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  1. Article: [Rezension von: Asian money markets, David C. Cole ... (eds.)]

    Chan, Kalok

    Journal of comparative economics : the journal of the Association for Comparative Economic Studies 1997,June = Vol. 24, Nr. 3, S. 362-364

    1997  Volume 24

    Author's details Kalok Chan
    Keywords 40;49
    Language English
    Publisher Elsevier
    Publishing place Amsterdam
    Document type Article
    ZDB-ID 715350-8
    ISSN 0147-5967
    Database ECONomics Information System

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  2. Article: Development of a signal-integrating reporter to monitor mitochondria-ER contacts.

    Yang, Zheng / Chan, David C

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Mitochondria-ER contact sites (MERCS) serve as hotspots for important cellular processes, including calcium homeostasis, phospholipid homeostasis, mitochondria dynamics, and mitochondrial quality control. MERCS reporters based on complementation of GFP ... ...

    Abstract Mitochondria-ER contact sites (MERCS) serve as hotspots for important cellular processes, including calcium homeostasis, phospholipid homeostasis, mitochondria dynamics, and mitochondrial quality control. MERCS reporters based on complementation of GFP fragments have been designed to visualize MERCS in real-time, but we find that they do not accurately respond to changes in MERCS content. Here, we utilize split LacZ complementing fragments to develop the first MERCS reporter system (termed SpLacZ-MERCS) that continuously integrates the MERCS information within a cell and generates a fluorescent output. Our system exhibits good organelle targeting, no artifactual tethering, and effective, dynamic tracking of the MERCS level in single cells. The SpLacZ-MERCS reporter was validated by drug treatments and genetic perturbations known to affect mitochondria-ER contacts. The signal-integrating nature of SpLacZ-MERCS may enable systematic identification of genes and drugs that regulate mitochondria-ER interactions. Our successful application of the split LacZ complementation strategy to study MERCS may be extended to study other forms of inter-organellar crosstalk.
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.14.580376
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Fusion activators enhance mitochondrial function.

    Rosencrans, William M / Chan, David C

    Mitochondrial communications

    2023  Volume 1, Page(s) 33–34

    Language English
    Publishing date 2023-03-12
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2590-2792
    ISSN (online) 2590-2792
    DOI 10.1016/j.mitoco.2023.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Incorporating chemical structures into scientific figures.

    Banerjee, Ruma / David, Yael / Chan, Jennifer C

    Trends in biochemical sciences

    2023  Volume 48, Issue 9, Page(s) 743–745

    Language English
    Publishing date 2023-08-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 194216-5
    ISSN 1362-4326 ; 0968-0004 ; 0376-5067
    ISSN (online) 1362-4326
    ISSN 0968-0004 ; 0376-5067
    DOI 10.1016/j.tibs.2023.06.003
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    Zs.A 1207: Show issues Location:
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  5. Article ; Online: Control of mitochondrial dynamics by a fusogenic lipid.

    Yang, Zheng / Chan, David C

    Trends in cell biology

    2023  Volume 33, Issue 12, Page(s) 1005–1006

    Abstract: Mitochondrial fusion enables cooperation between the mitochondrial population and is critical for mitochondrial function. Phosphatidic acid (PA) on the mitochondrial surface has a key role in mitochondrial fusion. A recent study by Su et al. shows that ... ...

    Abstract Mitochondrial fusion enables cooperation between the mitochondrial population and is critical for mitochondrial function. Phosphatidic acid (PA) on the mitochondrial surface has a key role in mitochondrial fusion. A recent study by Su et al. shows that the nucleoside diphosphate (NDP) kinase NME3 recognizes PA and mediates its effects on mitochondrial dynamics.
    MeSH term(s) Humans ; Mitochondrial Dynamics ; Mitochondria ; Lipids
    Chemical Substances Lipids
    Language English
    Publishing date 2023-10-17
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 30122-x
    ISSN 1879-3088 ; 0962-8924
    ISSN (online) 1879-3088
    ISSN 0962-8924
    DOI 10.1016/j.tcb.2023.10.006
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    Zs.A 3410: Show issues Location:
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  6. Article ; Online: Economic Incentives for Chest Physicians.

    Chan, David C / Gottlieb, Joshua D

    Chest

    2022  Volume 161, Issue 4, Page(s) 1122–1123

    MeSH term(s) Humans ; Motivation ; Physicians
    Language English
    Publishing date 2022-01-08
    Publishing country United States
    Document type Editorial
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2021.12.652
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  7. Article ; Online: K Grant Funding to Internal Medicine Specialties.

    Gallo, Robert J / Asch, Steven M / Chan, David C

    Journal of general internal medicine

    2023  Volume 39, Issue 2, Page(s) 348–350

    MeSH term(s) Humans ; United States ; Internal Medicine ; Biomedical Research
    Language English
    Publishing date 2023-10-30
    Publishing country United States
    Document type Letter
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-023-08483-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 2205: Show issues Location:
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  8. Article ; Online: The HRI branch of the integrated stress response selectively triggers mitophagy.

    Chakrabarty, Yogaditya / Yang, Zheng / Chen, Hsiuchen / Chan, David C

    Molecular cell

    2024  Volume 84, Issue 6, Page(s) 1090–1100.e6

    Abstract: To maintain mitochondrial homeostasis, damaged or excessive mitochondria are culled in coordination with the physiological state of the cell. The integrated stress response (ISR) is a signaling network that recognizes diverse cellular stresses, including ...

    Abstract To maintain mitochondrial homeostasis, damaged or excessive mitochondria are culled in coordination with the physiological state of the cell. The integrated stress response (ISR) is a signaling network that recognizes diverse cellular stresses, including mitochondrial dysfunction. Because the four ISR branches converge to common outputs, it is unclear whether mitochondrial stress detected by this network can regulate mitophagy, the autophagic degradation of mitochondria. Using a whole-genome screen, we show that the heme-regulated inhibitor (HRI) branch of the ISR selectively induces mitophagy. Activation of the HRI branch results in mitochondrial localization of phosphorylated eukaryotic initiation factor 2, which we show is sufficient to induce mitophagy. The HRI mitophagy pathway operates in parallel with the mitophagy pathway controlled by the Parkinson's disease related genes PINK1 and PARKIN and is mechanistically distinct. Therefore, HRI repurposes machinery that is normally used for translational initiation to trigger mitophagy in response to mitochondrial damage.
    MeSH term(s) Mitophagy/physiology ; Protein Kinases/genetics ; Protein Kinases/metabolism ; Autophagy/genetics ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Protein Processing, Post-Translational ; Signal Transduction
    Chemical Substances Protein Kinases (EC 2.7.-) ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2024.01.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5055: Show issues Location:
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  9. Article: Pneumomediastinum and subcutaneous emphysema complicating a patient with a lung abscess.

    Chan, Christopher / Ngai, Jenny C L / Chan, Ken K P / Ng, Joyce K C / Hui, David S C

    Respirology case reports

    2023  Volume 11, Issue 3, Page(s) e01090

    Abstract: ... with leucocytosis and raised C-reactive protein. Ultrasound-guided drainage revealed viscous pus requiring manual ...

    Abstract Pneumomediastinum and subcutaneous emphysema are conditions that carry significant morbidity. They are uncommonly seen as complications of lung abscess formation and prompt recognition and treatment is necessary. We present a 59-year-old male patient who complained of shortness of breath and chest pain for 2 weeks. Computed tomography (CT) of the thorax showed a left lower lobe lung abscess. This was associated with leucocytosis and raised C-reactive protein. Ultrasound-guided drainage revealed viscous pus requiring manual aspiration for adequate drainage. The patient later developed extensive pneumomediastinum and subcutaneous emphysema involving the pretracheal space, without evidence of pneumothorax. Left lower lobectomy was performed to control sepsis. The patient achieved a complete recovery following his surgery and antibiotic treatment, with interval resolution of pneumomediastinum and subcutaneous emphysema. We present the radiological and clinical features leading to the diagnosis of pneumomediastinum and subcutaneous emphysema.
    Language English
    Publishing date 2023-02-02
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2750180-2
    ISSN 2051-3380
    ISSN 2051-3380
    DOI 10.1002/rcr2.1090
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  10. Article ; Online: Mitochondrial Dynamics and Its Involvement in Disease.

    Chan, David C

    Annual review of pathology

    2019  Volume 15, Page(s) 235–259

    Abstract: The dynamic properties of mitochondria-including their fusion, fission, and degradation-are critical for their optimal function in energy generation. The interplay of fusion and fission confers widespread benefits on mitochondria, including efficient ... ...

    Abstract The dynamic properties of mitochondria-including their fusion, fission, and degradation-are critical for their optimal function in energy generation. The interplay of fusion and fission confers widespread benefits on mitochondria, including efficient transport, increased homogenization of the mitochondrial population, and efficient oxidative phosphorylation. These benefits arise through control of morphology, content exchange, equitable inheritance of mitochondria, maintenance of high-quality mitochondrial DNA, and segregation of damaged mitochondria for degradation. The key components of the machinery mediating mitochondrial fusion and fission belong to the dynamin family of GTPases that utilize GTP hydrolysis to drive mechanical work on biological membranes. Defects in this machinery cause a range of diseases that especially affect the nervous system. In addition, several common diseases, including neurodegenerative diseases and cancer, strongly affect mitochondrial dynamics.
    MeSH term(s) Animals ; DNA, Mitochondrial/physiology ; Disease/etiology ; Humans ; Mitochondria/genetics ; Mitochondria/metabolism ; Mitochondrial Diseases/complications ; Mitochondrial Dynamics/physiology ; Neurodegenerative Diseases
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2019-10-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2227429-7
    ISSN 1553-4014 ; 1553-4006
    ISSN (online) 1553-4014
    ISSN 1553-4006
    DOI 10.1146/annurev-pathmechdis-012419-032711
    Database MEDical Literature Analysis and Retrieval System OnLINE

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