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Article: Mild SARS-CoV-2 infections in children might be based on evolutionary biology and linked with host reactive oxidative stress and antioxidant capabilities.

Keles, E S

2020 Volume 36, Page(s) 100723

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to significant morbidity and mortality in elderly individuals. Children typically have mild illness with rare mortalities. Age and co-morbid medical conditions are the most ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to significant morbidity and mortality in elderly individuals. Children typically have mild illness with rare mortalities. Age and co-morbid medical conditions are the most important determinant of the infection outcome. Currently there is no clear explanation for the difference in disease severity and outcome in different age groups. Based on evolutionary biology and translational research this review suggests that the high antioxidant capacity of children leading to a balanced redox state is the key factor for mild SARS-CoV-2 infections in this age group. On the other hand, elderly individuals with low antioxidant capacity and low angiotensin-converting enzyme 2 expression are prone to severe infections by redox-sensitive immune modulation.
Keywords	covid19
Language	English
Publishing date	2020-06-24
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2750179-6
ISSN	2052-2975
ISSN	2052-2975
DOI	10.1016/j.nmni.2020.100723
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Association of NK cell subsets and cytotoxicity with FCGR3A gene polymorphism in functional NK cell deficiency.

Karaselek, Mehmet Ali / Kurar, Ercan / Keleş, Sevgi / Güner, Şükrü Nail / Reisli, İsmail

Revista da Associacao Medica Brasileira (1992)

2024 Volume 70, Issue 2, Page(s) e20230872

Abstract: Objective: The purpose of this study was to assess the association between clinical, laboratory, and functional analyses and polymorphism in the FCGR3A gene in individuals with functional NK cell deficiency.: Methods: A total of 15 functional NK cell ...

Abstract	Objective: The purpose of this study was to assess the association between clinical, laboratory, and functional analyses and polymorphism in the FCGR3A gene in individuals with functional NK cell deficiency. Methods: A total of 15 functional NK cell deficiency patients and 10 age-matched healthy controls underwent NK cell subgroup, cytotoxicity, and FCGR3A whole-exome analysis with next-generation sequencing. Results: Three different NK cell subsets (CD56brightCD16neg, CD56brightCD16int, and CD56dimCD16hi) were identified. No statistically significant difference was found in the ratio of CD56brightCD16neg cells between patients and controls. CD56brightCD16int and CD56dimCD16hi ratios were found to be significantly lower in patients. As a result of NK cell cytotoxicity analysis, a proportional decrease of K562 amount between patients and controls was found to be statistically significant (p<0.001). In the FCGR3A whole-exome analysis, all patients were found to be homozygous mutant for the c.526G > T (p.V176F) in exon 4, while three patients were homozygous wild type and 12 patients were heterozygous for the c.197T>A (p.L66H) in exon 3. Conclusion: In this study, a group of pediatric patients with suspected functional NK cell deficiency were evaluated and the findings indicated that NK subsets, cytotoxicity results, and FCGR3A gene polymorphism were found to be correlated with the clinical features. We conclude that this kind of study might contribute to follow-up the patients in time.
MeSH term(s)	Humans ; Child ; Heterozygote ; Killer Cells, Natural ; Polymorphism, Genetic ; Receptors, IgG/genetics
Chemical Substances	FCGR3A protein, human ; Receptors, IgG
Language	English
Publishing date	2024-02-26
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	731969-1
ISSN	1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
ISSN (online)	1806-9282
ISSN	0104-4230 ; 0004-5241 ; 0102-843X
DOI	10.1590/1806-9282.20230872
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Article: Shedding light on the next pandemic path, from outpatient to ICU, the effect of vitamin D deficiency in the SARS-CoV-2 pandemic.

Celikmen, F / Tunaligil, V / Keles, E C / Celikmen, D S M / Sarikaya, S

Frontiers in nutrition

2024 Volume 10, Page(s) 1268267

Abstract: Background: Vitamin D insufficiency is named "the pandemic of our era" by some experts. World Health Organization warns against a "deadlier outbreak" than the COVID-19 pandemic. Critical evidence is hereby for future pandemic prevention, with special ... ...

Abstract	Background: Vitamin D insufficiency is named "the pandemic of our era" by some experts. World Health Organization warns against a "deadlier outbreak" than the COVID-19 pandemic. Critical evidence is hereby for future pandemic prevention, with special emphasis on Vitamin D. Methods: A cross-sectional study was conducted with 172 unvaccinated adult participants, who presented to the emergency department. Blood measurements, radiological findings, and demographic features were evaluated in the four categories of "healthy adults, COVID-19 outpatients, hospitalized inpatients on the wards, and in the ICU." Results: Results were statistically significant in association with age, gender, weight, Vitamin D, glucose, urea, creatinine, leucocyte, aspartate transaminase, hemoglobin, C-reactive protein, troponin, platelet/thrombocyte, ferritin, D-dimer, triglycerate, glycated haemoglobin, lactate dehydrogenase measurements, and chest computed tomography features (each Conclusion: This article presents evidence to support the importance of Vitamin D for global public health. Patients with adequate levels of Vitamin D, glucose, urea, creatinine, leucocyte, aspartate transaminase, hemoglobin, C-reactive protein, troponin, platelet/thrombocyte, ferritin, D-dimer, triglycerate, glycated haemoglobin, lactate dehydrogenase are less likely to be admitted to ICU versus being outpatients. Factors include gender, age, weight, comorbidities, and computed tomography findings. The ultimate goal is to globally minimize preventable burdens of disease and death.
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2023.1268267
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Article ; Online: Mild SARS-CoV-2 infections in children might be based on evolutionary biology and linked with host reactive oxidative stress and antioxidant capabilities

Keles, E.S.

New Microbes and New Infections

2020 Volume 36, Page(s) 100723

Keywords	covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	2750179-6
ISSN	2052-2975
ISSN	2052-2975
DOI	10.1016/j.nmni.2020.100723
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Article ; Online: Effects of genotype and nutrient medium on obtaining haploid plants through ovary culture in cucumber.

Baktemur, Gökhan / Keleş, Davut / Kara, Ecem / Yıldız, Serhat / Taşkın, Hatıra

Molecular biology reports

2022 Volume 49, Issue 6, Page(s) 5451–5458

Abstract: Background: Cucumber is a species that breeding studies for variety development are carried out intensively. However, double haploidy technology, which aims to shorten the breeding process, has not yet reached the desired level.: Methods and results: ...

Abstract	Background: Cucumber is a species that breeding studies for variety development are carried out intensively. However, double haploidy technology, which aims to shorten the breeding process, has not yet reached the desired level. Methods and results: Three induction (M1: Murashige and Skoog (MS), 0.04 mg L Conclusions: According to the results of the research, 2,4-D added to the nutrient media seems to be successful in induction of ovary culture in cucumber. In plants determined as diploid according to ploidy analysis, doubled haploid situation should be checked by molecular analysis.
MeSH term(s)	2,4-Dichlorophenoxyacetic Acid/pharmacology ; Cucumis sativus/genetics ; Genotype ; Haploidy ; Nutrients ; Ovary ; Plant Breeding
Chemical Substances	2,4-Dichlorophenoxyacetic Acid (2577AQ9262)
Language	English
Publishing date	2022-02-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-022-07238-y
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Article: The role of multiple high-risk human papillomavirus infections for cervical biopsies and findings in colposcopic procedures

Akış, Serkan / Öztürk, Uğur Kemal / Keleş, Esra / Alınca, Cihat Murat / Kabaca, Canan / Api, Murat

Journal of the Turkish German Gynecological Association

2023 Volume 24, Issue 2, Page(s) 101–108

Abstract: Objective: The clinical outcome of high-risk HPV (hr-HPV) infection varies according to genotype(s ... Patients may harbor either one single hr-HPV (s-HPV) or multiple HPV (m-HPV) genotypes. Recently ... had a s-HPV and 25.5% had a m-HPV infection. The proportion of CIN 1, 2 and 3 per patient in the m-HPV ...

Abstract	Objective: The clinical outcome of high-risk HPV (hr-HPV) infection varies according to genotype(s). Patients may harbor either one single hr-HPV (s-HPV) or multiple HPV (m-HPV) genotypes. Recently, the relationship between m-HPV infections and high-grade dysplasia has been investigated, and controversial results have been obtained. Therefore, the clinical significance of m-HPV is not clear. This study aimed to evaluate which group is associated with higher grade dysplasia by analyzing colposcopic punch biopsies. Material and methods: A total of 690 patients who were scheduled for a diagnostic excisional procedure between April 2016 and January 2019 due to the detection of high-grade cervical intraepithelial neoplasia (CIN 2/3) in colposcopy were included. Patients who were not scheduled for colposcopic examination or cervical punch biopsy, or who were scheduled for an excisional procedure due to smear-biopsy incompatibility or persistent low-grade dysplasia were excluded. Patients with a negative HPV test and an unknown HPV genotype were also excluded. Results: Among the patients scheduled for excision (n=404), 74.5% had a s-HPV and 25.5% had a m-HPV infection. The proportion of CIN 1, 2 and 3 per patient in the m-HPV group was significantly higher than the s-HPV group (p=0.017). When this analysis was made for the number of CIN 2+3 per patient in the s-HPV and m-HPV groups, it was 1.29 (389/301) and 1.36 (140/103), respectively, and no difference was found (p=0.491). Conclusion: Patients in the m-HPV group, who underwent more colposcopic cervical biopsies, had higher numbers of CIN lesions, regardless of age and cytology results.
Language	English
Publishing date	2023-03-30
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2425806-4
ISSN	1309-0380 ; 1303-9695 ; 1309-0399
ISSN (online)	1309-0380 ; 1303-9695
ISSN	1309-0399
DOI	10.4274/jtgga.galenos.2023.2022-8-10
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Article ; Online: Comparison of telerehabilitation methods for patients with systemic sclerosis in the COVID-19 Era: A randomized controlled study.

Civi Karaaslan, Tugba / Tarakci, Ela / Keles, Ozal / Aslan Keles, Yasemin / Ugurlu, Serdal

Journal of hand therapy : official journal of the American Society of Hand Therapists

2023 Volume 36, Issue 4, Page(s) 751–769

Abstract: Study design: This was a single-blinded randomized clinical trial.: Introduction: Systemic sclerosis (SSc) is an autoimmune connective tissue disease that progresses with fibrosis. Patients with SSc need to be protected against epidemic diseases and ... ...

Abstract	Study design: This was a single-blinded randomized clinical trial. Introduction: Systemic sclerosis (SSc) is an autoimmune connective tissue disease that progresses with fibrosis. Patients with SSc need to be protected against epidemic diseases and provided for in terms of rehabilitation needs. Purpose of the study: To compare the effects of real-time telerehabilitation (RTT) and asynchronous telerehabilitation (AT) on individuals with SSc. Methods: Forty-two participants with SSc with a mean age of 44.17 ± 11.05 years were included in the study. The patients were randomly divided into three groups, RTT (n = 16), AT (n = 16), and control (n = 16) groups. A structured rehabilitation program was performed in real-time (RTT group) and asynchronously (AT group) for 40 minutes per day, in three sessions per week for 8 weeks. The participants' finger and wrist joint range of motion (ROM), upper extremity functions, grip strength, superficial sense of touch, activities of daily living (ADL), and general health status were assessed at baseline and after treatment. Results: After 8 weeks, there were improvements in finger ROM (effect size [ES] = 0.23 to 0.60), wrist ROM (ES = 0.45 to 0.83), upper extremity functions (ES = 0.61 to 1.00), and ADL parameters (ES = 0.74) in the RTT group (p < 0.05). Also, there were improvements in finger ROM (ES = 0.16 to 0.45) and hand functions (ES = 0.54 to 0.55) in the AT group (p < 0.05). The RTT and AT groups had better hand functions and finger ROM than the control group in (p < 0.05). In addition, the RTT group had better wrist ROM than the control group (p = 0.008). RTT was superior to AT only in lateral pinch strength (p = 0.025). Discussion: Experimental groups achieved a statistically significant change in ROM, upper extremity functions and ADL over time in concordance with prior investigations. Changes in grip strength, superficial sense of touch, and general health status scores differed from previous investigations and the between-group comparison was not statistically significant. Conclusions: Both RTT and AT may be effective in individuals with SSc, and RTT has additional benefits.
MeSH term(s)	Humans ; Adult ; Middle Aged ; Activities of Daily Living ; Telerehabilitation ; COVID-19/epidemiology ; Scleroderma, Systemic ; Upper Extremity ; Treatment Outcome
Language	English
Publishing date	2023-08-11
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	639284-2
ISSN	1545-004X ; 0894-1130
ISSN (online)	1545-004X
ISSN	0894-1130
DOI	10.1016/j.jht.2023.02.008
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Article: Mild SARS-CoV-2 infections in children might be based on evolutionary biology and linked with host reactive oxidative stress and antioxidant capabilities

Keles, E. S.

New Microbes New Infect.

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to significant morbidity and mortality in elderly individuals. Children typically have mild illness with rare mortalities. Age and co-morbid medical conditions are the most important determinant of the infection outcome. Currently there is no clear explanation for the difference in disease severity and outcome in different age groups. Based on evolutionary biology and translational research this review suggests that the high antioxidant capacity of children leading to a balanced redox state is the key factor for mild SARS-CoV-2 infections in this age group. On the other hand, elderly individuals with low antioxidant capacity and low angiotensin-converting enzyme 2 expression are prone to severe infections by redox-sensitive immune modulation.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #613770
Database	COVID19

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Article ; Online: Can endometrial compaction predict live birth rates in assisted reproductive technology cycles? A systematic review and meta-analysis.

Turkgeldi, E / Yildiz, S / Kalafat, E / Keles, I / Ata, B / Bozdag, G

Journal of assisted reproduction and genetics

2023 Volume 40, Issue 11, Page(s) 2513–2522

Abstract: Purpose: Endometrial compaction (EC) is defined as the difference in endometrial thickness from the end of the follicular phase to the day of embryo transfer (ET). We aimed to determine the role of EC in predicting assisted reproductive technology (ART) ...

Abstract	Purpose: Endometrial compaction (EC) is defined as the difference in endometrial thickness from the end of the follicular phase to the day of embryo transfer (ET). We aimed to determine the role of EC in predicting assisted reproductive technology (ART) success by conducting a meta-analysis of studies reporting the association between EC and clinical outcomes of ART. Methods: MEDLINE via PubMed, Web of Science, Scopus, and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched from the date of inception to May 19, 2023. The primary outcome was live birth rate (LBR) per ET. Secondary outcomes were live birth or ongoing pregnancy per ET, ongoing pregnancy per ET, clinical pregnancy per ET, and miscarriage per clinical pregnancy. Results: Fifteen studies were included. When data from all studies reporting live birth were pooled, overall LBR rates were comparable in cycles showing EC or not [RR = 0.97, 95%CI = 0.92 to 1.02; 10 studies, 11,710 transfer cycles]. In a subgroup of studies that included euploid ET cycles, a similar LBR for patients with and without EC was noted [RR = 0.99, 95%CI = 0.86 to 1.13, 4 studies, 1172 cycles]. The miscarriage rate did not seem to be affected by the presence or absence of EC [RR = 1.06, 95%CI = 0.90 to 1.24; 12 studies]. Conclusion: The predictive value of EC in determining LBR is limited, and assessment of EC may no longer be necessary, given these findings. Trial registration: PROSPERO CRD42023410389.
MeSH term(s)	Pregnancy ; Female ; Humans ; Abortion, Spontaneous ; Birth Rate ; Pregnancy Rate ; Reproductive Techniques, Assisted ; Embryo Transfer ; Live Birth/epidemiology
Language	English
Publishing date	2023-09-20
Publishing country	Netherlands
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	1112577-9
ISSN	1573-7330 ; 1058-0468
ISSN (online)	1573-7330
ISSN	1058-0468
DOI	10.1007/s10815-023-02942-5
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Article ; Online: Mild SARS-CoV-2 infections in children might be based on evolutionary biology and linked with host reactive oxidative stress and antioxidant capabilities

E.S. Keles

New Microbes and New Infections, Vol 36, Iss , Pp 100723- (2020)

2020

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to significant morbidity and mortality in elderly individuals. Children typically have mild illness with rare mortalities. Age and co-morbid medical conditions are the most important determinant of the infection outcome. Currently there is no clear explanation for the difference in disease severity and outcome in different age groups. Based on evolutionary biology and translational research this review suggests that the high antioxidant capacity of children leading to a balanced redox state is the key factor for mild SARS-CoV-2 infections in this age group. On the other hand, elderly individuals with low antioxidant capacity and low angiotensin-converting enzyme 2 expression are prone to severe infections by redox-sensitive immune modulation.
Keywords	Antioxidant ; children ; COVID19 ; evolutionary biology ; oxidative stress ; SARS-COV-2 ; Infectious and parasitic diseases ; RC109-216 ; covid19
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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