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Article: Outcome in very preterm infants: a population-based study from a regional center in Austria.

Konzett, Karin / Riedl, David / Blassnig-Ezeh, Anya / Gang, Stefanie / Simma, Burkhard

2024 Volume 12, Page(s) 1336469

Abstract: Aim: To determine short-term morbidity and mortality rates in the first state-wide Austrian neonatal cohort and comparison to (inter)national data.: Methods: Observational, population-based cohort study, analyzing data of preterm infants (<32 + 0 ... ...

Abstract	Aim: To determine short-term morbidity and mortality rates in the first state-wide Austrian neonatal cohort and comparison to (inter)national data. Methods: Observational, population-based cohort study, analyzing data of preterm infants (<32 + 0 weeks of gestation) born between 2007 and 2020 ( Results: Overall survival rate was 95%, survival free of major complications was 79%. Prevalence for BPD was 11.2%, surgical NEC 4.0%, severe IVH 4.6%, and for severe ROP 2.6%, respectively. In the extremely low gestational age neonates (ELGAN) born <28 weeks of gestation ( Conclusions: This study demonstrates a very low mortality rate that decreases over time. Short-term morbidities and survival free of major complications do not differ from (inter)national data in a similar group of very preterm infants. Standard operating procedures, simulation trainings and accordance to international trials may improve patient care and surpass center case loads.
Language	English
Publishing date	2024-02-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2024.1336469
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Psychomotor and Cognitive Outcome in Very Preterm Infants in Vorarlberg, Austria, 2007-2019.

Jenni, Fabio / Konzett, Karin / Gang, Stefanie / Sparr, Verena / Simma, Burkhard

Neuropediatrics

2023 Volume 55, Issue 2, Page(s) 90–96

Abstract: Aim: The aim of this study was to analyze neurodevelopmental outcome of very and extremely preterm infants in Vorarlberg, Austria, accessed with neurodevelopmental testing, at the corrected age of 24 months. This article also compared these results ... ...

Abstract	Aim: The aim of this study was to analyze neurodevelopmental outcome of very and extremely preterm infants in Vorarlberg, Austria, accessed with neurodevelopmental testing, at the corrected age of 24 months. This article also compared these results with (inter)national data and analyzed the impact of perinatal parameters. Methods: Population-based, retrospective multicenter study with data on very and extremely preterm infants born in Vorarlberg from 2007 to 2019 assessed with Bayley Scales of Infant Development (BSID-II/Bayley-III). Results: Included were 264 infants with a mean age of 29.0 (± 2.1) weeks of gestational age and a mean birth weight of 1177 (± 328.26) g; 172 infants underwent a BSID-II, 92 a Bayley-III assessment. The psychomotor developmental index (PDI) and mental developmental index (MDI) showed mean scores of 99.6 (± 14.4) and 91 (± 20.4), respectively. Adverse outcomes (scores <70) were assessed in 4.2% for PDI and 15.5% for MDI. In the extremely preterm group ( Conclusion: This study showed a remarkably good neurodevelopmental outcome in preterm infants with low rates of adverse outcome, similar to (inter)national reports, especially in the group of extremely preterm infants. Research is needed to explore the role of social factors and infants' environment, especially cognitive outcome and language skills.
MeSH term(s)	Humans ; Infant, Newborn ; Austria/epidemiology ; Cognition ; Infant, Extremely Premature ; Infant, Premature, Diseases/epidemiology ; Infant, Very Low Birth Weight
Language	English
Publishing date	2023-12-29
Publishing country	Germany
Document type	Multicenter Study ; Journal Article
ZDB-ID	573291-8
ISSN	1439-1899 ; 0174-304X
ISSN (online)	1439-1899
ISSN	0174-304X
DOI	10.1055/a-2236-4003
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Article: SARS-CoV-2-Seroprävalenz in Österreich. Die Situation vor der Omikronwelle.

Kerbl, Reinhold / Strenger, Volker / Bernar, Benoir / Zurl, Christoph / Simma, Burkhard

Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde

2022 Volume 170, Issue 6, Page(s) 487–489

Title translation	SARS-CoV-2 seroprevalence in Austria. The situation before the omicron wave.
Language	German
Publishing date	2022-04-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	137102-2
ISSN	1433-0474 ; 0026-9298
ISSN (online)	1433-0474
ISSN	0026-9298
DOI	10.1007/s00112-022-01491-y
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Article ; Online: Impact of Pediatric Emergency Care Applied Research Network Rules on Admission, Cranial Computed Tomography and Skull X-ray Rates in a Central European Hospital.

Poyntner, Lukas / Simma, Burkhard

Pediatric emergency care

2020 Volume 38, Issue 1, Page(s) e365–e370

Abstract: Objectives: Mild head injury is a common cause of pediatric emergency department visits. Cranial computed tomography (CCT) is the diagnostic standard, although it involves inherent radiation risks. Pediatric Emergency Care Applied Research Network ( ... ...

Abstract	Objectives: Mild head injury is a common cause of pediatric emergency department visits. Cranial computed tomography (CCT) is the diagnostic standard, although it involves inherent radiation risks. Pediatric Emergency Care Applied Research Network (PECARN) clinical prediction rules were developed to reduce the number of CCT scans. They provide a guideline for CCT use in mild head injuries, based on clinical parameters.Our study aims to evaluate the impact of PECARN rules on hospital admission and CCT rate in children with mild head injury. Methods: In this retrospective study, we investigated 729 children with mild head injury presenting in the pediatric emergency department between 2012 and 2016. We compared 2 groups, before and after implementation of PECARN criteria in clinical routine. Results: Of 729 included patients (417 male; 5.6 ± 4.8 years;) 380 were seen prior to implementation of the PECARN rules, compared to 349 patients afterwards. Overall admissions to the ward decreased significantly from 83.9% (n = 319) to 71.3% (n = 249) (P < 0.001), a 31.3% reduction. Calculated from all pediatric admissions, the rate of patients with mild head injury fell from 6.0% to 4.3% (P < 0.001).We recorded a nonsignificant decrease in the CCT rate, from 14.7% to 13.2% (P = 0.555).No readmissions were recorded. Conclusions: Our results show a significant reduction in the rate of hospital admission following implementation of the PECARN rules in our hospital. Already low, the CCT rate did not change after implementation.The PECARN rules appear to be safe because no readmissions were recorded.
MeSH term(s)	Child ; Craniocerebral Trauma/diagnostic imaging ; Decision Support Techniques ; Emergency Medical Services ; Emergency Service, Hospital ; Hospitals ; Humans ; Male ; Retrospective Studies ; Skull ; Tomography, X-Ray Computed ; X-Rays
Language	English
Publishing date	2020-11-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	632588-9
ISSN	1535-1815 ; 0749-5161
ISSN (online)	1535-1815
ISSN	0749-5161
DOI	10.1097/PEC.0000000000002293
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Article: Lernen über Grenzen

Simma, Burkhard

Pädiatrie & Pädologie

2016 Volume 51, Issue 3, Page(s) 95

Language	German
Document type	Article
ZDB-ID	123417-1
ISSN	0030-9338
Database	Current Contents Medicine

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Article ; Online: Two-year neurodevelopmental outcome in extremely preterm-born children: The Austrian Preterm Outcome Study Group.

Kiechl-Kohlendorfer, Ursula / Simma, Burkhard / Berger, Angelika / Urlesberger, Berndt / Wald, Martin / Haiden, Nadja / Fuiko, Renate / Ndayisaba, Jean-Pierre

Acta paediatrica (Oslo, Norway : 1992)

2024

Abstract: Aim: The current study determined the neurodevelopmental outcome of extremely preterm infants at 2 years of age.: Methods: All live-born infants 23-27 weeks of gestation born between 2011 and 2020 in Austria were included in a prospective registry. ... ...

Abstract	Aim: The current study determined the neurodevelopmental outcome of extremely preterm infants at 2 years of age. Methods: All live-born infants 23-27 weeks of gestation born between 2011 and 2020 in Austria were included in a prospective registry. Neurodevelopmental outcome at 2 years of corrected age was assessed using Bayley Scales of Infant Development for both motor and cognitive scores, along with a neurological examination and an assessment of neurosensory function. Results: 2378 out of 2905 (81.9%) live-born infants survived to 2 years of corrected age. Follow-up data were available for 1488 children (62.6%). Overall, 43.0% had no, 35.0% mild and 22.0% moderate-to-severe impairment. The percentage of children with moderate-to-severe neurodevelopmental impairment decreased with increasing gestational age and was 31.4%, 30.5%, 23.3%, 19.0% and 16.5% at 23, 24, 25, 26 and 27 weeks gestational age (p < 0.001). Results did not change over the 10-year period. In multivariate analysis, neonatal complications as well as male sex were significantly associated with an increased risk of neurodevelopmental impairment. Conclusion: In this cohort study, a 22.0% rate of moderate-to-severe neurodevelopmental impairment was observed among children born extremely preterm. This national data is important for both counselling parents and guiding the allocation of health resources.
Language	English
Publishing date	2024-03-03
Publishing country	Norway
Document type	Journal Article
ZDB-ID	203487-6
ISSN	1651-2227 ; 0365-1436 ; 0803-5253
ISSN (online)	1651-2227
ISSN	0365-1436 ; 0803-5253
DOI	10.1111/apa.17187
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Article ; Conference proceedings: Psychomotorischer und kognitiver Outcome von Frühgeborenen in Vorarlberg von 2007-2019

Jenni, Fabio / Sparr, Verena / Fußenegger, Barbara / Konzett, Karin / Blassnig-Ezeh, Anya / Simma, Burkhard

Zeitschrift für Geburtshilfe und Neonatologie

2023 Volume 227, Issue 03

Event/congress	Abstracts zur 49. Jahrestagung der Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin (GNPI), Hamburg, 2023-06-15
Language	German
Publishing date	2023-06-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	1226748-x
ISSN	1439-1651 ; 0948-2393 ; 0300-967X ; 1615-5300
ISSN (online)	1439-1651
ISSN	0948-2393 ; 0300-967X ; 1615-5300
DOI	10.1055/s-0043-1769416
Database	Thieme publisher's database

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Article: Psychomotor and Cognitive Outcome in Very Preterm Infants in Vorarlberg, Austria, 2007–2019

Jenni, Fabio / Konzett, Karin / Gang, Stefanie / Sparr, Verena / Simma, Burkhard

Neuropediatrics

2023 Volume 55, Issue 02, Page(s) 90–96

Abstract	Aim: The aim of this study was to analyze neurodevelopmental outcome of very and extremely preterm infants in Vorarlberg, Austria, accessed with neurodevelopmental testing, at the corrected age of 24 months. This article also compared these results with (inter)national data and analyzed the impact of perinatal parameters. Methods: Population-based, retrospective multicenter study with data on very and extremely preterm infants born in Vorarlberg from 2007 to 2019 assessed with Bayley Scales of Infant Development (BSID-II/Bayley-III). Results: Included were 264 infants with a mean age of 29.0 (± 2.1) weeks of gestational age and a mean birth weight of 1177 (± 328.26) g; 172 infants underwent a BSID-II, 92 a Bayley-III assessment. The psychomotor developmental index (PDI) and mental developmental index (MDI) showed mean scores of 99.6 (± 14.4) and 91 (± 20.4), respectively. Adverse outcomes (scores <70) were assessed in 4.2% for PDI and 15.5% for MDI. In the extremely preterm group ( n = 79), results for mean PDI were 100.1 (± 16.8) and for mean MDI 88.4 (± 22.4). Accordingly, adverse outcomes were assessed in 5.1% for PDI and in 20.3% for MDI. In addition to bronchopulmonary dysplasia and intraventricular hemorrhage Grade 3-4, head circumference at birth and patent ductus arteriosus were also identified as risk factors for poor outcome. Conclusion: This study showed a remarkably good neurodevelopmental outcome in preterm infants with low rates of adverse outcome, similar to (inter)national reports, especially in the group of extremely preterm infants. Research is needed to explore the role of social factors and infants' environment, especially cognitive outcome and language skills.
Keywords	very preterm infants ; neurodevelopmental outcome ; Bayley Scales of Infant Development ; perinatal risk factors
Language	English
Publishing date	2023-12-29
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	573291-8
ISSN	1439-1899 ; 0174-304X
ISSN (online)	1439-1899
ISSN	0174-304X
DOI	10.1055/a-2236-4003
Database	Thieme publisher's database

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Article ; Conference proceedings: Mortality and neonatal morbidity in very preterm infants in Vorarlberg, Austria – Does center case- load matter?

Konzett, Karin / Riedl, David / Blassnig-Ezeh, Anya / Gang, Stefanie / Simma, Burkhard

Zeitschrift für Geburtshilfe und Neonatologie

2023 Volume 227, Issue 03

Event/congress	Abstracts zur 49. Jahrestagung der Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin (GNPI), Hamburg, 2023-06-15
Language	English
Publishing date	2023-06-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	1226748-x
ISSN	1439-1651 ; 0948-2393 ; 0300-967X ; 1615-5300
ISSN (online)	1439-1651
ISSN	0948-2393 ; 0300-967X ; 1615-5300
DOI	10.1055/s-0043-1769412
Database	Thieme publisher's database

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Article ; Online: Chorioamnionitis and neurodevelopmental outcome in very preterm infants from 2007 to 2017-a population-based study.

Konzett, Karin / Riedl, David / Stark, Carmen / Simma, Burkhard

Acta paediatrica (Oslo, Norway : 1992)

2020 Volume 110, Issue 4, Page(s) 1201–1208

Abstract: Aim: The study compares neurodevelopmental outcome at 24 months corrected age of very preterm infants exposed to chorioamnionitis and controls. Peripartal parameters which may influence outcome are also investigated.: Methods: In this observational ... ...

Abstract	Aim: The study compares neurodevelopmental outcome at 24 months corrected age of very preterm infants exposed to chorioamnionitis and controls. Peripartal parameters which may influence outcome are also investigated. Methods: In this observational population-based study, very preterm infants born between 2007 and 2017 were eligible (n = 466) and included if a histological placental examination and a complete neurodevelopmental assessment (Bayley Scale of Infant Development II or III) (n = 168) were performed. Secondary analyses were calculated to identify peripartal factors that significantly influence mental and psychomotor outcome. Results: Included infants showed a mean MDI of 91.2 (SD = 20.7) and a mean PDI of 99.4 (SD = 14.8). Infants with (n = 71) and without (n = 97) chorioamnionitis did not statistically differ either with mean MDI (91.8 vs. 90.3 points; p = 0.29) or mean PDI (98.3 vs. 100.9 points; p = 0.81), even after controlling for gestational age, mean APGAR scores and administration of antenatal steroids. Bronchopulmonary dysplasia was identified as the most influential factor for both MDI (p = .024) and PDI (p = .004). Conclusion: We could not find an effect of chorioamnionitis on neurodevelopmental outcome of very preterm infants over an eleven-year period. Analysis shows that postnatal factors have higher impacts than does chorioamnionitis.
MeSH term(s)	Child ; Child Development ; Chorioamnionitis/epidemiology ; Female ; Gestational Age ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases/epidemiology ; Infant, Premature, Diseases/etiology ; Infant, Very Low Birth Weight ; Pregnancy
Language	English
Publishing date	2020-12-20
Publishing country	Norway
Document type	Journal Article
ZDB-ID	203487-6
ISSN	1651-2227 ; 0365-1436 ; 0803-5253
ISSN (online)	1651-2227
ISSN	0365-1436 ; 0803-5253
DOI	10.1111/apa.15715
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