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  1. Article: Report from "8th MITOCHONDRION: in memory of Professor Lech Wojtczak"

    Szewczyk, Adam

    Postepy biochemii

    2020  Volume 66, Issue 1, Page(s) 72

    Abstract: Relacja z "8th MITOCHONDRION: in memory of Professor Lech Wojtczak". ...

    Title translation Relacja z "8th MITOCHONDRION: in memory of Professor Lech Wojtczak".
    Abstract Relacja z "8th MITOCHONDRION: in memory of Professor Lech Wojtczak".
    MeSH term(s) History, 20th Century ; Mitochondria
    Language Polish
    Publishing date 2020-03-31
    Publishing country Poland
    Document type Festschrift ; Historical Article
    ZDB-ID 414019-9
    ISSN 0032-5422
    ISSN 0032-5422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 633: Show issues Location:
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  2. Article ; Online: Mitochondrial Ion Channels.

    Szabo, Ildiko / Szewczyk, Adam

    Annual review of biophysics

    2023  Volume 52, Page(s) 229–254

    Abstract: Mitochondria are involved in multiple cellular tasks, such as ATP synthesis, metabolism, metabolite and ion transport, regulation of apoptosis, inflammation, signaling, and inheritance of mitochondrial DNA. The majority of the correct functioning of ... ...

    Abstract Mitochondria are involved in multiple cellular tasks, such as ATP synthesis, metabolism, metabolite and ion transport, regulation of apoptosis, inflammation, signaling, and inheritance of mitochondrial DNA. The majority of the correct functioning of mitochondria is based on the large electrochemical proton gradient, whose component, the inner mitochondrial membrane potential, is strictly controlled by ion transport through mitochondrial membranes. Consequently, mitochondrial function is critically dependent on ion homeostasis, the disturbance of which leads to abnormal cell functions. Therefore, the discovery of mitochondrial ion channels influencing ion permeability through the membrane has defined a new dimension of the function of ion channels in different cell types, mainly linked to the important tasks that mitochondrial ion channels perform in cell life and death. This review summarizes studies on animal mitochondrial ion channels with special focus on their biophysical properties, molecular identity, and regulation. Additionally, the potential of mitochondrial ion channels as therapeutic targets for several diseases is briefly discussed.
    MeSH term(s) Animals ; Mitochondria ; Ion Channels ; Signal Transduction ; Biophysics
    Chemical Substances Ion Channels
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2434725-5
    ISSN 1936-1238 ; 1936-122X
    ISSN (online) 1936-1238
    ISSN 1936-122X
    DOI 10.1146/annurev-biophys-092622-094853
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Redox Regulation of Mitochondrial Potassium Channels Activity.

    Lewandowska, Joanna / Kalenik, Barbara / Wrzosek, Antoni / Szewczyk, Adam

    Antioxidants (Basel, Switzerland)

    2024  Volume 13, Issue 4

    Abstract: Redox reactions exert a profound influence on numerous cellular functions with mitochondria playing a central role in orchestrating these processes. This pivotal involvement arises from three primary factors: (1) the synthesis of reactive oxygen species ( ...

    Abstract Redox reactions exert a profound influence on numerous cellular functions with mitochondria playing a central role in orchestrating these processes. This pivotal involvement arises from three primary factors: (1) the synthesis of reactive oxygen species (ROS) by mitochondria, (2) the presence of a substantial array of redox enzymes such as respiratory chain, and (3) the responsiveness of mitochondria to the cellular redox state. Within the inner mitochondrial membrane, a group of potassium channels, including ATP-regulated, large conductance calcium-activated, and voltage-regulated channels, is present. These channels play a crucial role in conditions such as cytoprotection, ischemia/reperfusion injury, and inflammation. Notably, the activity of mitochondrial potassium channels is intricately governed by redox reactions. Furthermore, the regulatory influence extends to other proteins, such as kinases, which undergo redox modifications. This review aims to offer a comprehensive exploration of the modulation of mitochondrial potassium channels through diverse redox reactions with a specific focus on the involvement of ROS.
    Language English
    Publishing date 2024-04-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox13040434
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  4. Article: Current Challenges of Mitochondrial Potassium Channel Research.

    Kulawiak, Bogusz / Szewczyk, Adam

    Frontiers in physiology

    2022  Volume 13, Page(s) 907015

    Abstract: In this paper, the current challenges of mitochondrial potassium channels research were critically reviewed. Even though recent progress in understanding ... ...

    Abstract In this paper, the current challenges of mitochondrial potassium channels research were critically reviewed. Even though recent progress in understanding K
    Language English
    Publishing date 2022-05-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.907015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Pharmacological Characterization of a Recombinant Mitochondrial ROMK2 Potassium Channel Expressed in Bacteria and Reconstituted in Planar Lipid Bilayers.

    Krajewska, Milena / Szewczyk, Adam / Kulawiak, Bogusz / Koprowski, Piotr

    Membranes

    2023  Volume 13, Issue 3

    Abstract: In the inner mitochondrial membrane, several potassium channels that play a role in cell life and death have been identified. One of these channels is the ATP-regulated potassium channel ( ... ...

    Abstract In the inner mitochondrial membrane, several potassium channels that play a role in cell life and death have been identified. One of these channels is the ATP-regulated potassium channel (mitoK
    Language English
    Publishing date 2023-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2614641-1
    ISSN 2077-0375
    ISSN 2077-0375
    DOI 10.3390/membranes13030360
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  6. Article: Identification of information about adverse drug reactions in local medical journals using MEDLINE and Embase versus manual full text review.

    Ochyra, Bartłomiej / Szewczyk, Maciej / Przybyłkowski, Adam

    Przeglad epidemiologiczny

    2023  Volume 76, Issue 4, Page(s) 503–513

    Abstract: Introduction: Collecting information about drugs in clinical practice is essential for ongoing riskbenefit analysis of the drug use. Medical literature is an important source of new information on drug safety, in particular for the signal assessment. A ... ...

    Abstract Introduction: Collecting information about drugs in clinical practice is essential for ongoing riskbenefit analysis of the drug use. Medical literature is an important source of new information on drug safety, in particular for the signal assessment. A signal is an information about a new potentially causal association, or a new aspect of a known association (e.g. change in frequency or severity of the reaction) between a drug and an adverse event (AE).
    Aim of the study: To verify the effectiveness of the identification of adverse drug reaction (ADR) reports published in the local medical literature using MEDLINE and Embase, versus manual full text review of journals.
    Material and methods: The study was performed for 20 randomly selected drugs and 84 Polish medical journals and covers a review of 1,576 individual journal issues with 20,146 articles. Retrospective analysis of literature reports collected during manual full text review was performed and compared to the outcome of database search.
    Results: ADRs for analyzed drugs were identified only in 17 out of 84 journals, as a result of which 66 reports were analyzed. The majority of reports (55%) were found in local non-indexed journals. Three reports originated from journals indexed in MEDLINE and 9 reports from journals indexed in Embase were not found in these databases because databases do not fully cover conference abstracts and journal supplements. Moreover, while using databases for ADR report search there is a risk of missing up to 30% of ADR reports. The average gap between article publication date and database entry was 119 days.
    Conclusions: We verified that the effectiveness of the identification of ADR reports published in the local medical literature is more accurate based on manual full text review than by searching in bibliographic databases.
    MeSH term(s) Humans ; MEDLINE ; Retrospective Studies ; Poland ; Periodicals as Topic ; Drug-Related Side Effects and Adverse Reactions
    Language English
    Publishing date 2023-04-05
    Publishing country Poland
    Document type Review ; Journal Article
    ZDB-ID 421782-2
    ISSN 0033-2100
    ISSN 0033-2100
    DOI 10.32394/pe.76.41
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: External Hemin as an Inhibitor of Mitochondrial Large-Conductance Calcium-Activated Potassium Channel Activity.

    Walewska, Agnieszka / Szewczyk, Adam / Koprowski, Piotr

    International journal of molecular sciences

    2022  Volume 23, Issue 21

    Abstract: The mitochondrial large-conductance calcium-activated potassium channel ( ... ...

    Abstract The mitochondrial large-conductance calcium-activated potassium channel (mitoBK
    MeSH term(s) Hemin/pharmacology ; Hemin/metabolism ; Calcium/metabolism ; Mitochondria/metabolism ; Mitochondrial Membranes/metabolism ; Large-Conductance Calcium-Activated Potassium Channels/metabolism
    Chemical Substances Hemin (743LRP9S7N) ; Calcium (SY7Q814VUP) ; Large-Conductance Calcium-Activated Potassium Channels
    Language English
    Publishing date 2022-11-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232113391
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  8. Article ; Online: Targeting Mitochondrial Large-Conductance Calcium-Activated Potassium Channel by Hydrogen Sulfide via Heme-Binding Site.

    Walewska, Agnieszka / Szewczyk, Adam / Krajewska, Milena / Koprowski, Piotr

    The Journal of pharmacology and experimental therapeutics

    2022  Volume 381, Issue 2, Page(s) 137–150

    Abstract: Reperfusion together with the preceding ischemic period results in serious damage to brain and heart tissues. Activation of potassium channels from the inner mitochondrial membrane leads to cytoprotection during such events. The mitochondrial large- ... ...

    Abstract Reperfusion together with the preceding ischemic period results in serious damage to brain and heart tissues. Activation of potassium channels from the inner mitochondrial membrane leads to cytoprotection during such events. The mitochondrial large-conductance calcium-activated potassium channel (mitoBK
    MeSH term(s) Binding Sites ; Calcium/metabolism ; Heme/metabolism ; Hemin/metabolism ; Hydrogen Sulfide/metabolism ; Hydrogen Sulfide/pharmacology ; Iron/metabolism ; Large-Conductance Calcium-Activated Potassium Channels/metabolism
    Chemical Substances Large-Conductance Calcium-Activated Potassium Channels ; Heme (42VZT0U6YR) ; Hemin (743LRP9S7N) ; Iron (E1UOL152H7) ; Calcium (SY7Q814VUP) ; Hydrogen Sulfide (YY9FVM7NSN)
    Language English
    Publishing date 2022-02-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3106-9
    ISSN 1521-0103 ; 0022-3565
    ISSN (online) 1521-0103
    ISSN 0022-3565
    DOI 10.1124/jpet.121.001017
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  9. Article ; Online: Electrochemical studies of the mitochondrial ROMK2 potassium channel activity reconstituted into the free-standing and tethered bilayer lipid membranes.

    Stefanowska, Aleksandra / Koprowski, Piotr / Bednarczyk, Piotr / Szewczyk, Adam / Krysinski, Pawel

    Bioelectrochemistry (Amsterdam, Netherlands)

    2023  Volume 151, Page(s) 108372

    Abstract: The renal-outer-medullary‑potassium (ROMK2) channel modulates potassium transport in the kidney. It has been postulated that the ROMK2 is the pore-forming subunit of the mitochondrial ATP-sensitive potassium channel as a mediator of cardioprotection. In ... ...

    Abstract The renal-outer-medullary‑potassium (ROMK2) channel modulates potassium transport in the kidney. It has been postulated that the ROMK2 is the pore-forming subunit of the mitochondrial ATP-sensitive potassium channel as a mediator of cardioprotection. In this study, cell-free synthesis of the ROMK2 was performed in presence of membrane scaffold protein (MSP1D1) nanodiscs. Activity measurements were achieved after channel reconstitution into the planar lipid bilayer and tethered bilayer lipid membranes. Both methods allowed for monitoring of channel function, verified with channel blocking and activation/re-activation experiments. The primary function of the mitochondrial potassium channels is to regulate the potential of the mitochondrial membrane, which allows them to play an important role in cytoprotection. This work focuses on obtaining the ROMK2 using a cell-free expression system, followed by the incorporation of the channel protein into the lipid bilayer and studying the influence of voltage changes and molecular modulators on channel activity. Channel activity was measured after its reconstitution into two models of lipid bilayers - BLM (Bilayer Lipid Membrane) and tBLM (Tethered Bilayer Lipid Membrane) deposited on a solid gold electrode. These two model membranes and electrochemical measurements made it possible to measure the flux of K
    MeSH term(s) Lipid Bilayers/chemistry ; Potassium Channels ; Mitochondria/metabolism ; Membrane Proteins/metabolism ; Potassium
    Chemical Substances Lipid Bilayers ; Potassium Channels ; Membrane Proteins ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2023-01-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2010650-6
    ISSN 1878-562X ; 0302-4598 ; 1567-5394
    ISSN (online) 1878-562X
    ISSN 0302-4598 ; 1567-5394
    DOI 10.1016/j.bioelechem.2023.108372
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  10. Article ; Online: Bilingualism caught in a net: A new approach to understanding the complexity of bilingual experience.

    Kałamała, Patrycja / Chuderski, Adam / Szewczyk, Jakub / Senderecka, Magdalena / Wodniecka, Zofia

    Journal of experimental psychology. General

    2022  Volume 152, Issue 1, Page(s) 157–174

    Abstract: The growing importance of research on bilingualism in psychology and neuroscience motivates the need for a psychometric model that can be used to understand and quantify this phenomenon. This research is the first to meet this need. We reanalyzed two ... ...

    Abstract The growing importance of research on bilingualism in psychology and neuroscience motivates the need for a psychometric model that can be used to understand and quantify this phenomenon. This research is the first to meet this need. We reanalyzed two data sets (
    MeSH term(s) Young Adult ; Humans ; Multilingualism ; Language ; Linguistics ; Language Development ; Cognition
    Language English
    Publishing date 2022-08-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 189732-9
    ISSN 1939-2222 ; 0096-3445
    ISSN (online) 1939-2222
    ISSN 0096-3445
    DOI 10.1037/xge0001263
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