Article ; Online: Variation in HbA1c in Patients with Obesity and type 2 Diabetes Mellitus 12 months after Laparoscopic One-Anastomosis Gastric Bypass and Laparoscopic Roux-en-Y Gastric Bypass: a Retrospective Matched Cohort Study.
2024 Volume 34, Issue 3, Page(s) 940–946
Abstract: Background: Glycemic control is an important goal of bariatric surgery in patients with type 2 diabetes mellitus (T2DM) and obesity. The laparoscopic one-anastomosis gastric bypass (OAGB) has potential metabolic benefits over the laparoscopic Roux-en-Y ... ...
Abstract | Background: Glycemic control is an important goal of bariatric surgery in patients with type 2 diabetes mellitus (T2DM) and obesity. The laparoscopic one-anastomosis gastric bypass (OAGB) has potential metabolic benefits over the laparoscopic Roux-en-Y gastric bypass (RYGB). Aim of this study is to examine whether RYGB or OAGB grants better glycemic control 12 months post-surgery. Methods: For this retrospective cohort study, patients with T2DM and obesity, who underwent primary OAGB between 2008 and 2017 were reviewed. For each OAGB patient, three primary RYGB patients were matched for age, gender and body mass index (BMI). Glycemic control was expressed by the glycated hemoglobin (HbA1c), which was measured pre- and 12 months post-operatively. Weight loss was reported in percentage total weight loss (%TWL). Results: A total of 152 patients, of whom 38 had OAGB and 114 RYGB, were included. Mean (standard deviation (SD)) HbA1c was 7.49 (1.51)% in the OAGB group and 7.56(1.23)% in the RYGB group at baseline. Twelve months after surgery the mean (SD) HbA1c dropped to 5.73 (0.71)% after OAGB and 6.09 (0.76)% after RYGB (adjusted p = 0.011). The mean (SD) BMI was reduced from 42.5(6.3) kg/m Conclusion: This study indicates that OAGB leads to lower HbA1c one year after surgery compared to RYGB, without a difference in weight loss. Prospective (randomized) studies are needed to ascertain the most optimal metabolic treatment for patients with obesity and T2DM. |
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MeSH term(s) | Humans ; Gastric Bypass/adverse effects ; Obesity, Morbid/surgery ; Glycated Hemoglobin ; Retrospective Studies ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/surgery ; Prospective Studies ; Cohort Studies ; Obesity/surgery ; Obesity/etiology ; Laparoscopy ; Weight Loss |
Chemical Substances | Glycated Hemoglobin |
Language | English |
Publishing date | 2024-02-06 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 1070827-3 |
ISSN | 1708-0428 ; 0960-8923 |
ISSN (online) | 1708-0428 |
ISSN | 0960-8923 |
DOI | 10.1007/s11695-024-07067-x |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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