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Article ; Online: Structural Compromise Between Conflicted Spatial-Arrangements of Two Linkers in Metal-Organic Frameworks.

Lee, Gihyun / Kwon, Haejin / Lee, Sujeong / Oh, Moonhyun

Small methods

2023 Volume 7, Issue 6, Page(s) e2201586

Abstract: The structural control of metal-organic frameworks (MOFs) is essential for the development of superlative MOFs because the structural features of MOFs and their components play a critical role in determining their properties, and ultimately, their ... ...

Abstract	The structural control of metal-organic frameworks (MOFs) is essential for the development of superlative MOFs because the structural features of MOFs and their components play a critical role in determining their properties, and ultimately, their applications. The best components to endow the desired properties for MOFs are available via the appropriate choice from many existing chemicals or synthesizing new ones. However, to date, considerably less information exists regarding fine-tuning the MOF structures. Herein, a strategy for tuning MOF structures by merging two MOF structures into a single MOF, is demonstrated. Depending on the incorporated amounts and relative contributions of the two coexisting organic linkers, benzene-1,4-dicarboxylate (BDC
Language	English
Publishing date	2023-02-19
Publishing country	Germany
Document type	Journal Article
ISSN	2366-9608
ISSN (online)	2366-9608
DOI	10.1002/smtd.202201586
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Article ; Online: Unveiling nurses' end-of-life care experiences: Moral distress and impacts.

Lee, Myung Nam / Kwon, So-Hi / Yu, SuJeong / Park, Sook Hyun / Kwon, Sinyoung / Kim, Cho Hee / Park, Myung-Hee / Choi, Sung Eun / Kim, Sanghee / Kim, Sujeong

Nursing ethics

2024 , Page(s) 9697330241246086

Abstract: Background: Nurses providing care to patients with end-of-life or terminal illnesses often encounter ethically challenging situations leading to moral distress. However, existing quantitative studies have examined moral distress using instruments that ... ...

Abstract	Background: Nurses providing care to patients with end-of-life or terminal illnesses often encounter ethically challenging situations leading to moral distress. However, existing quantitative studies have examined moral distress using instruments that address general clinical situations rather than those specific to end-of-life care. Furthermore, qualitative studies have often been limited to participants from a single unit or those experiencing moral distress-induced circumstances. A comprehensive and integrated understanding of the overarching process of moral distress is vital to discern the unique circumstances surrounding end-of-life care and its consequential impacts. Research objectives: To explore the moral distress experiences of nurses who are frequently involved in caring for patients with end-of-life or terminal illnesses and apply it to two existing theories: the model of moral distress and the ecological model. Research design: A qualitative descriptive approach was employed. Participants and research context: Seven focus group interviews involving 30 nurses were performed. The subsequent transcriptions underwent rigorous content analysis. Ethical considerations: We obtained Institutional Review Board approval from a university. Focus group interviews were conducted with nurses who agreed to participate and signed the consent form. Findings: The moral distress-inducing factors and nurses' perceived impact of moral distress were identified and categorized based on moral distress theories and ecological models. A total of 15 categories and 30 subcategories across the following 4 domains were derived: (1) intrapersonal, (2) interpersonal, (3) organizational, and (4) structural factors. Conclusions: End-of-life-specific circumstances induced moral distress among nurses, with both negative and positive impacts identified. Effective organizational and policy support is essential to manage conflicts, form a healthy organizational culture, provide training, and prevent unnecessary expenses due to the negative consequences of moral distress.
Language	English
Publishing date	2024-04-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1200467-4
ISSN	1477-0989 ; 0969-7330
ISSN (online)	1477-0989
ISSN	0969-7330
DOI	10.1177/09697330241246086
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Article ; Online: Nurses' Perceived Needs and Barriers Regarding Pediatric Palliative Care: A Mixed-Methods Study.

Kang, Kyung-Ah / Yu, SuJeong / Kim, Cho Hee / Lee, Myung-Nam / Kim, Sujeong / Kwon, So-Hi / Kim, Sanghee / Kim, Hyun Sook / Park, Myung-Hee / Choi, Sung Eun

Journal of hospice and palliative care

2023 Volume 25, Issue 2, Page(s) 85–97

Abstract: Purpose: This study aimed to describe nurses' perceived needs and barriers to pediatric palliative care (PPC).: Methods: Mixed methods with an embedded design were applied. An online survey was conducted for nurses who participated in the End-of-Life ...

Abstract	Purpose: This study aimed to describe nurses' perceived needs and barriers to pediatric palliative care (PPC). Methods: Mixed methods with an embedded design were applied. An online survey was conducted for nurses who participated in the End-of-Life Nursing Education Consortium- Pediatric Palliative Care (ELNEC-PPC) train-the-trainer program, of whom 63 responded. Quantitative data were collected with a survey questionnaire developed through the Delphi method. The 47 items for needs and 15 items for barriers to PPC were analyzed with descriptive statistics. Qualitative data were collected through open- ended questions and analyzed with topic modeling techniques. Results: The mean scores of most subdomains of the PPC needs were 3.5 or higher out of 4, and those of PPC barriers ranged from 3.22 to 3.56, indicating the items in the questionnaire developed in this study properly reflect each factor. The needs for PPC were divided into 4 categories "children and adolescents," "families," "PPC management system," and "community-based PPC." Meanwhile, PPC barriers were divided into 3 categories "healthcare delivery system," "healthcare provider," and "client." The keywords derived from the topic modeling were perception, palliative, children, and education for necessities and lack, perception, medical care, professional care providers, service, and system for barriers to PPC. Conclusion: In this study, by using mixed-methods, items of nurses' perceived needs and barriers to PPC were identified, categorized, and weighted, and their meanings were explored. For the stable establishment of PPC, the priority should be given to improving perceptions of PPC, establishing an appropriate system, and training professional care providers.
Language	English
Publishing date	2023-08-10
Publishing country	Korea (South)
Document type	Journal Article
ISSN	2765-3080
ISSN (online)	2765-3080
DOI	10.14475/jhpc.2022.25.2.85
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Article: Impact of Wearing Face Masks on Patients with Severe Asthma During the COVID-19 Pandemic.

Sohn, Kyoung-Hee / Lee, Myung-Nam / Sim, Da Woon / Kim, Sujeong / Cho, You Sook / Kwon, Hyouk-Soo / Kim, Sang-Heon

Journal of asthma and allergy

2022 Volume 15, Page(s) 1065–1068

Language	English
Publishing date	2022-08-15
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494877-9
ISSN	1178-6965
ISSN	1178-6965
DOI	10.2147/JAA.S356912
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Article: Potential role of Fibrosis-4 score in hepatocellular carcinoma screening: The Kangbuk Samsung Health Study.

Shin, Sujeong / Sohn, Won / Chang, Yoosoo / Cho, Yoosun / Kwon, Min-Jung / Wild, Sarah H / Byrne, Christopher D / Ryu, Seungho

Hepatology research : the official journal of the Japan Society of Hepatology

2023

Abstract: Aim: Hepatocellular carcinoma (HCC) is a major cause of cancer-related death, with low survival rates worldwide. Fatty liver disease (FLD) significantly contributes to HCC. We studied the screening performance of different methods for identifying HCC in ...

Abstract	Aim: Hepatocellular carcinoma (HCC) is a major cause of cancer-related death, with low survival rates worldwide. Fatty liver disease (FLD) significantly contributes to HCC. We studied the screening performance of different methods for identifying HCC in patients with FLD or with metabolic risk factors for FLD. Methods: Korean adults (n = 340 825) without a prior HCC diagnosis were categorized into four groups: normal (G1), ≥2 metabolic risk factors (G2), FLD (G3), and viral liver disease or liver cirrhosis (G4). The National Cancer Registry data were used to identify HCC cases within 12 months. We assessed the area under the receiver operating characteristic curve, sensitivity, specificity, and positive and negative predictive values of individual or combined screening methods. Results: In 93 HCC cases, 71 were identified in G4, whereas 20 cases (21.5%) in G2 and G3 combined where ultrasound and Fibrosis-4 performed similarly to alpha-fetoprotein and ultrasound. In G2, Fibrosis-4 and ultrasound had the highest area under the receiver operating characteristic curve (0.93 [0.87-0.99]), whereas in G3, the combined screening methods had the highest area under the receiver operating characteristic curve (0.98 [0.95-1.00]). The positive predictive value was lower in G2 and G3 than in G4, but was >5% when restricted to a high Fibrosis-4 score. Conclusions: More than 21% of HCC cases were observed in patients with diagnosed FLD or at risk of FLD with metabolic risk factors. Nevertheless, screening for HCC in individuals without cirrhosis or viral hepatitis yielded very low results, despite the potential value of the Fibrosis-4 score in identifying individuals at high risk of HCC.
Language	English
Publishing date	2023-12-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1387041-5
ISSN	1386-6346 ; 0928-4346
ISSN	1386-6346 ; 0928-4346
DOI	10.1111/hepr.13999
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Zs.A 3826: Show issues

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Article ; Online: Systematic transcriptome analysis associated with physiological and chronological aging in

Ham, Seokjin / Kim, Sieun S / Park, Sangsoon / Kim, Eun Ji E / Kwon, Sujeong / Park, Hae-Eun H / Jung, Yoonji / Lee, Seung-Jae V

Genome research

2022 Volume 32, Issue 11-12, Page(s) 2003–2014

Abstract: Aging is associated with changes in a variety of biological processes at the transcriptomic level, including gene expression. Two types of aging occur during a lifetime: chronological and physiological aging. However, dissecting the difference between ... ...

Abstract	Aging is associated with changes in a variety of biological processes at the transcriptomic level, including gene expression. Two types of aging occur during a lifetime: chronological and physiological aging. However, dissecting the difference between chronological and physiological ages at the transcriptomic level has been a challenge because of its complexity. We analyzed the transcriptomic features associated with physiological and chronological aging using
MeSH term(s)	Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Aging/genetics ; Aging/metabolism ; Gene Expression Profiling ; Caenorhabditis elegans Proteins/genetics ; Transcriptome
Chemical Substances	Caenorhabditis elegans Proteins
Language	English
Publishing date	2022-11-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1284872-4
ISSN	1549-5469 ; 1088-9051 ; 1054-9803
ISSN (online)	1549-5469
ISSN	1088-9051 ; 1054-9803
DOI	10.1101/gr.276515.121
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Zs.A 3729: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 8: Show issues

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Article ; Online: An ancestral SARS-CoV-2 vaccine induces anti-Omicron variants antibodies by hypermutation.

Park, Seoryeong / Choi, Jaewon / Lee, Yonghee / Noh, Jinsung / Kim, Namphil / Lee, JinAh / Cho, Geummi / Kim, Sujeong / Yoo, Duck Kyun / Kang, Chang Kyung / Choe, Pyoeng Gyun / Kim, Nam Joong / Park, Wan Beom / Kim, Seungtaek / Oh, Myoung-Don / Kwon, Sunghoon / Chung, Junho

Nature communications

2024 Volume 15, Issue 1, Page(s) 3368

Abstract: The immune escape of Omicron variants significantly subsides by the third dose of an mRNA vaccine. However, it is unclear how Omicron variant-neutralizing antibodies develop under repeated vaccination. We analyze blood samples from 41 BNT162b2 vaccinees ... ...

Abstract	The immune escape of Omicron variants significantly subsides by the third dose of an mRNA vaccine. However, it is unclear how Omicron variant-neutralizing antibodies develop under repeated vaccination. We analyze blood samples from 41 BNT162b2 vaccinees following the course of three injections and analyze their B-cell receptor (BCR) repertoires at six time points in total. The concomitant reactivity to both ancestral and Omicron receptor-binding domain (RBD) is achieved by a limited number of BCR clonotypes depending on the accumulation of somatic hypermutation (SHM) after the third dose. Our findings suggest that SHM accumulation in the BCR space to broaden its specificity for unseen antigens is a counterprotective mechanism against virus variant immune escape.
MeSH term(s)	Humans ; COVID-19 Vaccines ; BNT162 Vaccine ; COVID-19/prevention & control ; SARS-CoV-2/genetics ; Antibodies, Neutralizing ; Antibodies, Viral
Chemical Substances	COVID-19 Vaccines ; BNT162 Vaccine ; Antibodies, Neutralizing ; Antibodies, Viral
Language	English
Publishing date	2024-04-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-47743-1
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Article ; Online: Age-dependent upregulation of Y RNAs in

Park, Sangsoon / Sohn, Jooyeon / Kwon, Sujeong / Kim, Eun Ji E / Jung, Yoonji / Park, Hae-Eun H / Kim, Sieun S / Lee, Seung-Jae V

microPublication biology

2021 Volume 2021

Abstract: Y RNA is a conserved small non-coding RNA whose functions in aging remain unknown. Here, we sought to determine the role ... ...

Abstract	Y RNA is a conserved small non-coding RNA whose functions in aging remain unknown. Here, we sought to determine the role of
Language	English
Publishing date	2021-09-27
Publishing country	United States
Document type	Journal Article
ISSN	2578-9430
ISSN (online)	2578-9430
DOI	10.17912/micropub.biology.000452
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Article ; Online: Mitochondrial aconitase suppresses immunity by modulating oxaloacetate and the mitochondrial unfolded protein response.

Kim, Eunah / Annibal, Andrea / Lee, Yujin / Park, Hae-Eun H / Ham, Seokjin / Jeong, Dae-Eun / Kim, Younghun / Park, Sangsoon / Kwon, Sujeong / Jung, Yoonji / Park, JiSoo / Kim, Sieun S / Antebi, Adam / Lee, Seung-Jae V

Nature communications

2023 Volume 14, Issue 1, Page(s) 3716

Abstract: Accumulating evidence indicates that mitochondria play crucial roles in immunity. However, the role of the mitochondrial Krebs cycle in immunity remains largely unknown, in particular at the organism level. Here we show that mitochondrial aconitase, ACO- ... ...

Abstract	Accumulating evidence indicates that mitochondria play crucial roles in immunity. However, the role of the mitochondrial Krebs cycle in immunity remains largely unknown, in particular at the organism level. Here we show that mitochondrial aconitase, ACO-2, a Krebs cycle enzyme that catalyzes the conversion of citrate to isocitrate, inhibits immunity against pathogenic bacteria in C. elegans. We find that the genetic inhibition of aco-2 decreases the level of oxaloacetate. This increases the mitochondrial unfolded protein response, subsequently upregulating the transcription factor ATFS-1, which contributes to enhanced immunity against pathogenic bacteria. We show that the genetic inhibition of mammalian ACO2 increases immunity against pathogenic bacteria by modulating the mitochondrial unfolded protein response and oxaloacetate levels in cultured cells. Because mitochondrial aconitase is highly conserved across phyla, a therapeutic strategy targeting ACO2 may eventually help properly control immunity in humans.
MeSH term(s)	Humans ; Animals ; Aconitate Hydratase/genetics ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Oxaloacetic Acid ; Oxaloacetates ; Unfolded Protein Response ; Mammals/metabolism
Chemical Substances	Aconitate Hydratase (EC 4.2.1.3) ; Oxaloacetic Acid (2F399MM81J) ; Oxaloacetates
Language	English
Publishing date	2023-06-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-39393-6
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Article ; Online: Mitochondria-mediated defense mechanisms against pathogens in Caenorhabditis elegans.

Kwon, Sujeong / Kim, Eun Ji E / Lee, Seung-Jae V

BMB reports

2018 Volume 51, Issue 6, Page(s) 274–279

Abstract: Mitochondria are crucial organelles that generate cellular energy and metabolites. Recent studies indicate that mitochondria also regulate immunity. In this review, we discuss key roles of mitochondria in immunity against pathogen infection and ... ...

Abstract	Mitochondria are crucial organelles that generate cellular energy and metabolites. Recent studies indicate that mitochondria also regulate immunity. In this review, we discuss key roles of mitochondria in immunity against pathogen infection and underlying mechanisms, focusing on discoveries using Caenorhabditis elegans. Various mitochondrial processes, including mitochondrial surveillance mechanisms, mitochondrial unfolded protein response (UPRmt), mitophagy, and reactive oxygen species (ROS) production, contribute to immune responses and resistance of C. elegans against pathogens. Biological processes of C. elegans are usually conserved across phyla. Thus, understanding the mechanisms of mitochondria-mediated defense responses in C. elegans may provide insights into similar mechanisms in complex organisms, including mammals. [BMB Reports 2018; 51(6): 274-279].
MeSH term(s)	Animals ; Caenorhabditis elegans/immunology ; Caenorhabditis elegans Proteins/immunology ; Immunity/physiology ; Mitochondria/immunology ; Mitochondrial Degradation ; Mitochondrial Proteins/immunology ; Reactive Oxygen Species/immunology ; Unfolded Protein Response
Chemical Substances	Caenorhabditis elegans Proteins ; Mitochondrial Proteins ; Reactive Oxygen Species
Language	English
Publishing date	2018-05-15
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2410389-5
ISSN	1976-670X ; 1976-6696
ISSN (online)	1976-670X
ISSN	1976-6696
DOI	10.5483/bmbrep.2018.51.6.111
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