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Article ; Online: Protein Biomarkers in Asthma.

Karaulov, Alexander V / Garib, Victoria / Garib, Firuz / Valenta, Rudolf

International archives of allergy and immunology

2018 Volume 175, Issue 4, Page(s) 189–208

Abstract: Asthma is a chronic disabling respiratory disease that can be triggered by a variety of factors, including allergens, respiratory infections, psychological factors, occupational agents, exercise, atmospheric pollutants, and drugs. The asthma syndrome has ...

Abstract	Asthma is a chronic disabling respiratory disease that can be triggered by a variety of factors, including allergens, respiratory infections, psychological factors, occupational agents, exercise, atmospheric pollutants, and drugs. The asthma syndrome has been treated for decades according to a "one-fits-all" treatment strategy based on bronchodilators and steroids. With the availability of new forms of treatment targeting the different pathomechanisms of the asthma syndrome, such as anti-immunoglobulin E and cytokine-targeting therapies, the interest in biomarkers that can dis criminate different forms of asthma according to their pathomechanisms has increased. This review attempts to provide an overview of protein biomarkers in asthma and how they might be used to discriminate different forms of asthma that may respond positively to sophisticated new targeted therapies.
MeSH term(s)	Asthma/diagnosis ; Biomarkers/analysis ; Biomarkers/metabolism ; Humans ; Proteins/analysis ; Proteins/metabolism
Chemical Substances	Biomarkers ; Proteins
Language	English
Publishing date	2018-03-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1108932-5
ISSN	1423-0097 ; 1018-2438
ISSN (online)	1423-0097
ISSN	1018-2438
DOI	10.1159/000486856
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Article: Milk of Cow and Goat, Immunized by Recombinant Protein Vaccine ZF-UZ-VAC2001(Zifivax), Contains Neutralizing Antibodies Against SARS-CoV-2 and Remains Active After Standard Milk Pasteurization.

Garib, Victoria / Katsamaki, Stefani / Turdikulova, Shahlo / Levitskaya, Yuliya / Zahidova, Nodira / Bus, Galina / Karamova, Kristina / Rakhmedova, Manona / Magbulova, Nigora / Bruhov, Alexander / Garib, Firuz Y / Abdurakhmonov, Ibrokhim Y

Frontiers in nutrition

2022 Volume 9, Page(s) 901871

Abstract: Here, we present the first experimental validation of the possibility for obtaining immune milk with neutralizing antibodies against SARS-CoV-2 from vaccinated cows and goat using approved recombinant protein human coronavirus vaccine, ZF-UZ-VAC2001, in ... ...

Abstract	Here, we present the first experimental validation of the possibility for obtaining immune milk with neutralizing antibodies against SARS-CoV-2 from vaccinated cows and goat using approved recombinant protein human coronavirus vaccine, ZF-UZ-VAC2001, in the Republic of Uzbekistan. In the period of 2 weeks after first vaccination, we detected the neutralizing antibodies against coronavirus in the blood serum of vaccinated animals. The neutralizing activity, in its peak on the 21st day after receiving the third dose (77th day from first dose), was effective in neutralization test using a live SARS-CoV-2 in Vero E6 cells, even after 120-fold serum titration. In cows receiving three dose of human vaccine, the MAGLUMI
Language	English
Publishing date	2022-06-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2022.901871
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Article: Protein Biomarkers in Asthma

Karaulov, Alexander V. / Garib, Victoria / Garib, Firuz / Valenta, Rudolf

International Archives of Allergy and Immunology

2018 Volume 175, Issue 4, Page(s) 189–208

Institution	Department of Clinical Immunology and Allergy, Sechenov First Moscow State Medical University, Moscow, Russian Federation International Network of Universities for Molecular Allergololgy and Immunology, Vienna, Austria Division of Immunopathology, Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria Department of Immunology, Russian Medical Academy of Postgraduate Continuing Education, Moscow, Russian Federation Department of Immunology, Lomonosov Moscow State University, Moscow, Russian Federation NRC Institute of Immunology FMBA of Russia, Moscow, Russian Federation
Abstract	Asthma is a chronic disabling respiratory disease that can be triggered by a variety of factors, including allergens, respiratory infections, psychological factors, occupational agents, exercise, atmospheric pollutants, and drugs. The asthma syndrome has been treated for decades according to a “one-fits-all” treatment strategy based on bronchodilators and steroids. With the availability of new forms of treatment targeting the different pathomechanisms of the asthma syndrome, such as anti-immunoglobulin E and cytokine-targeting therapies, the interest in biomarkers that can dis criminate different forms of asthma according to their pathomechanisms has increased. This review attempts to provide an overview of protein biomarkers in asthma and how they might be used to discriminate different forms of asthma that may respond positively to sophisticated new targeted therapies.
Keywords	Allergy ; Biomarkers ; Asthma ; Molecular allergology
Language	English
Publishing date	2018-03-26
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Review
ZDB-ID	1108932-5
ISSN	1423-0097 ; 1018-2438
ISSN (online)	1423-0097
ISSN	1018-2438
DOI	10.1159/000486856
Database	Karger publisher's database

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Article ; Online: Milk Allergen Micro-Array (MAMA) for Refined Detection of Cow's-Milk-Specific IgE Sensitization.

Garib, Victoria / Trifonova, Daria / Freidl, Raphaela / Linhart, Birgit / Schlederer, Thomas / Douladiris, Nikolaos / Pampura, Alexander / Dolotova, Daria / Lepeshkova, Tatiana / Gotua, Maia / Varlamov, Evgeniy / Beltyukov, Evgeny / Naumova, Veronika / Taka, Styliani / Kiyamova, Alina / Katsamaki, Stefani / Karaulov, Alexander / Valenta, Rudolf

Nutrients

2023 Volume 15, Issue 10

Abstract: Background: Immunoglobulin-E(IgE)-mediated hypersensitivity to cow's milk allergens is a frequent cause of severe and life-threatening anaphylactic reactions. Besides case histories and controlled food challenges, the detection of the IgE antibodies ... ...

Abstract	Background: Immunoglobulin-E(IgE)-mediated hypersensitivity to cow's milk allergens is a frequent cause of severe and life-threatening anaphylactic reactions. Besides case histories and controlled food challenges, the detection of the IgE antibodies specific to cow's milk allergens is important for the diagnosis of cow-milk-specific IgE sensitization. Cow´s milk allergen molecules provide useful information for the refined detection of cow-milk-specific IgE sensitization. Methods: A micro-array based on ImmunoCAP ISAC technology was developed and designated milk allergen micro-array (MAMA), containing a complete panel of purified natural and recombinant cow's milk allergens (caseins, α-lactalbumin, β-lactoglobulin, bovine serum albumin-BSA and lactoferrin), recombinant BSA fragments, and α-casein-, α-lactalbumin- and β-lactoglobulin-derived synthetic peptides. Sera from 80 children with confirmed symptoms related to cow's milk intake (without anaphylaxis: Results: The use of MAMA allowed a component-resolved diagnosis of IgE sensitization in each of the children suffering from cow's-milk-related anaphylaxis according to Sampson grades 1-5 requiring only 20-30 microliters of serum. IgE sensitization to caseins and casein-derived peptides was found in each of the children with Sampson grades of 4-5. Among the grade 1-3 patients, nine patients showed negative reactivity to caseins but showed IgE reactivity to alpha-lactalbumin ( Conclusions: The use of MAMA allows for the detection, using only a few microliters of serum, of IgE sensitization to multiple cow's milk allergens and allergen-derived peptides in cow-milk-allergic children with cow-milk-related anaphylaxis.
MeSH term(s)	Animals ; Female ; Cattle ; Milk ; Allergens ; Caseins ; Lactalbumin ; Anaphylaxis/diagnosis ; Milk Hypersensitivity ; Immunoglobulin E ; Peptides ; Lactoglobulins ; Milk Proteins
Chemical Substances	Allergens ; Caseins ; Lactalbumin (9013-90-5) ; Immunoglobulin E (37341-29-0) ; Peptides ; Lactoglobulins ; Milk Proteins
Language	English
Publishing date	2023-05-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15102401
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Article ; Online: Milk of cow and goat, immunized by recombinant protein vaccine ZF-UZ-VAC2001(Zifivax), contains neutralizing antibodies against SARS-CoV-2 and remains active after standard milk pasteurization

Garib, Victoria / Katsamaki, Stefani / Turdikulova, Shahlo U. / Levitskaya, Yuliya / Zakhidova, Nodira / Bus, Galina / Karamova, Kristina / Rakhmedova, Manona / Magbulova, Nigora / Bruhov, Alexsander / Garib, Firuz Y. / Abdurakhmonov, Ibrokhim Y.

bioRxiv

Abstract: Here we report the first experimental validation of the possibility for obtaining immune milk with neutralizing antibodies against SARS-CoV-2 from vaccinated cow and goat using recombinant protein human vaccine, ZF-UZ-VAC2001. In the period of two weeks ... ...

Abstract	Here we report the first experimental validation of the possibility for obtaining immune milk with neutralizing antibodies against SARS-CoV-2 from vaccinated cow and goat using recombinant protein human vaccine, ZF-UZ-VAC2001. In the period of two weeks after first vaccination, we detected the neutralizing antibodies against coronavirus in the blood serum of vaccinated animals. The neutralizing activity, in its peak on the 21st days after receiving the third dose (77th day from first dose), was effective in Neutralization Test using a live SARS-CoV-2 in Vero E6 cells, even after 120-fold serum titration. Colostrum of the first day after 3rd dose vaccinated cow after calving had a greater activity to neutralize the SARS-CoV-2 compared to colostrum of subsequent three days (4.080 μ/ml vs 2.106, 1.960 and 1.126 μ/ml), goat milk (1,486 μ/ml), and cow milk (0.222 μ/ml) in MAGLUMI® SARS-CoV-2 neutralizing antibody competitive chemiluminescence immunoassay. We observed a positive correlation of receptor-binding domain (RBD)-specific IgG antibodies between the serum of actively immunized cow and milk-feeding calf during the entire course of vaccination (r = 0.95, p = 0.027). We showed an optimal regime for immune milk pasteurization at 62.5°C for 30 min, which retained specific neutralizing activity to SARS-CoV-2, potentially useful for passive immunization against coronavirus infection threats.
Keywords	covid19
Language	English
Publishing date	2022-02-15
Publisher	Cold Spring Harbor Laboratory
Document type	Article ; Online
DOI	10.1101/2022.02.14.480298
Database	COVID19

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Article ; Online: Detection of genuine grass pollen sensitization in children by skin testing with a recombinant grass pollen hybrid.

Douladiris, Nikolaos / Garib, Victoria / Focke-Tejkl, Margit / Valenta, Rudolf / Papadopoulos, Nikolaos G / Linhart, Birgit

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

2018 Volume 30, Issue 1, Page(s) 59–65

Abstract: Background: Skin testing represents a commonly used first diagnostic method in clinical practice, but allergen extracts may vary in composition and often contain cross-reactive allergens and therefore do not always allow the precise identification of ... ...

Abstract	Background: Skin testing represents a commonly used first diagnostic method in clinical practice, but allergen extracts may vary in composition and often contain cross-reactive allergens and therefore do not always allow the precise identification of the sensitizing allergen source. Our aim was to investigate the suitability of a single recombinant hybrid molecule, consisting of the four major timothy grass pollen allergens (Phl p 1, Phl p 2, Phl p 5, and Phl p 6) for in vivo diagnosis of genuine grass pollen allergy in children suffering from pollinosis. Methods: Sixty-four children aged from 6 to 17 years with a positive skin reaction and/or specific IgE to grass pollen extract and respiratory symptoms of pollinosis as well as 9 control children with allergy to other allergen sources were studied. SPT was performed with the recombinant hybrid, the four recombinant timothy grass pollen allergens, and grass pollen extract. Specific IgE reactivity to 176 micro-arrayed allergen molecules was determined using ImmunoCAP ISAC technology. IgE reactivity to the hybrid was detected by non-denaturing RAST-based dot blot assay. Results: Genuine grass pollen sensitization was confirmed in 94% of the children with positive SPT to grass pollen extract by SPT and IgE reactivity to the hybrid. The four hybrid-negative children showed IgE reactivity to cross-reactive allergens such as Phl p 4, Phl p 11, and Phl p 12 and had also sensitizations to pollen allergens from unrelated plants. Conclusions: The recombinant hybrid molecule represents a useful tool for in vivo diagnosis of genuine grass pollen sensitization.
MeSH term(s)	Adolescent ; Allergens/immunology ; Child ; Humans ; Immunoblotting ; Immunoglobulin E/immunology ; Plant Proteins/immunology ; Pollen/immunology ; Recombinant Fusion Proteins/immunology ; Rhinitis, Allergic, Seasonal/diagnosis ; Rhinitis, Allergic, Seasonal/immunology ; Skin Tests/methods
Chemical Substances	Allergens ; Plant Proteins ; Recombinant Fusion Proteins ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2018-11-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1057059-7
ISSN	1399-3038 ; 0905-6157 ; 0906-5784
ISSN (online)	1399-3038
ISSN	0905-6157 ; 0906-5784
DOI	10.1111/pai.12991
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Article ; Online: The Molecular Allergen Recognition Profile in China as Basis for Allergen-Specific Immunotherapy.

D'souza, Nishelle / Weber, Milena / Sarzsinszky, Eszter / Vrtala, Susanne / Curin, Mirela / Schaar, Mirjam / Garib, Victoria / Focke-Tejkl, Margarete / Li, Yanqiu / Jones, Richard / Chen, Hao / Valenta, Rudolf / Sun, Baoqing

Frontiers in immunology

2021 Volume 12, Page(s) 719573

Abstract: Approximately 30% of the world population suffers from immunoglobulin-E (IgE)-mediated allergy. IgE-mediated allergy affects the respiratory tract, the skin and the gastrointestinal tract and may lead to life-threatening acute systemic manifestations ... ...

Abstract	Approximately 30% of the world population suffers from immunoglobulin-E (IgE)-mediated allergy. IgE-mediated allergy affects the respiratory tract, the skin and the gastrointestinal tract and may lead to life-threatening acute systemic manifestations such as anaphylactic shock. The symptoms of allergy are mediated by IgE-recognition of causative allergen molecules from different allergen sources. Today, molecular allergy diagnosis allows determining the disease-causing allergens to develop allergen-specific concepts for prevention and treatment of allergy. Allergen-specific preventive and therapeutic strategies include allergen avoidance, vaccination, and tolerance induction. The implementation of these preventive and therapeutic strategies requires a detailed knowledge of the relevant allergen molecules affecting a given population. China is the world´s most populous country with around 1.4 billion inhabitants and an estimated number of more than 400 million allergic patients. Research in allergy in China has dramatically increased in the last decade. We summarize in this review article what is known about the dominating allergen sources and allergen molecules in China and what further investigations could be performed to draw a molecular map of IgE sensitization for China as a basis for the implementation of systematic and rational allergen-specific preventive and therapeutic strategies to combat allergic diseases in this country.
MeSH term(s)	Allergens/immunology ; Biomarkers ; China ; Desensitization, Immunologic ; Disease Susceptibility ; Epitopes/immunology ; Humans ; Hypersensitivity/diagnosis ; Hypersensitivity/immunology ; Hypersensitivity/prevention & control ; Hypersensitivity/therapy ; Immunity ; Immunoglobulin E/immunology ; Molecular Diagnostic Techniques ; Vaccination ; Vaccines/immunology
Chemical Substances	Allergens ; Biomarkers ; Epitopes ; Vaccines ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2021-08-27
Publishing country	Switzerland
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.719573
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Article ; Online: Profound differences in IgE and IgG recognition of micro-arrayed allergens in hyper-IgE syndromes.

Garib, Victoria / Ben-Ali, Meriem / Kundi, Michael / Curin, Mirela / Yaakoubi, Roukaya / Ben-Mustapha, Imen / Mekki, Najla / Froeschl, Renate / Perkmann, Thomas / Valenta, Rudolf / Barbouche, Mohamed-Ridha

Allergy

2021 Volume 77, Issue 6, Page(s) 1761–1771

Abstract: Background: The specificities of IgE and IgG for allergen molecules in patients with inborn errors of immunity (IEI) have not been investigated in detail.: Objective: To study IgE and IgG antibody specificities in patients with defined hyper-IgE ... ...

Abstract	Background: The specificities of IgE and IgG for allergen molecules in patients with inborn errors of immunity (IEI) have not been investigated in detail. Objective: To study IgE and IgG antibody specificities in patients with defined hyper-IgE syndromes (HIES) using a comprehensive panel of allergen molecules. Methods: We used chips containing micro-arrayed allergen molecules to analyze allergen-specific IgE and IgG levels in sera from two groups of HIES patients: Autosomal recessive mutations in phosphoglucomutase-3 (PGM3); Autosomal dominant negative mutations of STAT3 (STAT3); and age-matched subjects with allergic sensitizations. Assays with rat basophil leukemia cells transfected with human FcεRI were performed to study the biological relevance of IgE sensitizations. Results: Median total IgE levels were significantly lower in the sensitized control group (212.9 kU/L) as compared to PGM3 (5042 kU/L) and STAT3 patients (2561 kU/L). However, PGM3 patients had significantly higher allergen-specific IgE levels and were sensitized to a larger number of allergen molecules as compared to STAT3 patients. Biological relevance of IgE sensitization was confirmed for PGM3 patients by basophil activation testing. PGM3 patients showed significantly lower cumulative allergen-specific IgG responses in particular to milk and egg allergens as compared to STAT3 patients and sensitized controls whereas total IgG levels were comparable to STAT3 patients and significantly higher than in controls. Conclusion: The analysis with multiple micro-arrayed allergen molecules reveals profound differences of allergen-specific IgE and IgG recognition in PGM3 and STAT3 patients which may be useful for classification of IEI and clinical characterization of patients.
MeSH term(s)	Allergens ; Humans ; Immunoglobulin E ; Immunoglobulin G/genetics ; Job Syndrome/diagnosis ; Job Syndrome/genetics ; Mutation
Chemical Substances	Allergens ; Immunoglobulin G ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2021-11-02
Publishing country	Denmark
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.15143
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Article ; Online: Determination of IgE and IgG reactivity to more than 170 allergen molecules in paper-dried blood spots.

Garib, Victoria / Rigler, Eva / Gastager, Felix / Campana, Raffaela / Dorofeeva, Yulia / Gattinger, Pia / Zhernov, Yury / Khaitov, Musa / Valenta, Rudolf

The Journal of allergy and clinical immunology

2018 Volume 143, Issue 1, Page(s) 437–440

MeSH term(s)	Allergens/chemistry ; Allergens/immunology ; Dried Blood Spot Testing/methods ; Female ; Humans ; Hypersensitivity/blood ; Hypersensitivity/immunology ; Immunoglobulin E/blood ; Immunoglobulin E/immunology ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Male ; Paper
Chemical Substances	Allergens ; Immunoglobulin G ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2018-11-01
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2018.08.047
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Article ; Online: Next-Generation of Allergen-Specific Immunotherapies: Molecular Approaches.

Curin, Mirela / Khaitov, Musa / Karaulov, Alexander / Namazova-Baranova, Leyla / Campana, Raffaela / Garib, Victoria / Valenta, Rudolf

Current allergy and asthma reports

2018 Volume 18, Issue 7, Page(s) 39

Abstract: Purpose of review: The aim of this article is to discuss how allergen-specific immunotherapy (AIT) can be improved through molecular approaches. We provide a summary of next-generation molecular AIT approaches and of their clinical evaluation. ... ...

Abstract	Purpose of review: The aim of this article is to discuss how allergen-specific immunotherapy (AIT) can be improved through molecular approaches. We provide a summary of next-generation molecular AIT approaches and of their clinical evaluation. Furthermore, we discuss the potential of next generation molecular AIT forms for the treatment of severe manifestations of allergy and mention possible future molecular strategies for the secondary and primary prevention of allergy. Recent findings: AIT has important advantages over symptomatic forms of allergy treatment but its further development is limited by the quality of the therapeutic antigen preparations which are derived from natural allergen sources. The field of allergy diagnosis is currently undergoing a dramatic improvement through the use of molecular testing with defined, mainly recombinant allergens which allows high-resolution diagnosis. Several studies demonstrate that molecular testing in early childhood can predict the development of symptomatic allergy later on in life. Clinical studies indicate that molecular AIT approaches have the potential to improve therapy of allergic diseases and may be used as allergen-specific forms of secondary and eventually primary prevention for allergy.
MeSH term(s)	Allergens/immunology ; Child ; Desensitization, Immunologic/methods ; Humans ; Hypersensitivity/immunology ; Hypersensitivity/prevention & control ; Molecular Medicine ; Primary Prevention
Chemical Substances	Allergens
Language	English
Publishing date	2018-06-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2057370-4
ISSN	1534-6315 ; 1529-7322
ISSN (online)	1534-6315
ISSN	1529-7322
DOI	10.1007/s11882-018-0790-x
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