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  1. Book: Handbook of transcription factor NF-kappaB

    Ghosh, Sankar

    2007  

    Title variant Transcription factor NF-kappaB
    Author's details ed. by Sankar Ghosh
    Keywords NF-kappa B
    Language English
    Size 232 S. : Ill., graph. Darst.
    Publisher CRC Press
    Publishing place Boca Raton, Fla. u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT014860731
    ISBN 0-8493-2794-6 ; 978-0-8493-2794-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 A 255 order for loan Magazin

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  2. Book: NF-KappaB

    Hayden, Matthew S. / Ghosh, Sankar

    (Immunological reviews ; 246)

    2012  

    Title variant NF-KB
    Author's details Matthew S. Hayden & Sankar Ghosh, guest ed
    Series title Immunological reviews ; 246
    Collection
    Language English
    Size 400 S. : Ill.
    Publisher Wiley-Blackwell
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT017434952
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 160 -246- verfügbar in Königswinter Königswinter

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  3. Book ; Online ; E-Book: DNA Barcoding and Molecular Phylogeny

    Trivedi, Subrata / Rehman, Hasibur / Saggu, Shalini / Panneerselvam, Chellasamy / Ghosh, Sankar K.

    2020  

    Abstract: This book presents a comprehensive overview of DNA barcoding and molecular phylogeny, along with a number of case studies. It discusses a number of areas where DNA barcoding can be applied, such as clinical microbiology, especially in relation to ... ...

    Author's details edited by Subrata Trivedi, Hasibur Rehman, Shalini Saggu, Chellasamy Panneerselvam, Sankar K. Ghosh
    Abstract This book presents a comprehensive overview of DNA barcoding and molecular phylogeny, along with a number of case studies. It discusses a number of areas where DNA barcoding can be applied, such as clinical microbiology, especially in relation to infection management; DNA database management; and plant -animal interactions, and also presents valuable information on the DNA barcoding and molecular phylogeny of microbes, algae, elasmobranchs, fishes, birds and ruminant mammals. Furthermore it features unique case studies describing DNA barcoding of reptiles dwelling in Saudi Arabian deserts, genetic variation studies in both wild and hatchery populations of Anabas testudineus, DNA barcoding and molecular phylogeny of Ichthyoplankton and juvenile fishes of Kuantan River in Malaysia, and barcoding and molecular phylogenetic analysis of indigenous bacteria from fishes dwelling in a tropical tidal river. Moreover, since prompt identification and management of invasive species is vital to prevent economic and ecological loss, the book includes a chapter on DNA barcoding of invasive species. Given its scope, this book will appeal not only to researchers, teachers and students around the globe, but also to general readers.
    Keywords Animal systematics ; Animal taxonomy ; Plant genetics ; Animal genetics ; Microbial genetics ; Microbial genomics ; Animal Systematics/Taxonomy/Biogeography ; Plant Genetics and Genomics ; Animal Genetics and Genomics ; Microbial Genetics and Genomics ; Codi genètic ; Cladística
    Subject code 614.1
    Language English
    Size 1 online resource (vi, 267 pages) :, illustrations
    Edition 2nd ed. 2020.
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-50075-6 ; 3-030-50074-8 ; 978-3-030-50075-7 ; 978-3-030-50074-0
    DOI 10.1007/978-3-030-50075-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: The Intricate Notch Signaling Dynamics in Therapeutic Realms of Cancer.

    Sen, Plaboni / Ghosh, Siddhartha Sankar

    ACS pharmacology & translational science

    2023  Volume 6, Issue 5, Page(s) 651–670

    Abstract: The Notch pathway is remarkably simple without the interventions of secondary messengers. It possesses a unique receptor-ligand interaction that imparts signaling upon cleavage of the receptor followed by the nuclear localization of its cleaved ... ...

    Abstract The Notch pathway is remarkably simple without the interventions of secondary messengers. It possesses a unique receptor-ligand interaction that imparts signaling upon cleavage of the receptor followed by the nuclear localization of its cleaved intracellular domain. It is found that the transcriptional regulator of the Notch pathway lies at the intersection of multiple signaling pathways that enhance the aggressiveness of cancer. The preclinical and clinical evidence supports the pro-oncogenic function of Notch signaling in various tumor subtypes. Owing to its oncogenic role, the Notch signaling pathway assists in enhanced tumorigenesis by facilitating angiogenesis, drug resistance, epithelial to mesenchymal transition, etc., which is also attributed to the poor outcome in patients. Therefore, it is extremely vital to discover a suitable inhibitor to downregulate the signal-transducing ability of Notch. The Notch inhibitory agents, such as receptor decoys, protease (ADAM and γ-secretase) inhibitors, and monoclonal/bispecific antibodies, are being investigated as candidate therapeutic agents. Studies conducted by our group exemplify the promising results in ablating tumorigenic aggressiveness by inhibiting the constituents of the Notch pathway. This review deals with the detailed mechanism of the Notch pathways and their implications in various malignancies. It also bestows us with the recent therapeutic advances concerning Notch signaling in the context of monotherapy and combination therapy.
    Language English
    Publishing date 2023-05-03
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2575-9108
    ISSN (online) 2575-9108
    DOI 10.1021/acsptsci.2c00239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: γ-Secretase Inhibitor Potentiates the Activity of Suberoylanilide Hydroxamic Acid by Inhibiting Its Ability to Induce Epithelial to Mesenchymal Transition and Stemness via Notch Pathway Activation in Triple-Negative Breast Cancer Cells.

    Sen, Plaboni / Ghosh, Siddhartha Sankar

    ACS pharmacology & translational science

    2023  Volume 6, Issue 10, Page(s) 1396–1415

    Abstract: Histone deacetylase inhibitors, such as suberoylanilide hydroxamic acid (SAHA), possess great therapeutic value for triple-negative breast cancer patients. However, their inherent ability to induce epithelial to mesenchymal transition in various ... ...

    Abstract Histone deacetylase inhibitors, such as suberoylanilide hydroxamic acid (SAHA), possess great therapeutic value for triple-negative breast cancer patients. However, their inherent ability to induce epithelial to mesenchymal transition in various malignancies has been of greater concern. Herein, we hypothesize that SAHA facilitates epithelial to mesenchymal transition (EMT) via activation of the Notch pathway. From the literature survey, it is evident that histone deacetylase mediates the formation of the co-repressor complex upon interacting with the DNA binding domain, thereby inhibiting the transcription of the Notch downstream genes. Hence, we hypothesize that the use of SAHA facilitates the transcriptional activation of the Notch target genes, by disrupting the co-repressor complex and recruiting the coactivator complex, thereby facilitating EMT. In this study, we have observed that SAHA upregulates the expression profile of the Notch downstream proteins (such as Notch intracellular domain, Hes-1, c-Myc, etc.) and the Notch ligands (such as Jagged-1 and Jagged-2), thereby aberrantly activating the signaling pathway. Therefore, we have focused on combination therapy using a γ-secretase inhibitor LY411575 that would enhance the efficacy of SAHA by blocking the canonical Notch pathway mediated via its intracellular domain. It was observed that co-treatment significantly mediates apoptosis, generates cellular reactive oxygen species, depolarizes mitochondria, and diminishes the stemness properties. Besides, it also mediates autophagy-independent cell death and diminishes the expression of inflammatory cytokines, along with the downregulation in the expression of the Notch downstream genes and mesenchymal markers. Altogether, our study provides a mechanistic basis for combating EMT potentiated by SAHA, which could be utilized as a rational strategy for the treatment of solid tumors, especially triple-negative breast cancer.
    Language English
    Publishing date 2023-09-05
    Publishing country United States
    Document type Journal Article
    ISSN 2575-9108
    ISSN (online) 2575-9108
    DOI 10.1021/acsptsci.3c00099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Engineered Hybrid Nanosystem for Homologous Targeting of EMT Induced Triple Negative Breast Cancer Cells.

    Saha, Muktashree / Ghosh, Siddhartha Sankar

    ACS applied bio materials

    2023  Volume 6, Issue 2, Page(s) 681–693

    Abstract: The increased mortality rate due to metastatic breast cancer with poor prognosis has raised concern over its effective therapy. Though various therapies and anticancer drugs have been approved, there is still a lack in the targeting of metastatic triple ... ...

    Abstract The increased mortality rate due to metastatic breast cancer with poor prognosis has raised concern over its effective therapy. Though various therapies and anticancer drugs have been approved, there is still a lack in the targeting of metastatic triple negative breast cancer (TNBC). We have developed a hybrid nanosystem that was synthesized by fusing exosomes from MCF-7 cells and nanovesicles from the MDA MB-231 cells that would be targeted. The developed nanosystem was characterized by various techniques like Western blotting, AFM, FETEM, DLS, CD, and fluorescence spectroscopy. The hybrid system was used for the delivery of an HDAC inhibitor, Trichostatin A (TSA), in combination with lapatinib (a tyrosine kinase inhibitor) for cotherapy of epithelial to mesenchymal transition (EMT) induced TNBC. This targeted cotherapy module had higher efficiency and effectivity in the reduction of metastatic ability and proliferation of EMT induced MDA MB-231 cells as compared to free inhibitor treatment or untargeted cotherapy. Reduction in the expression of the Wnt/β-catenin signaling pathway molecules like β-catenin (by 0.7 fold), Gsk3β (by 0.6 fold), and pGsk-3β (0.3 fold) was observed upon treatment. This subsequently resulted in the suppression of EMT markers, thereby resulting in reversing EMT to MET and suppressing metastatic breast cancer.
    MeSH term(s) Humans ; Epithelial-Mesenchymal Transition ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/metabolism ; Cell Line, Tumor ; Wnt Signaling Pathway ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2576-6422
    ISSN (online) 2576-6422
    DOI 10.1021/acsabm.2c00925
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Spin-Flip via Subtle Electronic Perturbation in Axially Ligated Diiron(III) Porphyrin Dimer.

    Chakraborty, Paulami / Ghosh, Niva / Awasthi, Nidhi / Rath, Sankar Prasad

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2024  , Page(s) e202400266

    Abstract: Spin state switching in the metal center is a crucial phenomenon in many enzymatic reactions in biology. The spin state alteration, a critical step in cytochrome P450 catalysis, is driven most likely through a weak perturbation upon substrate binding in ... ...

    Abstract Spin state switching in the metal center is a crucial phenomenon in many enzymatic reactions in biology. The spin state alteration, a critical step in cytochrome P450 catalysis, is driven most likely through a weak perturbation upon substrate binding in the enzyme, which is still not well clarified. In the current work, the spin state transition of iron(III) from high to intermediate via an admixed state is observed upon a subtle electronic perturbation to the sulphonate moieties coordinated axially to a diiron(III)porphyrin dimer. While electron-donating substituents stabilize the high-spin state of iron(III), strongly electron-withdrawing groups stabilize an intermediate-spin state, whereas the moderate electron-withdrawing nature of axial ligands resulted in an admixed state. Confirmation of the molecular structures and their spin states have been made utilizing single-crystal X-ray structure analysis, Mössbauer, magnetic, EPR, and
    Language English
    Publishing date 2024-02-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202400266
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Functional Implications of Intergenic GWAS SNPs in Immune-Related LncRNAs.

    Castellanos-Rubio, Ainara / Ghosh, Sankar

    Advances in experimental medicine and biology

    2022  Volume 1363, Page(s) 147–160

    Abstract: Genome wide association studies (GWAS) have identified many loci contributing to genetic variation of complex traits. Immune mediated disorders are complex diseases for which hundreds of risk alleles have been identified by GWAS. However, the intergenic ... ...

    Abstract Genome wide association studies (GWAS) have identified many loci contributing to genetic variation of complex traits. Immune mediated disorders are complex diseases for which hundreds of risk alleles have been identified by GWAS. However, the intergenic location of most of the signals has make it difficult to decipher their implication in disease pathogenesis. A significant number of immune disease-associated SNPs are located within long noncoding RNAs (lncRNAs). LncRNAs have gained importance due to their involvement in the regulation of a wide range of biological processes, including immune responses. GWAS SNPs located within lncRNAs can affect their regulatory capacity by modifying their secondary structure, altering their expression levels or regulating the transcription of different isoforms. In this review we discuss the functional implications of immune-related lncRNAs harboring disease associated SNPs on various disease conditions.
    MeSH term(s) Alleles ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Polymorphism, Single Nucleotide ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism
    Chemical Substances RNA, Long Noncoding
    Language English
    Publishing date 2022-02-26
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-92034-0_8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A standardized protocol for genetically stable artificial seed production of Ficus religiosa L. using ISSR fingerprinting.

    Kader, Abdul / Sinha, Sankar Narayan / Ghosh, Parthadeb

    Journal of applied genetics

    2023  Volume 64, Issue 2, Page(s) 275–287

    Abstract: Ficus religiosa LQuery. has several ornamental, medicinal, and economical applications. The in vivo propagation of this species has shown various limitations. Due to this reason, the present study efforts on genetically uniform artificial seed production ...

    Abstract Ficus religiosa LQuery. has several ornamental, medicinal, and economical applications. The in vivo propagation of this species has shown various limitations. Due to this reason, the present study efforts on genetically uniform artificial seed production from in vitro developed shoot tips of this species. The in vivo shoot tips were cultivated on Murashige and Skoog (MS) media containing different growth regulators. The maximum shoot response (93.67%) and the longest shoot length (3.85 cm) were exhibited with 0.5 mg L
    MeSH term(s) Ficus ; Seeds
    Language English
    Publishing date 2023-03-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1235302-4
    ISSN 2190-3883 ; 1234-1983
    ISSN (online) 2190-3883
    ISSN 1234-1983
    DOI 10.1007/s13353-023-00754-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Einzelsign.: Show issues

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  10. Article ; Online: Living Gut Bacteria Functionalized with Gold Nanoclusters and Drug for Facile Cancer Theranostics.

    Debasmita, Debashree / Ghosh, Siddhartha Sankar / Chattopadhyay, Arun

    ACS applied bio materials

    2023  Volume 6, Issue 2, Page(s) 628–639

    Abstract: Bacbots are potent self-propelling vehicles for targeted therapy that can be guided by chemical and biochemical stimuli of the host. In addition, they can be guided externally by the use of magnetic field or other physical forces. The challenge is to ... ...

    Abstract Bacbots are potent self-propelling vehicles for targeted therapy that can be guided by chemical and biochemical stimuli of the host. In addition, they can be guided externally by the use of magnetic field or other physical forces. The challenge is to incorporate drugs and diagnostic tools in living bacteria with retention of theranostic activity until reaching the targets and easy clearance of the remainder following the treatment. We report that living
    MeSH term(s) Humans ; Precision Medicine ; Gold ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; HeLa Cells ; Bacteria ; Neoplasms
    Chemical Substances Gold (7440-57-5) ; Antineoplastic Agents
    Language English
    Publishing date 2023-01-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2576-6422
    ISSN (online) 2576-6422
    DOI 10.1021/acsabm.2c00911
    Database MEDical Literature Analysis and Retrieval System OnLINE

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