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Article ; Online: Roles of Histone Deacetylase 4 in the Inflammatory and Metabolic Processes.

Kang, Hyunju / Park, Young-Ki / Lee, Ji-Young / Bae, Minkyung

2024

Abstract: Histone deacetylase 4 (HDAC4), a class IIa HDAC, has gained attention as a potential therapeutic target in treating inflammatory and metabolic processes based on its essential role in various biological pathways by deacetylating non-histone proteins, ... ...

Abstract	Histone deacetylase 4 (HDAC4), a class IIa HDAC, has gained attention as a potential therapeutic target in treating inflammatory and metabolic processes based on its essential role in various biological pathways by deacetylating non-histone proteins, including transcription factors. The activity of HDAC4 is regulated at the transcriptional, post-transcriptional, and post-translational levels. The functions of HDAC4 are tissue-dependent in response to endogenous and exogenous factors and their substrates. In particular, the association of HDAC4 with non-histone targets, including transcription factors, such as myocyte enhancer factor 2, hypoxia-inducible factor, signal transducer and activator of transcription 1, and forkhead box proteins, play a crucial role in regulating inflammatory and metabolic processes. This review summarizes the regulatory modes of HDAC4 activity and its functions in inflammation, insulin signaling and glucose metabolism, and cardiac muscle development.
Language	English
Publishing date	2024-03-22
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2602402-0
ISSN	2233-6087 ; 2233-6087
ISSN (online)	2233-6087
ISSN	2233-6087
DOI	10.4093/dmj.2023.0174
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Rhizorhabdus phycosphaerae

Kim, Minkyung / Bae, Junshik / Park, Woojun

International journal of systematic and evolutionary microbiology

2022 Volume 72, Issue 4

Abstract: A novel bacterial strain, designated ... ...

Abstract	A novel bacterial strain, designated MK52
MeSH term(s)	Bacterial Typing Techniques ; Base Composition ; DNA, Bacterial/genetics ; Fatty Acids/chemistry ; Microcystis/genetics ; Phospholipids/chemistry ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA ; Sodium Chloride ; Sphingomonadaceae/genetics
Chemical Substances	DNA, Bacterial ; Fatty Acids ; Phospholipids ; RNA, Ribosomal, 16S ; Sodium Chloride (451W47IQ8X)
Language	English
Publishing date	2022-04-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2002336-4
ISSN	1466-5034 ; 1466-5026
ISSN (online)	1466-5034
ISSN	1466-5026
DOI	10.1099/ijsem.0.005324
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Article ; Online: Beneficial Effects of Taurine on Metabolic Parameters in Animals and Humans.

Bae, Minkyung / Ahmed, Kainat / Yim, Jung-Eun

Journal of obesity & metabolic syndrome

2022 Volume 31, Issue 2, Page(s) 134–146

Abstract: Taurine (2-aminoethanesulfonic acid) is a non-essential amino acid mainly obtained through diet in humans. Despite the lack of research on the health effects of taurine in animals and humans, it is widely used as a dietary supplement. Evidence from human ...

Abstract	Taurine (2-aminoethanesulfonic acid) is a non-essential amino acid mainly obtained through diet in humans. Despite the lack of research on the health effects of taurine in animals and humans, it is widely used as a dietary supplement. Evidence from human and animal studies indicates that taurine is involved in conjugation of bile acids and regulation of blood pressure and has anti-oxidative, anti-inflammatory, and anti-obesogenic properties. Taurine can benefit both human and non-human animal health in multiple ways. However, few interventional and epidemiological studies regarding the beneficial impacts of taurine in humans and other animals have been conducted. Here, we review the evidence from animal and human studies showing that taurine protects against dyslipidemia, obesity, hypertension, and diabetes mellitus.
Language	English
Publishing date	2022-06-07
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	3021984-X
ISSN	2508-7576 ; 2508-6235
ISSN (online)	2508-7576
ISSN	2508-6235
DOI	10.7570/jomes21088
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fucoxanthin Attenuates the Reprogramming of Energy Metabolism during the Activation of Hepatic Stellate Cells.

Bae, Minkyung / Kim, Mi-Bo / Lee, Ji-Young

Nutrients

2022 Volume 14, Issue 9

Abstract: Hepatic stellate cells (HSC) play a major role in developing liver fibrosis. Upon activation during liver injury, activated HSC (aHSC) increase cell proliferation, fibrogenesis, contractility, chemotaxis, and cytokine release. We previously showed that ... ...

Abstract	Hepatic stellate cells (HSC) play a major role in developing liver fibrosis. Upon activation during liver injury, activated HSC (aHSC) increase cell proliferation, fibrogenesis, contractility, chemotaxis, and cytokine release. We previously showed that aHSC have increased mitochondrial respiration but decreased glycolysis compared to quiescent HSC (qHSC). We also demonstrated that fucoxanthin (FCX), a xanthophyll carotenoid, has an anti-fibrogenic effect in HSC. The objective of this study was to investigate whether FCX attenuates metabolic reprogramming occurring during HSC activation. Mouse primary HSC were activated in the presence or absence of FCX for seven days. aHSC displayed significantly decreased glycolysis and increased mitochondrial respiration compared to qHSC, which was ameliorated by FCX present during activation. In addition, FCX partially attenuated the changes in the expression of genes involved in glycolysis and mitochondrial respiration, including hexokinase 1 (
MeSH term(s)	Animals ; Energy Metabolism ; Hepatic Stellate Cells/metabolism ; Liver/metabolism ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/prevention & control ; Mice ; Xanthophylls/metabolism ; Xanthophylls/pharmacology
Chemical Substances	Xanthophylls ; fucoxanthin (06O0TC0VSM)
Language	English
Publishing date	2022-05-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14091902
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Astaxanthin Attenuates the Changes in the Expression of MicroRNAs Involved in the Activation of Hepatic Stellate Cells.

Bae, Minkyung / Kim, Mi-Bo / Lee, Ji-Young

Nutrients

2022 Volume 14, Issue 5

Abstract: We previously demonstrated that astaxanthin (ASTX), a xanthophyll carotenoid, has an antifibrogenic effect in hepatic stellate cells (HSC), primarily responsible for the accumulation of extracellular matrix protein during the development of liver ... ...

Abstract	We previously demonstrated that astaxanthin (ASTX), a xanthophyll carotenoid, has an antifibrogenic effect in hepatic stellate cells (HSC), primarily responsible for the accumulation of extracellular matrix protein during the development of liver fibrosis. Studies have shown that microRNAs (miRNAs) are involved in HSC activation. Therefore, we analyzed the expression of 84 miRNAs using miRNA arrays in primary mouse quiescent HSC (qHSC) and activated HSC (aHSC) treated with/without ASTX during their activation. Compared with qHSC, the expression of 14 miRNAs and 23 miRNAs was increased and decreased by more than 2-fold, respectively, in aHSC. Among the 14 miRNAs increased in aHSC, the expression of miR-192-5p, miR-382-5p, and miR-874-3p was reduced by ASTX. In addition, ASTX increased the expression of miR-19a-3p, miR-19b-3p, and miR-101a-3p among 23 miRNAs decreased in aHSC. Moreover, we confirmed miR-382-5p expression was ~15-fold higher in aHSC than qHSC, and ASTX markedly inhibited the induction measured by quantitative real-time PCR. We identified that the expression of
MeSH term(s)	Animals ; DNA-Binding Proteins/metabolism ; Hepatic Stellate Cells/metabolism ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/genetics ; Liver Cirrhosis/prevention & control ; Mice ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Nerve Tissue Proteins/metabolism ; Xanthophylls/metabolism ; Xanthophylls/pharmacology
Chemical Substances	DNA-Binding Proteins ; MicroRNAs ; Nerve Tissue Proteins ; Xanthophylls ; Zfp462 protein, mouse ; astaxanthine (8XPW32PR7I)
Language	English
Publishing date	2022-02-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14050962
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of Bilberry Extract on Hepatic Cholesterol Metabolism in HepG2 Cells

Jimin Hong / Minkyung Bae / Bohkyung Kim

Applied Sciences, Vol 13, Iss 1, p

2022 Volume 516

Abstract: Bilberry ( Vaccinium myrtillus L.), rich in polyphenols, has been claimed to have lipid-lowering effects, but its underlying mechanisms remain unclear. The effects of bilberry extract (BE) with antioxidant properties on hepatic lipid metabolism were ... ...

Abstract	Bilberry ( Vaccinium myrtillus L.), rich in polyphenols, has been claimed to have lipid-lowering effects, but its underlying mechanisms remain unclear. The effects of bilberry extract (BE) with antioxidant properties on hepatic lipid metabolism were investigated by measuring the genes for cholesterol biosynthesis and flux in HepG2 cells. The mRNA and protein levels of genes involved in cholesterol biosynthesis such as sterol regulatory element-binding protein 2 and 3-hydroxy-3-methylglutaryl coenzyme A reductase were decreased in BE-treated cells. BE posttranscriptionally upregulated low-density lipoprotein receptor in HepG2 cells. There was a marked reduction in genes for very low-density lipoprotein assembly by BE treatment. Furthermore, the expression of canalicular transporter for cholesterol and bile acids, such as ABCG8 and ABCB11, was significantly elevated by BE treatment. Downregulation of lipogenic genes and upregulation of fatty acid oxidation-related genes were observed in BE-treated HepG2 cells. The expressions of sirtuins were altered by BE treatment. These results support that the effects of BE on hepatic cholesterol metabolism may be attributed to the regulation of genes for hepatic cholesterol biosynthesis, transport and efflux.
Keywords	bilberry extract ; cholesterol ; hypercholesterolemia ; cardiovascular disease ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Astaxanthin Attenuates the Changes in the Expression of MicroRNAs Involved in the Activation of Hepatic Stellate Cells

Bae, Minkyung / Kim, Mi-Bo / Lee, Ji-Young

Nutrients. 2022 Feb. 24, v. 14, no. 5

2022

Abstract	We previously demonstrated that astaxanthin (ASTX), a xanthophyll carotenoid, has an antifibrogenic effect in hepatic stellate cells (HSC), primarily responsible for the accumulation of extracellular matrix protein during the development of liver fibrosis. Studies have shown that microRNAs (miRNAs) are involved in HSC activation. Therefore, we analyzed the expression of 84 miRNAs using miRNA arrays in primary mouse quiescent HSC (qHSC) and activated HSC (aHSC) treated with/without ASTX during their activation. Compared with qHSC, the expression of 14 miRNAs and 23 miRNAs was increased and decreased by more than 2-fold, respectively, in aHSC. Among the 14 miRNAs increased in aHSC, the expression of miR-192-5p, miR-382-5p, and miR-874-3p was reduced by ASTX. In addition, ASTX increased the expression of miR-19a-3p, miR-19b-3p, and miR-101a-3p among 23 miRNAs decreased in aHSC. Moreover, we confirmed miR-382-5p expression was ~15-fold higher in aHSC than qHSC, and ASTX markedly inhibited the induction measured by quantitative real-time PCR. We identified that the expression of Baz1a and Zfp462 from the predicted miR-382-5p target genes was significantly reduced in aHSC while increased by ASTX treatment similar to the levels in qHSC. The roles of Baz1a and Zfp462 in HSC activation and the antifibrogenic effect of ASTX need to be further investigated.
Keywords	astaxanthin ; extracellular matrix ; liver cirrhosis ; lutein ; mice ; microRNA ; quantitative polymerase chain reaction
Language	English
Dates of publication	2022-0224
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14050962
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Mini-Review on the Roles of Vitamin C, Vitamin D, and Selenium in the Immune System against COVID-19

Minkyung Bae / Hyeyoung Kim

Molecules, Vol 25, Iss 5346, p

2020 Volume 5346

Abstract: Low levels of micronutrients have been associated with adverse clinical outcomes during viral infections. Therefore, to maximize the nutritional defense against infections, a daily allowance of vitamins and trace elements for malnourished patients at ... ...

Abstract	Low levels of micronutrients have been associated with adverse clinical outcomes during viral infections. Therefore, to maximize the nutritional defense against infections, a daily allowance of vitamins and trace elements for malnourished patients at risk of or diagnosed with coronavirus disease 2019 (COVID-19) may be beneficial. Recent studies on COVID-19 patients have shown that vitamin D and selenium deficiencies are evident in patients with acute respiratory tract infections. Vitamin D improves the physical barrier against viruses and stimulates the production of antimicrobial peptides. It may prevent cytokine storms by decreasing the production of inflammatory cytokines. Selenium enhances the function of cytotoxic effector cells. Furthermore, selenium is important for maintaining T cell maturation and functions, as well as for T cell-dependent antibody production. Vitamin C is considered an antiviral agent as it increases immunity. Administration of vitamin C increased the survival rate of COVID-19 patients by attenuating excessive activation of the immune response. Vitamin C increases antiviral cytokines and free radical formation, decreasing viral yield. It also attenuates excessive inflammatory responses and hyperactivation of immune cells. In this mini-review, the roles of vitamin C, vitamin D, and selenium in the immune system are discussed in relation to COVID-19.
Keywords	COVID-19 ; infectious disease ; selenium ; virus ; vitamin C ; vitamin D ; Organic chemistry ; QD241-441
Subject code	610
Language	English
Publishing date	2020-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mini-Review on the Roles of Vitamin C, Vitamin D, and Selenium in the Immune System against COVID-19.

Bae, Minkyung / Kim, Hyeyoung

Molecules (Basel, Switzerland)

2020 Volume 25, Issue 22

Abstract	Low levels of micronutrients have been associated with adverse clinical outcomes during viral infections. Therefore, to maximize the nutritional defense against infections, a daily allowance of vitamins and trace elements for malnourished patients at risk of or diagnosed with coronavirus disease 2019 (COVID-19) may be beneficial. Recent studies on COVID-19 patients have shown that vitamin D and selenium deficiencies are evident in patients with acute respiratory tract infections. Vitamin D improves the physical barrier against viruses and stimulates the production of antimicrobial peptides. It may prevent cytokine storms by decreasing the production of inflammatory cytokines. Selenium enhances the function of cytotoxic effector cells. Furthermore, selenium is important for maintaining T cell maturation and functions, as well as for T cell-dependent antibody production. Vitamin C is considered an antiviral agent as it increases immunity. Administration of vitamin C increased the survival rate of COVID-19 patients by attenuating excessive activation of the immune response. Vitamin C increases antiviral cytokines and free radical formation, decreasing viral yield. It also attenuates excessive inflammatory responses and hyperactivation of immune cells. In this mini-review, the roles of vitamin C, vitamin D, and selenium in the immune system are discussed in relation to COVID-19.
MeSH term(s)	Antibodies, Viral/biosynthesis ; Ascorbic Acid/therapeutic use ; Betacoronavirus/drug effects ; Betacoronavirus/immunology ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/diet therapy ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/virology ; Cytokine Release Syndrome/diet therapy ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/prevention & control ; Cytokine Release Syndrome/virology ; Cytokines/antagonists & inhibitors ; Cytokines/biosynthesis ; Dietary Supplements ; Host-Pathogen Interactions/drug effects ; Host-Pathogen Interactions/immunology ; Humans ; Immune System/drug effects ; Immunologic Factors/therapeutic use ; Micronutrients/therapeutic use ; Pandemics/prevention & control ; Pneumonia, Viral/diet therapy ; Pneumonia, Viral/immunology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Selenium/therapeutic use ; T-Lymphocytes, Cytotoxic/drug effects ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Cytotoxic/virology ; Vitamin D/therapeutic use
Chemical Substances	Antibodies, Viral ; Cytokines ; Immunologic Factors ; Micronutrients ; Vitamin D (1406-16-2) ; Selenium (H6241UJ22B) ; Ascorbic Acid (PQ6CK8PD0R)
Keywords	covid19
Language	English
Publishing date	2020-11-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules25225346
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Article: Mini-Review on the Roles of Vitamin C, Vitamin D, and Selenium in the Immune System against COVID-19

Bae, Minkyung Kim Hyeyoung

Molecules

Abstract: Low levels of micronutrients have been associated with adverse clinical outcomes during viral infections Therefore, to maximize the nutritional defense against infections, a daily allowance of vitamins and trace elements for malnourished patients at risk ...

Abstract	Low levels of micronutrients have been associated with adverse clinical outcomes during viral infections Therefore, to maximize the nutritional defense against infections, a daily allowance of vitamins and trace elements for malnourished patients at risk of or diagnosed with coronavirus disease 2019 (COVID-19) may be beneficial Recent studies on COVID-19 patients have shown that vitamin D and selenium deficiencies are evident in patients with acute respiratory tract infections Vitamin D improves the physical barrier against viruses and stimulates the production of antimicrobial peptides It may prevent cytokine storms by decreasing the production of inflammatory cytokines Selenium enhances the function of cytotoxic effector cells Furthermore, selenium is important for maintaining T cell maturation and functions, as well as for T cell-dependent antibody production Vitamin C is considered an antiviral agent as it increases immunity Administration of vitamin C increased the survival rate of COVID-19 patients by attenuating excessive activation of the immune response Vitamin C increases antiviral cytokines and free radical formation, decreasing viral yield It also attenuates excessive inflammatory responses and hyperactivation of immune cells In this mini-review, the roles of vitamin C, vitamin D, and selenium in the immune system are discussed in relation to COVID-19
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #926923
Database	COVID19

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