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  1. Article ; Online: How Nurses Can Educate the "Thoughtless Person Playing with Penicillin".

    Escobar, Daniel J / Pegues, David A

    Joint Commission journal on quality and patient safety

    2020  Volume 46, Issue 11, Page(s) 605–607

    MeSH term(s) Humans ; Nurses ; Penicillins
    Chemical Substances Penicillins
    Language English
    Publishing date 2020-09-28
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 1189890-2
    ISSN 1938-131X ; 1549-425X ; 1553-7250 ; 1070-3241 ; 1549-3741
    ISSN (online) 1938-131X ; 1549-425X
    ISSN 1553-7250 ; 1070-3241 ; 1549-3741
    DOI 10.1016/j.jcjq.2020.09.012
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    Zs.B 2055: Show issues Location:
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  2. Article ; Online: Transmission risk of Oropouche fever across the Americas.

    Romero-Alvarez, Daniel / Escobar, Luis E / Auguste, Albert J / Del Valle, Sara Y / Manore, Carrie A

    Infectious diseases of poverty

    2023  Volume 12, Issue 1, Page(s) 47

    Abstract: Background: Vector-borne diseases (VBDs) are important contributors to the global burden of infectious diseases due to their epidemic potential, which can result in significant population and economic impacts. Oropouche fever, caused by Oropouche virus ( ...

    Abstract Background: Vector-borne diseases (VBDs) are important contributors to the global burden of infectious diseases due to their epidemic potential, which can result in significant population and economic impacts. Oropouche fever, caused by Oropouche virus (OROV), is an understudied zoonotic VBD febrile illness reported in Central and South America. The epidemic potential and areas of likely OROV spread remain unexplored, limiting capacities to improve epidemiological surveillance.
    Methods: To better understand the capacity for spread of OROV, we developed spatial epidemiology models using human outbreaks as OROV transmission-locality data, coupled with high-resolution satellite-derived vegetation phenology. Data were integrated using hypervolume modeling to infer likely areas of OROV transmission and emergence across the Americas.
    Results: Models based on one-support vector machine hypervolumes consistently predicted risk areas for OROV transmission across the tropics of Latin America despite the inclusion of different parameters such as different study areas and environmental predictors. Models estimate that up to 5 million people are at risk of exposure to OROV. Nevertheless, the limited epidemiological data available generates uncertainty in projections. For example, some outbreaks have occurred under climatic conditions outside those where most transmission events occur. The distribution models also revealed that landscape variation, expressed as vegetation loss, is linked to OROV outbreaks.
    Conclusions: Hotspots of OROV transmission risk were detected along the tropics of South America. Vegetation loss might be a driver of Oropouche fever emergence. Modeling based on hypervolumes in spatial epidemiology might be considered an exploratory tool for analyzing data-limited emerging infectious diseases for which little understanding exists on their sylvatic cycles. OROV transmission risk maps can be used to improve surveillance, investigate OROV ecology and epidemiology, and inform early detection.
    MeSH term(s) Humans ; Bunyaviridae Infections/epidemiology ; Orthobunyavirus ; Disease Outbreaks ; Americas
    Language English
    Publishing date 2023-05-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2689396-4
    ISSN 2049-9957 ; 2049-9957
    ISSN (online) 2049-9957
    ISSN 2049-9957
    DOI 10.1186/s40249-023-01091-2
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  3. Article ; Online: Transmembrane 163 (TMEM163) protein interacts with specific mammalian SLC30 zinc efflux transporter family members.

    Escobar, Adrian / Styrpejko, Daniel J / Ali, Saima / Cuajungco, Math P

    Biochemistry and biophysics reports

    2022  Volume 32, Page(s) 101362

    Abstract: Recently, we reported that TMEM163 is a zinc efflux transporter that likely belongs to the mammalian solute carrier 30 (Slc30/ZnT) subfamily of the cation diffusion facilitator (CDF) protein superfamily. We hypothesized that human TMEM163 forms ... ...

    Abstract Recently, we reported that TMEM163 is a zinc efflux transporter that likely belongs to the mammalian solute carrier 30 (Slc30/ZnT) subfamily of the cation diffusion facilitator (CDF) protein superfamily. We hypothesized that human TMEM163 forms functional heterodimers with certain ZNT proteins based on their overlapping subcellular localization with TMEM163 and previous reports that some ZNT monomers interact with each other. In this study, we heterologously expressed individual constructs with a unique peptide tag containing TMEM163, ZNT1, ZNT2, ZNT3, and ZNT4 (negative control) or co-expressed TMEM163 with each ZNT in cultured cells for co-immunoprecipitation (co-IP) experiments. We also co-expressed TMEM163 with two different peptide tags as a positive co-IP control. Western blot analyses revealed that TMEM163 dimerizes with itself but that it also heterodimerizes with ZNT1, ZNT2, ZNT3, and ZNT4 proteins. Confocal microscopy revealed that TMEM163 and ZNT proteins partially co-localize in cells, suggesting that they exist as homodimers and heterodimers in their respective subcellular sites. Functional zinc flux assays using Fluozin-3 and Newport Green dyes show that TMEM163/ZNT heterodimers exhibit similar efflux function as TMEM163 homodimers. Cell surface biotinylation revealed that the plasma membrane localization of TMEM163 is not markedly influenced by ZNT co-expression. Overall, our results show that the interaction between TMEM163 and distinct ZNT proteins is physiologically relevant and that their heterodimerization may serve to increase the functional diversity of zinc effluxers within specific tissues or cell types.
    Language English
    Publishing date 2022-10-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2831046-9
    ISSN 2405-5808 ; 2405-5808
    ISSN (online) 2405-5808
    ISSN 2405-5808
    DOI 10.1016/j.bbrep.2022.101362
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  4. Article: Changes in the climate suitability and growth rates of trees in eastern North America

    Bernal‐Escobar, Manuel / Zuleta, Daniel / Feeley, Kenneth J.

    Ecography. 2022 Sept., v. 2022, no. 9

    2022  

    Abstract: According to the ‘fitness‐suitability' hypothesis, ongoing changes in climate are expected to affect habitat suitability and hence species' fitness. In trees, differences in fitness may manifest as changes in growth rates, which will alter carbon uptake. ...

    Abstract According to the ‘fitness‐suitability' hypothesis, ongoing changes in climate are expected to affect habitat suitability and hence species' fitness. In trees, differences in fitness may manifest as changes in growth rates, which will alter carbon uptake. Using tree‐ring data, we calculated > 1.5 million annual stem growth rate estimates (standardized for tree size) for 15 677 trees representing 37 species from 558 populations throughout eastern North America. We used collections data and species distribution models to estimate each population's climatic suitability from 1900 to 2010. We then assessed the relationships between growth, suitability and time using linear mixed‐effects models. We found that stem growth rates decreased significantly through time independent of changes in climate suitability and that relationships between growth rates and climate suitability were highly variable across species. Contrary to expectations, we found that growth rates were negatively correlated with species' climate suitability, a relationship that was consistent over time for gymnosperms and became more negative through time for angiosperms. These results may suggest that stem growth rates are not a good proxy for fitness and/or that unidentified factors may be slowing tree growth and outweighing any potential benefits of climate change and increasing atmospheric CO₂ concentrations. Regardless of the cause, this finding indicates that we should not count on the increased growth of eastern North American trees to help offset anthropogenic carbon emissions.
    Keywords carbon ; carbon dioxide ; climate ; climate change ; geographical distribution ; growth rings ; habitats ; stem elongation ; tree growth ; trees ; North America
    Language English
    Dates of publication 2022-09
    Publishing place Blackwell Publishing Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 1112659-0
    ISSN 0906-7590
    ISSN 0906-7590
    DOI 10.1111/ecog.06298
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Infectious Diseases Consultation Associated With Reduced Mortality in Gram-Negative Bacteremia.

    Shulder, Stephanie / Tamma, Pranita D / Fiawoo, Suiyini / Dzintars, Kathryn / Escobar, Daniel / Livorsi, Daniel J / Malani, Anurag N / Palacio, Danica / Spivak, Emily S / Zimmerman, Matty / Bork, Jacqueline T

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 77, Issue 9, Page(s) 1234–1237

    Abstract: Gram-negative bacteremia (GN-BSI) can cause significant morbidity and mortality, but the benefit of infectious diseases consultation (IDC) is not well defined. A 24-site observational cohort study of unique hospitalized patients with 4861 GN-BSI episodes ...

    Abstract Gram-negative bacteremia (GN-BSI) can cause significant morbidity and mortality, but the benefit of infectious diseases consultation (IDC) is not well defined. A 24-site observational cohort study of unique hospitalized patients with 4861 GN-BSI episodes demonstrated a 40% decreased risk of 30-day mortality in patients with IDC compared to those without IDC.
    MeSH term(s) Humans ; Communicable Diseases ; Cohort Studies ; Bacteremia ; Referral and Consultation ; Retrospective Studies ; Gram-Negative Bacterial Infections
    Language English
    Publishing date 2023-07-04
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad383
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  6. Article: Mental health Narrative Community-Based Group Therapy in violence-displaced Afro-Colombians: a randomized controlled trial.

    Bonilla-Escobar, Francisco J / Fandiño-Losada, Andrés / Martinez-Buitrago, Diana M / Santaella-Tenorio, Julián / Escobar-Roldan, Iván / Tobón-García, Daniel / Muñoz-Morales, Edgar J / Babcock, Lori / Duarte-Davidson, Eva / Murray, Laura K / Gutierrez-Martinez, María I

    Medicine, conflict, and survival

    2023  Volume 39, Issue 1, Page(s) 28–47

    Abstract: This study aims to evaluate the effect of a mental health Narrative Community-Based Group Therapy (NCGT) in Afro-Colombian violence survivors. A randomized controlled trial was conducted in Buenaventura and Quibdó, Colombia. Afro-Colombian adults ( ...

    Abstract This study aims to evaluate the effect of a mental health Narrative Community-Based Group Therapy (NCGT) in Afro-Colombian violence survivors. A randomized controlled trial was conducted in Buenaventura and Quibdó, Colombia. Afro-Colombian adults (
    MeSH term(s) Adult ; Humans ; Colombia ; Mental Health ; Violence/psychology ; Mental Disorders/therapy ; Psychotherapy, Group
    Language English
    Publishing date 2023-02-23
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1314196-x
    ISSN 1362-3699
    ISSN 1362-3699
    DOI 10.1080/13623699.2023.2177951
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    Zs.B 2781: Show issues Location:
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  7. Article ; Online: Modeling the risk of aquatic species invasion spread through boater movements and river connections.

    Kinsley, Amy C / Kao, Szu-Yu Zoe / Enns, Eva A / Escobar, Luis E / Qiao, Huijie / Snellgrove, Nicholas / Muellner, Ulirich / Muellner, Petra / Muthukrishnan, Ranjan / Craft, Meggan E / Larkin, Daniel J / Phelps, Nicholas B D

    Conservation biology : the journal of the Society for Conservation Biology

    2024  , Page(s) e14260

    Abstract: Aquatic invasive species (AIS) are one of the greatest threats to the functioning of aquatic ecosystems worldwide. Once an invasive species has been introduced to a new region, many governments develop management strategies to reduce further spread. ... ...

    Abstract Aquatic invasive species (AIS) are one of the greatest threats to the functioning of aquatic ecosystems worldwide. Once an invasive species has been introduced to a new region, many governments develop management strategies to reduce further spread. Nevertheless, managing AIS in a new region is challenging because of the vast areas that need protection and limited resources. Spatial heterogeneity in invasion risk is driven by environmental suitability and propagule pressure, which can be used to prioritize locations for surveillance and intervention activities. To better understand invasion risk across aquatic landscapes, we developed a simulation model to estimate the likelihood of a waterbody becoming invaded with an AIS. The model included waterbodies connected via a multilayer network that included boater movements and hydrological connections. In a case study of Minnesota, we used zebra mussels (Dreissena polymorpha) and starry stonewort (Nitellopsis obtusa) as model species. We simulated the impacts of management scenarios developed by stakeholders and created a decision-support tool available through an online application provided as part of the AIS Explorer dashboard. Our baseline model revealed that 89% of new zebra mussel invasions and 84% of new starry stonewort invasions occurred through boater movements, establishing it as a primary pathway of spread and offering insights beyond risk estimates generated by traditional environmental suitability models alone. Our results highlight the critical role of interventions applied to boater movements to reduce AIS dispersal.
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 58735-7
    ISSN 1523-1739 ; 0888-8892
    ISSN (online) 1523-1739
    ISSN 0888-8892
    DOI 10.1111/cobi.14260
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    Z 4919: Show issues

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  8. Article: Severe recurrence of reactive infectious mucocutaneous eruption with extensive ocular involvement in an adult due to SARS-CoV-2.

    Wu, David / Lee, Ernest Y / Lifton, Jacob / Zullo, Shannon W / Seiger, Kira / Nadadur, Rangarajan / Fox, Lindy P / Escobar, Daniel J / Dobry, Allison S / Yung, Madeline / Kangelaris, Kirsten N / Arakaki, Ryan Y

    JAAD case reports

    2023  Volume 36, Page(s) 1–3

    Language English
    Publishing date 2023-02-16
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2022.12.026
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  9. Article ; Online: HER2+ esophageal carcinoma leptomeningeal metastases treated with intrathecal trastuzumab regimen.

    Wu, Scott A / Jia, Dan Tong / Schwartz, Margaret / Mulcahy, Mary / Guo, Kuanghua / Tate, Matthew C / Sachdev, Sean / Kostelecky, Nicolas / Escobar, David J / Brat, Daniel J / Heimberger, Amy B / Lukas, Rimas V

    CNS oncology

    2023  Volume 12, Issue 3, Page(s) CNS99

    Abstract: Materials & methods: ...

    Abstract Materials & methods:
    MeSH term(s) Humans ; Female ; Retrospective Studies ; Receptor, ErbB-2/therapeutic use ; Trastuzumab/adverse effects ; Breast Neoplasms/pathology ; Meningeal Carcinomatosis/drug therapy ; Carcinoma ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
    Chemical Substances Receptor, ErbB-2 (EC 2.7.10.1) ; Trastuzumab (P188ANX8CK)
    Language English
    Publishing date 2023-05-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2692808-5
    ISSN 2045-0915 ; 2045-0915
    ISSN (online) 2045-0915
    ISSN 2045-0915
    DOI 10.2217/cns-2022-0018
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  10. Article ; Online: Peacock mites on cocoa in Peru (Acari: Tuckerellidae: Tuckerella): their economic importance and a key to species

    Escobar-Garcia, Hector Alonso / de Andrade, Daniel Júnior / Beard, Jennifer J. / Ochoa, R.

    Systematic and applied acarology. 2021 Feb. 19, v. 26, no. 3, p. 519-528

    2021  , Page(s) 519–528

    Abstract: Seeds from the cocoa tree, Theobroma cacao L. (Malvaceae), make up the raw materials for cocoa which is used to produce chocolate. In Peru, cocoa is produced mainly by smallholder farmers under a small-scale agriculture model. During March and September ... ...

    Abstract Seeds from the cocoa tree, Theobroma cacao L. (Malvaceae), make up the raw materials for cocoa which is used to produce chocolate. In Peru, cocoa is produced mainly by smallholder farmers under a small-scale agriculture model. During March and September 2020, surveys of organic smallholding farms were conducted in four Districts of the Department of Piura in northwestern Peru. Three species of the family Tuckerellidae (peacock mites) were collected and identified from this region in Peru: namely Tuckerella ornata (Tucker), Tu. pavoniformis (Ewing), and Tu. knorri Baker & Tuttle. In this article, we report the presence of peacock mites affecting cocoa crops in Peru for the first time. The populations of peacock mites found in the cocoa trees were considerable and causing significant fruit damage. A key to the species of Tuckerella found in cocoa is presented.
    Keywords Acari ; Theobroma cacao ; acarology ; chocolate ; models ; plant damage ; small-scale farming ; taxonomic keys ; Peru
    Language English
    Dates of publication 2021-0219
    Size p. 519-528.
    Publishing place Systematic and Applied Acarology Society
    Document type Article ; Online
    Note NAL-AP-2-clean
    ZDB-ID 2027206-6
    ISSN 2056-6069 ; 1362-1971
    ISSN (online) 2056-6069
    ISSN 1362-1971
    DOI 10.11158/saa.26.3.2
    Database NAL-Catalogue (AGRICOLA)

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