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  1. Article ; Online: Organelles: The Emerging Signalling Chart of Mitochondrial Dynamics.

    Calì, Tito / Szabadkai, Gyorgy

    Current biology : CB

    2018  Volume 28, Issue 2, Page(s) R73–R75

    Abstract: Many molecular and functional details of single events in mitochondrial dynamics have been reported, but little is known about their coordination. A recent study describes how cellular ... ...

    Abstract Many molecular and functional details of single events in mitochondrial dynamics have been reported, but little is known about their coordination. A recent study describes how cellular Ca
    MeSH term(s) Actins ; Animals ; Calcium ; Constriction ; Mitochondria ; Mitochondrial Dynamics ; Polymerization
    Chemical Substances Actins ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2018-01-26
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2017.11.040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3208: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  2. Article ; Online: Determination of ATP, ADP, and AMP Levels by Reversed-Phase High-Performance Liquid Chromatography in Cultured Cells.

    Menegollo, Michela / Tessari, Isabella / Bubacco, Luigi / Szabadkai, Gyorgy

    Methods in molecular biology (Clifton, N.J.)

    2019  Volume 1925, Page(s) 223–232

    Abstract: Cytoplasmic and mitochondrial ... ...

    Abstract Cytoplasmic and mitochondrial Ca
    MeSH term(s) Adenosine Diphosphate/analysis ; Adenosine Monophosphate/analysis ; Adenosine Triphosphate/analysis ; Breast Neoplasms/chemistry ; Cell Line, Tumor ; Chromatography, High Pressure Liquid/methods ; Chromatography, Reverse-Phase/methods ; Female ; Humans ; MCF-7 Cells
    Chemical Substances Adenosine Monophosphate (415SHH325A) ; Adenosine Diphosphate (61D2G4IYVH) ; Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2019-01-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-9018-4_19
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  3. Article ; Online: Fantastic beasts and how to find them-Molecular identification of the mitochondrial ATP-sensitive potassium channel.

    Davidson, Sean M / Szabadkai, Gyorgy / Duchen, Michael R

    Cell calcium

    2019  Volume 84, Page(s) 102100

    Abstract: Despite reported sightings over many years, certain mitochondrial-specific channels have proven to be elusive beasts, evading molecular identification. However, combining modern genetics with a wave of their ion-sensing wand, researchers have managed to ... ...

    Abstract Despite reported sightings over many years, certain mitochondrial-specific channels have proven to be elusive beasts, evading molecular identification. However, combining modern genetics with a wave of their ion-sensing wand, researchers have managed to capture first the mitochondrial calcium uniporter, and now that semi-mythological beast, the mitochondrial ATP-sensitive potassium (mitoK
    MeSH term(s) Adenosine Triphosphate/metabolism ; Animals ; Humans ; KATP Channels/genetics ; KATP Channels/metabolism ; Mitochondria/metabolism ; Potassium/metabolism ; Potassium Channel Blockers/pharmacology ; Reperfusion Injury/metabolism
    Chemical Substances KATP Channels ; Potassium Channel Blockers ; Adenosine Triphosphate (8L70Q75FXE) ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2019-10-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 757687-0
    ISSN 1532-1991 ; 0143-4160
    ISSN (online) 1532-1991
    ISSN 0143-4160
    DOI 10.1016/j.ceca.2019.102100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1596: Show issues Location:
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  4. Article ; Online: Biclustering Analysis of Co-regulation Patterns in Nuclear-Encoded Mitochondrial Genes and Metabolic Pathways.

    Bentham, Robert B / Bryson, Kevin / Szabadkai, Gyorgy

    Methods in molecular biology (Clifton, N.J.)

    2019  Volume 1928, Page(s) 469–478

    Abstract: Transcription of a large set of nuclear-encoded genes underlies biogenesis of mitochondria, regulated by a complex network of transcription factors and co-regulators. A remarkable heterogeneity can be detected in the expression of these genes in ... ...

    Abstract Transcription of a large set of nuclear-encoded genes underlies biogenesis of mitochondria, regulated by a complex network of transcription factors and co-regulators. A remarkable heterogeneity can be detected in the expression of these genes in different cell types and tissues, and the recent availability of large gene expression compendiums allows the quantification of specific mitochondrial biogenesis patterns. We have developed a method to effectively perform this task. Massively correlated biclustering (MCbiclust) is a novel bioinformatics method that has been successfully applied to identify co-regulation patterns in large genesets, underlying essential cellular functions and determining cell types. The method has been recently evaluated and made available as a package in Bioconductor for R. One of the potential applications of the method is to compare expression of nuclear-encoded mitochondrial genes or larger sets of metabolism-related genes between different cell types or cellular metabolic states. Here we describe the essential steps to use MCbiclust as a tool to investigate co-regulation of mitochondrial genes and metabolic pathways.
    MeSH term(s) Algorithms ; Cluster Analysis ; Computational Biology/methods ; Databases, Genetic ; Gene Expression Profiling/methods ; Gene Expression Regulation ; Gene Regulatory Networks ; Genes, Mitochondrial ; Metabolic Networks and Pathways ; Mitochondria/metabolism
    Language English
    Publishing date 2019-02-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-9027-6_24
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  5. Article: What Makes You Can also Break You, Part III: Mitochondrial Permeability Transition Pore Formation by an Uncoupling Channel within the C-Subunit Ring of the F1FO ATP Synthase?

    Chinopoulos, Christos / Szabadkai, Gyorgy

    Frontiers in oncology

    2014  Volume 4, Page(s) 235

    Language English
    Publishing date 2014-09-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2014.00235
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  6. Article ; Online: Metabolic Profiling of Live Cancer Tissues Using NAD(P)H Fluorescence Lifetime Imaging.

    Blacker, Thomas S / Sewell, Michael D E / Szabadkai, Gyorgy / Duchen, Michael R

    Methods in molecular biology (Clifton, N.J.)

    2019  Volume 1928, Page(s) 365–387

    Abstract: Altered metabolism is a hallmark of cancer, both resulting from and driving oncogenesis. The NAD and NADP redox couples play a key role in a large number of the metabolic pathways involved. In their reduced forms, NADH and NADPH, these molecules are ... ...

    Abstract Altered metabolism is a hallmark of cancer, both resulting from and driving oncogenesis. The NAD and NADP redox couples play a key role in a large number of the metabolic pathways involved. In their reduced forms, NADH and NADPH, these molecules are intrinsically fluorescent. As the average time for fluorescence to be emitted following excitation by a laser pulse, the fluorescence lifetime, is exquisitely sensitive to changes in the local environment of the fluorophore, imaging the fluorescence lifetime of NADH and NADPH offers the potential for label-free monitoring of metabolic changes inside living tumors. Here, we describe the biological, photophysical, and methodological considerations required to establish fluorescence lifetime imaging (FLIM) of NAD(P)H as a routine method for profiling the metabolism of living cancer cells and tissues.
    MeSH term(s) Data Analysis ; Energy Metabolism ; Humans ; Liver Neoplasms/diagnosis ; Liver Neoplasms/metabolism ; Metabolome ; Metabolomics/methods ; Microscopy, Fluorescence ; NADP/metabolism ; Optical Imaging/methods ; Research Design
    Chemical Substances NADP (53-59-8)
    Language English
    Publishing date 2019-02-05
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-9027-6_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: What Makes You Can Also Break You, Part II: Mitochondrial Permeability Transition Pore Formation by Dimers of the F1FO ATP-Synthase?

    Szabadkai, Gyorgy / Chinopoulos, Christos

    Frontiers in oncology

    2013  Volume 3, Page(s) 140

    Language English
    Publishing date 2013-05-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2013.00140
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  8. Article: What makes you can also break you: mitochondrial permeability transition pore formation by the c subunit of the F(1)F(0) ATP-synthase?

    Chinopoulos, Christos / Szabadkai, Gyorgy

    Frontiers in oncology

    2013  Volume 3, Page(s) 25

    Language English
    Publishing date 2013-02-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2013.00025
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  9. Article ; Online: MCbiclust: a novel algorithm to discover large-scale functionally related gene sets from massive transcriptomics data collections.

    Bentham, Robert B / Bryson, Kevin / Szabadkai, Gyorgy

    Nucleic acids research

    2017  Volume 45, Issue 15, Page(s) 8712–8730

    Abstract: The potential to understand fundamental biological processes from gene expression data has grown in parallel with the recent explosion of the size of data collections. However, to exploit this potential, novel analytical methods are required, capable of ... ...

    Abstract The potential to understand fundamental biological processes from gene expression data has grown in parallel with the recent explosion of the size of data collections. However, to exploit this potential, novel analytical methods are required, capable of discovering large co-regulated gene networks. We found current methods limited in the size of correlated gene sets they could discover within biologically heterogeneous data collections, hampering the identification of multi-gene controlled fundamental cellular processes such as energy metabolism, organelle biogenesis and stress responses. Here we describe a novel biclustering algorithm called Massively Correlated Biclustering (MCbiclust) that selects samples and genes from large datasets with maximal correlated gene expression, allowing regulation of complex networks to be examined. The method has been evaluated using synthetic data and applied to large bacterial and cancer cell datasets. We show that the large biclusters discovered, so far elusive to identification by existing techniques, are biologically relevant and thus MCbiclust has great potential in the analysis of transcriptomics data to identify large-scale unknown effects hidden within the data. The identified massive biclusters can be used to develop improved transcriptomics based diagnosis tools for diseases caused by altered gene expression, or used for further network analysis to understand genotype-phenotype correlations.
    MeSH term(s) Algorithms ; Cluster Analysis ; Databases, Genetic ; Datasets as Topic ; Gene Expression Profiling/methods ; Gene Expression Profiling/statistics & numerical data ; Gene Expression Regulation ; Gene Regulatory Networks/physiology ; Genes, Regulator ; Genetic Association Studies/methods ; Genetic Association Studies/statistics & numerical data ; High-Throughput Nucleotide Sequencing/methods ; High-Throughput Nucleotide Sequencing/statistics & numerical data ; Humans ; Neoplasms/genetics ; Oligonucleotide Array Sequence Analysis/methods ; Oligonucleotide Array Sequence Analysis/statistics & numerical data ; Phenotype
    Language English
    Publishing date 2017-09-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkx590
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1067: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: Mitochondrial Permeability Transition: A Molecular Lesion with Multiple Drug Targets.

    Briston, Thomas / Selwood, David L / Szabadkai, Gyorgy / Duchen, Michael R

    Trends in pharmacological sciences

    2018  Volume 40, Issue 1, Page(s) 50–70

    Abstract: Mitochondrial permeability transition, as the consequence of opening of a mitochondrial permeability transition pore (mPTP), is a cellular catastrophe. Initiating bioenergetic collapse and cell death, it has been implicated in the pathophysiology of ... ...

    Abstract Mitochondrial permeability transition, as the consequence of opening of a mitochondrial permeability transition pore (mPTP), is a cellular catastrophe. Initiating bioenergetic collapse and cell death, it has been implicated in the pathophysiology of major human diseases, including neuromuscular diseases of childhood, ischaemia-reperfusion injury, and age-related neurodegenerative disease. Opening of the mPTP represents a major therapeutic target, as it can be mitigated by a number of compounds. However, clinical studies have so far been disappointing. We therefore address the prospects and challenges faced in translating in vitro findings to clinical benefit. We review the role of mPTP opening in disease, discuss recent findings defining the putative structure of the mPTP, and explore strategies to identify novel, clinically useful mPTP inhibitors, highlighting key considerations in the drug discovery process.
    MeSH term(s) Animals ; Cell Death/physiology ; Child ; Drug Discovery/methods ; Humans ; Mitochondria/metabolism ; Mitochondrial Membrane Transport Proteins/antagonists & inhibitors ; Mitochondrial Membrane Transport Proteins/metabolism ; Molecular Targeted Therapy ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/physiopathology ; Neuromuscular Diseases/drug therapy ; Neuromuscular Diseases/physiopathology ; Reperfusion Injury/drug therapy ; Reperfusion Injury/physiopathology
    Chemical Substances Mitochondrial Membrane Transport Proteins ; mitochondrial permeability transition pore
    Language English
    Publishing date 2018-12-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 282846-7
    ISSN 1873-3735 ; 0165-6147
    ISSN (online) 1873-3735
    ISSN 0165-6147
    DOI 10.1016/j.tips.2018.11.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 6: Show issues

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