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  1. Article ; Online: Stalking the link between reproduction and aging: After decades of research, it still remains a mystery whether and how reproduction drives the process of aging: After decades of research, it still remains a mystery whether and how reproduction drives the process of aging.

    Tatar, Marc

    EMBO reports

    2023  Volume 24, Issue 6, Page(s) e57374

    Abstract: The hypothesis that aging and number of offspring are linked with each other has attracted much attention and research, but evidence for it remains elusive. ...

    Abstract The hypothesis that aging and number of offspring are linked with each other has attracted much attention and research, but evidence for it remains elusive.
    MeSH term(s) Reproduction ; Aging
    Language English
    Publishing date 2023-05-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.15252/embr.202357374
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Aging Regulated Through a Stability Model of Insulin/Insulin Growth Factor Receptor Function.

    Tatar, Marc

    Frontiers in endocrinology

    2021  Volume 12, Page(s) 649880

    Abstract: Mutations of the insulin-like receptor ... ...

    Abstract Mutations of the insulin-like receptor in
    MeSH term(s) Aging ; Animals ; Binding Sites ; Caenorhabditis elegans ; Caenorhabditis elegans Proteins/metabolism ; Diapause ; Dimerization ; Drosophila Proteins/metabolism ; Drosophila melanogaster ; Female ; Insulin/metabolism ; Insulin Resistance ; Ligands ; Longevity ; Mutation ; Phenotype ; Phosphorylation ; Protein Binding ; Protein Domains ; Receptor Protein-Tyrosine Kinases/genetics ; Receptor Protein-Tyrosine Kinases/metabolism ; Receptor, IGF Type 1/genetics ; Receptor, IGF Type 1/metabolism ; Receptor, Insulin/metabolism ; Signal Transduction ; Substrate Specificity
    Chemical Substances Caenorhabditis elegans Proteins ; Drosophila Proteins ; Insulin ; Ligands ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; Receptor, IGF Type 1 (EC 2.7.10.1) ; Receptor, Insulin (EC 2.7.10.1)
    Language English
    Publishing date 2021-03-11
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2021.649880
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Combinatorial interventions in aging.

    Parkhitko, Andrey A / Filine, Elizabeth / Tatar, Marc

    Nature aging

    2023  Volume 3, Issue 10, Page(s) 1187–1200

    Abstract: ... combined manipulations additively increase their impact on common hallmarks of aging and lifespan ... different hallmarks, suggesting their joint manipulation may independently maximize their effects ...

    Abstract Insight on the underlying mechanisms of aging will advance our ability to extend healthspan, treat age-related pathology and improve quality of life. Multiple genetic and pharmacological manipulations extend longevity in different species, yet monotherapy may be relatively inefficient, and we have limited data on the effect of combined interventions. Here we summarize interactions between age-related pathways and discuss strategies to simultaneously retard these in different organisms. In some cases, combined manipulations additively increase their impact on common hallmarks of aging and lifespan, suggesting they quantitatively participate within the same pathway. In other cases, interactions affect different hallmarks, suggesting their joint manipulation may independently maximize their effects on lifespan and healthy aging. While most interaction studies have been conducted with invertebrates and show varying levels of translatability, the conservation of pro-longevity pathways offers an opportunity to identify 'druggable' targets relevant to multiple human age-associated pathologies.
    MeSH term(s) Humans ; Quality of Life ; Aging/genetics ; Longevity/genetics ; Healthy Aging/genetics
    Language English
    Publishing date 2023-10-02
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2662-8465
    ISSN (online) 2662-8465
    DOI 10.1038/s43587-023-00489-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Using Merocel Marked with Skin Marker as a Background in Microsurgical Anastomosis: Our Clinical Practice.

    Tatar, Burak Ergün / Erçin, Burak Sercan

    Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India

    2022  Volume 55, Issue 3, Page(s) 311–312

    Language English
    Publishing date 2022-07-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2118680-7
    ISSN 1998-376X ; 0970-0358
    ISSN (online) 1998-376X
    ISSN 0970-0358
    DOI 10.1055/s-0042-1750374
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Unraveling the Molecular Mechanism of Immunosenescence in

    Min, Kyung-Jin / Tatar, Marc

    International journal of molecular sciences

    2018  Volume 19, Issue 9

    Abstract: A common feature of the aging process is a decline in immune system performance. Extensive research has sought to elucidate how changes in adaptive immunity contribute to aging and to provide evidence showing that changes in innate immunity have an ... ...

    Abstract A common feature of the aging process is a decline in immune system performance. Extensive research has sought to elucidate how changes in adaptive immunity contribute to aging and to provide evidence showing that changes in innate immunity have an important role in the overall decline of net immune function.
    MeSH term(s) Aging/genetics ; Aging/immunology ; Animals ; Drosophila Proteins/genetics ; Drosophila Proteins/immunology ; Drosophila melanogaster/genetics ; Drosophila melanogaster/immunology ; Drosophila melanogaster/microbiology ; Ecdysterone/immunology ; Ecdysterone/metabolism ; Feedback, Physiological ; Gastrointestinal Microbiome/immunology ; Gene Expression Regulation ; Immunity, Innate ; Immunosenescence/genetics ; Insulin/genetics ; Insulin/immunology ; Insulin-Like Growth Factor I/genetics ; Insulin-Like Growth Factor I/immunology ; Juvenile Hormones/immunology ; Juvenile Hormones/metabolism ; Models, Biological ; Signal Transduction
    Chemical Substances Drosophila Proteins ; Insulin ; Juvenile Hormones ; Ecdysterone (5289-74-7) ; Insulin-Like Growth Factor I (67763-96-6)
    Language English
    Publishing date 2018-08-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms19092472
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A Current Diagnostic and Therapeutic Challenge: Tinea Capitis.

    Ion, Ana / Popa, Liliana Gabriela / Porumb-Andrese, Elena / Dorobanțu, Alexandra Maria / Tătar, Raluca / Giurcăneanu, Călin / Orzan, Olguța Anca

    Journal of clinical medicine

    2024  Volume 13, Issue 2

    Abstract: Tinea capitis is a dermatophyte scalp infection with a marked prevalence among the pediatric ...

    Abstract Tinea capitis is a dermatophyte scalp infection with a marked prevalence among the pediatric population. However, in the last few years, its epidemiology has changed due to increasing population migration worldwide. Host-specific and environmental factors contribute to the pathogenesis of tinea capitis. Clinically, tinea capitis may present as a subtle hair loss accompanied by scalp scaling, alopecia with scaly patches, or alopecia with black dots. A more severe form of tinea capitis is represented by kerion celsi, which clinically presents as a tender plaque covered by pustules and crusts. If left untreated, this dermatophytic infection may resolve with permanent scarring and alopecia. The pathological changes found in tinea capitis are reflected by a spectrum of clinical changes. Zoophilic infections typically prompt an extensive inflammatory reaction, while anthropophilic dermatophytoses often lack inflammation and result in more persistent lesions. Tinea capitis typically requires systemic antifungal therapy. Griseofulvin, terbinafine, itraconazole, and fluconazole are the main antifungal agents used. Currently, the duration of antifungal therapy varies based on the clinical presentation and type of dermatophyte involved. Through the reported cases and literature review, we aim to emphasize the importance of the early recognition of atypical variants of tinea capitis in immunocompetent children for the prompt initiation of systemic antifungal therapy, minimizing the need for prolonged treatment. Additionally, we emphasize the importance of regular laboratory testing during systemic antifungal therapy, particularly liver enzyme tests, to prevent adverse events, especially in cases requiring long-term treatment.
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13020376
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  7. Article ; Online: Extracellular matrix induced by steroids and aging through a G-protein-coupled receptor in a

    Zheng, Wenjing / Ocorr, Karen / Tatar, Marc

    Disease models & mechanisms

    2020  Volume 13, Issue 6

    Abstract: Aldosterone is produced by the mammalian adrenal cortex to modulate blood pressure and fluid balance; however, excessive, prolonged aldosterone promotes fibrosis and kidney failure. How aldosterone triggers disease may involve actions independent of its ... ...

    Abstract Aldosterone is produced by the mammalian adrenal cortex to modulate blood pressure and fluid balance; however, excessive, prolonged aldosterone promotes fibrosis and kidney failure. How aldosterone triggers disease may involve actions independent of its canonical mineralocorticoid receptor. Here, we present a
    MeSH term(s) Age Factors ; Aldosterone ; Animals ; Animals, Genetically Modified ; Collagen Type IV/genetics ; Collagen Type IV/metabolism ; Disease Models, Animal ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Ecdysone ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Extracellular Matrix/genetics ; Extracellular Matrix/metabolism ; Extracellular Matrix/pathology ; Fibrosis ; Kidney/metabolism ; Kidney/pathology ; Kidney Diseases/chemically induced ; Kidney Diseases/genetics ; Kidney Diseases/metabolism ; Kidney Diseases/pathology ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Receptors, Invertebrate Peptide/genetics ; Receptors, Invertebrate Peptide/metabolism ; Receptors, Steroid/genetics ; Receptors, Steroid/metabolism ; Signal Transduction
    Chemical Substances Collagen Type IV ; Drosophila Proteins ; Prc protein, Drosophila ; Receptors, Invertebrate Peptide ; Receptors, Steroid ; ecdysone receptor ; Ecdysone (3604-87-3) ; Aldosterone (4964P6T9RB) ; Egfr protein, Drosophila (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2020-06-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.041301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: DraiNet: AI-driven decision support in pneumothorax and pleural effusion management.

    Tatar, Ozan Can / Akay, Mustafa Alper / Metin, Semih

    Pediatric surgery international

    2023  Volume 40, Issue 1, Page(s) 30

    Abstract: ... The integration of DraiNet as an AI-driven decision support system marks a significant advancement in pediatric ...

    Abstract Objective: This study presents DraiNet, a deep learning model developed to detect pneumothorax and pleural effusion in pediatric patients and aid in assessing the necessity for tube thoracostomy. The primary goal is to utilize DraiNet as a decision support tool to enhance clinical decision-making in the management of these conditions.
    Methods: DraiNet was trained on a diverse dataset of pediatric CT scans, carefully annotated by experienced surgeons. The model incorporated advanced object detection techniques and underwent evaluation using standard metrics, such as mean Average Precision (mAP), to assess its performance.
    Results: DraiNet achieved an impressive mAP score of 0.964, demonstrating high accuracy in detecting and precisely localizing abnormalities associated with pneumothorax and pleural effusion. The model's precision and recall further confirmed its ability to effectively predict positive cases.
    Conclusion: The integration of DraiNet as an AI-driven decision support system marks a significant advancement in pediatric healthcare. By combining deep learning algorithms with clinical expertise, DraiNet provides a valuable tool for non-surgical teams and emergency room doctors, aiding them in making informed decisions about surgical interventions. With its remarkable mAP score of 0.964, DraiNet has the potential to enhance patient outcomes and optimize the management of critical conditions, including pneumothorax and pleural effusion.
    MeSH term(s) Humans ; Child ; Pneumothorax/therapy ; Pneumothorax/surgery ; Thoracostomy/methods ; Pleural Effusion/surgery ; Chest Tubes ; Tomography, X-Ray Computed
    Language English
    Publishing date 2023-12-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 632773-4
    ISSN 1437-9813 ; 0179-0358
    ISSN (online) 1437-9813
    ISSN 0179-0358
    DOI 10.1007/s00383-023-05609-5
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  9. Article ; Online: Reproductive aging in invertebrate genetic models.

    Tatar, Marc

    Annals of the New York Academy of Sciences

    2010  Volume 1204, Page(s) 149–155

    Abstract: The invertebrate genetic systems of Caenorhabditis elegans and Drosophila melanogaster are emerging models to understand the underlying mechanisms of reproductive aging and the relationship between reproduction and lifespan. Both animals show progressive ...

    Abstract The invertebrate genetic systems of Caenorhabditis elegans and Drosophila melanogaster are emerging models to understand the underlying mechanisms of reproductive aging and the relationship between reproduction and lifespan. Both animals show progressive decline in egg production beginning at early middle age, caused in part by reduction in germline stem cell proliferation as well as in survival of developing eggs. Molecular genetic analysis reveals that insulin and TGF-beta signaling are regulators of germline stem cell maintenance and proliferation during aging. Furthermore, the lifespan of both C. elegans and D. melanogaster appears to be regulated by signaling that depends on the presence of germline stem cells in the adult gonad. These invertebrate models provide powerful tools to dissect conserved causes of reproductive aging.
    MeSH term(s) Aging/genetics ; Aging/physiology ; Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans/physiology ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Drosophila melanogaster/physiology ; Insulin/metabolism ; Invertebrates/genetics ; Invertebrates/physiology ; Models, Animal ; Reproduction/genetics ; Reproduction/physiology ; Transforming Growth Factor beta/metabolism
    Chemical Substances Insulin ; Transforming Growth Factor beta
    Language English
    Publishing date 2010-08-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1111/j.1749-6632.2010.05522.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The plate half-full: status of research on the mechanisms of dietary restriction in Drosophila melanogaster.

    Tatar, Marc

    Experimental gerontology

    2010  Volume 46, Issue 5, Page(s) 363–368

    Abstract: It has been almost two decades since dietary restriction was first shown to increase Drosophila lifespan. Since then, understanding this phenomenon advanced as groups worked to identify what quality of restricted diet matters: calories or a specific ... ...

    Abstract It has been almost two decades since dietary restriction was first shown to increase Drosophila lifespan. Since then, understanding this phenomenon advanced as groups worked to identify what quality of restricted diet matters: calories or a specific nutrient. The problem is complex because is it difficult to measure what a fly actually consumes. A powerful solution uses the geometric framework of nutrition where diets in many combinations can be tested for their effects on lifespan and reproduction while measuring intake. Applied to Drosophila, it is now clear that specific nutrients, not calories, mediate longevity. The geometric framework also reveals a nutritional basis for the trade-off between reproduction and lifespan. This complements a stable-isotope analysis that tracked the allocation of nitrogen, carbon and essential amino acids into eggs versus reproduction. Together, these studies show that it is not possible to explain how DR extends lifespan through a mechanism were resources are simply reallocated to somatic maintenance away from reproduction. Although promising in principle, genetic analysis of DR mechanisms has had limited success. To be productive, studies must include enough diets at appropriate concentrations. In reviewing the best data, there is little evidence to date for any gene to be required for DR to increase Drosophila lifespan, including insulin signaling or 4eBP. Strong analyses of genes required for DR should be a priority in future research with Drosophila and this may be made most robust by considering the effect of mutants in the context of the geometric framework.
    MeSH term(s) Aging/physiology ; Animals ; Caloric Restriction ; Drosophila melanogaster/physiology ; Food Deprivation/physiology ; Models, Animal
    Language English
    Publishing date 2010-12-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 390992-x
    ISSN 1873-6815 ; 0531-5565
    ISSN (online) 1873-6815
    ISSN 0531-5565
    DOI 10.1016/j.exger.2010.12.002
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