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Article ; Online: Mini review: Recent progress in RT-LAMP enabled COVID-19 detection.

Thompson, Dorian / Lei, Yu

Sensors and actuators reports

2020 Volume 2, Issue 1, Page(s) 100017

Abstract: The coronavirus disease 2019 (COVID-19) pandemic has infected millions of people around the globe. The outbreak caused by the novel coronavirus (SARS-CoV-2) poses a great health risk to the public. Therefore, rapid and accurate diagnosis of the virus ... ...

Abstract	The coronavirus disease 2019 (COVID-19) pandemic has infected millions of people around the globe. The outbreak caused by the novel coronavirus (SARS-CoV-2) poses a great health risk to the public. Therefore, rapid and accurate diagnosis of the virus plays a crucial role in treatment of the disease and saving lives. The current standard method for coronavirus detection is the reverse transcription polymerase chain reaction (RT-PCR) method. However, laboratory-based RT-PCR test for SARS-COV-2 requires complex facilities and elaborate training of operators, thus suffering from limit testing capacity and delayed results. Consequently, isothermal PCR such as loop-mediated isothermal amplification (LAMP) has been emerging as a great alternative to the RT-PCR method. LAMP possesses some fundamental advantages such as amplification at a constant temperature, exclusion of a thermal cycler, a faster test result, and potentially a larger diagnostic capacity, while maintaining similar sensitivity and specificity, thus making it more suitable than the RT-PCR for monitoring a pandemic. Starting with a brief introduction of the working principle of LAMP method, this review summarizes recent progress in LAMP-enabled SARS-CoV-2 viral RNA detection. Lastly, future research directions are discussed. This critical review will motivate biosensor community in furthering the present research, which may pave the road for rapid and large-scale screening of SARS-CoV-2.
Language	English
Publishing date	2020-08-15
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2666-0539
ISSN (online)	2666-0539
DOI	10.1016/j.snr.2020.100017
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mini review

Thompson, Dorian / Lei, Yu

Sensors and Actuators Reports

Recent progress in RT-LAMP enabled COVID-19 detection

2020 Volume 2, Issue 1, Page(s) 100017

Keywords	covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ISSN	2666-0539
DOI	10.1016/j.snr.2020.100017
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Mini Review: Recent progress in RT-LAMP enabled COVID-19 detection

Thompson, Dorian / Lei, Yu

Sensors and Actuators Reports

Abstract: The coronavirus disease 2019 (COVID-19) pandemic has infected millions of people around the globe The outbreak caused by the novel coronavirus (SARS-CoV-2) poses a great health risk to the public Therefore, rapid and accurate diagnosis of the virus plays ...

Abstract	The coronavirus disease 2019 (COVID-19) pandemic has infected millions of people around the globe The outbreak caused by the novel coronavirus (SARS-CoV-2) poses a great health risk to the public Therefore, rapid and accurate diagnosis of the virus plays a crucial role in treatment of the disease and saving lives The current standard method for coronavirus detection is the Reverse Transcription Polymerase Chain Reaction (RT-PCR) method However, laboratory-based RT-PCR test for SARS-COV-2 requires complex facilities and elaborate training of operators, thus suffering from limit testing capacity and delayed results Consequently, isothermal PCR such as Loop-mediated isothermal amplification (LAMP) has been emerging as a great alternative to the RT-PCR method LAMP possesses some fundamental advantages such as amplification at a constant temperature, no need of a thermal cycler, a faster test result, and potentially a larger diagnostic capacity, while maintaining similar sensitivity and specificity, thus making it more suitable than the RT-PCR for monitoring a pandemic Starting with a brief introduction of the working principle of LAMP method, this review summarizes recent progress in LAMP-enabled SARS-CoV-2 viral RNA detection Lastly, future research directions are discussed This critical review will motivate biosensor community in furthering the present research, which may pave the road for rapid and large-scale screening of SARS-CoV-2
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #714342
Database	COVID19

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Article ; Online: Associations of adverse childhood experiences and suicidal behaviors in adulthood in a U.S. nationally representative sample.

Thompson, Martie P / Kingree, J B / Lamis, Dorian

Child: care, health and development

2018 Volume 45, Issue 1, Page(s) 121–128

Abstract: Background: Suicide is a leading cause of death among adolescents and young adults. The current study extends the research linking adverse childhood experiences (ACEs) to suicidal behaviors by testing these associations using a nationally representative ...

Abstract	Background: Suicide is a leading cause of death among adolescents and young adults. The current study extends the research linking adverse childhood experiences (ACEs) to suicidal behaviors by testing these associations using a nationally representative sample, assessing for suicide ideation and attempts in adulthood, controlling for established risk factors for suicidality, and measuring a broad array of ACEs. Methods: The sample included 9,421 participants from the National Longitudinal Study of Adolescent Health who participated in four waves of assessments spanning 13 years. We examined longitudinal associations between eight different ACEs (physical, sexual, and emotional abuse, neglect, parental death, incarceration, alcoholism, and family suicidality) with suicidal ideation and suicide attempts in adulthood, while controlling for depression, problem alcohol use, drug use, delinquency, impulsivity, gender, race, age, and urbanicity. We also tested for cumulative associations of ACEs with suicide ideation and attempts. Results: Logistic regression analyses indicated that physical, sexual, and emotional abuse, parental incarceration, and family history of suicidality each increased the risk by 1.4 to 2.7 times for suicidal ideation and suicide attempts in adulthood. The accumulation of ACEs increased the odds of suicide ideation and attempts. Compared with those with no ACEs, the odds of seriously considering suicide or attempting suicide in adulthood increased more than threefold among those with three or more ACEs. Conclusions: Intervention strategies need to prevent ACEs from occurring and, if they do occur, should take into account the impact of cumulative ACEs on suicide risk. Future research should focus on identifying mediating mechanisms for the ACEs-suicidality association using longitudinal research designs and determine which ACEs are most important to include in a cumulative ACE measure.
MeSH term(s)	Adolescent ; Adult Survivors of Child Abuse/psychology ; Adult Survivors of Child Abuse/statistics & numerical data ; Adverse Childhood Experiences/statistics & numerical data ; Female ; Health Surveys ; Humans ; Longitudinal Studies ; Male ; Medical History Taking/statistics & numerical data ; Suicidal Ideation ; Suicide, Attempted/psychology ; Suicide, Attempted/statistics & numerical data ; United States/epidemiology ; Young Adult
Language	English
Publishing date	2018-09-02
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	223039-2
ISSN	1365-2214 ; 0305-1862
ISSN (online)	1365-2214
ISSN	0305-1862
DOI	10.1111/cch.12617
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Article: A first aid training course for primary health care providers in Nagorno Karabagh: assessing knowledge retention.

Thompson, Michael E / Harutyunyan, Tsovinar L / Dorian, Alina H

Prehospital and disaster medicine

2012 Volume 27, Issue 6, Page(s) 509–514

Abstract: Introduction: Conflict in the South Caucasus' Nagorno Karabagh region has damaged health facilities and disrupted the delivery of services and supplies as well as led to depletion of human and fixed capital and weakened the de facto government's ability ...

Abstract	Introduction: Conflict in the South Caucasus' Nagorno Karabagh region has damaged health facilities and disrupted the delivery of services and supplies as well as led to depletion of human and fixed capital and weakened the de facto government's ability to provide training for health care providers. Problem: In response to documented medical training deficits, the American University of Armenia organized a first aid training course (FATC) for primary health care providers within the scope of the USAID-funded Humanitarian Assistance Project in Nagorno Karabagh. This paper reports the follow-up assessments conducted to inform policy makers regarding FATC knowledge and skill retention and the potential need for periodic refresher training. Methods: Follow-up assessments were conducted six months and 18 months following the FATC to assess the retention of knowledge, attitudes, and self-reported practices. Eighty-four providers participated in the first follow-up and 210 in the second. The assessment tool contained items addressing the use and quality of the first aid skills, trainee's evaluation of the course, and randomly selected test questions to assess knowledge retention. Results: At both follow-up points, the participants' assessment of the course was positive. More than 85% of the trainees self-assessed their skills as "excellent" or "good" and noted that skills were frequently practiced. Scores of approximately 58% on knowledge tests at both the first and second follow-ups indicated no knowledge decay between the first and second survey waves, but substantial decline from the immediate post-test assessment in the classroom. Conclusion: The trainees assessed the FATC as effective, and the skills covered as important and well utilized. Knowledge retention was modest, but stable. Refresher courses are necessary to reverse the decay of technical knowledge and to ensure proper application in the field.
MeSH term(s)	Armenia ; Clinical Competence ; First Aid ; Humans ; Inservice Training ; Primary Health Care ; Retention (Psychology)
Language	English
Publishing date	2012-12
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1025975-2
ISSN	1945-1938 ; 1049-023X
ISSN (online)	1945-1938
ISSN	1049-023X
DOI	10.1017/S1049023X1200132X
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Article ; Online: Identifying priority healthcare trainings in frozen conflict situations: The case of Nagorno Karabagh.

Thompson, Michael E / Dorian, Alina H / Harutyunyan, Tsovinar L

Conflict and health

2010 Volume 4, Issue 1, Page(s) 21

Abstract: Introduction: Health care in post-war situations, where the system's human and fixed capital are depleted, is challenging. The addition of a frozen conflict situation, where international recognition of boundaries and authorities are lacking, introduces ...

Abstract	Introduction: Health care in post-war situations, where the system's human and fixed capital are depleted, is challenging. The addition of a frozen conflict situation, where international recognition of boundaries and authorities are lacking, introduces further complexities. Case description: Nagorno Karabagh (NK) is an ethnically Armenian territory locked within post-Soviet Azerbaijan and one such frozen conflict situation. This article highlights the use of evidence-based practice and community engagement to determine priority areas for health care training in NK. Drawing on the precepts of APEXPH (Assessment Protocol for Excellence in Public Health) and MAPP (Mobilizing for Action through Planning and Partnerships), this first-of-its-kind assessment in NK relied on in-depth interviews and focus group discussions supplemented with expert assessments and field observations. Training options were evaluated against a series of ethical and pragmatic principles. Discussion and evaluation: A unique factor among the ethical and pragmatic considerations when prioritizing among alternatives was NK's ambiguous political status and consequent sponsor constraints. Training priorities differed across the region and by type of provider, but consensus prioritization emerged for first aid, clinical Integrated Management of Childhood Illnesses, and Adult Disease Management. These priorities were then incorporated into the training programs funded by the sponsor. Conclusions: Programming responsive to both the evidence-base and stakeholder priorities is always desirable and provides a foundation for long-term planning and response. In frozen conflict, low resource settings, such an approach is critical to balancing the community's immediate humanitarian needs with sponsor concerns and constraints.
Language	English
Publishing date	2010-12-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2273783-2
ISSN	1752-1505 ; 1752-1505
ISSN (online)	1752-1505
ISSN	1752-1505
DOI	10.1186/1752-1505-4-21
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Article: Roman food refuse: urban archaeobotany in Pompeii, Regio VI, Insula 1

Murphy, Charlene / Thompson, Gill / Fuller, Dorian Q

Vegetation history and archaeobotany. 2013 Sept., v. 22, no. 5

2013

Abstract: Although world-renowned as an archaeological site, there have been few research projects in Pompeii looking at the spatial and chronological patterning of plant food use from an archaeobotanical perspective. The recent 12� years of archaeological ... ...

Abstract	Although world-renowned as an archaeological site, there have been few research projects in Pompeii looking at the spatial and chronological patterning of plant food use from an archaeobotanical perspective. The recent 12� years of archaeological excavations (1995–2006) by the Anglo-American Project in Pompeii have provided a rare opportunity to investigate a whole city block (Regione VI, Insula 1). This included a blanket sampling strategy of all contexts where archaeobotanical macro-remains, both carbonised and calcium phosphate replaced material, have been recovered, the results from which are reported here. The low density scatters of recurrent taxa from the majority of contexts examined in this study suggest that they were composed of table waste and kitchen food preparation waste and represent an expected ‘background noise’ of Roman cooking and consumption. This includes the standard ‘Mediterranean package’ of olives, grapes, figs, cereals and pulses. The general lack of evidence for crop-processing within the insula suggests that this was probably carried out elsewhere, probably within the city’s hinterland. These results support the established view that Pompeii was a fully urbanised city in the 1st century B.C. There appears to be an increase in olive consumption in the 1st century A.D., which may be suggested to correlate with ‘Romanisation’ and an increase in olive growing in the region.
Keywords	calcium phosphates ; cooking ; figs ; foods ; grains ; grapes ; kitchen waste ; olives ; research projects ; solid wastes
Language	English
Dates of publication	2013-09
Size	p. 409-419.
Publishing place	Springer-Verlag
Document type	Article
ZDB-ID	1481434-1
ISSN	1617-6278 ; 0939-6314
ISSN (online)	1617-6278
ISSN	0939-6314
DOI	10.1007/s00334-012-0385-8
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Identifying priority healthcare trainings in frozen conflict situations

Dorian Alina H / Thompson Michael E / Harutyunyan Tsovinar L

Conflict and Health, Vol 4, Iss 1, p

The case of Nagorno Karabagh

2010 Volume 21

Abstract: Abstract Introduction Health care in post-war situations, where the system's human and fixed capital are depleted, is challenging. The addition of a frozen conflict situation, where international recognition of boundaries and authorities are lacking, ... ...

Abstract	Abstract Introduction Health care in post-war situations, where the system's human and fixed capital are depleted, is challenging. The addition of a frozen conflict situation, where international recognition of boundaries and authorities are lacking, introduces further complexities. Case description Nagorno Karabagh (NK) is an ethnically Armenian territory locked within post-Soviet Azerbaijan and one such frozen conflict situation. This article highlights the use of evidence-based practice and community engagement to determine priority areas for health care training in NK. Drawing on the precepts of APEXPH (Assessment Protocol for Excellence in Public Health) and MAPP (Mobilizing for Action through Planning and Partnerships), this first-of-its-kind assessment in NK relied on in-depth interviews and focus group discussions supplemented with expert assessments and field observations. Training options were evaluated against a series of ethical and pragmatic principles. Discussion and Evaluation A unique factor among the ethical and pragmatic considerations when prioritizing among alternatives was NK's ambiguous political status and consequent sponsor constraints. Training priorities differed across the region and by type of provider, but consensus prioritization emerged for first aid, clinical Integrated Management of Childhood Illnesses, and Adult Disease Management. These priorities were then incorporated into the training programs funded by the sponsor. Conclusions Programming responsive to both the evidence-base and stakeholder priorities is always desirable and provides a foundation for long-term planning and response. In frozen conflict, low resource settings, such an approach is critical to balancing the community's immediate humanitarian needs with sponsor concerns and constraints.
Keywords	Public aspects of medicine ; RA1-1270 ; Medicine ; R ; DOAJ:Public Health ; DOAJ:Health Sciences
Language	English
Publishing date	2010-12-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
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Article: Modeling of Diffusion of Acetone in UiO-66

Wardzala, Jacob J / Ruffley, Jonathan P / Goodenough, Isabella / Schmidt, Allie M / Shukla, Priyanka B / Wei, Xin / Bagusetty, Abhishek / De Souza, Mattheus / Das, Prasenjit / Thompson, Dorian J / Karwacki, Christopher J / Wilmer, Christopher E / Borguet, Eric / Rosi, Nathaniel L / Johnson, J. Karl

Journal of physical chemistry. 2020 Dec. 17, v. 124, no. 52

2020

Abstract: Highly porous zirconium-based metal–organic frameworks (MOFs) have been widely studied as materials for sorption and destruction of chemical warfare agents (CWAs). It is important to understand the diffusion of CWAs, their reaction products, and ... ...

Abstract	Highly porous zirconium-based metal–organic frameworks (MOFs) have been widely studied as materials for sorption and destruction of chemical warfare agents (CWAs). It is important to understand the diffusion of CWAs, their reaction products, and environmental molecules through MOFs to utilize these materials for protection against CWA threats. As a first step toward this goal, we study adsorption and diffusion of acetone in pristine UiO-66. We have chosen to study UiO-66 because it has been demonstrated to be effective for destruction of CWAs and simulants; we use acetone because it is a prototypical polar organic molecule small enough to be expected to diffuse fairly rapidly through nondefective UiO-66. We specifically examine the impact of framework flexibility and hydrogen bonding between acetone and the OH groups on the nodes of the framework on the diffusivity of acetone. We find that inclusion of flexibility is essential for meaningful predictions of diffusion of acetone. We have identified the dynamics of the three linkers making up the triangular window between adjacent pores as the critical factor in controlling diffusion of acetone. We demonstrate from experiments and first-principles calculations that acetone readily hydrogen bonds to UiO-66 framework OH groups. We have modified the classical potential for UiO-66 to accurately model the framework–acetone hydrogen bonds, which are not accounted for in many MOF potentials. We find that hydrogen bonding decreases the diffusivity by about 1 order of magnitude at low loading and about a factor of 3 at high loading. Thus, proper accounting of hydrogen bonding and framework flexibility are both critical for obtaining physically realistic values of diffusivities for acetone and similar-sized polar molecules in UiO-66.
Keywords	acetone ; adsorption ; diffusivity ; hydrogen
Language	English
Dates of publication	2020-1217
Size	p. 28469-28478.
Publishing place	American Chemical Society
Document type	Article
Note	NAL-AP-2-clean
ISSN	1932-7455
DOI	10.1021/acs.jpcc.0c07040
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Single-cell quantitative expression of nicotinic acetylcholine receptor mRNA in rat hippocampal interneurons.

Jackson, Doris C / Burgon, Richard M / Thompson, Spencer / Sudweeks, Sterling N

PloS one

2024 Volume 19, Issue 4, Page(s) e0301592

Abstract: Hippocampal interneurons are a very diverse population of cells. Using single-cell quantitative PCR to analyze rat CA1 hippocampal interneurons, we quantified neuronal nicotinic acetylcholine receptor (nAChR) mRNA subunit expression and detailed possible ...

Abstract	Hippocampal interneurons are a very diverse population of cells. Using single-cell quantitative PCR to analyze rat CA1 hippocampal interneurons, we quantified neuronal nicotinic acetylcholine receptor (nAChR) mRNA subunit expression and detailed possible nAChR subtype combinations for the α2, α3, α4, α5, α7, β2, β3, and β4 subunits. We also compared the expression detected in the stratum oriens and the stratum radiatum hippocampal layers. We show that the majority of interneurons in the CA1 of the rat hippocampus contain detectable levels of nAChR subunit mRNA. Our results highlight the complexity of the CA1 nAChR population. Interestingly, the α3 nAChR subunit is one of the highest expressed subunit mRNAs in this population, while the α4 is one of the least likely subunits to be detected in CA1 interneurons. The β2 nAChR subunit is the highest expressed beta subunit mRNA in these cells. In addition, Pearson's correlation coefficient values are calculated to identify significant differences between the nAChR subunit combinations expressed in the CA1 stratum oriens and the stratum radiatum. Statistical analysis also indicates that there are likely over 100 different nAChR subunit mRNA combinations expressed in rat CA1 interneurons. These results provide a valid avenue for identifying nAChR subtype targets that may be effective hippocampus-specific pharmacological targets.
MeSH term(s)	Rats ; Animals ; RNA, Messenger/metabolism ; Receptors, Nicotinic/genetics ; Receptors, Nicotinic/metabolism ; Interneurons/metabolism ; Neurons/metabolism ; Hippocampus/metabolism
Chemical Substances	RNA, Messenger ; Receptors, Nicotinic
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0301592
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