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  1. Article ; Online: Surgical Treatment of Atrial Fibrillation.

    Wolf, Randall K

    Methodist DeBakey cardiovascular journal

    2021  Volume 17, Issue 1, Page(s) 56–64

    Abstract: The surgical treatment of atrial fibrillation (AF) has evolved significantly over the last 20 years and even more so in the last 5 years. There are now many clinically successful surgical procedures focused on eliminating AF and AF-related stroke. This ... ...

    Abstract The surgical treatment of atrial fibrillation (AF) has evolved significantly over the last 20 years and even more so in the last 5 years. There are now many clinically successful surgical procedures focused on eliminating AF and AF-related stroke. This review discusses the current types of surgical AF procedures, including minimally invasive and hybrid, and may assist clinicians in understanding the various surgical AF options available to patients today.
    MeSH term(s) Ablation Techniques/adverse effects ; Action Potentials ; Anti-Arrhythmia Agents/therapeutic use ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/physiopathology ; Atrial Fibrillation/surgery ; Autonomic Denervation/adverse effects ; Autonomic Nervous System/physiopathology ; Autonomic Nervous System/surgery ; Heart Atria/innervation ; Heart Rate ; Humans ; Maze Procedure ; Stroke/diagnostic imaging ; Stroke/physiopathology ; Stroke/prevention & control ; Treatment Outcome
    Chemical Substances Anti-Arrhythmia Agents
    Language English
    Publishing date 2021-03-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2544079-2
    ISSN 1947-6108 ; 1947-6094
    ISSN (online) 1947-6108
    ISSN 1947-6094
    DOI 10.14797/VNDG5944
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A perspicacious view.

    Wolf, Randall K

    Innovations (Philadelphia, Pa.)

    2012  Volume 1, Issue 1, Page(s) 1–2

    Language English
    Publishing date 2012-02-24
    Publishing country United States
    Document type Journal Article
    ISSN 1556-9845
    ISSN 1556-9845
    DOI 10.1177/155698450500100101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Treatment of lone atrial fibrillation: minimally invasive pulmonary vein isolation, partial cardiac denervation and excision of the left atrial appendage.

    Wolf, Randall K

    Annals of cardiothoracic surgery

    2014  Volume 3, Issue 1, Page(s) 98–104

    Abstract: ... of AF (Wolf technique). From our experience in over 1,000 cases there have been many lessons learned ... 1 to 9 years out from the Wolf technique. The patients' ages ranged from 15 to 87 years old. The AF ... The follow-up included 7-day continuous monitoring. There were no deaths (personal review). The Wolf ...

    Abstract Since 1999, my colleagues and I have diligently pursued a minimally invasive surgical, beating-heart, left atrial isolation technique that is offered to patients with lone atrial fibrillation (AF). We began clinical cases in 2003. In 2005, we reported our initial experience with video-assisted bilateral pulmonary vein (PV) isolation and left atrial appendage (LAA) exclusion for the minimally invasive treatment of AF (Wolf technique). From our experience in over 1,000 cases there have been many lessons learned in the evaluation, selection and minimally invasive surgical treatment of patients with lone AF. In our experience we have had zero mortality and no conversions to sternotomy. Recently we reviewed 157 patients who are now 1 to 9 years out from the Wolf technique. The patients' ages ranged from 15 to 87 years old. The AF-free rate for paroxysmal AF was 92%, for persistent AF 85%, and for long-standing persistent AF 75%. The follow-up included 7-day continuous monitoring. There were no deaths (personal review). The Wolf technique is a safe and effective treatment for selected patients with lone AF.
    Language English
    Publishing date 2014-02-03
    Publishing country China
    Document type Journal Article
    ZDB-ID 2713627-9
    ISSN 2304-1021 ; 2225-319X
    ISSN (online) 2304-1021
    ISSN 2225-319X
    DOI 10.3978/j.issn.2225-319X.2014.01.06
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Ultralow energy cardioversion in a pig model of atrial fibrillation: A feasibility study.

    Elgalad, Abdelmotagaly / Moctezuma-Ramirez, Angel / de Oliveira Cardoso, Cristiano / John, Mathews / Pergolizzi, Joseph / Wolf, Randall K

    Heart rhythm

    2022  Volume 19, Issue 6, Page(s) 1008–1010

    MeSH term(s) Animals ; Atrial Fibrillation/therapy ; Electric Countershock ; Feasibility Studies ; Swine
    Language English
    Publishing date 2022-01-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2022.01.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Minimally invasive surgery for atrial fibrillation-Wolf Mini Maze procedure.

    Wolf, Randall K / Burgess, Sandra

    Annals of cardiothoracic surgery

    2014  Volume 3, Issue 1, Page(s) 122–123

    Language English
    Publishing date 2014-02-03
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2713627-9
    ISSN 2304-1021 ; 2225-319X
    ISSN (online) 2304-1021
    ISSN 2225-319X
    DOI 10.3978/j.issn.2225-319X.2014.01.09
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Expert Opinions on the Debate of Pericardial Reconstruction in Cardiovascular Surgery: To Close or Not to Close?

    Rego, Alfredo / Boyd, W Douglas / Gongora, Enrique / Johnson Iii, William E / Munfakh, Nabil A / Pirris, John / Wolf, Randall K

    The heart surgery forum

    2022  Volume 25, Issue 1, Page(s) E008–E019

    Abstract: Background: As of 2019, pericardial closure was performed in only a small portion of the over 320,000 cardiac surgeries performed annually. However, evidence regarding the benefits of pericardial closure or reconstruction has been accruing, particularly ...

    Abstract Background: As of 2019, pericardial closure was performed in only a small portion of the over 320,000 cardiac surgeries performed annually. However, evidence regarding the benefits of pericardial closure or reconstruction has been accruing, particularly with the publication of the RECON study in 2019.  Methods: This group of authors convened to try to arrive at consensus expert opinion regarding pericardial reconstruction. Structured topic questions initially were used to stimulate discussion. Subsequently, a survey of proposed expert opinion statements was conducted among the authors. Based on that survey, consensus expert opinion statements and recommendations were compiled.
    Results: The expert opinions encompass various topics relating to pericardial reconstruction, including definitions, benefits/risks, and technique. Observed benefits include reductions in: (1) adhesions; (2) postoperative pericardial effusion, atrial fibrillation, and bleeding; and (3) readmissions and length of hospital stay. Expert opinion recommendations regarding surgical technique are compiled into a single chart. Complete pericardial reconstruction should be performed, using native pericardial tissue if available and viable; if not feasible, a patch may be used. Patches that stimulate the formation of site-specific tissue in situ (such as natural extracellular matrix) may have additional benefits (including bioregenerative properties and lack of inflammatory response). Closure should be taut, but tension-free. Adequate drainage of the closed pericardium must be ensured.
    Conclusions: Based on available data and collective surgical experience, we endorse pericardial reconstruction as standard approach in appropriately selected patients. We also endorse adoption of standardized pericardial reconstruction techniques to optimize patient outcomes and improve evidence quality in future studies.
    MeSH term(s) Cardiac Surgical Procedures/methods ; Expert Testimony ; Humans ; Pericardial Effusion/surgery ; Pericardium/surgery ; Reconstructive Surgical Procedures
    Language English
    Publishing date 2022-01-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2069188-9
    ISSN 1522-6662 ; 1098-3511
    ISSN (online) 1522-6662
    ISSN 1098-3511
    DOI 10.1532/hsf.3943
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Invited commentary.

    Wolf, Randall K

    The Annals of thoracic surgery

    2008  Volume 86, Issue 5, Page(s) 1663

    MeSH term(s) Aged ; Animals ; Atrial Fibrillation/diagnostic imaging ; Atrial Fibrillation/surgery ; Catheter Ablation ; Disease Models, Animal ; Dogs ; Echocardiography ; Ethanol/administration & dosage ; Female ; Ganglionectomy ; Humans ; Male
    Chemical Substances Ethanol (3K9958V90M)
    Language English
    Publishing date 2008-11
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2008.07.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The Future of Surgery and ISMICS.

    Wolf, Randall K

    Innovations (Philadelphia, Pa.)

    2006  Volume 1, Issue 6, Page(s) 285–292

    Language English
    Publishing date 2006
    Publishing country United States
    Document type Journal Article
    ISSN 1556-9845
    ISSN 1556-9845
    DOI 10.1097/IMI.0b013e31802f43d8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Minimally invasive surgical treatment of atrial fibrillation.

    Wolf, Randall K

    Seminars in thoracic and cardiovascular surgery

    2007  Volume 19, Issue 4, Page(s) 311–318

    Abstract: Surgical ablation for atrial fibrillation (AF) can now be successfully performed utilizing minimally invasive techniques, as surgeon experience with these approaches has increased, and technologic advances in minimally invasive instrumentation have been ... ...

    Abstract Surgical ablation for atrial fibrillation (AF) can now be successfully performed utilizing minimally invasive techniques, as surgeon experience with these approaches has increased, and technologic advances in minimally invasive instrumentation have been made. Surgical management of atrial fibrillation, as well as our minimally invasive approach, will be discussed in depth.
    MeSH term(s) Atrial Fibrillation/physiopathology ; Atrial Fibrillation/surgery ; Cardiac Surgical Procedures/instrumentation ; Cardiac Surgical Procedures/methods ; Electrophysiology ; Humans ; Minimally Invasive Surgical Procedures/instrumentation ; Minimally Invasive Surgical Procedures/methods
    Language English
    Publishing date 2007
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1038278-1
    ISSN 1532-9488 ; 1043-0679
    ISSN (online) 1532-9488
    ISSN 1043-0679
    DOI 10.1053/j.semtcvs.2007.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Dynamic Response of Donor-Derived Cell-Free DNA Following Treatment of Acute Rejection in Kidney Allografts.

    Wolf-Doty, Theresa K / Mannon, Roslyn B / Poggio, Emilio D / Hinojosa, Randall J / Hiller, David / Bromberg, Jonathan S / Brennan, Daniel C

    Kidney360

    2021  Volume 2, Issue 4, Page(s) 729–736

    Abstract: Background: The quantification of rejection treatment efficacy has been insufficient using traditional markers due, in part, to the lagging response of serum creatinine and histologic alterations on biopsy specimens. Donor-derived cell-free DNA (dd- ... ...

    Abstract Background: The quantification of rejection treatment efficacy has been insufficient using traditional markers due, in part, to the lagging response of serum creatinine and histologic alterations on biopsy specimens. Donor-derived cell-free DNA (dd-cfDNA) is a molecular marker of injury that may assess allograft injury after rejection.
    Methods: Retrospective review of the DART study identified 70 patients who had a clinically indicated biopsy, simultaneous dd-cfDNA measurement, and at least one follow-up dd-cfDNA within 3 months post-treatment. Thirty-five patients had no biopsy-proven rejection and no rejection treatment (NR), 16 patients had no biopsy-proven rejection but did receive rejection treatment (CR), 9 patients had diagnosis of ABMR/mixed rejection on biopsy and received rejection treatment (ABMR), and 10 patients had diagnosis of TCMR and received rejection treatment (TCMR). The CR, ABMR, and TCMR groups combined to form a rejection (R) group.
    Results: In the R group, median dd-cfDNA values at baseline and 1 month were 0.62% and 0.35% (n=21 pairs, p=0.34), and at baseline and 2-3 months were 0.77% and 0.21% (n=23 pairs, p=0.002). In TCMR, median dd-cfDNA values at baseline and 1 month were 1.13% and 0.37% (n=5 pairs, p=0.63), and at baseline and 2-3 months were 0.25% and 0.12% (n=9 pairs, p=0.004). In ABMR, median dd-cfDNA values at baseline and 1 month were 1.61% and 1.2 % (n=6 pairs, p>0.99), and at baseline and 2-3 months were 3.85% and 1.32% (n=6 pairs, p=0.09). In CR, median dd-cfDNA values at baseline and 1 month were 0.31% and 0.29% (n=10 pairs, p=0.38), and at baseline and 2-3 months were 0.38% and 0.17% (n=8 pairs, p=0.31). Lastly, in NR, median dd-cfDNA values at baseline and 1 month were 0.23% and 0.18% (n=21 pairs, p=0.10), and at baseline and 2-3 months were 0.33% and 0.17% (n=26 pairs, p=0.003). Changes in serum creatinine across 1 month and 2-3 months following rejection were similar.
    Conclusions: dd-cfDNA may be a useful dynamic biomarker to assess the health of the kidney allograft following rejection treatment.
    MeSH term(s) Allografts ; Cell-Free Nucleic Acids ; Graft Rejection/diagnosis ; Humans ; Kidney/surgery ; Kidney Transplantation/adverse effects
    Chemical Substances Cell-Free Nucleic Acids
    Language English
    Publishing date 2021-02-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000042021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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