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  1. Article ; Online: PESAVENTO, Sandra Jatahy. História & história cultural. 2ª Edição. Belo Horizonte

    Diogo da Silva Roiz

    Pensamento Plural, Vol 1, Iss 2, Pp 181-

    Autêntica, 2005. 132p.

    2008  Volume 186

    Keywords Social Sciences ; H ; Social sciences (General) ; H1-99
    Language English
    Publishing date 2008-06-01T00:00:00Z
    Publisher Universidade Federal de Pelotas
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Book ; Online: Project-Based Learning: implementação no primeiro ano de um curso de Engenharia

    Alves, Anabela Carvalho / Fernandes, Sandra / Moreira, Francisco / Lima, Rui Manuel Sá Pereira / Sousa, Rui Manuel Alves Silva / Mesquita, Diana Isabel Araújo / van Hattum-Janssen, Natascha

    2021  

    Keywords Environmental science, engineering & technology ; Designed for differentiated learning ; Engenharia ; ensino superior ; Ensino por projetos
    Size 1 electronic resource (162 pages)
    Publishing place Braga
    Document type Book ; Online
    Note Portuguese ; Open Access
    HBZ-ID HT021233344
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Comparative Perspectives on the Rise of the Brazilian Novel

    da Silva, Ana Cláudia Suriani / Vasconcelos, Sandra Guardini

    2020  

    Abstract: Comparative Perspectives on the Rise of the Brazilian Novel presents a framework of comparative literature based on a systemic and empirical approach to the study of the novel and applies that framework to the analysis of key nineteenth-century Brazilian ...

    Abstract Comparative Perspectives on the Rise of the Brazilian Novel presents a framework of comparative literature based on a systemic and empirical approach to the study of the novel and applies that framework to the analysis of key nineteenth-century Brazilian novels. The works under examination were published during the period in which the forms and procedures of the novel were acclimatized as the genre established and consolidated itself in Brazil. The 15 original essays by experienced and early career scholars explore the links between themes, narrative paradigms, and techniques of Brazilian, European and North American novels and the development of the Brazilian novel. The European and North American novels cover a wide range of literary traditions and periods, and are in conversation with the different novelistic trends that characterize the rise of the genre in Brazil. Chapters reflect on both canonical and lesser-known Brazilian works from a comparatist perspective: from the first novel by an Afro-Brazilian woman, Maria Firmina dos Reis's Ursula (1859) to Machado de Assis's Dom Casmurro (1900); and from José de Alencar's Indianist novel, Iracema (1865), to Júlia Lopes de Almeida's A Falência (The Bankruptcy, 1901)
    Keywords Literature (General)
    Size 1 electronic resource ( pages)
    Publisher UCL Press
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020589388
    ISBN 9781787354715 ; 1787354717
    DOI 10.14324/111.9781787354715
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Vitamin D deficiency or insufficiency is associated with lower urinary tract symptoms.

    da Silva, Sandra Barbosa

    International braz j urol : official journal of the Brazilian Society of Urology

    2022  Volume 48, Issue 2, Page(s) 326–327

    MeSH term(s) Humans ; Lower Urinary Tract Symptoms/etiology ; Vitamin D Deficiency/complications
    Language English
    Publishing date 2022-02-16
    Publishing country Brazil
    Document type Editorial ; Comment
    ZDB-ID 2206649-4
    ISSN 1677-6119 ; 1677-5538
    ISSN (online) 1677-6119
    ISSN 1677-5538
    DOI 10.1590/S1677-5538.IBJU.2021.0645.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Vitamin D deficiency or insufficiency is associated with lower urinary tract symptoms.

    da Silva, Sandra Barbosa

    International braz j urol : official journal of the Brazilian Society of Urology

    2022  Volume 48, Issue 2, Page(s) 326–327

    MeSH term(s) Humans ; Lower Urinary Tract Symptoms/etiology ; Prevalence ; Vitamin D Deficiency/complications
    Language English
    Publishing date 2022-09-27
    Publishing country Brazil
    Document type Editorial ; Comment
    ZDB-ID 2206649-4
    ISSN 1677-6119 ; 1677-5538
    ISSN (online) 1677-6119
    ISSN 1677-5538
    DOI 10.1590/S1677-5538.IBJU.2021.0645.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Special Issue on Drug-Membrane Interactions Volume II.

    Pinheiro, Marina / Silva, Sandra G

    Membranes

    2022  Volume 12, Issue 10

    Abstract: There is no life without cells and there are no cells without membranes [ ... ]. ...

    Abstract There is no life without cells and there are no cells without membranes [...].
    Language English
    Publishing date 2022-10-20
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2614641-1
    ISSN 2077-0375
    ISSN 2077-0375
    DOI 10.3390/membranes12101018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Editorial Comment: Effect of a low-calorie diet on 24-hour urinary parameters of obese adults with idiopathic calcium oxalate kidney stones.

    da Silva, Sandra Barbosa

    International braz j urol : official journal of the Brazilian Society of Urology

    2021  Volume 47, Issue 6, Page(s) 1148–1149

    MeSH term(s) Adult ; Calcium ; Calcium Oxalate ; Caloric Restriction ; Humans ; Kidney Calculi ; Obesity/complications
    Chemical Substances Calcium Oxalate (2612HC57YE) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-09-01
    Publishing country Brazil
    Document type Editorial ; Comment
    ZDB-ID 2206649-4
    ISSN 1677-6119 ; 1677-5538
    ISSN (online) 1677-6119
    ISSN 1677-5538
    DOI 10.1590/S1677-5538.IBJU.2021.0140.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  8. Book: Manual de Euglenophyceae pigmentadas

    Federle Consoni, Karina / Alves da Silva, Sandra Maria

    2011  

    Author's details Karina Federle Consoni ; Sandra Maria Alves da Silva
    Language Portuguese
    Size 71 S., Ill.
    Edition 1. ed.
    Publisher Ed. da ULBRA
    Publishing place Canoas
    Publishing country Brazil
    Document type Book
    HBZ-ID HT018296479
    ISBN 978-85-7528-415-5 ; 85-7528-415-0
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    148/290 available for loan (reading room) Freihandmagazin (U1)

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  9. Article ; Online: A review of poly(ADP-ribose)polymerase-1 (PARP1) role and its inhibitors bearing pyrazole or indazole core for cancer therapy.

    Bastos, Inês M / Rebelo, Sandra / Silva, Vera L M

    Biochemical pharmacology

    2024  Volume 221, Page(s) 116045

    Abstract: Cancer is a disease with a high mortality rate characterized by uncontrolled proliferation of abnormal cells. The hallmarks of cancer evidence the acquired cells characteristics that promote the growth of malignant tumours, including genomic instability ... ...

    Abstract Cancer is a disease with a high mortality rate characterized by uncontrolled proliferation of abnormal cells. The hallmarks of cancer evidence the acquired cells characteristics that promote the growth of malignant tumours, including genomic instability and mutations, the ability to evade cellular death and the capacity of sustaining proliferative signalization. Poly(ADP-ribose) polymerase-1 (PARP1) is a protein that plays key roles in cellular regulation, namely in DNA damage repair and cell survival. The inhibition of PARP1 promotes cellular death in cells with homologous recombination deficiency, and therefore, the interest in PARP protein has been rising as a target for anticancer therapies. There are already some PARP1 inhibitors approved by Food and Drug Administration (FDA), such as Olaparib and Niraparib. The last compound presents in its structure an indazole core. In fact, pyrazoles and indazoles have been raising interest due to their various medicinal properties, namely, anticancer activity. Derivatives of these compounds have been studied as inhibitors of PARP1 and presented promising results. Therefore, this review aims to address the importance of PARP1 in cell regulation and its role in cancer. Moreover, it intends to report a comprehensive literature review of PARP1 inhibitors, containing the pyrazole and indazole scaffolds, published in the last fifteen years, focusing on structure-activity relationship aspects, thus providing important insights for the design of novel and more effective PARP1 inhibitors.
    MeSH term(s) Adenosine Diphosphate Ribose ; Cell Cycle ; Indazoles/pharmacology ; Indazoles/therapeutic use ; Neoplasms/drug therapy ; Neoplasms/enzymology ; Pyrazoles/pharmacology ; Pyrazoles/therapeutic use ; United States ; Humans ; Animals ; Poly (ADP-Ribose) Polymerase-1/antagonists & inhibitors ; Poly (ADP-Ribose) Polymerase-1/metabolism
    Chemical Substances Adenosine Diphosphate Ribose (20762-30-5) ; Indazoles ; pyrazole (3QD5KJZ7ZJ) ; Pyrazoles ; PARP1 protein, human (EC 2.4.2.30) ; Poly (ADP-Ribose) Polymerase-1 (EC 2.4.2.30)
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 208787-x
    ISSN 1873-2968 ; 0006-2952
    ISSN (online) 1873-2968
    ISSN 0006-2952
    DOI 10.1016/j.bcp.2024.116045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 19: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Cardiac Blood-Based Biomarkers of Myocardial Stress as Predictors of Atrial Fibrillation Development in Patients With Embolic Stroke of Undetermined Source/Cryptogenic Stroke: A Systematic Review and Meta-Analysis.

    Justo, Ana Sofia da Silva / Nóbrega, Sandra Micaela Abreu / Silva, Ana Luísa Aires

    Journal of clinical neurology (Seoul, Korea)

    2024  

    Abstract: Background and purpose: Undiagnosed atrial fibrillation (AF) is a major risk factor for stroke that can go unnoticed in individuals with embolic stroke of undetermined source (ESUS) or cryptogenic stroke (CS). Early detection is critical for stroke ... ...

    Abstract Background and purpose: Undiagnosed atrial fibrillation (AF) is a major risk factor for stroke that can go unnoticed in individuals with embolic stroke of undetermined source (ESUS) or cryptogenic stroke (CS). Early detection is critical for stroke prognosis and secondary prevention. This study aimed to determine if blood biomarkers of myocardial stress can accurately predict AF in patients with ESUS/CS, which would allow the identification of those who would benefit from closer monitoring.
    Methods: In February 2023 we performed a systematic date-unrestricted search of three databases for studies on patients with ESUS/CS who were subsequently diagnosed with AF. We examined the relationships between AF and serum myocardial stress markers such as brain natriuretic peptide (BNP), N-terminal-pro-BNP (NT-proBNP), midregional proatrial natriuretic peptide, and troponin.
    Results: Among the 1,527 studies reviewed, 23 eligible studies involving 6,212 participants, including 864 with AF, were analyzed. A meta-analysis of 9 studies indicated that they demonstrated a clear association between higher NT-proBNP levels and an increased risk of AF, with adjusted and raw data indicating 3.06- and 9.03-fold higher AF risks, respectively. Lower NT-proBNP levels had a pooled negative predictive value of 91.7%, indicating the potential to rule out AF with an 8% false-negative rate.
    Conclusions: Further research is required to fully determine the potential of biomarkers for AF detection after stroke, as results from previous studies lack homogeneity. However, lower NT-proBNP levels have potential in ruling out AF in patients with ESUS/CS. Combining them with other relevant biomarkers may enhance the precision of identifying patients who will not benefit from extended monitoring, which would optimize resource allocation and patient care.
    Language English
    Publishing date 2024-01-01
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2500489-X
    ISSN 2005-5013 ; 1738-6586
    ISSN (online) 2005-5013
    ISSN 1738-6586
    DOI 10.3988/jcn.2023.0068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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