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Article: A Narrative Review on Neuro-Ophthalmological Manifestations That May Occur during Pregnancy.

Anton, Nicoleta / Bogdănici, Camelia Margareta / Branișteanu, Daniel Constantin / Armeanu, Theodora / Ilie, Ovidiu-Dumitru / Doroftei, Bogdan

Life (Basel, Switzerland)

2024 Volume 14, Issue 4

Abstract: Aim: As a medical condition, pregnancy mandates the simultaneous treatment of both the mother and the fetus, making it a distinctive aspect of clinical medicine.: Material and method: We analyze the physiological changes occurring in the eyes and ... ...

Abstract	Aim: As a medical condition, pregnancy mandates the simultaneous treatment of both the mother and the fetus, making it a distinctive aspect of clinical medicine. Material and method: We analyze the physiological changes occurring in the eyes and brain during pregnancy, as well as the neuro-ophthalmological manifestations that can occur during pregnancy. Studies published in both English and other languages, case reports, and reviews from 2011 to 2023 onwards were included. All surveys were acquired by exploring the databases. Results: We found a total of 2135 articles that showcase neuro-ophthalmic changes related to pregnancy: review and research articles (Science Direct 804, Web of Science 923, Scopus 345, and 63 Pub Med). In total, 86 studies were examined after applying the inclusion and exclusion criteria. Bilateral papilledema can be a warning sign for intracranial hypertension or cerebral venous sinus thrombosis. Additionally, when unilateral, it is important to differentially diagnose anterior ischemic optic neuropathy secondary to a hypercoagulant, compressive or inflammatory optic neuropathy, optic neuritis, or even orbital pseudotumor state. Severe eclampsia and preeclampsia can manifest as choroidal infarction, serous retinal detachment, and even cortical blindness. There can also be implications at the level of cranial nerves or transient Horner syndrome. Conclusions: Evaluating and treating a pregnant woman with neuro-ophthalmological manifestations is challenging. The obstetrician closely follows and has a medical relationship with the pregnant woman; hence he/she might be the first to be informed about the general condition of the pregnant woman or might request an ophthalmologic examination tailored to each specific case.
Language	English
Publishing date	2024-03-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life14040431
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Narrative Review Discussing the Efficiency of Personalized Dosing Algorithm of Follitropin Delta for Ovarian Stimulation and the Reproductive and Clinical Outcomes.

Doroftei, Bogdan / Ilie, Ovidiu-Dumitru / Anton, Nicoleta / Marcu, Olivia-Andreea / Scripcariu, Ioana-Sadyie / Ilea, Ciprian

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 2

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-01-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13020177
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Article: The Implications of SARS-CoV-2 Infection in a Series of Neuro-Ophthalmological Manifestations-Case Series and Literature Review.

Anton, Nicoleta / Bogdănici, Camelia Margareta / Brănișteanu, Daniel Constantin / Ilie, Ovidiu-Dumitru / Pavel, Irina Andreea / Doroftei, Bogdan

Journal of clinical medicine

2023 Volume 12, Issue 11

Abstract: The global pandemic impact of the COVID-19 infection included clinical manifestations that affected several organs and systems, with various neuro-ophthalmological manifestations associated with the infection. These are rare and occur either secondary to ...

Abstract	The global pandemic impact of the COVID-19 infection included clinical manifestations that affected several organs and systems, with various neuro-ophthalmological manifestations associated with the infection. These are rare and occur either secondary to the presence of the virus or by an autoimmune mechanism secondary to viral antigens. The manifestations are atypical, being present even in the absence of the systemic symptoms typical of a SARS-CoV-2 infection. In this article, we introduce a series of three clinical cases with neuro-ophthalmological manifestations associated with COVID infection that were shown in Ophthalmology Clinic of St. Spiridon Emergency Hospital. Case 1 is that of a 45-year-old male patient with no personal history of general pathology or ophthalmology, with binocular diplopia, painful red eyes, and lacrimal hypersecretion with a sudden onset of about 4 days. Based on the evaluations, a positive diagnosis of orbital cellulitis in both eyes is made. Case 2 is that of a 52-year-old female patient with general PPA (personal pathological antecedents) of SARS-CoV-2 infection 1 month prior to presentation with decreased visual acuity in the right eye and a positive central scotoma, preceded by photopsia and vertigo with balance disorders. The diagnosis is made at the right eye for retrobulbar optic neuritis and post-SARS-CoV-2 infection status. The last clinical case is that of a 55-year-old male patient known to have high blood pressure (HBP) with a sudden, painless decrease in VARE approximately 3 weeks post-SARS-CoV-2 immunization (Pfizer vaccine first dose). The diagnosis is made after consulting all the RE results for central retinal vein thrombosis. Conclusions: Although the cases were quickly and efficiently investigated and the treatment was administered adequately by a multidisciplinary team (cases 1 and 3), the evolution was not favorable in all three situations. Atypical neuro-ophthalmological manifestations can also be present in the absence of systemic symptoms typical of SARS-CoV-2 infection.
Language	English
Publishing date	2023-05-31
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12113795
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Retrospective Narrative Mini-Review Regarding the Seminal Microbiota in Infertile Male.

Doroftei, Bogdan / Ilie, Ovidiu-Dumitru / Dabuleanu, Ana-Maria / Hutanu, Delia / Vaduva, Constantin-Cristian

Medicina (Kaunas, Lithuania)

2022 Volume 58, Issue 8

Abstract: ... ...

Abstract	Background
MeSH term(s)	Adult ; Animals ; Female ; Humans ; Infertility, Male ; Male ; Mice ; Microbiota ; RNA, Ribosomal, 16S/genetics ; Rats ; Retrospective Studies ; Semen ; Spermatozoa ; Zebrafish
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2022-08-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina58081067
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Article ; Online: Testing the Accuracy of the ARIMA Models in Forecasting the Spreading of COVID-19 and the Associated Mortality Rate.

Ilie, Ovidiu-Dumitru / Ciobica, Alin / Doroftei, Bogdan

Medicina (Kaunas, Lithuania)

2020 Volume 56, Issue 11

Abstract: Background and objectives: ...

Abstract	Background and objectives:
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/mortality ; Forecasting ; Humans ; Incidence ; Models, Statistical ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/mortality ; Prevalence ; Reproducibility of Results ; Romania/epidemiology ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-10-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina56110566
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Article ; Online: The pregnancy rate among Romanian adolescents: an eleven years (2009--2020) observational, retrospective study from a single center.

Doroftei, Bogdan / Ilie, Ovidiu Dumitru / Maftei, Radu / Dabuleanu, Ana Maria / Scripcariu, Ioana / Anton, Emil / Puha, Bogdan

Ginekologia polska

2022

Abstract: Objectives: It has been recently documented that Romania has the highest prevalence of adolescent pregnancy in Europe.: Material and methods: Therefore, the present study aims to offer a conclusive view of the current situation by assessing a series ... ...

Abstract	Objectives: It has been recently documented that Romania has the highest prevalence of adolescent pregnancy in Europe. Material and methods: Therefore, the present study aims to offer a conclusive view of the current situation by assessing a series of parameters in the last 11 years. Results: Throughout the present manuscript, we showed that 1788 pregnancies occurred in the last 11 years in just one center from the northeastern region of Romania. The Kolmogorov-Smirnov test (p < 0.05) performed suggests that gestational age does not follow a normal distribution; an interval during which 899 (50.27%) male and 889 (49.72%) female babies were born. There were a total of 1383 (86.00%) deliveries at full-term and 225 (13.99%) were under 37 weeks. Of 1788 teenage girls, 1467 (82.04%) were from the rural area, whereas 321 (17.95%) from the urban area. Conclusions: Fortunately, one common feature that we observed was that starting from 2017 there was a significant reduction within the last 2 studied parameters, the situation being much more fluctuating until 2014.
Language	English
Publishing date	2022-01-24
Publishing country	Poland
Document type	Journal Article
ZDB-ID	130894-4
ISSN	2543-6767 ; 0017-0011
ISSN (online)	2543-6767
ISSN	0017-0011
DOI	10.5603/GP.a2021.0132
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: An Unusual Case of Urachal Cyst Misdiagnosed as a Paraovarian Cyst: Ultrasound Assessment and Differential Diagnosis.

Ilea, Ciprian / Ilie, Ovidiu-Dumitru / Stoian, Irina-Liviana / Scripcariu, Ioana-Sadyie / Doroftei, Bogdan

Diagnostics (Basel, Switzerland)

2022 Volume 12, Issue 12

Abstract: The urachus is an embryologic remnant of the cloaca that usually degenerates after birth, resulting from the obliteration of the allantois, whose role is to connect the bladder to the umbilicus. Incomplete removal of the lumen may give rise to different ... ...

Abstract	The urachus is an embryologic remnant of the cloaca that usually degenerates after birth, resulting from the obliteration of the allantois, whose role is to connect the bladder to the umbilicus. Incomplete removal of the lumen may give rise to different malformations of the median umbilical ligament after birth. Although in the pediatric population urachus are common, most cases are asymptomatic and may go unrecognized until adulthood and give rise to cysts, rarely reported in the literature. Thus, in this manuscript we present the circumstances of a 43-year-old Romanian woman showing hypogastric pain of moderate intensity for three weeks, radiation in the left lower limb, menstrual cycle abnormalities, and dysmenorrhea. Based on the initial examinations, a paraovarian cyst measuring 80 mm was noted. Through the subsequent magnetic resonance imaging (MRI) conducted, a hypoechoic mass was detected, and the patient underwent a tumorectomy and partial cystectomy. A 9.7/7.5-cm tumor was excised, and the anatomopathological result was urachal mucinous cystadenoma. It came to our attention that relatively scarce data were found in the literature, with only seven studies with the diagnosis of the urachal cyst.
Language	English
Publishing date	2022-12-14
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics12123166
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Article: A Mini-Review Regarding the Clinical Outcomes of In Vitro Fertilization (IVF) Following Pre-Implantation Genetic Testing (PGT)-Next Generation Sequencing (NGS) Approach.

Doroftei, Bogdan / Ilie, Ovidiu-Dumitru / Anton, Nicoleta / Armeanu, Theodora / Ilea, Ciprian

Diagnostics (Basel, Switzerland)

2022 Volume 12, Issue 8

Abstract: Background: PGT-based NGS revolutionized the field of reproductive medicine, becoming an integrated component within current assisted reproductive technology (ART) protocols.: Methods: We searched the literature published in the last half a decade in ...

Abstract	Background: PGT-based NGS revolutionized the field of reproductive medicine, becoming an integrated component within current assisted reproductive technology (ART) protocols. Methods: We searched the literature published in the last half a decade in four databases (PubMed/Medline, ISI Web of Knowledge, ScienceDirect, and Scopus) between 2018 and 2022. Results: A total of 1388 articles were filtered, from which 60 met, initially, the eligibility criteria, but only 42 were included (≥100 patients/couples-62,465 patients and 6628 couples in total) in the present mini-review. In total, forty-two (70.0%) reported reproductive outcomes, while eighteen (30.0%) had distinct objectives. Furthermore, Conclusions: PGT using NGS proved to be an excellent companion that folds within the current ascending tendency among couples that require specialty care. We strongly encourage future studies to provide a systematic overview expanded at a larger scale on the role of the PGT-NGS.
Language	English
Publishing date	2022-08-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics12081911
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: An Updated Narrative Mini-Review on the Microbiota Changes in Antenatal and Post-Partum Depression.

Doroftei, Bogdan / Ilie, Ovidiu-Dumitru / Diaconu, Roxana / Hutanu, Delia / Stoian, Irina / Ilea, Ciprian

Diagnostics (Basel, Switzerland)

2022 Volume 12, Issue 7

Abstract: Background: Antenatal depression (AND) and post-partum depression (PPD) are long-term debilitating psychiatric disorders that significantly influence the composition of the gut flora of mothers and infants that starts from the intrauterine life. Not ... ...

Abstract	Background: Antenatal depression (AND) and post-partum depression (PPD) are long-term debilitating psychiatric disorders that significantly influence the composition of the gut flora of mothers and infants that starts from the intrauterine life. Not only does bacterial ratio shift impact the immune system, but it also increases the risk of potentially life-threatening disorders. Material and methods: Therefore, we conducted a narrative mini-review aiming to gather all evidence published between 2018-2022 regarding microflora changes in all three stages of pregnancy. Results: We initially identified 47 potentially eligible studies, from which only 7 strictly report translocations; 3 were conducted on rodent models and 4 on human patients. The remaining studies were divided based on their topic, precisely focused on how probiotics, breastfeeding, diet, antidepressants, exogenous stressors, and plant-derived compounds modulate in a bidirectional way upon behavior and microbiota. Almost imperatively, dysbacteriosis cause cognitive impairments, reflected by abnormal temperament and personality traits that last up until 2 years old. Thankfully, a distinct technique that involves fecal matter transfer between individuals has been perfected over the years and was successfully translated into clinical practice. It proved to be a reliable approach in diminishing functional non- and gastrointestinal deficiencies, but a clear link between depressive women's gastrointestinal/vaginal microbiota and clinical outcomes following reproductive procedures is yet to be established. Another gut-dysbiosis-driving factor is antibiotics, known for their potential to trigger inflammation. Fortunately, the studies conducted on mice that lack microbiota offer, without a shadow of a doubt, insight. Conclusions: It can be concluded that the microbiota is a powerful organ, and its optimum functionality is crucial, likely being the missing puzzle piece in the etiopathogenesis of psychiatric disorders.
Language	English
Publishing date	2022-06-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics12071576
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Article ; Online: The Very First Romanian Unruptured 13-Weeks Gestation Tubal Ectopic Pregnancy.

Ilea, Ciprian / Ilie, Ovidiu-Dumitru / Marcu, Olivia-Andreea / Stoian, Irina / Doroftei, Bogdan

Medicina (Kaunas, Lithuania)

2022 Volume 58, Issue 9

Abstract: Tubal ectopic pregnancies remain a challenging and life-threatening obstetric condition in the early stages that unavoidably lead to abortion or rupture, further reflected by the associated maternal mortality. Therefore, in the present case report, we ... ...

Abstract	Tubal ectopic pregnancies remain a challenging and life-threatening obstetric condition in the early stages that unavoidably lead to abortion or rupture, further reflected by the associated maternal mortality. Therefore, in the present case report, we report the experience of a 36-year-old woman who presented to our Emergency Department with a history of moderate hypogastric pain, mild vaginal bleeding, and bilateral mastalgia, symptoms that started 20 days ago after uterine curettage for a declarative eight-week pregnancy. On admission, a physical examination showed regular standard signs. The ultrasound examination revealed in the left abdominal flank a gestational sac with a live fetus corresponding to the gestational age of 13 weeks. Given the position of the gestational sac, we suspected a possible abdominal pregnancy. Independently on her human chorionic gonadotropin (hCG) of 33.980 mIU/mL and hemoglobin (Hb) of 13.4 g/dL, the exact location of the pregnancy following ultrasound was hard to establish. Magnetic resonance imaging (MRI) examination was requested, after which we suspected the diagnosis of ovarian pregnancy. Given the paraclinical and clinical context of the worsening of painful symptoms, we decided to perform an exploratory laparoscopy in the multidisciplinary team (digestive and vascular surgeon) that showed the existence of a tubal pregnancy.
MeSH term(s)	Adult ; Chorionic Gonadotropin ; Female ; Gestational Age ; Humans ; Infant ; Pregnancy ; Pregnancy, Tubal/diagnostic imaging ; Pregnancy, Tubal/surgery ; Romania ; Uterus
Chemical Substances	Chorionic Gonadotropin
Language	English
Publishing date	2022-08-25
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina58091160
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