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Article ; Online: Bias, quality and reporting in health research: differences and tools for appraisal.

Garegnani, Luis Ignacio

BMJ evidence-based medicine

2023 Volume 28, Issue 6, Page(s) 407–409

MeSH term(s)	Humans ; Bias ; Evidence-Based Medicine
Language	English
Publishing date	2023-11-22
Publishing country	England
Document type	Journal Article
ISSN	2515-4478
ISSN (online)	2515-4478
DOI	10.1136/bmjebm-2023-112260
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Misleading clinical evidence and systematic reviews on ivermectin for COVID-19.

Garegnani, Luis Ignacio / Madrid, Eva / Meza, Nicolás

BMJ evidence-based medicine

2021 Volume 27, Issue 3, Page(s) 156–158

MeSH term(s)	COVID-19 ; Humans ; Ivermectin/therapeutic use ; SARS-CoV-2
Chemical Substances	Ivermectin (70288-86-7)
Language	English
Publishing date	2021-04-22
Publishing country	England
Document type	Journal Article
ISSN	2515-4478
ISSN (online)	2515-4478
DOI	10.1136/bmjebm-2021-111678
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Post-covid-19 conditions in adults: systematic review and meta-analysis of health outcomes in controlled studies.

Franco, Juan Victor Ariel / Garegnani, Luis Ignacio / Metzendorf, Maria-Inti / Heldt, Katharina / Mumm, Rebekka / Scheidt-Nave, Christa

BMJ medicine

2024 Volume 3, Issue 1, Page(s) e000723

Abstract: Objective: To assess the impact of post-covid-19 conditions among adults.: Design: Systematic review and meta-analysis of health outcomes in controlled studies.: Data sources: Two sources were searched from database inception to 20 October 2022: ... ...

Abstract	Objective: To assess the impact of post-covid-19 conditions among adults. Design: Systematic review and meta-analysis of health outcomes in controlled studies. Data sources: Two sources were searched from database inception to 20 October 2022: Cochrane covid-19 study register (comprising Cochrane Central Register of Controlled Trials, Medline, Embase, clinicalTrials.gov, World Health Organization's International Clinical Trials Registry Platform, medRxiv) and WHO's covid-19 research database. Eligibility criteria: Cohort studies recruiting more than 100 participants with a control group and a follow-up of at least 12 weeks were included. Adults who were documented to have SARS-CoV-2 infection based on clinical, imaging, or laboratory criteria were included. Data extraction and synthesis: Two independent reviewers extracted data. The main outcomes included quality of life, functionality in daily activities, use of resources, recovery rates (cluster of symptoms), and the incidence of new medical diagnoses. Data were pooled using a random effects model. The risk of bias was assessed with the Joanna Briggs Institute critical appraisal tool for cohort studies. Results: We included 63 controlled cohort studies, encompassing more than 96 million participants. Based on five studies, we found a reduction in overall quality of life between individuals with confirmed SARS-CoV-2 infection versus controls at six to 24 months follow-up, although heterogeneity was very high (mean difference in EQ-5D scale -5.28 (95% confidence interval -7.88 to 2.68; I Conclusion: Evidence suggests functional impairment after SARS-CoV-2 infection, in addition to a higher use of resources and a higher incidence of widely varying medical diagnoses. These results should be interpreted with caution, considering the high heterogeneity across studies and study limitations related to outcome measurement and attrition of participants. Systematic review registration: Open Science Framework, osf.io/drm39.
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Journal Article
ISSN	2754-0413
ISSN (online)	2754-0413
DOI	10.1136/bmjmed-2023-000723
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Diaphragmatic dysfunction associated with invasive mechanical ventilation in critically ill adult patients

Tocalini, Pablo / Vicente, Antonela / Carballo, Juan Manuel / Garegnani, Luis Ignacio

Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina)

2021 Volume 78, Issue 2, Page(s) 197–206

Abstract: Invasive mechanical ventilation (VMI) is a life support therapy that is not free of complications, such as ventilator induced diaphragmatic dysfunction, which is characterized by atrophy and weakness of the muscle. Interest in this pathology seems to be ... ...

Title translation	[Disfunción diafragmática asociada a la ventilación mecánica invasiva en pacientes adultos críticamente enfermos]
Abstract	Invasive mechanical ventilation (VMI) is a life support therapy that is not free of complications, such as ventilator induced diaphragmatic dysfunction, which is characterized by atrophy and weakness of the muscle. Interest in this pathology seems to be based on the association found with negative clinical results. The prevalence ranges between 29 and 80%, probably due to the variability between the different diagnostic methods and the time of evaluation. The gold standard continues to be the transdiaphragmatic negative pressure generated by the bilateral stimulation of the phrenic nerves, although due to the lack of practicality, diaphragmatic ultrasound began to be used. Although it has several modalities, not all of them have correlation analysis with the gold standard. Another problem arises when analyzing the independent association between pathology and VMI, since confusing factors are not easy to isolate.
MeSH term(s)	Adult ; Critical Illness ; Humans ; Respiration, Artificial ; Retrospective Studies
Language	Spanish
Publishing date	2021-06-28
Publishing country	Argentina
Document type	Journal Article
ZDB-ID	390127-0
ISSN	1853-0605 ; 0014-6722 ; 0301-7281
ISSN (online)	1853-0605
ISSN	0014-6722 ; 0301-7281
DOI	10.31053/1853.0605.v78.n2.28458
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Disfunción diafragmática asociada a la ventilación mecánica invasiva en pacientes adultos críticamente enfermos

Pablo Tocalini / Antonela Vicente / Juan Manuel Carballo / Luis Ignacio Garegnani

Revista de la Facultad de Ciencias Médicas de Córdoba, Vol 78, Iss

2021 Volume 2

Abstract: La ventilación mecánica invasiva (VMI) es una terapia de soporte vital que no está exenta de complicaciones, como la disfunción diafragmática inducida por la ventilación mecánica, que se caracteriza por atrofia y debilidad de dicho musculo. El interés en ...

Abstract	La ventilación mecánica invasiva (VMI) es una terapia de soporte vital que no está exenta de complicaciones, como la disfunción diafragmática inducida por la ventilación mecánica, que se caracteriza por atrofia y debilidad de dicho musculo. El interés en esta patología parece estar basado en la asociación encontrada con resultados clínicos negativos. La prevalencia oscila entre 29 y 80%, probablemente debido a la variabilidad entre los diferentes métodos diagnósticos y el momento de la evaluación. El patrón de oro continúa siendo la presión negativa transdiafragmática generada por la estimulación bilateral de los nervios frénicos, aunque por la falta de practicidad, se comenzó a utilizar la ecografía diafragmática. Si bien cuenta con varias modalidades, no todas tienen análisis de correlación con el patrón de oro. Otra problemática surge al momento de analizar la asociación independiente entre la patología y la VMI, ya que los factores confusores no son sencillos de aislar.
Keywords	mortalidad ; diafragma ; epidemiología ; respiracion artificial ; unidades de cuidados intensivos ; Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Universidad Nacional de Córdoba
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinical trials with sequential analysis that were early-stopped: How to interpret them?

Garegnani, Luis Ignacio / Arancibia, Marcelo / Madrid, Eva / Franco, Juan Víctor Ariel

Medwave

2020 Volume 20, Issue 5, Page(s) e7930

Abstract: Sequential analysis of clinical trials allows researchers a continuous monitoring of emerging data and greater security to avoid subjecting the trial participants to a less effective therapy before the inferiority is evident, while controlling the ... ...

Title translation	Ensayos clínicos con análisis secuencial y su interrupción precoz ¿cómo interpretarlos?
Abstract	Sequential analysis of clinical trials allows researchers a continuous monitoring of emerging data and greater security to avoid subjecting the trial participants to a less effective therapy before the inferiority is evident, while controlling the overall error rate. Although it has been widely used since its development, sequential analysis is not problem-free. Among them main issues to be mentioned are the balance between safety and efficacy, overestimation of the effect size of interventions and conditional bias. In this review, we develop different aspects of this methodology and the impact of including early-stopped clinical trials in systematic reviews with meta-analysis.
MeSH term(s)	Clinical Trials as Topic/methods ; Data Analysis ; Early Termination of Clinical Trials ; Humans ; Meta-Analysis as Topic ; Research Design ; Systematic Reviews as Topic
Language	English
Publishing date	2020-06-05
Publishing country	Chile
Document type	Journal Article ; Review
ZDB-ID	2818022-7
ISSN	0717-6384 ; 0717-6384
ISSN (online)	0717-6384
ISSN	0717-6384
DOI	10.5867/medwave.2020.05.7930
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Rapid reviews: definitions and uses.

Tapia-Benavente, Luis / Vergara-Merino, Laura / Garegnani, Luis Ignacio / Ortiz-Muñoz, Luis / Loézar Hernández, Cristóbal / Vargas-Peirano, Manuel

Medwave

2021 Volume 21, Issue 1, Page(s) e8090

Abstract: This article is the first in a collaborative methodological series of narrative reviews on biostatistics and clinical epidemiology. This review aims to present rapid reviews, compare them with systematic reviews, and mention how they can be used. Rapid ... ...

Title translation	Revisiones rápidas: definiciones y usos.
Abstract	This article is the first in a collaborative methodological series of narrative reviews on biostatistics and clinical epidemiology. This review aims to present rapid reviews, compare them with systematic reviews, and mention how they can be used. Rapid reviews use a methodology like systematic reviews, but through shortcuts applied, they can attain answers in less than six months and with fewer resources. Decision-makers use them in both America and Europe. There is no consensus on which shortcuts have the least impact on the reliability of conclusions, so rapid reviews are heterogeneous. Users of rapid reviews should identify these shortcuts in the methodology and be cautious when interpreting the conclusions, although they generally reach answers concordant with those obtained through a formal systematic review. The principal value of rapid reviews is to respond to health decision-makers needs when the context demands answers in limited time frames.
MeSH term(s)	Biostatistics ; Decision Support Techniques ; Epidemiology ; Europe ; Evidence-Based Medicine ; Humans ; Reproducibility of Results ; Systematic Reviews as Topic
Language	English
Publishing date	2021-01-05
Publishing country	Chile
Document type	Journal Article ; Review
ZDB-ID	2818022-7
ISSN	0717-6384 ; 0717-6384
ISSN (online)	0717-6384
ISSN	0717-6384
DOI	10.5867/medwave.2021.01.8090
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Rapid reviews

Luis Tapia-Benavente / Laura Vergara-Merino / Luis Ignacio Garegnani / Luis Ortiz-Muñoz / Cristóbal Loézar Hernández / Manuel Vargas-Peirano

Medwave, Vol 21, Iss 01, Pp e8090-e

definitions and uses

2021 Volume 8090

Abstract	This article is the first in a collaborative methodological series of narrative reviews on biostatistics and clinical epidemiology. This review aims to present rapid reviews, compare them with systematic reviews, and mention how they can be used. Rapid reviews use a methodology like systematic reviews, but through shortcuts applied, they can attain answers in less than six months and with fewer resources. Decision-makers use them in both America and Europe. There is no consensus on which shortcuts have the least impact on the reliability of conclusions, so rapid reviews are heterogeneous. Users of rapid reviews should identify these shortcuts in the methodology and be cautious when interpreting the conclusions, although they generally reach answers concordant with those obtained through a formal systematic review. The principal value of rapid reviews is to respond to health decision-makers’ needs when the context demands answers in limited time frames
Keywords	evidence- based medicine ; decision support techniques ; review literature as topic ; systematic reviews as topic ; review ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	410
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Medwave Estudios Limitada
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Advocating for evidence-informed decisions to make healthcare fit for each person.

Franco, Juan Victor Ariel / Dwan, Kerry / Garegnani, Luis Ignacio / Kunneman, Marleen / Madrid, Eva / Metzendorf, Maria-Inti / Meza, Nicolás / Nunan, David / Richards, Georgia C / Riganti, Paula / Veroniki, Areti Angeliki

BMJ evidence-based medicine

2022 Volume 27, Issue 2, Page(s) 65–66

MeSH term(s)	Decision Making ; Delivery of Health Care ; Humans
Language	English
Publishing date	2022-03-10
Publishing country	England
Document type	Editorial
ISSN	2515-4478
ISSN (online)	2515-4478
DOI	10.1136/bmjebm-2022-111953
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Patients' participation in government-sponsored guidelines in Latin America: a cross-sectional study.

Garegnani, Luis Ignacio / Meza, Nicolás / Rosón-Rodriguez, Pablo / Escobar-Liquitay, Camila Micaela / Arancibia, Marcelo / Madrid, Eva / Franco, Juan Victor Ariel

BMJ evidence-based medicine

2021 Volume 27, Issue 1, Page(s) 21–26

Abstract: Background: It is recommended that patients actively participate in clinical practice guideline (CPG) development, which allows consideration of their values and preferences and improves adherence to recommendations. The development of CPGs throughout ... ...

Abstract	Background: It is recommended that patients actively participate in clinical practice guideline (CPG) development, which allows consideration of their values and preferences and improves adherence to recommendations. The development of CPGs throughout Latin America is variable and diverse, and the inclusion of patients' participation is unknown. Objectives: To evaluate the methods of patients' participation in government-sponsored CPGs in Latin America, the type of CPG development and the use of Grading of Recommendations, Assessment, Development and Evaluation (GRADE) methods. Design: Cross-sectional study. We included CPGs developed over the last 10 years through a comprehensive hand search in official national government websites and biomedical databases. Main outcome measure: The type of patients' participation was coded according to five predefined categories. We also report the proportion of application of GRADE methods. Results: We included 408 CPGs from 10 countries: 74% (n=303) were de novo development, 13%(n=55) used an adaptation method and 10%(n=41) used both adaptation and de novo methods. Only 45% (n=185) applied the GRADE approach, ranging from 14% (n=12) of CPGs in Brazil to 89% (n=56) of CPGs in Colombia. Only 23% (n=95) of CPGs included at least one method of patients' participation. Mexico was one of the largest CPG producers (100 CPGs), but none included methods of patients' participation; in turn, in countries with lower production of government-sponsored CPGs, patients' participation was found in almost 88%. Guidelines using the GRADE approach were more likely to use methods of patients' participation. These methods were highly variable: 46% (n=44) incorporated patients in the panel, 81% (n=77) searched for evidence about patients' values and preferences, 43% (n=39) used an external review of the draft recommendations by patients, 38% (n=36) used public comments, and 2% included other methods for stakeholders' participation. Conclusion: Only one quarter of government-sponsored CPGs in the Latin American region incorporated a method for patients' participation, which varied considerably across the selected countries. These findings highlight the need to improve CPG development methods to systematically incorporate patients' values and preferences when drafting recommendations.
MeSH term(s)	Cross-Sectional Studies ; Databases, Factual ; Government ; Humans ; Latin America ; Patient Participation
Language	English
Publishing date	2021-03-05
Publishing country	England
Document type	Journal Article
ISSN	2515-4478
ISSN (online)	2515-4478
DOI	10.1136/bmjebm-2020-111530
Database	MEDical Literature Analysis and Retrieval System OnLINE

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