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  1. Article ; Online: Subspecialty referrals and consultation: it's time to partner with primary care paediatricians.

    Harahsheh, Ashraf S

    Cardiology in the young

    2022  , Page(s) 1–4

    Language English
    Publishing date 2022-08-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1078466-4
    ISSN 1467-1107 ; 1047-9511
    ISSN (online) 1467-1107
    ISSN 1047-9511
    DOI 10.1017/S1047951122002578
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  2. Article ; Online: Kawasaki Disease Outcomes: It's Not Just the Heart!

    Harahsheh, Ashraf S

    Hospital pediatrics

    2022  Volume 12, Issue 3, Page(s) e110–e112

    MeSH term(s) Humans ; Mucocutaneous Lymph Node Syndrome/diagnosis ; Mucocutaneous Lymph Node Syndrome/therapy
    Language English
    Publishing date 2022-01-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2154-1671
    ISSN (online) 2154-1671
    DOI 10.1542/hpeds.2021-006466
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  3. Article ; Online: Empowering pediatric providers more: mastering management of common complaints.

    Harahsheh, Ashraf S / Hamburger, Ellen K / de Winter, J Peter

    European journal of pediatrics

    2023  Volume 182, Issue 11, Page(s) 4767–4770

    MeSH term(s) Humans ; Power, Psychological ; Pediatricians
    Language English
    Publishing date 2023-08-17
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 194196-3
    ISSN 1432-1076 ; 0340-6199 ; 0943-9676
    ISSN (online) 1432-1076
    ISSN 0340-6199 ; 0943-9676
    DOI 10.1007/s00431-023-05158-y
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  4. Article ; Online: Trisomy 13, Large Ventricular Septal Defect With Failure to Thrive: Family Wishes to Have Complete Repair.

    Harahsheh, Ashraf S / Cohen, Meryl S

    The Annals of thoracic surgery

    2020  Volume 108, Issue 5, Page(s) 1278–1280

    MeSH term(s) Attitude to Health ; Bioethical Issues ; Cardiac Surgical Procedures/ethics ; Clinical Decision-Making/ethics ; Decision Making, Shared ; Failure to Thrive/complications ; Family/psychology ; Heart Septal Defects, Ventricular/complications ; Heart Septal Defects, Ventricular/surgery ; Humans ; Infant ; Male ; Trisomy 13 Syndrome/complications ; Trisomy 13 Syndrome/surgery
    Language English
    Publishing date 2020-01-14
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2019.06.001
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  5. Article ; Online: Cardiac Effects of COVID-19 Infection, MIS-C, and the Vaccine in Infants and Children: What Is Known and Future Implications.

    Schwartz, Bryanna N / Harahsheh, Ashraf S / Krishnan, Anita / Martin, Gerard R

    American journal of perinatology

    2022  Volume 39, Issue S 01, Page(s) S1–S6

    Abstract: The cardiac effects of novel coronavirus disease 2019 (COVID-19) infection on the pediatric heart has become an area of particular interest as elevated cardiac enzymes and abnormalities on echocardiogram and electrocardiogram were seen in a portion of ... ...

    Abstract The cardiac effects of novel coronavirus disease 2019 (COVID-19) infection on the pediatric heart has become an area of particular interest as elevated cardiac enzymes and abnormalities on echocardiogram and electrocardiogram were seen in a portion of children affected by the virus. In this article, we review the cardiac manifestations of acute COVID-19 infection, multisystem inflammatory syndrome in children, and postvaccine myocarditis. The limited research on the effects of COVID-19 on neonates and infants is also reported. KEY POINTS: · Cardiac involvement from MIS-C is much higher than the risk of COVID-19 vaccine-induced myocarditis.. · Neonates and infants have overall been less affected by COVID-19 than adults and older children.. · At this point in time, there is limited research on the cardiac effects of COVID-19 in neonates..
    MeSH term(s) Adult ; Infant, Newborn ; Child ; Infant ; Humans ; Adolescent ; COVID-19 ; COVID-19 Vaccines ; Myocarditis ; Vaccines
    Chemical Substances COVID-19 Vaccines ; Vaccines
    Language English
    Publishing date 2022-10-28
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 605671-4
    ISSN 1098-8785 ; 0735-1631
    ISSN (online) 1098-8785
    ISSN 0735-1631
    DOI 10.1055/s-0042-1757238
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  6. Article: Short-term Cardiovascular Complications of Multi-system Inflammatory Syndrome in Children (MIS-C) in Adolescents and Children.

    Hejazi, Omar I / Loke, Yue-Hin / Harahsheh, Ashraf S

    Current pediatrics reports

    2021  Volume 9, Issue 4, Page(s) 93–103

    Abstract: Purpose of review: We provide the readers with a review of cardiac complications in children with multi-system inflammatory syndrome in children (MIS-C) and its short-term outcomes.: Recent findings: Recent reports described the acute cardiac ... ...

    Abstract Purpose of review: We provide the readers with a review of cardiac complications in children with multi-system inflammatory syndrome in children (MIS-C) and its short-term outcomes.
    Recent findings: Recent reports described the acute cardiac manifestations of MIS-C in children and provided a glimpse of the short-term outcomes.
    Summary: Children with MIS-C have been reported to acutely have variable degrees of cardiac findings including abnormal cardiac enzymes, abnormal electrocardiographs, decreased systolic function, coronary artery abnormalities from coronary dilation to giant aneurysms, mitral valve regurgitation, tricuspid valve regurgitation, aortic valve insufficiency, pericardial effusion, diastolic dysfunction, abnormal cardiac strain, and abnormal cardiac MRI. The majority of these abnormalities resolved during short-term follow-up. Further studies are needed to assess if transient or persistent cardiac complications are associated with long-term adverse cardiac events in children with MIS-C.
    Supplementary information: The online version contains supplementary material available at 10.1007/s40124-021-00258-5.
    Language English
    Publishing date 2021-10-22
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 2167-4841
    ISSN 2167-4841
    DOI 10.1007/s40124-021-00258-5
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  7. Article ; Online: Multisystem inflammatory syndrome in children: Is there a linkage to Kawasaki disease?

    Loke, Yue-Hin / Berul, Charles I / Harahsheh, Ashraf S

    Trends in cardiovascular medicine

    2020  Volume 30, Issue 7, Page(s) 389–396

    Abstract: Since 1967, researches have hunted for an etiology for Kawasaki Disease (KD). Meanwhile, the 2019 Coronavirus Disease (COVID-19) pandemic has produced a strange new illness termed multisystem inflammatory syndrome in children (MIS-C) and raised hopes ... ...

    Abstract Since 1967, researches have hunted for an etiology for Kawasaki Disease (KD). Meanwhile, the 2019 Coronavirus Disease (COVID-19) pandemic has produced a strange new illness termed multisystem inflammatory syndrome in children (MIS-C) and raised hopes that a cause for KD may be identified. This current review paper discusses KD and its potential connection to pediatric COVID-19 and MIS-C illness.
    MeSH term(s) COVID-19 ; Child ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Diagnosis, Differential ; Female ; Humans ; Incidence ; Male ; Mucocutaneous Lymph Node Syndrome/diagnosis ; Mucocutaneous Lymph Node Syndrome/epidemiology ; Pandemics/prevention & control ; Pandemics/statistics & numerical data ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Risk Assessment ; Systemic Inflammatory Response Syndrome/diagnosis ; Systemic Inflammatory Response Syndrome/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-07-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1097434-9
    ISSN 1873-2615 ; 1050-1738
    ISSN (online) 1873-2615
    ISSN 1050-1738
    DOI 10.1016/j.tcm.2020.07.004
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    Zs.A 3419: Show issues Location:
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  8. Article: Cardiac Effects of COVID-19 Infection, MIS-C, and the Vaccine in Infants and Children: What Is Known and Future Implications

    Schwartz, Bryanna N. / Harahsheh, Ashraf S. / Krishnan, Anita / Martin, Gerard R.

    American Journal of Perinatology

    2022  Volume 39, Issue S 01, Page(s) S1–S6

    Abstract: The cardiac effects of novel coronavirus disease 2019 (COVID-19) infection on the pediatric heart has become an area of particular interest as elevated cardiac enzymes and abnormalities on echocardiogram and electrocardiogram were seen in a portion of ... ...

    Abstract The cardiac effects of novel coronavirus disease 2019 (COVID-19) infection on the pediatric heart has become an area of particular interest as elevated cardiac enzymes and abnormalities on echocardiogram and electrocardiogram were seen in a portion of children affected by the virus. In this article, we review the cardiac manifestations of acute COVID-19 infection, multisystem inflammatory syndrome in children, and postvaccine myocarditis. The limited research on the effects of COVID-19 on neonates and infants is also reported.
    Key Points: Cardiac involvement from MIS-C is much higher than the risk of COVID-19 vaccine-induced myocarditis. Neonates and infants have overall been less affected by COVID-19 than adults and older children. At this point in time, there is limited research on the cardiac effects of COVID-19 in neonates.
    Keywords pediatric cardiology ; COVID-19 ; multisystem inflammatory syndrome in children ; MIS-N ; COVID-19 myocarditis
    Language English
    Publishing date 2022-10-28
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 605671-4
    ISSN 1098-8785 ; 0735-1631
    ISSN (online) 1098-8785
    ISSN 0735-1631
    DOI 10.1055/s-0042-1757238
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  9. Article ; Online: SARS-CoV-2 Variants and Multisystem Inflammatory Syndrome in Children.

    McCrindle, Brian W / Harahsheh, Ashraf S / Handoko, Ryan / Raghuveer, Geetha / Portman, Michael A / Khoury, Michael / Newburger, Jane W / Lee, Simon / Jain, Supriya S / Khare, Manaswitha / Dahdah, Nagib / Manlhiot, Cedric

    The New England journal of medicine

    2023  Volume 388, Issue 17, Page(s) 1624–1626

    MeSH term(s) Child ; Humans ; COVID-19/complications ; COVID-19/virology ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome/diagnosis ; Systemic Inflammatory Response Syndrome/etiology ; Systemic Inflammatory Response Syndrome/virology
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2215074
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  10. Article ; Online: Impact of protein-losing enteropathy in children who underwent the Fontan operation.

    Alkofair, Baneen / Alruwaili, Abdulmajeed / Gai, Jiaxiang / Harahsheh, Ashraf S

    Cardiology in the young

    2020  Volume 30, Issue 9, Page(s) 1273–1280

    Abstract: Previous reports have identified risk factors associated with development of post-Fontan protein-losing enteropathy. Less is known about the economic impact and resource utilisation required for post-Fontan protein-losing enteropathy in the current era. ... ...

    Abstract Previous reports have identified risk factors associated with development of post-Fontan protein-losing enteropathy. Less is known about the economic impact and resource utilisation required for post-Fontan protein-losing enteropathy in the current era. We conducted a single-centre retrospective study to assess the impact of post-Fontan protein-losing enteropathy on transplant-free survival. We also described resource utilisation and treatment variations among post-Fontan protein-losing enteropathy patients. Children who received care at our centre between 2009 and 2017 after the Fontan surgery were eligible. Initial admissions for the Fontan operative procedure were excluded. Demographics, hospital admissions, resource utilisation, medications and charges were reviewed. Patients were divided into two groups based on the presence of post-Fontan protein-losing enteropathy. Of the 343 patients screened, 147 met the eligibility criteria. Of these, 28 (19%) developed protein-losing enteropathy. After adjusting for follow-up duration, the protein-losing enteropathy group had higher number of encounters (2.15 ± 2.16 versus 1.47 ± 2.56, p 0.002), hospital length of stay (days) (25 ± 51.3 versus 11.4 ± 41.7, p < 0.0001) and total charges (2018US$) (388,489 ± 759,859 versus 202,725 ± 1,076,625, p < 0.0001). Encounters for patients with protein-losing enteropathy utilised more therapies. Among those with protein-losing enteropathy, use of digoxin was associated with slightly decreased odds for mortality and/or transplant (0.95, confidence interval 0.90-0.99, p 0.021). The 10-year transplant-free survival for patients with/without protein-losing enteropathy was 65.7/97.3% (p 0.002), respectively. Post-Fontan protein-losing enteropathy is associated with reduced 10-year transplant-free survival, higher resource utilisation, charges and medication use compared with the non-protein-losing enteropathy group. Practice variation among post-Fontan protein-losing-enteropathy patients is common. Further larger studies are needed to assess the impact of standardisation on the well-being of children with post-Fontan protein-losing enteropathy.
    MeSH term(s) Child ; Fontan Procedure/adverse effects ; Heart Defects, Congenital/surgery ; Humans ; Postoperative Complications ; Protein-Losing Enteropathies/epidemiology ; Protein-Losing Enteropathies/etiology ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2020-07-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1078466-4
    ISSN 1467-1107 ; 1047-9511
    ISSN (online) 1467-1107
    ISSN 1047-9511
    DOI 10.1017/S1047951120001985
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