe vera polysaccharides: pectins increased cell wall reinforcement and interactions, while highly acetylated acemannan retained water for sustained plant functions. This study highlights the crucial role of Aloe vera polysaccharides in enhancing plant resilience to water and salinity stress, leading to improved functional properties.
    Language English
    Publishing date 2024-04-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.131601
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Effects of Aging and Nerve Growth Factor on Neuropeptide Expression and Cholinergic Innervation of the Rat Basolateral Amygdala.

    Pereira, Pedro A / Tavares, Marta / Laires, Miguel / Mota, Bárbara / Madeira, Maria Dulce / Paula-Barbosa, Manuel M / Cardoso, Armando

    Biology

    2024  Volume 13, Issue 3

    Abstract: The basolateral amygdala (BLA) contains interneurons that express neuropeptide Y (NPY) and vasoactive intestinal polypeptide (VIP), both of which are involved in the regulation of functions and behaviors that undergo deterioration with aging. There is ... ...

    Abstract The basolateral amygdala (BLA) contains interneurons that express neuropeptide Y (NPY) and vasoactive intestinal polypeptide (VIP), both of which are involved in the regulation of functions and behaviors that undergo deterioration with aging. There is considerable evidence that, in some brain areas, the expression of NPY and VIP might be modulated by acetylcholine. Importantly, the BLA is one of the brain regions that has one of the densest cholinergic innervations, which arise mainly from the basal forebrain cholinergic neurons. These cholinergic neurons depend on nerve growth factor (NGF) for their survival, connectivity, and function. Thus, in this study, we sought to determine if aging alters the densities of NPY- and VIP-positive neurons and cholinergic varicosities in the BLA and, in the affirmative, if those changes might rely on insufficient trophic support provided by NGF. The number of NPY-positive neurons was significantly reduced in aged rats, whereas the number of VIP-immunoreactive neurons was unaltered. The decreased NPY expression was fully reversed by the infusion of NGF in the lateral ventricle. The density of cholinergic varicosities was similar in adult and old rats. On the other hand, the density of cholinergic varicosities is significantly higher in old rats treated with NGF than in adult and old rats. Our results indicate a dissimilar resistance of different populations of BLA interneurons to aging. Furthermore, the present data also show that the BLA cholinergic innervation is particularly resistant to aging effects. Finally, our results also show that the reduced NPY expression in the BLA of aged rats can be related to changes in the NGF neurotrophic support.
    Language English
    Publishing date 2024-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology13030155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The nutrient games – Plasmodium metabolism during hepatic development

    Lahree, Aparajita / Mello-Vieira, João / Mota, Maria M.

    Trends in Parasitology. 2023 Apr. 13,

    2023  

    Abstract: Malaria is a febrile illness caused by species of the protozoan parasite Plasmodium and is characterized by recursive infections of erythrocytes, leading to clinical symptoms and pathology. In mammals, Plasmodium parasites undergo a compulsory ... ...

    Abstract Malaria is a febrile illness caused by species of the protozoan parasite Plasmodium and is characterized by recursive infections of erythrocytes, leading to clinical symptoms and pathology. In mammals, Plasmodium parasites undergo a compulsory intrahepatic development stage before infecting erythrocytes. Liver-stage parasites have a metabolic configuration to facilitate the replication of several thousand daughter parasites. Their metabolism is of interest to identify cellular pathways essential for liver infection, to kill the parasite before onset of the disease. In this review, we summarize the current knowledge on nutrient acquisition and biosynthesis by liver-stage parasites mostly generated in murine malaria models, gaps in knowledge, and challenges to create a holistic view of the development and deficiencies in this field.
    Keywords Plasmodium ; Protozoa ; biosynthesis ; erythrocytes ; liver ; malaria ; mice ; parasites ; parasitology ; metabolism ; hepatocyte
    Language English
    Dates of publication 2023-0413
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Pre-press version ; Use and reproduction
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2023.03.013
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: The Nobel Prize for the insulin discovery.

    Mota, Maria / Catrinoiu, Doina

    Diabetes research and clinical practice

    2021  Volume 180, Page(s) 108950

    MeSH term(s) Humans ; Insulin ; Insulin, Regular, Human ; Nobel Prize
    Chemical Substances Insulin ; Insulin, Regular, Human
    Language English
    Publishing date 2021-07-14
    Publishing country Ireland
    Document type Letter
    ZDB-ID 632523-3
    ISSN 1872-8227 ; 0168-8227
    ISSN (online) 1872-8227
    ISSN 0168-8227
    DOI 10.1016/j.diabres.2021.108950
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  10. Article ; Online: Plasmodium

    M'Bana, Viriato / Lahree, Aparajita / Marques, Sofia / Slavic, Ksenija / Mota, Maria M

    iScience

    2022  Volume 25, Issue 5, Page(s) 104281

    Abstract: Parasite-derived PVM-resident proteins are critical for complete parasite development inside hepatocytes, although the function of most of these proteins remains unknown. Here, we show that the upregulated in infectious sporozoites 4 (UIS4) protein, ... ...

    Abstract Parasite-derived PVM-resident proteins are critical for complete parasite development inside hepatocytes, although the function of most of these proteins remains unknown. Here, we show that the upregulated in infectious sporozoites 4 (UIS4) protein, resident at the PVM, interacts with the host cell actin. By suppressing filamentous actin formation, UIS4 avoids parasite elimination. Host cell actin dynamics increases around UIS4-deficient parasites, which is associated with subsequent parasite elimination. Notably, parasite elimination is impaired significantly by the inhibition of host myosin-II, possibly through relieving the compression generated by actomyosin complexes at the host-parasite interface. Together, these data reveal that UIS4 has a critical role in the evasion of host defensive mechanisms, enabling hence EEF survival and development.
    Language English
    Publishing date 2022-04-22
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2022.104281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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