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  1. Article: Carte blanche à l’hôpital Cochin.

    Dusser, D

    Revue de pneumologie clinique

    2018  Volume 74, Issue 5, Page(s) 265–266

    Title translation White card to the Hôpital Cochin.
    MeSH term(s) Adult ; Biomedical Research/trends ; Cystic Fibrosis/genetics ; Hospital Units ; Hospitals, University/organization & administration ; Humans ; Paris ; Pulmonary Medicine/organization & administration ; Pulmonary Medicine/standards ; Pulmonary Medicine/trends
    Language French
    Publishing date 2018-10-15
    Publishing country France
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 605736-6
    ISSN 1776-2561 ; 0761-8417 ; 0032-5821
    ISSN (online) 1776-2561
    ISSN 0761-8417 ; 0032-5821
    DOI 10.1016/j.pneumo.2018.09.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Une nouvelle série sur les maladies des voies aériennes distales.

    Dusser, D

    Revue des maladies respiratoires

    2012  Volume 29, Issue 10, Page(s) 1185

    Title translation A new series on diseases affecting the distal airways.
    MeSH term(s) Congresses as Topic ; France ; Humans ; Publishing ; Respiratory Tract Diseases/diagnosis ; Respiratory Tract Diseases/etiology ; Respiratory Tract Diseases/genetics ; Respiratory Tract Diseases/therapy ; Serial Publications/trends
    Language French
    Publishing date 2012-12
    Publishing country France
    Document type Editorial
    ZDB-ID 605743-3
    ISSN 1776-2588 ; 0301-0279 ; 0761-8425
    ISSN (online) 1776-2588
    ISSN 0301-0279 ; 0761-8425
    DOI 10.1016/j.rmr.2012.11.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Safety of tiotropium in patients with asthma.

    Dusser, Daniel / Ducharme, Francine M

    Therapeutic advances in respiratory disease

    2019  Volume 13, Page(s) 1753466618824010

    Abstract: Given the high proportion of patients with asthma who remain uncontrolled despite controller treatment, there remains a need for the development of more effective treatment options with a proven safety and tolerability profile. Recently, asthma ... ...

    Abstract Given the high proportion of patients with asthma who remain uncontrolled despite controller treatment, there remains a need for the development of more effective treatment options with a proven safety and tolerability profile. Recently, asthma guidelines have evolved to incorporate new therapies, including long-acting muscarinic antagonists (LAMAs) and biologics. Here we focus on the safety profile of tiotropium, a LAMA, using data from the large-scale UniTinA-asthma
    MeSH term(s) Administration, Inhalation ; Adolescent ; Adult ; Aged ; Animals ; Anti-Asthmatic Agents/administration & dosage ; Anti-Asthmatic Agents/adverse effects ; Asthma/drug therapy ; Asthma/physiopathology ; Bronchodilator Agents/administration & dosage ; Bronchodilator Agents/adverse effects ; Child ; Cholinergic Antagonists/administration & dosage ; Cholinergic Antagonists/adverse effects ; Dose-Response Relationship, Drug ; Glucocorticoids/administration & dosage ; Humans ; Tiotropium Bromide/administration & dosage ; Tiotropium Bromide/adverse effects
    Chemical Substances Anti-Asthmatic Agents ; Bronchodilator Agents ; Cholinergic Antagonists ; Glucocorticoids ; Tiotropium Bromide (XX112XZP0J)
    Language English
    Publishing date 2019-02-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2476459-0
    ISSN 1753-4666 ; 1753-4658
    ISSN (online) 1753-4666
    ISSN 1753-4658
    DOI 10.1177/1753466618824010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Une nouvelle série sur l'atteinte des voies aériennes distales dans la BPCO.

    Dusser, D

    Revue des maladies respiratoires

    2011  Volume 28, Issue 2, Page(s) 127

    Title translation Distal airways in COPD: a new series in Rev Mal Respir.
    MeSH term(s) Humans ; Pulmonary Disease, Chronic Obstructive/complications
    Language French
    Publishing date 2011-02
    Publishing country France
    Document type Editorial
    ZDB-ID 605743-3
    ISSN 1776-2588 ; 0301-0279 ; 0761-8425
    ISSN (online) 1776-2588
    ISSN 0301-0279 ; 0761-8425
    DOI 10.1016/j.rmr.2011.01.001
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  5. Article: Traitement de l'asthme de l'adulte.

    Dusser, Daniel

    La Revue du praticien

    2011  Volume 61, Issue 3, Page(s) 359–64, 367

    Abstract: Asthma treatment should be conducted in three successive steps: identify and reduce exposure to risk factors, determine whether the patient requires a permanent controller medication which should be adapted to its asthma severity and education of the ... ...

    Title translation Treatment of adult asthma.
    Abstract Asthma treatment should be conducted in three successive steps: identify and reduce exposure to risk factors, determine whether the patient requires a permanent controller medication which should be adapted to its asthma severity and education of the patient who should acquire a minimum knowledge on his disease. Controller medications mostly involve inhaled medications because they are delivered in the airways where they are needed and they reduce their systemic effects. Controller medications are dominated by inhaled corticosteroids either alone or in association with inhaled beta-2 sympathomimetics. The main objective is to achieve and to maintain asthma control. Asthma control is assessed using six items which determine whether asthma is controlled, partially controlled or uncontrolled. Guidelines allow to adapt the intensity of anti-inflammatory controller medication (mostly inhaled corticosteroids) given alone or in association with inhaled beta-2 sympathomimetics to asthma control and taking into account the treatment steps of the patient at the time of evaluation. Severe asthma could justify exceptional treatments (such as omalizumab) which indications are the domain of specialists.
    MeSH term(s) Adult ; Asthma/drug therapy ; Asthma/prevention & control ; Asthma/therapy ; Humans
    Language French
    Publishing date 2011-03
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
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  6. Article: Double-blind, double-dummy, multinational, multicenter, parallel-group design clinical trial of clinical non-inferiority of formoterol 12 microg/unit dose in a b.i.d. regimen administered via an HFA-propellant-pMDI or a dry powder inhaler in a 12-week treatment period of moderate to severe stable persistent asthma in adult patients.

    Dusser, D / Vicaut, E / Lefrançois, G

    Respiration; international review of thoracic diseases

    2005  Volume 72 Suppl 1, Page(s) 20–27

    Abstract: Background: Pressurized metered-dose inhalers (pMDIs) have traditionally used CFCs as propellants. However, the worldwide phase-out of CFCs has necessitated the development of new pMDIs that use alternative propellants. One such replacement is the ... ...

    Abstract Background: Pressurized metered-dose inhalers (pMDIs) have traditionally used CFCs as propellants. However, the worldwide phase-out of CFCs has necessitated the development of new pMDIs that use alternative propellants. One such replacement is the hydrofluoroalkane HFA-134a.
    Objectives: This study sought to establish the clinical non-inferiority of a new HFA-134a-containing pMDI to a conventional dry powder inhaler (DPI) in the administration of formoterol to adult patients with moderate-to-severe, stable persistent asthma. The secondary aim was to collect safety data in a multiple-dose long-term study.
    Methods: During this multicenter, double-blind, parallel study, 500 patients were randomized to receive 12 microg of formoterol twice daily for 12 weeks via either an HFA pMDI or a DPI. If necessary, the dose could be increased to 24 microg twice daily. At baseline, all patients (aged 18-70 years) had an FEV1 40-80% of predicted and a documented positive response to the reversibility test.
    Results: After 12 weeks' therapy, the adjusted mean morning PEFR was 343.69 l/min in the formoterol HFA pMDI group and 344.56 l/min in the formoterol DPI group. Because the lower limit of the 95% CI for the between-group difference (-11.64 l/min) was well within the non-inferiority margin (-20 l/min), the HFA device was deemed clinically non-inferior to the DPI device. This finding was confirmed when evening PEFR and FEV1 were assessed. Both formulations of formoterol were well tolerated during prolonged multiple dosing.
    Conclusions: This study provides evidence that the new HFA-formulated formoterol pMDI has a similar efficacy and safety profile to the conventional formoterol DPI in the treatment of patients with moderate-to-severe asthma.
    MeSH term(s) Adult ; Aerosol Propellants ; Aged ; Asthma/drug therapy ; Asthma/physiopathology ; Bronchodilator Agents/administration & dosage ; Bronchodilator Agents/adverse effects ; Bronchodilator Agents/therapeutic use ; Double-Blind Method ; Drug Administration Schedule ; Ethanolamines/administration & dosage ; Ethanolamines/adverse effects ; Ethanolamines/therapeutic use ; Female ; Forced Expiratory Volume/drug effects ; Formoterol Fumarate ; Humans ; Hydrocarbons, Fluorinated ; Male ; Metered Dose Inhalers ; Middle Aged ; Nebulizers and Vaporizers ; Peak Expiratory Flow Rate/drug effects ; Powders ; Severity of Illness Index ; Treatment Outcome
    Chemical Substances Aerosol Propellants ; Bronchodilator Agents ; Ethanolamines ; Hydrocarbons, Fluorinated ; Powders ; Formoterol Fumarate (W34SHF8J2K)
    Language English
    Publishing date 2005
    Publishing country Switzerland
    Document type Clinical Trial ; Clinical Trial, Phase III ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 206674-9
    ISSN 1423-0356 ; 0025-7931
    ISSN (online) 1423-0356
    ISSN 0025-7931
    DOI 10.1159/000083689
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Evaluating response to biologics in severe asthma: Precision or guesstimation?

    Taillé, C / Devillier, P / Dusser, D / Humbert, M / Maurer, C / Roche, N

    Respiratory medicine and research

    2021  Volume 80, Page(s) 100813

    MeSH term(s) Anti-Asthmatic Agents/therapeutic use ; Asthma/drug therapy ; Biological Products/therapeutic use ; Data Collection ; Humans
    Chemical Substances Anti-Asthmatic Agents ; Biological Products
    Language English
    Publishing date 2021-02-05
    Publishing country France
    Document type Editorial
    ISSN 2590-0412
    ISSN (online) 2590-0412
    DOI 10.1016/j.resmer.2021.100813
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  8. Article ; Online: Rheumatoid arthritis-associated bronchiectasis.

    Puéchal, Xavier / Bienvenu, Thierry / Dusser, Daniel

    Lancet (London, England)

    2019  Volume 393, Issue 10185, Page(s) 2035–2036

    MeSH term(s) Arthritis, Rheumatoid ; Bronchiectasis ; Humans ; Microbiota
    Language English
    Publishing date 2019-06-13
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(19)30020-0
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  9. Article ; Online: Prévention des exacerbations de bronchopneumopathie chronique obstructive.

    Dusser, Daniel

    Presse medicale (Paris, France : 1983)

    2008  Volume 37, Issue 11, Page(s) 1604–1608

    Abstract: Exacerbations of chronic obstructive pulmonary disease (COPD) aggravate disease course, induce increased morbidity and mortality, impair quality of life, and raise the direct costs of COPD. Their prevention is essential and is an integral part of the ... ...

    Title translation Prevention of chronic obstructive pulmonary disease exacerbations.
    Abstract Exacerbations of chronic obstructive pulmonary disease (COPD) aggravate disease course, induce increased morbidity and mortality, impair quality of life, and raise the direct costs of COPD. Their prevention is essential and is an integral part of the COPD program defined by French health authorities for the 2005-2010 period. Both pharmacologic and nonpharmacologic approaches have been shown to be effective in preventing exacerbations, but these treatments are still underused and misused. Important nonpharmacologic therapies that directly decrease the risk of exacerbation or hospitalization include smoking cessation, oxygen therapy, pulmonary rehabilitation, and education. Most of the drugs available for long-term management of COPD have significant effects on the frequency of exacerbations: tiotropium and salmeterol, each used alone, as well as fixed combinations of salmeterol/fluticasone or formoterol/budesonide. Tiotropium reduces the frequency of exacerbation in both moderate and severe COPD. Inhaled glucocorticosteroid agents are not recommended alone. They must be prescribed only with a long-acting bronchodilator and only to patients with severe disease and repeated exacerbations. Influenza vaccination is recommended.
    MeSH term(s) Bronchodilator Agents/therapeutic use ; Cost of Illness ; France ; Humans ; Oxygen Inhalation Therapy ; Patient Education as Topic ; Pulmonary Disease, Chronic Obstructive/economics ; Pulmonary Disease, Chronic Obstructive/prevention & control ; Pulmonary Disease, Chronic Obstructive/psychology ; Quality of Life ; Respiratory Therapy ; Smoking Cessation
    Chemical Substances Bronchodilator Agents
    Language French
    Publishing date 2008-11
    Publishing country France
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 120943-7
    ISSN 2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
    ISSN (online) 2213-0276
    ISSN 0032-7867 ; 0755-4982 ; 0301-1518
    DOI 10.1016/j.lpm.2008.08.003
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  10. Article ; Online: Les exacerbations de bronchopneumopathie chronique obstructive et leur impact sur l'histoire naturelle de la maladie.

    Dusser, Daniel

    Presse medicale (Paris, France : 1983)

    2008  Volume 37, Issue 11, Page(s) 1599–1603

    Abstract: Exacerbations can occur at each stage of chronic obstructive pulmonary disease (COPD), but their frequency and severity increase with disease progression. Today exacerbations are known to have severe immediate and delayed consequences. They aggravate ... ...

    Title translation Chronic obstructive pulmonary disease exacerbations and their impact on the long-term natural history of the disease.
    Abstract Exacerbations can occur at each stage of chronic obstructive pulmonary disease (COPD), but their frequency and severity increase with disease progression. Today exacerbations are known to have severe immediate and delayed consequences. They aggravate symptoms (dyspnea, cough, and sputum), airflow, and FEV1 decline and impair quality of life--all durably, with prolonged recovery time. They increase the risk of death. Their economic consequences are substantial, accounting for 60% of direct cost associated with COPD - 3 and 9 billion euros per year. Prevention of exacerbations is a major public health objective and is an integral part of the COPD program defined by French health authorities for the 2005-2010 period. It is essential to improve quality of life and prevent worsening of the long-term course of COPD.
    MeSH term(s) Airway Obstruction/physiopathology ; Cost of Illness ; Cough/physiopathology ; Disease Progression ; Dyspnea/physiopathology ; Forced Expiratory Volume/physiology ; France ; Humans ; Pulmonary Disease, Chronic Obstructive/economics ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Pulmonary Disease, Chronic Obstructive/psychology ; Quality of Life ; Sputum/physiology
    Language French
    Publishing date 2008-11
    Publishing country France
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 120943-7
    ISSN 2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
    ISSN (online) 2213-0276
    ISSN 0032-7867 ; 0755-4982 ; 0301-1518
    DOI 10.1016/j.lpm.2008.08.004
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