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  1. Book ; Online ; E-Book: Pathophysiology of disease

    Hammer, Gary D. / McPhee, Stephen J.

    an introduction to clinical medicine

    2019  

    Author's details edited by Gary D. Hammer, Stephen J. McPhee
    Keywords Fisiologia patològica ; Medicina clínica ; Clinical medicine ; Physiology, Pathological ; Enfermedad ; Medicina
    Language English
    Edition Eighth edition
    Publisher McGraw Hill ; 2019
    Publishing place New York
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-260-02651-5 ; 978-1-260-02650-4 ; 1-260-02650-7 ; 978-1-260-02651-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Pathophysiology of disease

    Hammer, Gary D. / MacPhee, Stephen J.

    an introduction to clinical medicine

    (A Lange medical book)

    2014  

    Author's details ed. by Gary D. Hammer ; Stephen J. McPhee
    Series title A Lange medical book
    Subject code 616.07
    Language English
    Size XV, 762 S. : Ill., graph. Darst.
    Edition 7. ed.
    Publisher McGraw-Hill Education Medical
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT018289679
    ISBN 978-0-07-180600-8 ; 0-07-180600-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 2285 available for loan (reading room) Lesesaal EG

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  3. Book: Adrenocortical carcinoma

    Hammer, Gary D. / Else, Tobias

    2011  

    Author's details Gary D. Hammer ; Tobias Else, ed
    Language English
    Size XV, 546 S. : Ill., graph. Darst., 23cm
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT016630019
    ISBN 0-387-77235-9 ; 978-0-387-77235-6 ; 9780387772363 ; 0387772367
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 A 6383 order for loan Magazin

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  4. Article ; Online: Targeting of a New Node in Lipid Metabolism as a Potential Treatment Strategy for ACC.

    LaPensee, Christopher R / Hammer, Gary D

    Endocrinology

    2023  Volume 164, Issue 3

    MeSH term(s) Humans ; Adrenocortical Carcinoma/metabolism ; Mitotane ; Lipid Metabolism ; Lipolysis ; Lipid Droplets/metabolism ; Adrenal Cortex Neoplasms/metabolism
    Chemical Substances Mitotane (78E4J5IB5J)
    Language English
    Publishing date 2023-01-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/endocr/bqad003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.72: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Bones and adrenal organogenesis: how embryonic osteocalcin influences lifelong adrenal function.

    Dumontet, Typhanie / Hammer, Gary D

    The Journal of clinical investigation

    2022  Volume 132, Issue 4

    Abstract: Osteocalcin is a hormone produced in bones by osteoblasts during bone formation. Numerous studies have demonstrated that adrenal gland-derived glucocorticoids inhibit osteocalcin production, which can ultimately cause deleterious bones loss. This loss ... ...

    Abstract Osteocalcin is a hormone produced in bones by osteoblasts during bone formation. Numerous studies have demonstrated that adrenal gland-derived glucocorticoids inhibit osteocalcin production, which can ultimately cause deleterious bones loss. This loss establishes a unidirectional endocrine relationship between the adrenal glands and bone, however, whether osteocalcin reciprocally regulates glucocorticoid secretion remains unclear. In this issue of the JCI, Yadav and colleagues address how bone-derived osteocalcin influences adrenal organogenesis and function. Using a large variety of animal models, the authors established that embryonic osteocalcin signaling, specifically through the GPR158 receptor, regulates postnatal adrenal steroid concentrations throughout life. This work has translational potential, and we await future investigations that determine whether modulating osteocalcin levels could promote endogenous adrenocortical function in adrenocortical hypoplasia and glucocorticoid deficiency.
    MeSH term(s) Animals ; Bone and Bones ; Glucocorticoids/pharmacology ; Osteoblasts ; Osteocalcin/genetics ; Osteogenesis/drug effects
    Chemical Substances Glucocorticoids ; Osteocalcin (104982-03-8)
    Language English
    Publishing date 2022-02-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI157200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.184: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  6. Article ; Online: Bones and adrenal organogenesis

    Typhanie Dumontet / Gary D. Hammer

    The Journal of Clinical Investigation, Vol 132, Iss

    how embryonic osteocalcin influences lifelong adrenal function

    2022  Volume 4

    Abstract: Osteocalcin is a hormone produced in bones by osteoblasts during bone formation. Numerous studies have demonstrated that adrenal gland–derived glucocorticoids inhibit osteocalcin production, which can ultimately cause deleterious bones loss. This loss ... ...

    Abstract Osteocalcin is a hormone produced in bones by osteoblasts during bone formation. Numerous studies have demonstrated that adrenal gland–derived glucocorticoids inhibit osteocalcin production, which can ultimately cause deleterious bones loss. This loss establishes a unidirectional endocrine relationship between the adrenal glands and bone, however, whether osteocalcin reciprocally regulates glucocorticoid secretion remains unclear. In this issue of the JCI, Yadav and colleagues address how bone-derived osteocalcin influences adrenal organogenesis and function. Using a large variety of animal models, the authors established that embryonic osteocalcin signaling, specifically through the GPR158 receptor, regulates postnatal adrenal steroid concentrations throughout life. This work has translational potential, and we await future investigations that determine whether modulating osteocalcin levels could promote endogenous adrenocortical function in adrenocortical hypoplasia and glucocorticoid deficiency.
    Keywords Medicine ; R
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher American Society for Clinical Investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Update on Biology and Genomics of Adrenocortical Carcinomas: Rationale for Emerging Therapies.

    Lerario, Antonio Marcondes / Mohan, Dipika R / Hammer, Gary D

    Endocrine reviews

    2022  Volume 43, Issue 6, Page(s) 1051–1073

    Abstract: The adrenal glands are paired endocrine organs that produce steroid hormones and catecholamines required for life. Adrenocortical carcinoma (ACC) is a rare and often fatal cancer of the peripheral domain of the gland, the adrenal cortex. Recent research ... ...

    Abstract The adrenal glands are paired endocrine organs that produce steroid hormones and catecholamines required for life. Adrenocortical carcinoma (ACC) is a rare and often fatal cancer of the peripheral domain of the gland, the adrenal cortex. Recent research in adrenal development, homeostasis, and disease have refined our understanding of the cellular and molecular programs controlling cortical growth and renewal, uncovering crucial clues into how physiologic programs are hijacked in early and late stages of malignant neoplasia. Alongside these studies, genome-wide approaches to examine adrenocortical tumors have transformed our understanding of ACC biology, and revealed that ACC is composed of distinct molecular subtypes associated with favorable, intermediate, and dismal clinical outcomes. The homogeneous transcriptional and epigenetic programs prevailing in each ACC subtype suggest likely susceptibility to any of a plethora of existing and novel targeted agents, with the caveat that therapeutic response may ultimately be limited by cancer cell plasticity. Despite enormous biomedical research advances in the last decade, the only potentially curative therapy for ACC to date is primary surgical resection, and up to 75% of patients will develop metastatic disease refractory to standard-of-care adjuvant mitotane and cytotoxic chemotherapy. A comprehensive, integrated, and current bench-to-bedside understanding of our field's investigations into adrenocortical physiology and neoplasia is crucial to developing novel clinical tools and approaches to equip the one-in-a-million patient fighting this devastating disease.
    MeSH term(s) Humans ; Adrenocortical Carcinoma/drug therapy ; Adrenocortical Carcinoma/genetics ; Adrenal Cortex Neoplasms/drug therapy ; Adrenal Cortex Neoplasms/genetics ; Mitotane/therapeutic use ; Adrenal Glands ; Genomics
    Chemical Substances Mitotane (78E4J5IB5J)
    Language English
    Publishing date 2022-05-23
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 603096-8
    ISSN 1945-7189 ; 0163-769X
    ISSN (online) 1945-7189
    ISSN 0163-769X
    DOI 10.1210/endrev/bnac012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1562: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: 5th International ACC Symposium: Introduction.

    Hammer, Gary D

    Hormones & cancer

    2016  Volume 7, Issue 1, Page(s) 1–2

    MeSH term(s) Adrenal Cortex Neoplasms/diagnosis ; Adrenal Cortex Neoplasms/pathology ; Adrenal Cortex Neoplasms/therapy ; Adrenal Glands/pathology ; Humans
    Language English
    Publishing date 2016-01-04
    Publishing country United States
    Document type Congress ; Editorial ; Introductory Journal Article
    ZDB-ID 2543318-0
    ISSN 1868-8500 ; 1868-8500
    ISSN (online) 1868-8500
    ISSN 1868-8500
    DOI 10.1007/s12672-015-0248-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Stem cell function and plasticity in the normal physiology of the adrenal cortex.

    Hammer, Gary D / Basham, Kaitlin J

    Molecular and cellular endocrinology

    2020  Volume 519, Page(s) 111043

    Abstract: The adrenal cortex functions to produce steroid hormones necessary for life. To maintain its functional capacity throughout life, the adrenal cortex must be continually replenished and rapidly repaired following injury. Moreover, the adrenal responds to ... ...

    Abstract The adrenal cortex functions to produce steroid hormones necessary for life. To maintain its functional capacity throughout life, the adrenal cortex must be continually replenished and rapidly repaired following injury. Moreover, the adrenal responds to endocrine-mediated organismal needs, which are highly dynamic and necessitate a precise steroidogenic response. To meet these diverse needs, the adrenal employs multiple cell populations with stem cell function. Here, we discuss the literature on adrenocortical stem cells using hematopoietic stem cells as a benchmark to examine the functional capacity of particular cell populations, including those located in the capsule and peripheral cortex. These populations are coordinately regulated by paracrine and endocrine signaling mechanisms, and display remarkable plasticity to adapt to different physiological and pathological conditions. Some populations also exhibit sex-specific activity, which contributes to highly divergent proliferation rates between sexes. Understanding mechanisms that govern adrenocortical renewal has broad implications for both regenerative medicine and cancer.
    MeSH term(s) Adrenal Cortex/cytology ; Adrenal Cortex/physiology ; Animals ; Cell Plasticity/physiology ; Female ; Humans ; Male ; Models, Biological ; Sex Characteristics ; Stem Cells/cytology ; Stem Cells/metabolism ; Wnt Signaling Pathway
    Language English
    Publishing date 2020-10-12
    Publishing country Ireland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 187438-x
    ISSN 1872-8057 ; 0303-7207
    ISSN (online) 1872-8057
    ISSN 0303-7207
    DOI 10.1016/j.mce.2020.111043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1127: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Drug repurposing using high-throughput screening identifies a promising drug combination to treat adrenocortical carcinoma.

    Lerario, Antonio M / Hammer, Gary D

    Oncotarget

    2018  Volume 9, Issue 70, Page(s) 33245–33246

    Language English
    Publishing date 2018-09-07
    Publishing country United States
    Document type News ; Comment
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.26091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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