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  1. Book: Poisoning and Drug Overdose, Eighth Edition

    Anderson, Ilene B / Benowitz, Neal L / Blanc, Paul D / Kim-Katz, Susan Y / Lewis, Justin C / Wu, Alan H B / Olson, Kent R / Smollin, Craig

    2022  

    Author's details Kent R. Olson, MD, FACEP Medical Director California Poison ontrol System, San Francisco Division San Francisco General Hospital Attenting Emergency Physician Elden Hospital Medcial Center Clinical Professor of Medicine, Pediatrics, and Pharmacy University of California, San Francisco
    Language English
    Size 784 p.
    Edition 8
    Publisher McGraw Hill LLC
    Document type Book
    Note PDA Manuell_16
    Format 136 x 209 x 30
    ISBN 9781264259083 ; 1264259085
    Database PDA

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  2. Article ; Online: How an intrinsically disordered regulatory subunit assembles a PP1:eIF2 complex.

    Jones, Alexander C / Wu, Jian / Taylor, Susan S

    Cell reports

    2024  Volume 43, Issue 4, Page(s) 114011

    Abstract: Fatalska et al. ...

    Abstract Fatalska et al.
    MeSH term(s) Protein Phosphatase 1/metabolism ; Humans ; Eukaryotic Initiation Factor-2/metabolism ; Intrinsically Disordered Proteins/metabolism ; Intrinsically Disordered Proteins/chemistry ; Protein Binding ; Phosphorylation ; Protein Subunits/metabolism ; Protein Subunits/chemistry ; Mutation
    Chemical Substances Protein Phosphatase 1 (EC 3.1.3.16) ; Eukaryotic Initiation Factor-2 ; Intrinsically Disordered Proteins ; Protein Subunits
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2024.114011
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  3. Article ; Online: 3D Traction Force Microscopy in Biological Gels: From Single Cells to Multicellular Spheroids.

    Cheung, Brian C H / Abbed, Rana J / Wu, Mingming / Leggett, Susan E

    Annual review of biomedical engineering

    2024  

    Abstract: Cell traction force plays a critical role in directing cellular functions, such as proliferation, migration, and differentiation. Current understanding of cell traction force is largely derived from 2D measurements where cells are plated on 2D substrates. ...

    Abstract Cell traction force plays a critical role in directing cellular functions, such as proliferation, migration, and differentiation. Current understanding of cell traction force is largely derived from 2D measurements where cells are plated on 2D substrates. However, 2D measurements do not recapitulate a vital aspect of living systems, that is, cells actively remodel their surrounding extracellular matrix (ECM), and the remodeled ECM, in return, can have a profound impact on cell phenotype and traction force generation. This reciprocal adaptivity of living systems is encoded in the material properties of biological gels. In this review, we summarize recent progress in measuring cell traction force for cells embedded within 3D biological gels, with an emphasis on cell-ECM cross talk. We also provide perspectives on tools and techniques that could be adapted to measure cell traction force in complex biochemical and biophysical environments. Expected final online publication date for the
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1448425-0
    ISSN 1545-4274 ; 1523-9829
    ISSN (online) 1545-4274
    ISSN 1523-9829
    DOI 10.1146/annurev-bioeng-103122-031130
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  4. Article ; Online: Point-Counterpoint: What's in a Name? Clinical Microbiology Laboratories Should Use Nomenclature Based on Current Taxonomy.

    Carroll, Karen C / Munson, Erik / Butler-Wu, Susan M / Patrick, Sheila

    Journal of clinical microbiology

    2023  Volume 61, Issue 1, Page(s) e0173222

    Abstract: INTRODUCTION The mnemonic SPICE ( ...

    Abstract INTRODUCTION The mnemonic SPICE (
    MeSH term(s) Humans ; Laboratories ; Bacteria/genetics ; Enterobacter aerogenes
    Language English
    Publishing date 2023-01-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/jcm.01732-22
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  5. Article ; Online: Chemoradiation to Improve Local Control, and Thereby Overall Survival for Limited Stage Nasal NKTCL.

    Wu, Susan Y / Pinnix, Chelsea C

    International journal of radiation oncology, biology, physics

    2021  Volume 111, Issue 5, Page(s) 1105–1106

    MeSH term(s) Chemoradiotherapy ; Humans ; Lymphoma, Extranodal NK-T-Cell/drug therapy ; Nose ; Prognosis
    Language English
    Publishing date 2021-11-18
    Publishing country United States
    Document type Editorial
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2021.09.046
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  6. Article: Established and new horizons in radiotherapy for breast cancer.

    Wu, Trudy C / McCloskey, Susan A

    Therapeutic advances in medical oncology

    2023  Volume 15, Page(s) 17588359231161415

    Abstract: Modern advances in diagnostics, surgery, systemic therapies, and radiotherapy (RT) have drastically revolutionized treatment strategies for breast cancer. This review outlines current and evolving treatment paradigms for RT in the breast-conserving ... ...

    Abstract Modern advances in diagnostics, surgery, systemic therapies, and radiotherapy (RT) have drastically revolutionized treatment strategies for breast cancer. This review outlines current and evolving treatment paradigms for RT in the breast-conserving therapy and post-mastectomy setting. In early-stage breast cancer, there is active investigation in expanding eligibility for omission of RT in women with more biologically favorable tumors and growing options to effectively irradiate less breast tissue and shorten RT treatment courses. For locally advanced breast cancer, we discuss several patient cohorts in which the necessity of post-mastectomy RT (PMRT) is commonly debated. Ongoing efforts to better refine indications for PMRT and evaluate the feasibility of hypofractionated PMRT are being studied. Metastasis-directed therapy with ablative RT is an emerging topic of interest in many cancers, including its role and impact in oligometastatic breast cancer. In this review, we will discuss the rationale for current standard of care and address in greater detail the aforementioned concepts.
    Language English
    Publishing date 2023-03-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2503443-1
    ISSN 1758-8359 ; 1758-8340
    ISSN (online) 1758-8359
    ISSN 1758-8340
    DOI 10.1177/17588359231161415
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  7. Article ; Online: Working retirees in Taiwan: examining determinants of different working status after retirement.

    Wu, Tai-Kang / Ku, Li-Jung Elizabeth / Chang, Jer-Hao / Chiu, Ching-Ju / Hu, Susan C

    BMC geriatrics

    2024  Volume 24, Issue 1, Page(s) 224

    Abstract: This study aims to investigate the factors influencing the work status of retirees after retirement, especially focusing on self-employment and unpaid work. Data was taken and analyzed from the "Taiwan Health and Retirement Study," a nationally ... ...

    Abstract This study aims to investigate the factors influencing the work status of retirees after retirement, especially focusing on self-employment and unpaid work. Data was taken and analyzed from the "Taiwan Health and Retirement Study," a nationally representative sample of retired personnel aged 50-74 in 2015-2016. Four types of work status were classified after retirement: Fully retired, Paid work, Self-employment, and Unpaid work. Multinomial regression analysis was used to explore the factors related to participation in paid, self-employed, and unpaid work. Results show that pre-retirement occupation was significantly associated with paid work after retirement. For example, retirees in Taiwan who were employed by private enterprises or self-employed before retirement were more likely to engage in paid work after retirement than civil servants before retirement. Two other factors, namely pre-retirement job stress and work flexibility, prolong the careers of retired workers, especially in self-employment and unpaid work after retirement. Gender also significantly affects the choice of work after retirement. These findings can be used as a reference for future policies on the aging labor force.
    MeSH term(s) Humans ; Retirement ; Taiwan/epidemiology ; Aging
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059865-8
    ISSN 1471-2318 ; 1471-2318
    ISSN (online) 1471-2318
    ISSN 1471-2318
    DOI 10.1186/s12877-024-04849-x
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  8. Article: A high burden of diabetes and ankle brachial index abnormalities exists in Mexican Americans in South Texas.

    Prasad, Anand / Choh, Audrey C / Gonzalez, Nelson D / Garcia, Marlene / Lee, Miryoung / Watt, Gordon / Maria Vasquez, Liliana / Laing, Susan / Wu, Shenghui / McCormick, Joseph B / Fisher-Hoch, Susan

    Preventive medicine reports

    2024  Volume 38, Page(s) 102604

    Abstract: Ethnic differences exist in the United States in the interrelated problems of diabetes (DM), peripheral arterial disease (PAD), and leg amputations. The purpose of this study was to determine the prevalence and risk factor associations for subclinical ... ...

    Abstract Ethnic differences exist in the United States in the interrelated problems of diabetes (DM), peripheral arterial disease (PAD), and leg amputations. The purpose of this study was to determine the prevalence and risk factor associations for subclinical PAD in a population sample of Mexican Americans using the ankle brachial (ABI) index. The ABI-High (higher of the two ankle pressures/highest brachial pressure) and ABI-Low (lower of the two ankle pressures/highest brachial pressure) were calculated to define PAD. Toe brachial index (TBI) was also calculated. 746 participants were included with an age of 53.4 ± 0.9 years, 28.3 % had diabetes mellitus (DM), 12.6 % were smokers, and 51.2 % had hypertension (HTN). Using ABI-High ≤ 0.9, the prevalence of PAD was 2.7 %. This rose to 12.7 % when an ABI-Low ≤ 0.9 was used; 4.0 % of the population had an ABI-High > 1.4. The prevalence of TBI < 0.7 was 3.9 %. DM was a significant risk factor for ABI-High ≤ 0.9 and ABI-High > 1.4, and TBI < 0.7. Increased age, HTN, smoking was associated with ABI-High ≤ 0.9, while being male was associated with ABI-High > 1.4. Increased age, smoking, and lower education were all associated with abnormal TBI. Despite relatively younger mean age than other studied Hispanic cohorts, the present population has a high burden of ABI abnormalities. DM was a consistent risk factor for PAD. These abnormalities indicate an important underlying substrate of vascular and metabolic disease that may predispose this population to the development of symptomatic PAD and incident amputations.
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2785569-7
    ISSN 2211-3355
    ISSN 2211-3355
    DOI 10.1016/j.pmedr.2024.102604
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  9. Article ; Online: A distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche.

    Zepeda-Rivera, Martha / Minot, Samuel S / Bouzek, Heather / Wu, Hanrui / Blanco-Míguez, Aitor / Manghi, Paolo / Jones, Dakota S / LaCourse, Kaitlyn D / Wu, Ying / McMahon, Elsa F / Park, Soon-Nang / Lim, Yun K / Kempchinsky, Andrew G / Willis, Amy D / Cotton, Sean L / Yost, Susan C / Sicinska, Ewa / Kook, Joong-Ki / Dewhirst, Floyd E /
    Segata, Nicola / Bullman, Susan / Johnston, Christopher D

    Nature

    2024  Volume 628, Issue 8007, Page(s) 424–432

    Abstract: Fusobacterium nucleatum (Fn), a bacterium present in the human oral cavity and rarely found in the lower gastrointestinal tract of healthy ... ...

    Abstract Fusobacterium nucleatum (Fn), a bacterium present in the human oral cavity and rarely found in the lower gastrointestinal tract of healthy individuals
    MeSH term(s) Animals ; Humans ; Mice ; Adenoma/microbiology ; Case-Control Studies ; Colorectal Neoplasms/microbiology ; Colorectal Neoplasms/pathology ; Feces/microbiology ; Fusobacterium nucleatum/classification ; Fusobacterium nucleatum/genetics ; Fusobacterium nucleatum/isolation & purification ; Fusobacterium nucleatum/pathogenicity ; Gastrointestinal Tract/metabolism ; Gastrointestinal Tract/microbiology ; Genome, Bacterial/genetics ; Mouth/microbiology ; Female
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-024-07182-w
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  10. Article: Protein Kinase Structure and Dynamics: Role of the αC-β4 Loop.

    Wu, Jian / Jonniya, Nisha A / Hirakis, Sophia P / Olivieri, Cristina / Veglia, Gianluigi / Kornev, Alexandr P / Taylor, Susan S

    bioRxiv : the preprint server for biology

    2023  

    Abstract: ... at the interface between the N- and C-lobes. In addition, we delved more deeply into the structure of the apo C ... subunit, which lacks ATP. While apo C-subunit showed no significant changes in backbone dynamics of the αC ... suggests disruption of communication between the N- and C-lobes in the F100A mutant, which would be ...

    Abstract Although the αC-β4 loop is a stable feature of all protein kinases, the importance of this motif as a conserved element of secondary structure, as well as its links to the hydrophobic architecture of the kinase core, has been underappreciated. We first review the motif and then describe how it is linked to the hydrophobic spine architecture of the kinase core, which we first discovered using a computational tool, Local Spatial Pattern (LSP) alignment. Based on NMR predictions that a mutation in this motif abolishes the synergistic high-affinity binding of ATP and a pseudo substrate inhibitor, we used LSP to interrogate the F100A mutant. This comparison highlights the importance of the αC-β4 loop and key residues at the interface between the N- and C-lobes. In addition, we delved more deeply into the structure of the apo C-subunit, which lacks ATP. While apo C-subunit showed no significant changes in backbone dynamics of the αC-β4 loop, we found significant differences in the side chain dynamics of K105. The LSP analysis suggests disruption of communication between the N- and C-lobes in the F100A mutant, which would be consistent with the structural changes predicted by the NMR spectroscopy.
    Language English
    Publishing date 2023-10-16
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.08.31.555822
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