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  1. Article ; Online: PCSK9 Inhibition: A Novel Approach to Attenuate Cardiovascular and Liver Aging.

    Ungvari, Zoltan

    JACC. Basic to translational science

    2023  Volume 8, Issue 10, Page(s) 1354–1356

    Language English
    Publishing date 2023-10-23
    Publishing country United States
    Document type Editorial
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2023.08.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Role of Vitamin D Deficiency in the Pathogenesis of Cardiovascular and Cerebrovascular Diseases.

    Pál, Éva / Ungvári, Zoltán / Benyó, Zoltán / Várbíró, Szabolcs

    Nutrients

    2023  Volume 15, Issue 2

    Abstract: Deficiency in vitamin D (VitD), a lipid-soluble vitamin and steroid hormone, affects approximately 24% to 40% of the population of the Western world. In addition to its well-documented effects on the musculoskeletal system, VitD also contributes ... ...

    Abstract Deficiency in vitamin D (VitD), a lipid-soluble vitamin and steroid hormone, affects approximately 24% to 40% of the population of the Western world. In addition to its well-documented effects on the musculoskeletal system, VitD also contributes importantly to the promotion and preservation of cardiovascular health via modulating the immune and inflammatory functions and regulating cell proliferation and migration, endothelial function, renin expression, and extracellular matrix homeostasis. This brief overview focuses on the cardiovascular and cerebrovascular effects of VitD and the cellular, molecular, and functional changes that occur in the circulatory system in VitD deficiency (VDD). It explores the links among VDD and adverse vascular remodeling, endothelial dysfunction, vascular inflammation, and increased risk for cardiovascular and cerebrovascular diseases. Improved understanding of the complex role of VDD in the pathogenesis of atherosclerotic cardiovascular diseases, stroke, and vascular cognitive impairment is crucial for all cardiologists, dietitians, and geriatricians, as VDD presents an easy target for intervention.
    MeSH term(s) Humans ; Cardiovascular System ; Stroke/etiology ; Vitamin D ; Vitamin D Deficiency/epidemiology ; Vitamins ; Cerebrovascular Disorders/epidemiology ; Cardiovascular Diseases/epidemiology
    Chemical Substances Vitamin D (1406-16-2) ; Vitamins
    Language English
    Publishing date 2023-01-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15020334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Prognostic significance of a signature based on senescence-related genes in colorectal cancer.

    Ungvari, Zoltan / Ungvari, Anna / Bianchini, Giampaolo / Győrffy, Balázs

    GeroScience

    2024  

    Abstract: Colorectal cancer, recognized as a quintessential age-related disease, underscores the intricate interplay between aging mechanisms and disease pathogenesis. Cellular senescence, a DNA damage-induced cellular stress response, is characterized by cell ... ...

    Abstract Colorectal cancer, recognized as a quintessential age-related disease, underscores the intricate interplay between aging mechanisms and disease pathogenesis. Cellular senescence, a DNA damage-induced cellular stress response, is characterized by cell cycle arrest, the expression of an inflammatory senescence-associated secretory phenotype, and alterations in extracellular matrix metabolism. It is widely recognized as a fundamental and evolutionarily conserved mechanism of aging. Guided by geroscience principles, which assert that the pathogenesis of age-related diseases involves cellular mechanisms of aging, this study delves into the role of senescence-related genes in colon cancer progression. Leveraging a gene set reflective of senescence-associated pathways, we employed uni- and multivariate Cox proportional hazards survival analysis combined with the determination of the false discovery rate to analyze correlations between gene expression and survival. The integrated database of 1130 colon cancer specimens with available relapse-free survival time and relapse event data from ten independent cohorts provided a robust platform for survival analyses. We identified senescence-related genes associated with differential expression levels linked to shorter survival. Our findings unveil a prognostic signature utilizing cellular senescence-related genes (hazard ratio: 2.73, 95% CI 2.12-3.52, p = 6.4E - 16), offering valuable insights into survival prediction in colon cancer. Multivariate analysis underscored the independence of the senescence-related signature from available epidemiological and pathological variables. This study highlights the potential of senescence-related genes as prognostic biomarkers. Overall, our results underscore the pivotal role of cellular senescence, a fundamental mechanism of aging, in colon cancer progression.
    Language English
    Publishing date 2024-04-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2886586-8
    ISSN 2509-2723 ; 2509-2715
    ISSN (online) 2509-2723
    ISSN 2509-2715
    DOI 10.1007/s11357-024-01164-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1502: Show issues Location:
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  4. Article ; Online: NO Deficiency Compromises Inter- and Intrahemispheric Blood Flow Adaptation to Unilateral Carotid Artery Occlusion.

    Hricisák, László / Pál, Éva / Nagy, Dorina / Delank, Max / Polycarpou, Andreas / Fülöp, Ágnes / Sándor, Péter / Sótonyi, Péter / Ungvári, Zoltán / Benyó, Zoltán

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: Carotid artery stenosis (CAS) affects approximately 5-7.5% of older adults and is recognized as a significant risk factor for vascular cognitive impairment (VCI). The impact of CAS on cerebral blood flow (CBF) within the ipsilateral hemisphere relies on ... ...

    Abstract Carotid artery stenosis (CAS) affects approximately 5-7.5% of older adults and is recognized as a significant risk factor for vascular cognitive impairment (VCI). The impact of CAS on cerebral blood flow (CBF) within the ipsilateral hemisphere relies on the adaptive capabilities of the cerebral microcirculation. In this study, we aimed to test the hypothesis that the impaired availability of nitric oxide (NO) compromises CBF homeostasis after unilateral carotid artery occlusion (CAO). To investigate this, three mouse models exhibiting compromised production of NO were tested: NOS1 knockout, NOS1/3 double knockout, and mice treated with the NO synthesis inhibitor L-NAME. Regional CBF changes following CAO were evaluated using laser-speckle contrast imaging (LSCI). Our findings demonstrated that NOS1 knockout, NOS1/3 double knockout, and L-NAME-treated mice exhibited impaired CBF adaptation to CAO. Furthermore, genetic deficiency of one or two NO synthase isoforms increased the tortuosity of pial collaterals connecting the frontoparietal and temporal regions. In conclusion, our study highlights the significant contribution of NO production to the functional adaptation of cerebrocortical microcirculation to unilateral CAO. We propose that impaired bioavailability of NO contributes to the impaired CBF homeostasis by altering inter- and intrahemispheric blood flow redistribution after unilateral disruption of carotid artery flow.
    MeSH term(s) Animals ; Mice ; Nitric Oxide ; NG-Nitroarginine Methyl Ester/pharmacology ; Cerebrovascular Circulation ; Carotid Artery Diseases ; Carotid Stenosis ; Carotid Artery, Common
    Chemical Substances Nitric Oxide (31C4KY9ESH) ; NG-Nitroarginine Methyl Ester (V55S2QJN2X)
    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25020697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The future of healthy aging: translation of geroscience discoveries to public health practice.

    Ungvari, Zoltan / Adany, Roza

    European journal of public health

    2021  Volume 31, Issue 3, Page(s) 455–456

    MeSH term(s) Forecasting ; Healthy Aging ; Humans ; Public Health Practice
    Language English
    Publishing date 2021-02-15
    Publishing country England
    Document type Editorial
    ZDB-ID 1129243-x
    ISSN 1464-360X ; 1101-1262
    ISSN (online) 1464-360X
    ISSN 1101-1262
    DOI 10.1093/eurpub/ckaa212
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3499: Show issues Location:
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  6. Article ; Online: PCSK9: an emerging player in cardiometabolic aging and its potential as a therapeutic target and biomarker.

    Csiszar, Anna / Tarantini, Stefano / Yabluchanskiy, Andriy / Ungvari, Zoltan

    GeroScience

    2023  Volume 46, Issue 1, Page(s) 257–263

    Abstract: Proprotein convertase subtilisin/kexin type 9 (PCSK9), renowned for its pivotal role in low-density lipoprotein (LDL) regulation, has emerged as a compelling regulator of cardiometabolic aging. Beyond its well-established involvement in cholesterol ... ...

    Abstract Proprotein convertase subtilisin/kexin type 9 (PCSK9), renowned for its pivotal role in low-density lipoprotein (LDL) regulation, has emerged as a compelling regulator of cardiometabolic aging. Beyond its well-established involvement in cholesterol metabolism, PCSK9's multifaceted influence on the aging processes of the cardiovascular and metabolic systems is garnering increasing attention. This review delves into the evolving landscape of PCSK9 in the context of cardiometabolic aging, offering fresh insights into its potential implications. Drawing inspiration from pioneering research conducted by the Pacher laboratory (Arif et al., Geroscience, 2023, PMID: 37726433), we delve into the intricate interplay of PCSK9 within the aging heart and liver, shedding light on its newfound significance. Recent studies underscore PCSK9's pivotal role in liver aging, suggesting intriguing connections between hepatic aging, lipid metabolism, and cardiovascular health. Additionally, we explore the therapeutic potential of PCSK9 as both a target and a biomarker, within the context of age-related cardiovascular disease.
    MeSH term(s) Humans ; Proprotein Convertase 9/metabolism ; Receptors, LDL/metabolism ; Biomarkers ; Cardiovascular Diseases ; Aging
    Chemical Substances PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; Receptors, LDL ; Biomarkers
    Language English
    Publishing date 2023-12-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2886586-8
    ISSN 2509-2723 ; 2509-2715
    ISSN (online) 2509-2723
    ISSN 2509-2715
    DOI 10.1007/s11357-023-01003-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1502: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Psychological resilience and competence: key promoters of successful aging and flourishing in late life.

    Zábó, Virág / Csiszar, Anna / Ungvari, Zoltan / Purebl, György

    GeroScience

    2023  Volume 45, Issue 5, Page(s) 3045–3058

    Abstract: Many individuals, both in the public and within the field of psychology, often perceive aging as a burden that negatively impacts intellectual and mental health. Our present study aims to challenge this notion by identifying the crucial components of ... ...

    Abstract Many individuals, both in the public and within the field of psychology, often perceive aging as a burden that negatively impacts intellectual and mental health. Our present study aims to challenge this notion by identifying the crucial components of positive mental health in later life. These components not only promote positive mental health but also actively contribute to it, even under difficult circumstances. To accomplish this, we first offer a concise review of well-being and mental health models that highlight the psychological aspects of flourishing in late life. We then introduce a psychological competence-based model for positive mental health, which aligns with the concept of positive aging. Subsequently, we present a measurement tool suitable for practical applications. Finally, we provide a comprehensive overview of positive aging, drawing on methodological guidelines and existing research findings concerning sustainable positive mental health in later life. We examine the evidence indicating that psychological resilience (the capacity to adapt and recover from adversity or stress) and competence (skills and abilities to effectively cope with challenges across various life domains) significantly contribute to slowing down biological aging processes. Furthermore, we discuss insights into the relationship between psychological factors and aging derived from research on Blue Zones (regions characterized by a higher proportion of individuals experiencing longer, healthier lives).
    MeSH term(s) Humans ; Resilience, Psychological ; Mental Health ; Aging/psychology ; Health Status
    Language English
    Publishing date 2023-07-07
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2886586-8
    ISSN 2509-2723 ; 2509-2715
    ISSN (online) 2509-2723
    ISSN 2509-2715
    DOI 10.1007/s11357-023-00856-9
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1502: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Disruption of Vitamin D Signaling Impairs Adaptation of Cerebrocortical Microcirculation to Carotid Artery Occlusion in Hyperandrogenic Female Mice.

    Nagy, Dorina / Hricisák, László / Walford, Guillaume Peter / Lékai, Ágnes / Karácsony, Gábor / Várbíró, Szabolcs / Ungvári, Zoltán / Benyó, Zoltán / Pál, Éva

    Nutrients

    2023  Volume 15, Issue 18

    Abstract: Vitamin D deficiency contributes to the pathogenesis of age-related cerebrovascular diseases, including ischemic stroke. Sex hormonal status may also influence the prevalence of these disorders, indicated by a heightened vulnerability among ... ...

    Abstract Vitamin D deficiency contributes to the pathogenesis of age-related cerebrovascular diseases, including ischemic stroke. Sex hormonal status may also influence the prevalence of these disorders, indicated by a heightened vulnerability among postmenopausal and hyperandrogenic women. To investigate the potential interaction between sex steroids and disrupted vitamin D signaling in the cerebral microcirculation, we examined the cerebrovascular adaptation to unilateral carotid artery occlusion (CAO) in intact, ovariectomized, and hyperandrogenic female mice with normal or functionally inactive vitamin D receptor (VDR). We also analyzed the morphology of leptomeningeal anastomoses, which play a significant role in the compensation. Ablation of VDR by itself did not impact the cerebrocortical adaptation to CAO despite the reduced number of pial collaterals. While ovariectomy did not undermine compensatory mechanisms following CAO, androgen excess combined with VDR inactivity resulted in prolonged hypoperfusion in the cerebral cortex ipsilateral to the occlusion. These findings suggest that the cerebrovascular consequences of disrupted VDR signaling are less pronounced in females, providing a level of protection even after ovariectomy. Conversely, even short-term androgen excess with lacking VDR signaling may lead to unfavorable outcomes of ischemic stroke, highlighting the complex interplay between sex steroids and vitamin D in terms of cerebrovascular diseases.
    MeSH term(s) Mice ; Humans ; Female ; Animals ; Vitamin D ; Microcirculation ; Androgens ; Receptors, Calcitriol ; Carotid Artery Diseases ; Vitamins ; Ischemic Stroke ; Carotid Arteries
    Chemical Substances Vitamin D (1406-16-2) ; Androgens ; Receptors, Calcitriol ; Vitamins
    Language English
    Publishing date 2023-09-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15183869
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Editorial: Endocrine regulation of aging: impacts of humoral factors and circulating mediators.

    Petersen, Benjamin / Negri, Sharon / Milan, Madison / Reyff, Zeke / Ballard, Cade / Ihuoma, Jennifer / Ungvari, Zoltan / Tarantini, Stefano

    Frontiers in endocrinology

    2024  Volume 15, Page(s) 1387435

    MeSH term(s) Longevity/physiology
    Language English
    Publishing date 2024-03-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2024.1387435
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  10. Article ; Online: The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment.

    Ungvari, Anna / Gulej, Rafal / Csik, Boglarka / Mukli, Peter / Negri, Sharon / Tarantini, Stefano / Yabluchanskiy, Andriy / Benyo, Zoltan / Csiszar, Anna / Ungvari, Zoltan

    Nutrients

    2023  Volume 15, Issue 21

    Abstract: As aging societies in the western world face a growing prevalence of vascular cognitive impairment and Alzheimer's disease (AD), understanding their underlying causes and associated risk factors becomes increasingly critical. A salient concern in the ... ...

    Abstract As aging societies in the western world face a growing prevalence of vascular cognitive impairment and Alzheimer's disease (AD), understanding their underlying causes and associated risk factors becomes increasingly critical. A salient concern in the western dietary context is the high consumption of methionine-rich foods such as red meat. The present review delves into the impact of this methionine-heavy diet and the resultant hyperhomocysteinemia on accelerated cerebrovascular and brain aging, emphasizing their potential roles in cognitive impairment. Through a comprehensive exploration of existing evidence, a link between high methionine intake and hyperhomocysteinemia and oxidative stress, mitochondrial dysfunction, inflammation, and accelerated epigenetic aging is drawn. Moreover, the microvascular determinants of cognitive deterioration, including endothelial dysfunction, reduced cerebral blood flow, microvascular rarefaction, impaired neurovascular coupling, and blood-brain barrier (BBB) disruption, are explored. The mechanisms by which excessive methionine consumption and hyperhomocysteinemia might drive cerebromicrovascular and brain aging processes are elucidated. By presenting an intricate understanding of the relationships among methionine-rich diets, hyperhomocysteinemia, cerebrovascular and brain aging, and cognitive impairment, avenues for future research and potential therapeutic interventions are suggested.
    MeSH term(s) Humans ; Methionine ; Hyperhomocysteinemia/complications ; Cognitive Dysfunction ; Brain ; Cerebrovascular Circulation ; Diet/adverse effects ; Alzheimer Disease/etiology
    Chemical Substances Methionine (AE28F7PNPL)
    Language English
    Publishing date 2023-11-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15214662
    Database MEDical Literature Analysis and Retrieval System OnLINE

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