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Book ; Thesis: Cytotoxizität gadoliniumhaltiger Kontrastmittel auf renale Tubuluszellen in vitro

Reichert, Sonja

Vergleich eines nichtionischen iodhaltigen Röntgenkontrastmittels mit gadoliniumhaltigen Kontrastmitteln bei gleichen molaren Konzentrationen und Konzentrationen gleicher Röntgendichte

2011

Author's details	vorgelegt von Sonja Reichert geb. Kohlbacher
Language	German
Size	108 S. : Ill., graph. Darst., 30 cm
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Erlangen, Nürnberg, Univ., Diss., 2011
HBZ-ID	HT016912659
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

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Article ; Online: Examining a Remote Group-Based Type 2 Diabetes Self-Management Education Program in the COVID-19 Era Using the ORBIT Model: Small 6-Week Feasibility Study.

Hiemstra, Madison S / Reichert, Sonja M / Mitchell, Marc S

JMIR formative research

2024 Volume 8, Page(s) e46418

Abstract: Background: To date, most group-based diabetes self-management education (DSME) programs for type 2 diabetes (T2D) have been delivered in person. The rapid transition to remote care at the outset of the COVID-19 pandemic presented opportunities to test, ...

Abstract	Background: To date, most group-based diabetes self-management education (DSME) programs for type 2 diabetes (T2D) have been delivered in person. The rapid transition to remote care at the outset of the COVID-19 pandemic presented opportunities to test, evaluate, and iterate a new remote DSME program. Objective: We aim to refine the delivery and evaluation of a multicomponent remote DSME program for adults living with T2D by examining several feasibility outcomes. Methods: We recruited a convenience sample of patients from a London, Canada, outpatient diabetes clinic (serving high-risk, low-income adults) to participate in a 6-week, single cohort feasibility study from November 2020 to March 2021. This small ORBIT phase 1b feasibility study represents the first in a planned series guided by the ORBIT model for developing behavioral interventions for chronic diseases (phase 1: design; phase 2: preliminary testing; phase 3: efficacy; and phase 4: effectiveness). The feasibility of delivering and evaluating a remote DSME program, including (1) live video education classes, (2) individualized physical activity (PA) prescription and counseling, and (3) intermittently scanned continuous glucose and wearable PA monitoring, was assessed. Feasibility outcomes included recruitment and retention rates, program adherence, and acceptability (ie, technology issues and exit survey feedback). PA was assessed with Fitbit Inspire 2 (Fitbit Inc) and estimated glycated hemoglobin (HbA Results: A total of 10 adults living with T2D were recruited (female 60%; age 49.9, SD 14.3 years; estimated HbA Conclusions: This ORBIT phase 1b study served to refine the delivery (eg, automatic study data upload process recommended to reduce participant burden) and evaluation (eg, purposeful sampling of participants with baseline HbA Trial registration: ClinicalTrials.gov NCT04498819; https://clinicaltrials.gov/study/NCT04498819.
Language	English
Publishing date	2024-01-29
Publishing country	Canada
Document type	Journal Article
ISSN	2561-326X
ISSN (online)	2561-326X
DOI	10.2196/46418
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Use of once-daily oral semaglutide and associated clinical outcomes among adults with type 2 diabetes in routine clinical practice in Canada: A multicentre, prospective real-world study (PIONEER REAL Canada).

Jain, Akshay B / Reichert, Sonja M / Amadid, Hanan / Braae, Uffe C / Bradley, Ryan M / Kim, James W / Soo, Victoria / Yale, Jean-François

Diabetes, obesity & metabolism

2024 Volume 26, Issue 5, Page(s) 1799–1807

Abstract: Aim: PIONEER REAL Canada examined real-world clinical outcomes associated with the use of once-daily oral semaglutide in adults with type 2 diabetes.: Materials and methods: This was a 34- to 44-week, multicentre, prospective, open-label, non- ... ...

Abstract	Aim: PIONEER REAL Canada examined real-world clinical outcomes associated with the use of once-daily oral semaglutide in adults with type 2 diabetes. Materials and methods: This was a 34- to 44-week, multicentre, prospective, open-label, non-interventional study in adults who were treatment-naive to injectable glucose-lowering medication and initiated oral semaglutide in routine clinical practice. The primary endpoint was the change in glycated haemoglobin (HbA1c) from baseline to the end of the study (EoS). Secondary endpoints assessed at EoS were change from baseline in body weight (BW); the proportion of participants reaching HbA1c levels <7% and the composite endpoints, HbA1c reduction ≥1% point with BW reduction ≥3% and ≥5%; and treatment satisfaction measured using Diabetes Treatment Satisfaction Questionnaires (DTSQ) status and change. Primary analyses were based on the in-study observation period. Results: In total, 182 participants initiated oral semaglutide (mean age, 58.6 years; HbA1c, 8.0%; BW, 93.7 kg). The estimated changes (95% confidence interval) from baseline to EoS in HbA1c and BW were -1.09% points (-1.24, -0.94; p < .0001) and -7.17% (-8.24, -6.11; p < .0001), respectively. At EoS, 53.7% of participants had HbA1c levels <7%; 39.3% and 31.6% reached HbA1c reduction ≥1% point plus BW reduction ≥3% and ≥5%, respectively. Treatment satisfaction significantly increased (DTSQ status, +4.47 points; DTSQ change, 11.83 points; both p < .0001). At EoS, 75.3% of participants remained on oral semaglutide (55.5% received oral semaglutide 14 mg). No new safety signals were identified for oral semaglutide. Conclusions: In PIONEER REAL Canada, participants treated with oral semaglutide in routine clinical practice experienced clinically relevant reductions in HbA1c and BW and increased treatment satisfaction.
MeSH term(s)	Adult ; Humans ; Middle Aged ; Diabetes Mellitus, Type 2/drug therapy ; Hypoglycemic Agents/adverse effects ; Glycated Hemoglobin ; Prospective Studies ; Glucagon-Like Peptides/adverse effects ; Body Weight ; Canada/epidemiology
Chemical Substances	Hypoglycemic Agents ; semaglutide (53AXN4NNHX) ; Glycated Hemoglobin ; Glucagon-Like Peptides (62340-29-8)
Language	English
Publishing date	2024-03-11
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	1454944-x
ISSN	1463-1326 ; 1462-8902
ISSN (online)	1463-1326
ISSN	1462-8902
DOI	10.1111/dom.15493
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5442: Show issues

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Article ; Online: Limitations of hemoglobin A

Zhu, Nemin Adam / Reichert, Sonja / Harris, Stewart B

Canadian family physician Medecin de famille canadien

2020 Volume 66, Issue 2, Page(s) 112–114

MeSH term(s)	Aged ; Blood Glucose Self-Monitoring/standards ; Diabetes Mellitus, Type 2/blood ; Female ; Glycated Hemoglobin A/analysis ; Glycemic Control/methods ; Humans ; Male ; Middle Aged
Chemical Substances	Glycated Hemoglobin A
Language	English
Publishing date	2020-02-14
Publishing country	Canada
Document type	Case Reports ; Journal Article
ZDB-ID	603565-6
ISSN	1715-5258 ; 0008-350X
ISSN (online)	1715-5258
ISSN	0008-350X
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Zs.B 2236: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Responding to vulnerable patients with multimorbidity: an interprofessional team approach.

Brown, Judith B / Reichert, Sonja M / Boeckxstaens, Pauline / Stewart, Moira / Fortin, Martin

BMC primary care

2022 Volume 23, Issue 1, Page(s) 62

Abstract: Background: People with multimorbidity, who may be more vulnerable to certain social determinants of health, often require care by an interprofessional primary healthcare (PHC) team that can tailor their approach to address the multiple and complex ... ...

Abstract	Background: People with multimorbidity, who may be more vulnerable to certain social determinants of health, often require care by an interprofessional primary healthcare (PHC) team that can tailor their approach to address the multiple and complex needs of this population. This paper describes how the needs of vulnerable patients experiencing multimorbidity are identified and provided care by innovative interprofessional PHC teams during an innovative one-hour consultation, outside of usual care. Methods: This was a descriptive qualitative study. Forty-eight interviews were conducted with 20 allied healthcare professionals: (e.g., social work, pharmacy); 19 physicians (e.g., psychiatry, internal medicine, family medicine); and 9 decision makers. The thematic analysis was iterative using an individual and team approach to identify the main themes and exemplar quotations for illustration. Results: Participants described patients with multimorbidity who were vulnerable as those experiencing major challenges accessing and navigating the healthcare system. Mental health issues were a major contributor to being vulnerable and often linked to common social determinants of health. Cultural factors were identified as potentially causing patients to be vulnerable. Participants articulated how the collaborative nature of the team generated new ideas and facilitated creative recommendations designed to meet the specific needs of each patient. Conclusions: This one-time consultation went beyond the assessment of a patient's multimorbidity by including a psycho-social-contextual understanding of vulnerability within the healthcare system. Findings may have important clinical and policy implications in the adoption and implementation of this approach and further assist vulnerable patients with multimorbidity in having their complex needs addressed.
MeSH term(s)	Delivery of Health Care ; Family Practice ; Humans ; Multimorbidity ; Patient Care Team ; Qualitative Research
Language	English
Publishing date	2022-03-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2731-4553
ISSN (online)	2731-4553
DOI	10.1186/s12875-022-01670-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Commentary on: "Effects of Regular Physical Activity on the Cognitive Performance of Type 2 Diabetic Patients: A Systematic Review" by Podolski et al. (Metab Syndr Relat Disord 2017;15:481-493).

Shellington, Erin M / Reichert, Sonja M / Petrella, Robert J

Metabolic syndrome and related disorders

2018 Volume 16, Issue 6, Page(s) 255–261

Abstract: Type 2 diabetes mellitus (T2DM) imparts an increased risk for cognitive decline, specifically executive function, which is important to maintain for diabetes self-management. There is evidence to suggest that exercise improves cognition in healthy older ... ...

Abstract	Type 2 diabetes mellitus (T2DM) imparts an increased risk for cognitive decline, specifically executive function, which is important to maintain for diabetes self-management. There is evidence to suggest that exercise improves cognition in healthy older adults; however, the literature in adults with T2DM is lacking. This commentary is in complement to Podolski et al.'s systematic review evaluating the effects of physical activity on cognitive function in adults with T2DM. We have included eight additional studies and further highlight their conclusions on the heterogeneity of the literature thus far. Three current issues with the literature are as follows: (1) variability in interventions (e.g., aerobic, resistance, lifestyle, and yoga), (2) variability in cognitive outcome measures, and (3) lack of detailed description of the population studied, for example, baseline glycated hemoglobin (A1C) values. Overall, making it difficult to compare these studies and draw final conclusions. Thus, the efficacy for exercise to improve cognition in adults with T2DM is not yet well understood. Potential ways to mitigate these limitations could be for future studies that (1) use robust methodology whenever possible, that is, randomized controlled trials, (2) to follow current guideline-derived exercise recommendations for adults with T2DM, and (3) utilize cognitive outcome measures that are consistent across studies. The hope is that these consistencies in turn will help to determine the efficacy of exercise on cognitive function in adults with T2DM and therefore, allow national organizations to develop recommendations and guidelines for healthcare practitioners to follow.
MeSH term(s)	Aged ; Cognition ; Cognitive Dysfunction ; Diabetes Mellitus, Type 2 ; Exercise ; Glycated Hemoglobin A ; Humans
Chemical Substances	Glycated Hemoglobin A
Language	English
Publishing date	2018-05-16
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2151220-6
ISSN	1557-8518 ; 1540-4196
ISSN (online)	1557-8518
ISSN	1540-4196
DOI	10.1089/met.2018.0021
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5950: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Determinants of sustained stabilization of beta-cell function following short-term insulin therapy in type 2 diabetes.

Retnakaran, Ravi / Pu, Jiajie / Emery, Alexandra / Harris, Stewart B / Reichert, Sonja M / Gerstein, Hertzel C / McInnes, Natalia / Kramer, Caroline K / Zinman, Bernard

Nature communications

2023 Volume 14, Issue 1, Page(s) 4514

Abstract: In early type 2 diabetes, the strategy of "induction" with short-term intensive insulin therapy followed by "maintenance" with metformin can stabilize pancreatic beta-cell function in some patients but not others. We thus sought to elucidate determinants ...

Abstract	In early type 2 diabetes, the strategy of "induction" with short-term intensive insulin therapy followed by "maintenance" with metformin can stabilize pancreatic beta-cell function in some patients but not others. We thus sought to elucidate determinants of sustained stabilization of beta-cell function. In this secondary analysis of ClinicalTrials.Gov NCT02192424, adults with ≤5-years diabetes duration were randomized to 3-weeks induction insulin therapy (glargine/lispro) followed by metformin maintenance either with or without intermittent 2-week courses of insulin every 3-months for 2-years. Sustained stabilization (higher beta-cell function at 2-years than at baseline) was achieved in 55 of 99 participants. Independent predictors of sustained stabilization were the change in beta-cell function during induction and changes in hepatic insulin resistance and alanine aminotransferase during maintenance. Thus, initial reversibility of beta-cell dysfunction during induction and subsequent preservation of hepatic insulin sensitivity during maintenance are associated with sustained stabilization of beta-cell function following short-term insulin and metformin.ClinicalTrials.Gov NCT02192424.
MeSH term(s)	Adult ; Humans ; Insulin ; Diabetes Mellitus, Type 2/drug therapy ; Hypoglycemic Agents/therapeutic use ; Glycated Hemoglobin ; Metformin/therapeutic use ; Insulin Resistance ; Blood Glucose
Chemical Substances	Insulin ; Hypoglycemic Agents ; Glycated Hemoglobin ; Metformin (9100L32L2N) ; Blood Glucose
Language	English
Publishing date	2023-07-27
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-40287-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Glucagon-like peptide 1 receptor agonists in end-staged kidney disease and kidney transplantation: A narrative review.

Clemens, Kristin K / Ernst, Jaclyn / Khan, Tayyab / Reichert, Sonja / Khan, Qasim / LaPier, Heather / Chiu, Michael / Stranges, Saverio / Sahi, Gurleen / Castrillon-Ramirez, Fabio / Moist, Louise

Nutrition, metabolism, and cardiovascular diseases : NMCD

2023 Volume 33, Issue 6, Page(s) 1111–1120

Abstract: Aims: Glucagon-like peptide 1 receptor agonists (GLP-1RA) improve glycemic control and promote weight loss in type 2 diabetes (DM2) and obesity. We identified studies describing the metabolic benefits of GLP-1RA in end-staged kidney disease (ESKD) and ... ...

Abstract	Aims: Glucagon-like peptide 1 receptor agonists (GLP-1RA) improve glycemic control and promote weight loss in type 2 diabetes (DM2) and obesity. We identified studies describing the metabolic benefits of GLP-1RA in end-staged kidney disease (ESKD) and kidney transplantation. Data synthesis: We searched for randomized controlled trials (RCTs) and observational studies that investigated the metabolic benefits of GLP-1RA in ESKD and kidney transplantation. We summarized the effect of GLP-1RA on measures of obesity and glycemic control, examined adverse events, and explored adherence with therapy. In small RCTs of patients with DM2 on dialysis, liraglutide for up to 12 weeks lowered HbA1c by 0.8%, reduced time in hyperglycemia by ∼2%, lowered blood glucose by 2 mmol/L and reduced weight by 1-2 kg, compared with placebo. In prospective studies inclusive of ESKD, 12 months of semaglutide reduced HbA1c by 0.8%, and contributed to weight losses of 8 kg. In retrospective cohort studies in DM2 and kidney transplantation, 12 months of GLP-1RA lowered HbA1c by 2%, and fasting glucose by ∼3 mmol/L compared with non-use, and in some reports, weight losses of up to 4 kg were described. Gastrointestinal (GI) side effects were most commonly reported, with hypoglycemia described with GLP-1RA in hemodialysis, particularly in those using insulin. Conclusions: GLP-1RA are growing in popularity in those with DM2 and obesity. In small RCTs and observational cohort studies modest glycemic and weight benefits have been described in ESKD and transplantation, but GI side effects may limit adherence. Larger and longer term studies of GLP-1RA remain important.
MeSH term(s)	Humans ; Hypoglycemic Agents/adverse effects ; Glycated Hemoglobin ; Kidney Transplantation/adverse effects ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/drug therapy ; Liraglutide/adverse effects ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/surgery ; Weight Loss ; Obesity/drug therapy ; Glucagon-Like Peptide-1 Receptor/agonists
Chemical Substances	Hypoglycemic Agents ; Glycated Hemoglobin ; Liraglutide (839I73S42A) ; Glucagon-Like Peptide-1 Receptor
Language	English
Publishing date	2023-04-05
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1067704-5
ISSN	1590-3729 ; 0939-4753
ISSN (online)	1590-3729
ISSN	0939-4753
DOI	10.1016/j.numecd.2023.03.023
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Zs.A 3149: Show issues

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Article ; Online: Nonconventional diabetes-related care strategies for patients with chronic kidney disease: A scoping review of the literature.

Clemens, Kristin K / Kalatharan, Vinusha / Ryan, Bridget L / Reichert, Sonja

Journal of comorbidity

2019 Volume 9, Page(s) 2235042X19831918

Abstract: Background: Patients with diabetes and chronic kidney disease (CKD) are at high risk of diabetes-related complications. Diabetes care can support these individuals, but outpatient clinic appointments can be difficult to attend, given their already high ... ...

Abstract	Background: Patients with diabetes and chronic kidney disease (CKD) are at high risk of diabetes-related complications. Diabetes care can support these individuals, but outpatient clinic appointments can be difficult to attend, given their already high burden of multimorbidity. Methods: We systematically searched the medical and grey literature for studies that evaluated the effect of nonconventional diabetes care strategies on diabetes-related outcomes in adults with stages 2-5 CKD or using dialysis (end of search December 30, 2017). We included both randomized-controlled trials and observational studies. Study selection and data extraction were completed by two independent reviewers. Diabetes-related outcomes included glycemic, blood pressure, and lipid control, along with microvascular complications, macrovascular complications, and death. Results: After screening 2177 relevant citations, we identified 34 studies which met inclusion. The majority were observational studies. Studies were frequently small, single-centered, and excluded patients with more advanced CKD. Nonconventional diabetes care strategies included community-based care, unique self-management and education programs, nurse-led care clinics, dialysis-based diabetes programs, telemedicine, and interdisciplinary care clinics. Programs were most often developed by study investigators. Although there were limitations to several of the included studies, programs were described to have modest effects on physiologic outcomes, and in some cases, diabetes-related complications and death. Conclusions: Nonconventional diabetes-related care might be helpful to patients with CKD. Prior to developing and implementing programs, however, it will be important to study them more rigorously, understand their acceptability to patients, and evaluate their costs and feasibility in a real-world setting.
Language	English
Publishing date	2019-03-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2831678-2
ISSN	2235-042X ; 2235-042X
ISSN (online)	2235-042X
ISSN	2235-042X
DOI	10.1177/2235042X19831918
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Article ; Online: Combining dynamic material flow analysis and life cycle assessment to evaluate environmental benefits of recycling – A case study for direct and hydrometallurgical closed-loop recycling of electric vehicle battery systems

Rosenberg, Sonja / Kurz, Leonard / Huster, Sandra / Wehrstein, Steven / Kiemel, Steffen / Schultmann, Frank / Reichert, Frederik / Wörner, Ralf / Glöser-Chahoud, Simon

Resources, Conservation & Recycling. 2023 Nov., v. 198 p.107145-

2023

Abstract: We conduct a life cycle assessment (LCA) for two recycling processes, a hydrometallurgical and a direct recycling route. Both show ecological benefits compared to production with virgin material (between 2.76–4.55 kg CO2e/ kg battery for NMC111 and ... ...

Abstract	We conduct a life cycle assessment (LCA) for two recycling processes, a hydrometallurgical and a direct recycling route. Both show ecological benefits compared to production with virgin material (between 2.76–4.55 kg CO2e/ kg battery for NMC111 and NMC811 less greenhouse gas emissions). In contrast to previous works, we combine the LCA results with a dynamic material flow model. This allows the evaluation of the influence on ecological benefits of admixture limits for directly recycled cathode material in a closed-loop recycling system over a time in which the newly produced battery systems and the amount of end-of-life traction batteries grows. We show that for such a closed-loop recycling system, the choice of different allocation methods, namely cut-off or avoided burden approach, may lead to significantly varying results of up to 85% in ecological benefits. We further conclude that combining production with both recycling routes can achieve the lowest greenhouse gas emissions for our closed-loop scenarios.
Keywords	batteries ; case studies ; cathodes ; electric vehicles ; greenhouse gases ; life cycle assessment ; material flow analysis ; models ; Electric vehicle battery system ; Closed-loop supply chains ; Recycling ; Environmental benefits
Language	English
Dates of publication	2023-11
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	1498716-8
ISSN	0921-3449
ISSN	0921-3449
DOI	10.1016/j.resconrec.2023.107145
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