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  1. Article ; Online: Is there a safe level for adding sodium to food versus is it safe to reduce dietary sodium intake?

    Campbell, Norm R C / McLean, Rachael M / He, Feng J / MacGregor, Graham A

    Journal of hypertension

    2024  Volume 42, Issue 4, Page(s) 607–608

    MeSH term(s) Humans ; Sodium, Dietary/adverse effects
    Chemical Substances Sodium, Dietary
    Language English
    Publishing date 2024-02-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000003678
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1885: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 614: Show issues

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  2. Article ; Online: Extraction of Nitric Acid and Uranium with DEHiBA under High Loading Conditions.

    Hall, Gabriel B / Campbell, Emily L / Bessen, Nathan P / Graham, Trent R / Cho, Herman / RisenHuber, Matthew / Heller, Forrest D / Lumetta, Gregg J

    Inorganic chemistry

    2023  Volume 62, Issue 17, Page(s) 6711–6721

    Abstract: The mechanism by which high concentrations (1.5 M ... ...

    Abstract The mechanism by which high concentrations (1.5 M in
    Language English
    Publishing date 2023-04-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c00288
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Anomalous binocular vision in African Harrier-Hawks.

    Portugal, Steven J / Ozturk, Rana / Murn, Campbell P / Potier, Simon / Martin, Graham R

    Current biology : CB

    2023  Volume 33, Issue 21, Page(s) R1142–R1143

    Abstract: An animal's visual field is the three-dimensional space around its head from which it can extract visual information at any ... ...

    Abstract An animal's visual field is the three-dimensional space around its head from which it can extract visual information at any instant
    MeSH term(s) Animals ; Vision, Binocular ; Hawks ; Visual Fields ; Eye ; Eagles
    Language English
    Publishing date 2023-11-02
    Publishing country England
    Document type Letter
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2023.09.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3208: Show issues Location:
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  4. Article ; Online: Comment on: Less sodium and more potassium to reduce cardiovascular risk and the PURE study.

    Campbell, Norm R C / He, Feng J / McLean, Rachael M / Cappuccio, Francesco P / MacGregor, Graham M

    European heart journal open

    2023  Volume 3, Issue 5, Page(s) oead096

    Language English
    Publishing date 2023-09-30
    Publishing country England
    Document type Journal Article
    ISSN 2752-4191
    ISSN (online) 2752-4191
    DOI 10.1093/ehjopen/oead096
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  5. Article ; Online: Correction: Postnatal infection surveillance by telephone in Dar es Salaam, Tanzania: An observational cohort study.

    Woodd, Susannah L / Kabanywanyi, Abdunoor M / Rehman, Andrea M / Campbell, Oona M R / Kagambo, Asila / Martiasi, Warda / Day, Louise T / Aiken, Alexander M / Graham, Wendy J

    PloS one

    2023  Volume 18, Issue 6, Page(s) e0287801

    Abstract: This corrects the article DOI: 10.1371/journal.pone.0254131.]. ...

    Abstract [This corrects the article DOI: 10.1371/journal.pone.0254131.].
    Language English
    Publishing date 2023-06-23
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0287801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Validation of actigraphy sleep metrics in children aged 8 to 16 years: considerations for device type, placement and algorithms.

    Meredith-Jones, K A / Haszard, J J / Graham-DeMello, A / Campbell, A / Stewart, T / Galland, B C / Cox, A / Kennedy, G / Duncan, S / Taylor, R W

    The international journal of behavioral nutrition and physical activity

    2024  Volume 21, Issue 1, Page(s) 40

    Abstract: Background: Actigraphy is often used to measure sleep in pediatric populations, despite little confirmatory evidence of the accuracy of existing sleep/wake algorithms. The aim of this study was to determine the performance of 11 sleep algorithms in ... ...

    Abstract Background: Actigraphy is often used to measure sleep in pediatric populations, despite little confirmatory evidence of the accuracy of existing sleep/wake algorithms. The aim of this study was to determine the performance of 11 sleep algorithms in relation to overnight polysomnography in children and adolescents.
    Methods: One hundred thirty-seven participants aged 8-16 years wore two Actigraph wGT3X-BT (wrist, waist) and three Axivity AX3 (wrist, back, thigh) accelerometers over 24-h. Gold standard measures of sleep were obtained using polysomnography (PSG; Embletta MPRPG, ST + Proxy and TX Proxy) in the home environment, overnight. Epoch by epoch comparisons of the Sadeh (two algorithms), Cole-Kripke (three algorithms), Tudor-Locke (four algorithms), Count-Scaled (CS), and HDCZA algorithms were undertaken. Mean differences from PSG values were calculated for various sleep outcomes.
    Results: Overall, sensitivities were high (mean ± SD: 91.8%, ± 5.6%) and specificities moderate (63.8% ± 13.8%), with the HDCZA algorithm performing the best overall in terms of specificity (87.5% ± 1.3%) and accuracy (86.4% ± 0.9%). Sleep outcome measures were more accurately measured by devices worn at the wrist than the hip, thigh or lower back, with the exception of sleep efficiency where the reverse was true. The CS algorithm provided consistently accurate measures of sleep onset: the mean (95%CI) difference at the wrist with Axivity was 2 min (-6; -14,) and the offset was 10 min (5, -19). Several algorithms provided accurate measures of sleep quantity at the wrist, showing differences with PSG of just 1-18 min a night for sleep period time and 5-22 min for total sleep time. Accuracy was generally higher for sleep efficiency than for frequency of night wakings or wake after sleep onset. The CS algorithm was more accurate at assessing sleep period time, with narrower 95% limits of agreement compared to the HDCZA (CS:-165 to 172 min; HDCZA: -212 to 250 min).
    Conclusion: Although the performance of existing count-based sleep algorithms varies markedly, wrist-worn devices provide more accurate measures of most sleep measures compared to other sites. Overall, the HDZCA algorithm showed the greatest accuracy, although the most appropriate algorithm depends on the sleep measure of focus.
    MeSH term(s) Child ; Adolescent ; Humans ; Actigraphy ; Reproducibility of Results ; Sleep ; Polysomnography ; Algorithms
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2134691-4
    ISSN 1479-5868 ; 1479-5868
    ISSN (online) 1479-5868
    ISSN 1479-5868
    DOI 10.1186/s12966-024-01590-x
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  7. Article ; Online: A Method to Detect Cytochrome c Oxidase Activity and Mitochondrial Proteins in Oligodendrocytes.

    Campbell, Graham R / Mahad, Don J

    Methods in molecular biology (Clifton, N.J.)

    2019  Volume 1936, Page(s) 333–342

    Abstract: Cytochrome c oxidase or mitochondrial respiratory chain complex IV is where over 90% of oxygen is consumed. The relationship between complex IV activity and mitochondrial proteins, which provides a guide to understanding the mechanisms in primary ... ...

    Abstract Cytochrome c oxidase or mitochondrial respiratory chain complex IV is where over 90% of oxygen is consumed. The relationship between complex IV activity and mitochondrial proteins, which provides a guide to understanding the mechanisms in primary mitochondrial disorders, has been determined by histochemistry (complex IV activity) and immunohistochemistry in serial sections. In the central nervous system (CNS), mitochondrial activity and immunoreactivity have been determined in populations of cells in serial sections as capturing cells in more than one section is difficult. In this report, we describe a method to determine complex IV activity in relation to mitochondrial proteins at a single-cell level in the CNS. We performed complex IV histochemistry and immunohistochemistry consecutively in snap-frozen sections. Although the product of complex IV histochemistry reduces the sensitivity of standard immunohistochemistry (secondary antibody and ABC method), the biotin-free Menapath polymer detection system enables mitochondrial proteins to be detected following complex IV histochemistry. The co-occurring chromogens may then be separately visualized and analyzed using multispectral imaging. Our technique is applicable for exploring mitochondrial defects within single cells, including oligodendrocytes, in a variety of CNS disorders and animal models of those diseases.
    MeSH term(s) Animals ; Central Nervous System/metabolism ; Electron Transport Complex IV/analysis ; Humans ; Immunohistochemistry ; Mitochondrial Proteins/analysis ; Oligodendroglia/metabolism ; Rats ; Single-Cell Analysis/methods
    Chemical Substances Mitochondrial Proteins ; Electron Transport Complex IV (EC 1.9.3.1)
    Language English
    Publishing date 2019-02-28
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-9072-6_19
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  8. Article ; Online: Immune Checkpoint Inhibition as a Strategy in the Neoadjuvant Treatment of Locally Advanced Rectal Cancer.

    Hanna, Catherine R / O'Cathail, Séan M / Graham, Janet / Adams, Richard / Roxburgh, Campbell S D

    Journal of immunotherapy and precision oncology

    2021  Volume 4, Issue 2, Page(s) 86–104

    Abstract: The treatment of locally advanced rectal cancer (LARC) has seen major advances over the past 3 decades, with multimodality treatment now standard of care. Combining surgical resection with radiotherapy and/or chemotherapy can reduce local recurrence from ...

    Abstract The treatment of locally advanced rectal cancer (LARC) has seen major advances over the past 3 decades, with multimodality treatment now standard of care. Combining surgical resection with radiotherapy and/or chemotherapy can reduce local recurrence from around 20% to approximately 5%. Despite improvements in local control, distant recurrence and subsequent survival rates have not changed. Immune checkpoint inhibitors have improved patient outcomes in several solid tumor types in the neoadjuvant, adjuvant, and advanced disease setting; however, in colorectal cancer, most clinical trials have been performed in the metastatic setting and the benefits confined to microsatellite instability-high tumors. In this article, we review the current preclinical and clinical evidence for using immune checkpoint inhibition in the treatment of LARC and discuss the rationale for specifically exploring the use of this therapy in the neoadjuvant setting. We summarize and discuss relevant clinical trials that are currently in setup and recruiting to test this treatment strategy and reflect on unanswered questions that still need to be addressed within future research efforts.
    Language English
    Publishing date 2021-03-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3032799-4
    ISSN 2590-017X ; 2666-2345
    ISSN (online) 2590-017X
    ISSN 2666-2345
    DOI 10.36401/JIPO-20-31
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  9. Article ; Online: Comment on Hogas et al. Salt, Not Always a Cardiovascular Enemy? A Mini-Review and Modern Perspective.

    Campbell, Norm R C / Cappuccio, Francesco P / McLean, Rachael M / He, Feng J / MacGregor, Graham A

    Medicina (Kaunas, Lithuania)

    2022  Volume 59, Issue 1

    Abstract: Hogas et al. recently published their perspective on dietary salt in a mini review [ ... ]. ...

    Abstract Hogas et al. recently published their perspective on dietary salt in a mini review [...].
    MeSH term(s) Humans ; Sodium Chloride, Dietary/adverse effects
    Chemical Substances Sodium Chloride, Dietary
    Language English
    Publishing date 2022-12-27
    Publishing country Switzerland
    Document type Review ; Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59010051
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  10. Article ; Online: Correction

    Susannah L Woodd / Abdunoor M Kabanywanyi / Andrea M Rehman / Oona M R Campbell / Asila Kagambo / Warda Martiasi / Louise T Day / Alexander M Aiken / Wendy J Graham

    PLoS ONE, Vol 18, Iss 6, p e

    Postnatal infection surveillance by telephone in Dar es Salaam, Tanzania: An observational cohort study.

    2023  Volume 0287801

    Abstract: This corrects the article DOI:10.1371/journal.pone.0254131.]. ...

    Abstract [This corrects the article DOI:10.1371/journal.pone.0254131.].
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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