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Article: Long-term functional and structural outcomes after large chorioretinectomy for ruptured globe following blunt trauma.

Mura, Marco / Iannetta, Danilo / Pellegrini, Marco / Engelbrecht, Leonore A / Sarti, Laura / Parmeggiani, Francesco / Badawi, Abdulrahman / Dhibi, Hassan / Al Sulaiman, Sulaiman

International journal of retina and vitreous

2023 Volume 9, Issue 1, Page(s) 52

Abstract: Background: The purpose of this study was to present a modified surgical technique involving pars plana vitrectomy with large chorioretinectomy for eyes with rupture of the globe due to severe ocular blunt trauma.: Methods: This retrospective study ... ...

Abstract	Background: The purpose of this study was to present a modified surgical technique involving pars plana vitrectomy with large chorioretinectomy for eyes with rupture of the globe due to severe ocular blunt trauma. Methods: This retrospective study included consecutive patients with rupture of the globe due to blunt trauma who were treated at the King Khaled Eye Specialist Hospital (Riyadh, Saudi Arabia). All patients underwent 25-gauge pars plana vitrectomy with large chorioretinectomies involving all the tissue around the posterior scleral wounds. Outcome measures included best-corrected visual acuity (BCVA), anatomical success and globe survival, rates of complications. Results: 15 eyes of 15 patients were included. Mean BCVA was 2.88 ± 0.13 logMAR at presentation, and significantly improved to 0.83 ± 0.28 logMAR (P < 0.001), with 10 patients (67%) achieving a final BCVA ≥ 20/200. Anatomical success and globe survival were achieved in 11 (73%) and 15 (100%) of eyes, respectively. Postoperative complications included retinal detachment in 6 eyes (40%), epiretinal membrane in 6 (40%), hypotony in 4 (26%), PVR in 2 (13%). Conclusions: Pars plana vitrectomy with large chorioretinectomy is an effective treatment for globe rupture following severe blunt trauma, yielding good visual outcomes and anatomical success rates.
Language	English
Publishing date	2023-08-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2836254-8
ISSN	2056-9920
ISSN	2056-9920
DOI	10.1186/s40942-023-00492-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: New insights into hepatitis B virus lymphotropism: Implications for HBV-related lymphomagenesis.

Svicher, Valentina / Salpini, Romina / D'Anna, Stefano / Piermatteo, Lorenzo / Iannetta, Marco / Malagnino, Vincenzo / Sarmati, Loredana

Frontiers in oncology

2023 Volume 13, Page(s) 1143258

Abstract: HBV is one of the most widespread hepatitis viruses worldwide, and a correlation between chronic infection and liver cancer has been clearly reported. The carcinogenic capacity of HBV has been reported for other solid tumors, but the largest number of ... ...

Abstract	HBV is one of the most widespread hepatitis viruses worldwide, and a correlation between chronic infection and liver cancer has been clearly reported. The carcinogenic capacity of HBV has been reported for other solid tumors, but the largest number of studies focus on its possible lymphomagenic role. To update the correlation between HBV infection and the occurrence of lymphatic or hematologic malignancies, the most recent evidence from epidemiological and
Language	English
Publishing date	2023-03-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1143258
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Article ; Online: Laser flare and cell photometry to measure inflammation after cataract surgery: a tool to predict the risk of cystoid macular edema.

De Maria, Michele / Coassin, Marco / Iannetta, Danilo / Fontana, Luigi

International ophthalmology

2021 Volume 41, Issue 6, Page(s) 2293–2300

Abstract: Purpose: To review the current adoption of laser flare and cell photometry (LFCP) in the setting of modern cataract surgery to analyze inflammation aiming to identify evidence of a correlation between LFCP values and the risk of cystoid macular edema ( ... ...

Abstract	Purpose: To review the current adoption of laser flare and cell photometry (LFCP) in the setting of modern cataract surgery to analyze inflammation aiming to identify evidence of a correlation between LFCP values and the risk of cystoid macular edema (CME) development. Methods: An extensive PubMed literature search was performed to review all the published studies investigating inflammation by LFCP after uncomplicated phacoemulsification. The following keywords were used: cataract surgery, cystoid macular edema, anterior chamber inflammation, laser flare, and cell photometry. Results: Seventy-eight original articles investigating inflammation by LFCP were selected. Macula alterations were searched in 12 (15%) trials, by optical coherence tomography or fluorescein angiography in 11 (14%) and 1 (1%) studies, respectively. Among them, 9 (12%) papers investigated the correlation between LFCP values and cystic changes to the macula: 7 (9%) and 2 (3%) studies identified a positive and negative correlation, respectively. Three (4%) papers did not perform any correlation analysis. Conclusion: CME, as a consequence of uncontrolled postoperative inflammation, is a common cause for unfavorable visual outcomes following uncomplicated phacoemulsification with IOL implantation. After surgery, intraocular inflammation is generally assessed by qualitative methods. Although well-established and practical in uveitis, they are inadequate to detect the modest inflammatory response that usually occurs after uneventful phacoemulsification. LFCP correlate with the chance of macula alteration after surgery and higher the values higher the risk of CME. The quantitative analysis of intraocular inflammation by LFCP after cataract surgery might be a tool to predict the risk of pseudophakic CME.
MeSH term(s)	Cataract ; Humans ; Inflammation/diagnosis ; Inflammation/etiology ; Lasers ; Macular Edema/diagnosis ; Macular Edema/epidemiology ; Macular Edema/etiology ; Phacoemulsification/adverse effects ; Photometry ; Postoperative Complications/diagnosis ; Postoperative Complications/etiology ; Tomography, Optical Coherence
Language	English
Publishing date	2021-03-21
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	800087-6
ISSN	1573-2630 ; 0165-5701
ISSN (online)	1573-2630
ISSN	0165-5701
DOI	10.1007/s10792-021-01779-0
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Zs.A 1479: Show issues

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Article: T Lymphocyte Subset Counts and Interferon-Gamma Production in Adults and Children with COVID-19: A Narrative Review.

De Rose, Domenico Umberto / Pace, Pier Giorgio / Ceccherini-Silberstein, Francesca / Dotta, Andrea / Andreoni, Massimo / Sarmati, Loredana / Iannetta, Marco

Journal of personalized medicine

2023 Volume 13, Issue 5

Abstract: Adults and children exhibit a broad range of clinical outcomes from SARS-CoV-2 infection, with minimal to mild symptoms, especially in the pediatric age. However, some children present with a severe hyperinflammatory post-infectious complication named ... ...

Abstract	Adults and children exhibit a broad range of clinical outcomes from SARS-CoV-2 infection, with minimal to mild symptoms, especially in the pediatric age. However, some children present with a severe hyperinflammatory post-infectious complication named multisystem inflammatory syndrome in children (MIS-C), mainly affecting previously healthy subjects. Understanding these differences is still an ongoing challenge, that can lead to new therapeutic strategies and avoid unfavorable outcomes. In this review, we discuss the different roles of T lymphocyte subsets and interferon-γ (IFN-γ) in the immune responses of adults and children. Lymphopenia can influence these responses and represent a good predictor for the outcome, as reported by most authors. The increased IFN-γ response exhibited by children could be the starting point for the activation of a broad response that leads to MIS-C, with a significantly higher risk than in adults, although a single IFN signature has not been identified. Multicenter studies with large cohorts in both age groups are still needed to study SARS-CoV-2 pathogenesis with new tools and to understand how is possible to better modulate immune responses.
Language	English
Publishing date	2023-04-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13050755
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Article ; Online: HBcAb Positivity as a Risk Factor for Missing HIV RNA Undetectability after the 3TC+DTG Switch.

Malagnino, Vincenzo / Mulas, Tiziana / Teti, Elisabetta / Basso, Monica / Giobbia, Mario / Geremia, Nicholas / Battagin, Giuliana / Abi Aad, Yasmine / Vincensini, Jean-Paul / Iannetta, Marco / Parisi, Saverio Giuseppe / Sarmati, Loredana / Lacombe, Karine

Viruses

2024 Volume 16, Issue 3

Abstract: Hepatitis B Core antibody (HBcAb) positivity is the surrogate marker of hepatitis B occult infection. This condition is not a contraindication for switching to two-drug (2DR) antiretroviral therapy; however, the removal of tenofovir may contribute to ... ...

Abstract	Hepatitis B Core antibody (HBcAb) positivity is the surrogate marker of hepatitis B occult infection. This condition is not a contraindication for switching to two-drug (2DR) antiretroviral therapy; however, the removal of tenofovir may contribute to poor control of HBV replication. A multicentre retrospective cohort study investigated the impact of HBcAb positivity on HIV control in patients switching to a 2DR with Lamivudine and Dolutegravir (3TC-DTG). In this study, a comparison analysis was conducted between HBcAb-positive and -negative PLWH regarding HIV-RNA suppression, considering: (1): Target Not Detected (TND) < 20 cp/mL; (2) Target Detected (TD) < 20 cp/mL; and (3) Detectable > 20 cp/mL and <50 cp/mL and >50 copies/mL. A total of 267 patients on 2DR with 3TC-DTG were included. In comparison to HBcAb-negative, HBcAb-positive patients were older (45 years [35-54]) and had a lower CD4+ nadir (248 vs. 349 cells/mmc,
MeSH term(s)	Humans ; Lamivudine/therapeutic use ; Anti-HIV Agents/therapeutic use ; Retrospective Studies ; HIV Infections/drug therapy ; Heterocyclic Compounds, 3-Ring/therapeutic use ; Risk Factors ; RNA ; Hepatitis B/drug therapy ; Oxazines ; Piperazines ; Pyridones
Chemical Substances	Lamivudine (2T8Q726O95) ; dolutegravir (DKO1W9H7M1) ; Anti-HIV Agents ; Heterocyclic Compounds, 3-Ring ; RNA (63231-63-0) ; Oxazines ; Piperazines ; Pyridones
Language	English
Publishing date	2024-02-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v16030348
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Article: Viscoelastics Enable Dissection of Anterior Closed Funnels in Proliferative Vitreoretinopathy: A Retrospective Case Series.

Iannetta, Danilo / de Smet, Marc D / Valsecchi, Nicola / Fontana, Luigi / Chhablani, Jay

Case reports in ophthalmology

2024 Volume 15, Issue 1, Page(s) 394–398

Abstract: Introduction: The present study aimed to describe a case series of patients in which a cohesive ophthalmic viscous device (OVD) was used to viscodissect and posteriorly displace the retina in cases of total retinal detachment complicated by ... ...

Abstract	Introduction: The present study aimed to describe a case series of patients in which a cohesive ophthalmic viscous device (OVD) was used to viscodissect and posteriorly displace the retina in cases of total retinal detachment complicated by proliferative vitreoretinopathy, operated with minimally invasive pars plana vitrectomy. Case presentations: Three patients with a mean age of 67 years were included in the present study. One eye was aphakic, while the others were pseudophakic. OVD injection was performed through the limbus in the aphakic eye and via pars plana in the pseudophakic eyes. In all cases, the OVD injection led to a posterior displacement of the detached retina with a smooth dissection. No complications related to the surgery were observed. At the last follow-up visit, the retina was attached in all cases, with an improvement in visual acuity. Conclusion: To conclude, the injection of a cohesive OVD anterior to the detached retina allowed to posteriorize and viscodissect to some extent the retina, facilitating the implant of trocars.
Language	English
Publishing date	2024-04-25
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2577666-6
ISSN	1663-2699
ISSN	1663-2699
DOI	10.1159/000535795
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Article ; Online: Utility of accessible SARS-CoV-2 specific immunoassays in vaccinated adults with a history of advanced HIV infection.

Ferrari, Ludovica / Ruggiero, Alessandra / Stefani, Chiara / Benedetti, Livia / Piermatteo, Lorenzo / Andreassi, Eleonora / Caldara, Federica / Zace, Drieda / Pagliari, Matteo / Ceccherini-Silberstein, Francesca / Jones, Christopher / Iannetta, Marco / Geretti, Anna Maria

Scientific reports

2024 Volume 14, Issue 1, Page(s) 8337

Abstract: Accessible SARS-CoV-2-specific immunoassays may inform clinical management in people with HIV, particularly in case of persisting immunodysfunction. We prospectively studied their application in vaccine recipients with HIV, purposely including ... ...

Abstract	Accessible SARS-CoV-2-specific immunoassays may inform clinical management in people with HIV, particularly in case of persisting immunodysfunction. We prospectively studied their application in vaccine recipients with HIV, purposely including participants with a history of advanced HIV infection. Participants received one (n = 250), two (n = 249) or three (n = 42) doses of the BNT162b2 vaccine. Adverse events were documented through questionnaires. Sample collection occurred pre-vaccination and a median of 4 weeks post-second dose and 14 weeks post-third dose. Anti-spike and anti-nucleocapsid antibodies were measured with the Roche Elecsys chemiluminescence immunoassays. Neutralising activity was evaluated using the GenScript cPass surrogate virus neutralisation test, following validation against a Plaque Reduction Neutralization Test. T-cell reactivity was assessed with the Roche SARS-CoV-2 IFNγ release assay. Primary vaccination (2 doses) was well tolerated and elicited measurable anti-spike antibodies in 202/206 (98.0%) participants. Anti-spike titres varied widely, influenced by previous SARS-CoV-2 exposure, ethnicity, intravenous drug use, CD4 counts and HIV viremia as independent predictors. A third vaccine dose significantly boosted anti-spike and neutralising responses, reducing variability. Anti-spike titres > 15 U/mL correlated with neutralising activity in 136/144 paired samples (94.4%). Three participants with detectable anti-S antibodies did not develop cPass neutralising responses post-third dose, yet displayed SARS-CoV-2 specific IFNγ responses. SARS-CoV-2 vaccination is well-tolerated and immunogenic in adults with HIV, with responses improving post-third dose. Anti-spike antibodies serve as a reliable indicator of neutralising activity. Discordances between anti-spike and neutralising responses were accompanied by detectable IFN-γ responses, underlining the complexity of the immune response in this population.
MeSH term(s)	Adult ; Animals ; Humans ; SARS-CoV-2 ; BNT162 Vaccine ; COVID-19 Vaccines/adverse effects ; HIV Infections ; COVID-19/prevention & control ; Immunoassay ; Antibodies ; Spiders ; Vaccination ; Antibodies, Viral ; Antibodies, Neutralizing
Chemical Substances	BNT162 Vaccine ; COVID-19 Vaccines ; Antibodies ; Antibodies, Viral ; Antibodies, Neutralizing
Language	English
Publishing date	2024-04-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-58597-4
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Article ; Online: Drug-Induced Progressive Multifocal Leukoencephalopathy (PML): A Systematic Review and Meta-Analysis.

Rindi, Lorenzo Vittorio / Zaçe, Drieda / Braccialarghe, Neva / Massa, Barbara / Barchi, Virginia / Iannazzo, Roberta / Fato, Ilenia / De Maria, Francesco / Kontogiannis, Dimitra / Malagnino, Vincenzo / Sarmati, Loredana / Iannetta, Marco

Drug safety

2024 Volume 47, Issue 4, Page(s) 333–354

Abstract: Introduction: Progressive multifocal leukoencephalopathy (PML) was first described among patients affected by hematological or solid tumors. Following the human immunodeficiency virus (HIV) epidemic, people living with HIV have represented most cases ... ...

Abstract	Introduction: Progressive multifocal leukoencephalopathy (PML) was first described among patients affected by hematological or solid tumors. Following the human immunodeficiency virus (HIV) epidemic, people living with HIV have represented most cases for more than a decade. With the diffusion of highly active antiretroviral therapy, this group progressively decreased in favor of patients undergoing treatment with targeted therapy/immunomodulators. In this systematic review and meta-analysis, the objective was to assess which drugs are most frequently related to PML development, and report the incidence of drug-induced PML through a meta-analytic approach. Methods: The electronic databases MEDLINE, EMBASE, ClinicalTrials.gov, Web of Science and the Canadian Agency for Drugs and Technologies in Health Database (CADTH) were searched up to May 10, 2022. Articles that reported the risk of PML development after treatment with immunomodulatory drugs, including patients of both sexes under the age of 80 years, affected by any pathology except HIV, primary immunodeficiencies or malignancies, were included in the review. The incidence of drug-induced PML was calculated based on PML cases and total number of patients observed per 100 persons and the observation time. Random-effect metanalyses were conducted for each drug reporting pooled incidence with 95% confidence intervals (CI) and median (interquartile range [IQR]) of the observation time. Heterogeneity was measured by I Results: A total of 103 studies were included in the systematic review. In our analysis, we found no includible study reporting cases of PML during the course of treatment with ocrelizumab, vedolizumab, abrilumab, ontamalimab, teriflunomide, daclizumab, inebilizumab, basiliximab, tacrolimus, belimumab, infliximab, firategrast, disulone, azathioprine or danazole. Dalfampridine, glatiramer acetate, dimethyl fumarate and fingolimod show a relatively safe profile, although some cases of PML have been reported. The meta-analysis showed an incidence of PML cases among patients undergoing rituximab treatment for multiple sclerosis (MS) of 0.01 cases/100 persons (95% CI - 0.08 to 0.09; I Conclusions: A higher risk of drug-related PML in patients whose immune system is not additionally depressed by means of neoplasms, HIV or concomitant medications is found in the neurological field. This risk is higher in MS treatment, and specifically during long-term natalizumab therapy. While this drug is still routinely prescribed in this field, considering the efficacy in reducing MS relapses, in other areas it could play a smaller role, and be gradually replaced by other safer and more recently approved agents.
MeSH term(s)	Male ; Female ; Humans ; Aged, 80 and over ; Natalizumab/adverse effects ; Leukoencephalopathy, Progressive Multifocal/chemically induced ; Leukoencephalopathy, Progressive Multifocal/epidemiology ; Canada ; Immunologic Factors/adverse effects ; Multiple Sclerosis/drug therapy ; HIV Infections/drug therapy
Chemical Substances	Natalizumab ; Immunologic Factors
Language	English
Publishing date	2024-02-07
Publishing country	New Zealand
Document type	Meta-Analysis ; Systematic Review
ZDB-ID	1018059-x
ISSN	1179-1942 ; 0114-5916
ISSN (online)	1179-1942
ISSN	0114-5916
DOI	10.1007/s40264-023-01383-4
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Article: Resistance to Ceftazidime/Avibactam in

Campogiani, Laura / Vitale, Pietro / Lodi, Alessandra / Imeneo, Alessandra / Fontana, Carla / D'Agostini, Cartesio / Compagno, Mirko / Coppola, Luigi / Spalliera, Ilaria / Malagnino, Vincenzo / Teti, Elisabetta / Iannetta, Marco / Andreoni, Massimo / Sarmati, Loredana

Antibiotics (Basel, Switzerland)

2023 Volume 12, Issue 5

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-04-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics12050820
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Article ; Online: Admission eGFR predicts in-hospital mortality independently of admission glycemia and C-peptide in patients with type 2 diabetes mellitus and COVID-19.

Infante, Marco / Pieri, Massimo / Lupisella, Santina / Mohamad, Ali / Bernardini, Sergio / Della-Morte, David / Fabbri, Andrea / De Stefano, Alberto / Iannetta, Marco / Ansaldo, Lorenzo / Crea, Angela / Andreoni, Massimo / Morello, Maria

Current medical research and opinion

2023 Volume 39, Issue 4, Page(s) 505–516

Abstract: Objective: Type 2 diabetes mellitus (T2DM) and impaired kidney function are associated with a higher risk of poor outcomes of coronavirus disease 2019 (COVID-19). We conducted a retrospective study in hospitalized T2DM patients with COVID-19 to assess ... ...

Abstract	Objective: Type 2 diabetes mellitus (T2DM) and impaired kidney function are associated with a higher risk of poor outcomes of coronavirus disease 2019 (COVID-19). We conducted a retrospective study in hospitalized T2DM patients with COVID-19 to assess the association between in-hospital mortality and admission values of different hematological/biochemical parameters, including estimated glomerular filtration rate (eGFR), plasma glucose and C-peptide (the latter serving as a marker of beta-cell function). Methods: The study included T2DM patients with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection who were consecutively admitted to our Institution between 1 October 2020 and 1 April 2021. Results: Patients ( Conclusions: Admission eGFR and WBC count predict in-hospital COVID-19 mortality among T2DM patients, independently of traditional risk factors, APG and random plasma C-peptide. Hospitalized patients with COVID-19 and comorbid T2DM associated with impaired kidney function at admission should be considered at high risk for adverse outcomes and death.
MeSH term(s)	Humans ; COVID-19/complications ; SARS-CoV-2 ; Diabetes Mellitus, Type 2/complications ; C-Peptide ; Retrospective Studies ; Glomerular Filtration Rate ; Hospital Mortality ; Blood Glucose
Chemical Substances	C-Peptide ; Blood Glucose
Language	English
Publishing date	2023-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	80296-7
ISSN	1473-4877 ; 0300-7995
ISSN (online)	1473-4877
ISSN	0300-7995
DOI	10.1080/03007995.2023.2177380
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