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  1. Article ; Online: Missing links in pressure ulcer research--an interdisciplinary overview.

    Olesen, Christian Gammelgaard / de Zee, Mark / Rasmussen, John

    Journal of applied physiology (Bethesda, Md. : 1985)

    2010  Volume 108, Issue 6, Page(s) 1458–1464

    Abstract: This paper surveys the literature on the etiology of sitting-acquired deep tissue pressure ulcers from three different viewpoints. The first viewpoint is identification of risk factors related to seated posture. The second viewpoint focuses on the ... ...

    Abstract This paper surveys the literature on the etiology of sitting-acquired deep tissue pressure ulcers from three different viewpoints. The first viewpoint is identification of risk factors related to seated posture. The second viewpoint focuses on the external factors that can cause necrosis to human cells, such as ischemia and compression. The third viewpoint focuses on computational models of the human buttocks to calculate where stress concentrations occur. Each viewpoint contributes to the understanding of pressure ulcer etiology, but in combination they cover the multiple scales from cell to organism, and the combined insight can provide important information toward a full understanding of the phenomenon. It is concluded that the following three questions must be answered by future research. 1) Does compressive stress alone explain cell death, or is it necessary to consider the full three-dimensional strain tensor in the tissues? 2) How does the change in posture-induced load applied on the human buttocks change the stress distribution in the deep muscle tissue? 3) Is it possible to optimize the seated posture in a computational model to reduce the deeper tissue loads?
    MeSH term(s) Animals ; Biomedical Research/trends ; Humans ; Models, Biological ; Pressure Ulcer/etiology ; Pressure Ulcer/pathology ; Pressure Ulcer/physiopathology ; Spinal Cord Injuries/complications ; Spinal Cord Injuries/pathology ; Spinal Cord Injuries/physiopathology
    Language English
    Publishing date 2010-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
    ISSN (online) 1522-1601
    ISSN 0021-8987 ; 0161-7567 ; 8750-7587
    DOI 10.1152/japplphysiol.01006.2009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Elliptical posts allow for detailed control of non-equibiaxial straining of cell cultures.

    Olesen, Christian Gammelgaard / Pennisi, Christian Pablo / de Zee, Mark / Zachar, Vladimir / Rasmussen, John

    Journal of tissue viability

    2013  Volume 22, Issue 2, Page(s) 52–56

    Abstract: Background: A modification of the Flexcell system that allows imposition of homogenous, controlled non-equibiaxial strains to cell cultures is developed and experimentally validated. The Flexcell system by default applies equibiaxial strain to cell ... ...

    Abstract Background: A modification of the Flexcell system that allows imposition of homogenous, controlled non-equibiaxial strains to cell cultures is developed and experimentally validated. The Flexcell system by default applies equibiaxial strain to cell cultures, meaning no shear strain, while soft tissue cells in vivo are subjected to a range of mechanical deformations including shear strain caused by activities of daily living. Shear strains are suspected to play an important role in tissue necrosis.
    Method: The Flexcell system was redesigned using a finite element model in order to obtain large areas of the membrane in a controlled, uniform non-equibiaxial strain state.
    Results: The redesign was manufactured and the resulting strains were experimentally validated by means of image analysis methods. The results showed that the system could be used for experiments varying the shear strain.
    Conclusion: The result allows scientists and experimentalists to apply detailed control of the strain tensor applied to tissue samples in two dimensions.
    MeSH term(s) Cell Culture Techniques/instrumentation ; Cell Culture Techniques/methods ; Fibroblasts/cytology ; Fibroblasts/physiology ; Finite Element Analysis ; Humans ; Pressure Ulcer/pathology ; Pressure Ulcer/physiopathology ; Stress, Mechanical
    Language English
    Publishing date 2013-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1282604-2
    ISSN 0965-206X
    ISSN 0965-206X
    DOI 10.1016/j.jtv.2013.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Is a computer-based measurement method superior to a recommended manual method by the ROHO(®) Group to assess pressure in the sitting position?

    Andreasen, Jane / Olesen, Christian Gammelgaard / Rasmussen, John / Nielsen, Susanne Kaasgaard / Nguyen, Lone / Larsen, Peter

    Australian occupational therapy journal

    2013  Volume 60, Issue 5, Page(s) 350–355

    Abstract: Background: In clinical practice, a manual-based assessment is standard procedure to adjust the air pressure in the ROHO(®) cushion in seated position. Recently, a computerized pressure system method was developed to support the clinical adjustment of ... ...

    Abstract Background: In clinical practice, a manual-based assessment is standard procedure to adjust the air pressure in the ROHO(®) cushion in seated position. Recently, a computerized pressure system method was developed to support the clinical adjustment of air in the ROHO(®) cushion to reduce the pressure in the seated position. To our knowledge, no studies have investigated the reliability between the manual method mostly used in clinical practice and the alternative computer-based assessment of the pressure in the seated position.
    Aim: The objective was to test intra-tester and inter-tester reliability and evaluate if a computer-based measurement method is superior to a manual method to reduce pressure in the seated position. The cushion used was a Roho Quadtro select(®) high profile.
    Methods: An intra-tester and inter-tester reliability study was conducted in 2010 at the Department of Occupational Therapy and Physiotherapy, Aalborg Hospital, Aarhus University Hospital, Denmark. Subjects included were two occupational therapists and 20 healthy subjects. The outcome measures were obtained using a pressure imaging system that could register pressure distribution in the sitting area.
    Results: The study did not show high intra-class correlation coefficients neither in the intra-tester nor in the inter-tester reliability for manual or computer-based methods in reducing pressure in the seating position.
    Conclusions: The current company-recommended air pressure adjustment procedure seems unreliable. The technical superiority of the computer-based method over the manual method has not been established.
    MeSH term(s) Adult ; Biomechanical Phenomena ; Computers ; Female ; Humans ; Male ; Middle Aged ; Observer Variation ; Occupational Therapy/instrumentation ; Occupational Therapy/methods ; Posture/physiology ; Pressure Ulcer/physiopathology ; Pressure Ulcer/prevention & control ; Reproducibility of Results
    Language English
    Publishing date 2013-10
    Publishing country Australia
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604554-6
    ISSN 1440-1630 ; 0045-0766
    ISSN (online) 1440-1630
    ISSN 0045-0766
    DOI 10.1111/j.1440-1630.2012.01024.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Uniaxial cyclic strain drives assembly and differentiation of skeletal myocytes.

    Pennisi, Cristian Pablo / Olesen, Christian Gammelgaard / de Zee, Mark / Rasmussen, John / Zachar, Vladimir

    Tissue engineering. Part A

    2011  Volume 17, Issue 19-20, Page(s) 2543–2550

    Abstract: Ex vivo engineering of skeletal muscle represents an exciting new area of biotechnology. Although the ability of skeletal muscle cells to sense and respond to mechanical forces is well known, strategies based on the use of mechanical stimuli to optimize ... ...

    Abstract Ex vivo engineering of skeletal muscle represents an exciting new area of biotechnology. Although the ability of skeletal muscle cells to sense and respond to mechanical forces is well known, strategies based on the use of mechanical stimuli to optimize myogenesis in vitro remain limited. In this work, we describe a simple but powerful method based on uniaxial cyclic tensile strain (CTS) to induce assembly and differentiation of skeletal myocytes in vitro. Confluent mouse myoblastic precursors cultured on flexible-bottomed culture plates were subjected to either uniaxial or equibiaxial CTS. The uniaxial CTS protocol resulted in a highly aligned array of cross-striated fibers, with the major axis of most cells aligned perpendicularly to the axis of strain. In addition, a short period of myogenin activation and significant increase in the myotube/myoblast ratio and percentage of myosin-positive myotubes was found, indicating an enhanced cell differentiation. In contrast, cells under equibiaxial strain regimen had no clear orientation and displayed signs of membrane damage and impaired differentiation. These results, thus, demonstrate that the selection of a proper paradigm is a key element when discussing the relevance of mechanical stimulation for myogenesis in vitro. This study provides a rational framework to optimize engineering of functional skeletal muscle.
    MeSH term(s) Animals ; Cell Differentiation ; Cell Line ; Cell Shape ; Mice ; Muscle Fibers, Skeletal/cytology ; Muscle Fibers, Skeletal/metabolism ; Stress, Mechanical
    Language English
    Publishing date 2011-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2420582-5
    ISSN 1937-335X ; 1937-3341
    ISSN (online) 1937-335X
    ISSN 1937-3341
    DOI 10.1089/ten.TEA.2011.0089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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