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Article ; Online: Erratum to "BCGΔBCG1419c and BCG differ in induction of autophagy, c-di-GMP content, proteome, and progression of lung pathology in Mycobacterium tuberculosis HN878-infected male BALB/c mice" [Vaccine 41(26) (2023) 3824-3835].

Aceves-Sánchez, Michel de Jesús / Barrios-Payán, Jorge Alberto / Segura-Cerda, Cristian Alfredo / Flores-Valdez, Mario Alberto / Mata-Espinosa, Dulce / Pedroza-Roldán, César / Yadav, Rahul / Saini, Deepak Kumar / de la Cruz, Miguel Angel / Ares, Miguel A / Bielefeldt-Ohmann, Helle / Baay-Guzmán, Guillermina / Vergne, Isabelle / Velázquez-Fernández, Jesús Bernardino / Barba León, Jeannette / Hernández-Pando, Rogelio

Vaccine

2024 Volume 42, Issue 7, Page(s) 1852–1853

Language	English
Publishing date	2024-02-15
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2024.02.030
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Article ; Online: BCG∆BCG1419c and BCG differ in induction of autophagy, c-di-GMP content, proteome, and progression of lung pathology in Mycobacterium tuberculosis HN878-infected male BALB/c mice.

Vaccine

2023 Volume 41, Issue 26, Page(s) 3824–3835

Abstract: The efficacy of BCG vaccines against Mycobacterium tuberculosis (Mtb) strains of lineage 2 (Beijing) in preclinical models and humans has been questioned. We have developed BCG∆BCG1419c, by deletion of BCG1419c in BCG Pasteur, which improved control of ... ...

Abstract	The efficacy of BCG vaccines against Mycobacterium tuberculosis (Mtb) strains of lineage 2 (Beijing) in preclinical models and humans has been questioned. We have developed BCG∆BCG1419c, by deletion of BCG1419c in BCG Pasteur, which improved control of tuberculosis (TB) in preclinical models. Here, we compared the capacity of BCG and BCG∆BCG1419c to induce autophagy in murine macrophages, modify c-di-GMP content and transcript levels of BCG1416c, encoding the enzyme responsible for c-di-GMP synthesis/degradation, and of BCG1419c, encoding the phosphodiesterase involved in c-di-GMP degradation. Furthermore, we evaluated proteomic differences in vitro and compared protection against TB produced by a low dose of the HN878-Beijing strain at 3- and 6-months post-infection. We found that BCG∆BCG1419c induced more autophagy and produced different levels of c-di-GMP as well as different transcription of BCG1416c with no expression of BCG1419c. BCG∆BCG1419c differentially produced several proteins, including some involved in interaction with host cells. Vaccination with either BCG strain led to control of bacillary burden in lungs and spleen at 3- but not 6-months post-infection, whereas it reduced pneumonic areas compared with unvaccinated controls at 6 months post-infection. Vaccination with BCG∆BCG1419c delayed progression of lung necrosis as this was observed only at 6 months post-infection. Taken together, compared with BCG, BCG∆BCG1419c increased autophagy, presented different levels of c-di-GMP and transcription of BCG1416c in vitro in a growth-phase dependent manner, modified its proteome and delayed progression of lung pathology produced by a highly virulent Beijing strain.
MeSH term(s)	Humans ; Male ; Animals ; Mice ; Mycobacterium tuberculosis ; BCG Vaccine ; Proteome ; Mice, Inbred BALB C ; Proteomics ; Tuberculosis/prevention & control ; Lung ; Mycobacterium bovis
Chemical Substances	BCG Vaccine ; Proteome ; bis(3',5')-cyclic diguanylic acid (61093-23-0)
Language	English
Publishing date	2023-05-08
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2023.04.065
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Article ; Online: Supracondylar humeral fractures and lateral elbow condyle fractures in children: association between body weight, clinical signs, and fracture severity.

Peña-Martínez, Victor / Tamez-Mata, Yadira / García-Limón, Mariel / Simental-Mendía, Mario / DE LA Garza-Salazar, José F / Moreno-González, Alberto / Acosta-Olivo, Carlos

Minerva pediatrics

2020 Volume 75, Issue 5, Page(s) 697–702

Abstract: Background: The objective of our study was to investigate the association between body weight, clinical signs and surgical time, and the severity of elbow fractures sustained exclusively by a ground-level fall in children.: Methods: Patients aged 2- ... ...

Abstract	Background: The objective of our study was to investigate the association between body weight, clinical signs and surgical time, and the severity of elbow fractures sustained exclusively by a ground-level fall in children. Methods: Patients aged 2-11 years with elbow fracture caused exclusively by a ground-level fall were included. BMI was plotted on the sex-specific BMI-for-age percentile growth chart to obtain the BMI percentile. The elbow fractures were classified according to Gartland Classification for supracondylar fractures and the Song Classification for lateral humeral condyle fracture. Our main outcome measurement was Body Mass Index and fracture severity according Gartland or Song classifications. Results: A total of 175 patients with elbow fractures were included in this study. The mean age of total population was 5.4 years (±2.4). The majority of our patients were male (61.7%), nearly of 48% were overweight or obese patients. The ecchymosis and puckering were the clinical sign more frequent in more severe fractures. Conclusions: Our data presented did not observe a direct relation between obesity and the severity of elbow humeral fractures in the pediatric population with a ground-level fall.
MeSH term(s)	Humans ; Child ; Male ; Female ; Elbow ; Treatment Outcome ; Retrospective Studies ; Humeral Fractures/etiology ; Humeral Fractures/epidemiology ; Humeral Fractures/surgery ; Obesity/complications ; Elbow Fractures ; Humerus
Language	English
Publishing date	2020-05-15
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3062664-X
ISSN	2724-5780
ISSN (online)	2724-5780
DOI	10.23736/S2724-5276.20.05585-1
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Article ; Online: Pathophysiological characterization of MERRF patient-specific induced neurons generated by direct reprogramming.

Villanueva-Paz, Marina / Povea-Cabello, Suleva / Villalón-García, Irene / Suárez-Rivero, Juan M / Álvarez-Córdoba, Mónica / de la Mata, Mario / Talaverón-Rey, Marta / Jackson, Sandra / Sánchez-Alcázar, José A

Biochimica et biophysica acta. Molecular cell research

2019 Volume 1866, Issue 5, Page(s) 861–881

Abstract: Mitochondrial diseases are a group of rare heterogeneous genetic disorders caused by total or partial mitochondrial dysfunction. They can be caused by mutations in nuclear or mitochondrial DNA (mtDNA). MERRF (Myoclonic Epilepsy with Ragged-Red Fibers) ... ...

Abstract	Mitochondrial diseases are a group of rare heterogeneous genetic disorders caused by total or partial mitochondrial dysfunction. They can be caused by mutations in nuclear or mitochondrial DNA (mtDNA). MERRF (Myoclonic Epilepsy with Ragged-Red Fibers) syndrome is one of the most common mitochondrial disorders caused by point mutations in mtDNA. It is mainly caused by the m.8344A > G mutation in the tRNA
MeSH term(s)	Adult ; Cellular Reprogramming ; Cellular Reprogramming Techniques ; DNA, Mitochondrial/genetics ; DNA, Mitochondrial/metabolism ; Dermis/metabolism ; Dermis/pathology ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Humans ; MERRF Syndrome/genetics ; MERRF Syndrome/metabolism ; MERRF Syndrome/pathology ; Male ; Middle Aged ; Neurons/metabolism ; Neurons/pathology ; Point Mutation
Chemical Substances	DNA, Mitochondrial
Language	English
Publishing date	2019-02-22
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	60-7
ISSN	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbamcr.2019.02.010
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Article ; Online: BCG∆BCG1419c and BCG differ in induction of autophagy, c-di-GMP content, proteome, and progression of lung pathology in Mycobacterium tuberculosis HN878-infected male BALB/c mice

Aceves-Sánchez, Michel de Jesús / Barrios-Payán, Jorge Alberto / Segura-Cerda, Cristian Alfredo / Flores-Valdez, Mario Alberto / Mata-Espinosa, Dulce / Pedroza-Roldán, César / Yadav, Rahul / Saini, Deepak Kumar / de la Cruz, Miguel Angel / Ares, Miguel A. / Bielefeldt-Ohmann, Helle / Baay-Guzmán, Guillermina / Vergne, Isabelle / Bernardino Velázquez-Fernández, Jesús / Barba León, Jeannette / Hernández-Pando, Rogelio

Vaccine. 2023 May 08,

2023

Abstract	The efficacy of BCG vaccines against Mycobacterium tuberculosis (Mtb) strains of lineage 2 (Beijing) in preclinical models and humans has been questioned. We have developed BCG∆BCG1419c, by deletion of BCG1419c in BCG Pasteur, which improved control of tuberculosis (TB) in preclinical models. Here, we compared the capacity of BCG and BCG∆BCG1419c to induce autophagy in murine macrophages, modify c-di-GMP content and transcript levels of BCG1416c, encoding the enzyme responsible for c-di-GMP synthesis/degradation, and of BCG1419c, encoding the phosphodiesterase involved in c-di-GMP degradation. Furthermore, we evaluated proteomic differences in vitro and compared protection against TB produced by a low dose of the HN878-Beijing strain at 3- and 6-months post-infection. We found that BCG∆BCG1419c induced more autophagy and produced different levels of c-di-GMP as well as different transcription of BCG1416c with no expression of BCG1419c. BCG∆BCG1419c differentially produced several proteins, including some involved in interaction with host cells. Vaccination with either BCG strain led to control of bacillary burden in lungs and spleen at 3- but not 6-months post-infection, whereas it reduced pneumonic areas compared with unvaccinated controls at 6 months post-infection. Vaccination with BCG∆BCG1419c delayed progression of lung necrosis as this was observed only at 6 months post-infection. Taken together, compared with BCG, BCG∆BCG1419c increased autophagy, presented different levels of c-di-GMP and transcription of BCG1416c in vitro in a growth-phase dependent manner, modified its proteome and delayed progression of lung pathology produced by a highly virulent Beijing strain.
Keywords	Mycobacterium tuberculosis ; autophagy ; cyclic GMP ; enzymes ; lungs ; macrophages ; males ; mice ; necrosis ; proteome ; proteomics ; spleen ; tuberculosis ; vaccination ; vaccines ; virulence ; China ; Beijing ; HN878 ; BCG ; BCG∆BCG1419c
Language	English
Dates of publication	2023-0508
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2023.04.065
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Article ; Online: Anterior cruciate ligament injuries treated with quadriceps tendon autograft versus hamstring autograft: A randomized controlled trial.

Vilchez-Cavazos, Felix / Dávila-Martínez, Agustín / Garza-Castro, Santiago de la / Simental-Mendía, Mario / Garay-Mendoza, Domingo / Tamez-Mata, Yadira / Peña-Martínez, Victor / Acosta-Olivo, Carlos

Cirugia y cirujanos

2020 Volume 88, Issue 1, Page(s) 76–81

Abstract: Background: One of the most common grafts used to repair anterior cruciate ligament (ACL) rupture is the hamstring tendon (HT) autograft. However, another proposed option to repair the ACL is the quadriceps tendon (QT) autograft. This study aimed to ... ...

Title translation	Lesiones de ligamento cruzado anterior tratadas con autoinjerto de tendón de cuádriceps versus autoinjerto de isquiotibiales: estudio controlado aleatorizado.
Abstract	Background: One of the most common grafts used to repair anterior cruciate ligament (ACL) rupture is the hamstring tendon (HT) autograft. However, another proposed option to repair the ACL is the quadriceps tendon (QT) autograft. This study aimed to compare the pain and clinical results between patients with ACL injury treated with QT autograft and with HT autograft. Materials and methods: The Ethics and Investigation Committee of our institution approved the study. The patients were randomized into two groups: one group was treated with QT autograft and the other group was treated with HT autograft. The patients were evaluated preoperatively and postoperatively using the Lysholm-Tegner score, International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Form, and visual analog scale (VAS), at 2 weeks and 1, 3, 6, and 12 months. Results: A total of 28 patients with a primary ACL injury were included in the study. No significant differences in VAS pain, Lysholm knee and Tegner activity scale scores, and IKDC score between the HT and QT groups were observed at any time point. All patients had favorable outcomes and significantly improved evaluation scores. Conclusion: The patients treated with QT autograft had clinical results and post-operative pain similar to those of patients treated with HT autograft for ACL reconstruction.
MeSH term(s)	Adult ; Anterior Cruciate Ligament Injuries/rehabilitation ; Anterior Cruciate Ligament Injuries/surgery ; Anterior Cruciate Ligament Reconstruction/methods ; Anterior Cruciate Ligament Reconstruction/rehabilitation ; Autografts ; Female ; Hamstring Tendons/transplantation ; Humans ; Male ; Pain Measurement/methods ; Pain, Postoperative/diagnosis ; Quadriceps Muscle/transplantation ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2020-01-17
Publishing country	Mexico
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	730699-4
ISSN	2444-054X ; 0009-7411
ISSN (online)	2444-054X
ISSN	0009-7411
DOI	10.24875/CIRU.19001001
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Article ; Online: Severe acute respiratory coronavirus virus 2 (SARS-CoV-2) infection among hospital workers in a severely affected institution in Madrid, Spain: A surveillance cross-sectional study.

Pérez-García, Felipe / Pérez-Zapata, Aurora / Arcos, Naroa / De la Mata, Manuel / Ortiz, María / Simón, Encarnación / Hervás Fernández, Irene / González Ventosa, Victoria / Muñoz Monte, Mario / González Arroyo, Javier / Pérez-Tanoira, Ramón / Cuadros-González, Juan

Infection control and hospital epidemiology

2020 Volume 42, Issue 7, Page(s) 803–809

Abstract: Objective: To analyze the impact of the coronavirus disease 2019 (COVID-19) pandemic in workers of a hospital located in one of the most affected areas in Spain.: Design, settings, and patients: Cross-sectional study performed between March and May ... ...

Abstract	Objective: To analyze the impact of the coronavirus disease 2019 (COVID-19) pandemic in workers of a hospital located in one of the most affected areas in Spain. Design, settings, and patients: Cross-sectional study performed between March and May 2020 over all workers of a secondary hospital in Madrid, Spain. Methods: We employed polymerase chain reaction (PCR, for symptomatic individuals) and serology (for both PCR-negative symptomatic workers and asymptomatic workers) as diagnostic tests for severe acute respiratory coronavirus virus 2 (SARS-CoV-2). We analyzed the prevalence of the virus in healthcare workers (HCWs) and nonhealthcare workers (nHCWs). We also collected information about the use of personal protective equipment (PPEs) and possible contacts prior to infection. Results: In total, 2,963 workers were included: 1,092 were symptomatic, and of these, 539 were positive by PCR (49.4% of symptomatic workers). From the remaining symptomatic workers, 197 (35.6%) were positive by serology. Regarding asymptomatic workers, 345 were positive by serology (31.9% of infected workers). In total, 1,081 (36.5%) presented a positive diagnostic test for SARS-CoV-2. Infection rates were different between HCWs (37.4%) and nHCWs (29.8%) (P = .006). In the multivariate logistic regression analysis, the use of PPE (protective: OR, 0.56; 95% CI, 0.44-0.72; P < .001) and previous contact with COVID-19 patients (risk factor: OR, 1.69; 95% CI, 1.28-2.24; P < .001) were independent factors that were associated with SAS-CoV-2 infection. Conclusions: Overall, >36% of our workers became infected with SARS-CoV-2, and the rate of asymptomatic infections accounted for almost 32% of all SARS-CoV-2 infections. We detected differences in the rates of infection between HCWs and nHCWs. The use of PPE and previous contact with COVID-19 patients were associated with SARS-CoV-2 infection.
MeSH term(s)	COVID-19 ; Cross-Sectional Studies ; Health Personnel ; Hospitals ; Humans ; Personnel, Hospital ; SARS-CoV-2 ; Spain/epidemiology
Keywords	covid19
Language	English
Publishing date	2020-10-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	639378-0
ISSN	1559-6834 ; 0195-9417 ; 0899-823X
ISSN (online)	1559-6834
ISSN	0195-9417 ; 0899-823X
DOI	10.1017/ice.2020.1303
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Article ; Online: Atherosclerosis and Coenzyme Q

Suárez-Rivero, Juan M / Pastor-Maldonado, Carmen J / de la Mata, Mario / Villanueva-Paz, Marina / Povea-Cabello, Suleva / Álvarez-Córdoba, Mónica / Villalón-García, Irene / Suárez-Carrillo, Alejandra / Talaverón-Rey, Marta / Munuera, Manuel / Sánchez-Alcázar, José A

International journal of molecular sciences

2019 Volume 20, Issue 20

Abstract: Atherosclerosis is the most common cause of cardiac deaths worldwide. Classically, atherosclerosis has been explained as a simple arterial lipid deposition with concomitant loss of vascular elasticity. Eventually, this condition can lead to consequent ... ...

Abstract	Atherosclerosis is the most common cause of cardiac deaths worldwide. Classically, atherosclerosis has been explained as a simple arterial lipid deposition with concomitant loss of vascular elasticity. Eventually, this condition can lead to consequent blood flow reduction through the affected vessel. However, numerous studies have demonstrated that more factors than lipid accumulation are involved in arterial damage at the cellular level, such as inflammation, autophagy impairment, mitochondrial dysfunction, and/or free-radical overproduction. In order to consider the correction of all of these pathological changes, new approaches in atherosclerosis treatment are necessary. Ubiquinone or coenzyme Q
MeSH term(s)	Atherosclerosis/drug therapy ; Dietary Supplements ; Humans ; Ubiquinone/analogs & derivatives ; Ubiquinone/therapeutic use ; Vitamins/therapeutic use
Chemical Substances	Vitamins ; Ubiquinone (1339-63-5) ; coenzyme Q10 (EJ27X76M46)
Language	English
Publishing date	2019-10-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms20205195
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Article ; Online: The Connections Among Autophagy, Inflammasome and Mitochondria.

de Lavera, Isabel / Pavon, Ana Delgado / Paz, Marina Villanueva / Oropesa-Avila, Manuel / de la Mata, Mario / Alcocer-Gomez, Elizabet / Garrido-Maraver, Juan / Cotan, David / Alvarez-Cordoba, Monica / Sanchez-Alcazar, Jose A

Current drug targets

2017 Volume 18, Issue 9, Page(s) 1030–1038

Abstract: Background: The molecular crosstalk between inflammation and autophagy is an emerging field of research that is essential for the understanding of multicellular organism homeostasis and how these processes influence a variety of pathological conditions.! ...

Abstract	Background: The molecular crosstalk between inflammation and autophagy is an emerging field of research that is essential for the understanding of multicellular organism homeostasis and how these processes influence a variety of pathological conditions. Objective: In this review, we briefly describe the relationship between autophagy and inflammasome activation. The central role that mitochondria play in both cellular processes is also discussed. Conclusion: Inflammasome and autophagy often modulate each other by common inhibitory mechanisms that are controlled by different input pathways. Thus, inflammasome components coordinate autophagy and autophagy regulates inflammasome activation, making the balance between both processes a fundamental player in cellular homeostasis.
Language	English
Publishing date	2017
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2064859-5
ISSN	1873-5592 ; 1389-4501
ISSN (online)	1873-5592
ISSN	1389-4501
DOI	10.2174/1389450117666160527143143
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Article ; Online: Coenzyme Q

de la Mata, Mario / Cotán, David / Oropesa-Ávila, Manuel / Villanueva-Paz, Marina / de Lavera, Isabel / Álvarez-Córdoba, Mónica / Luzón-Hidalgo, Raquel / Suárez-Rivero, Juan M / Tiscornia, Gustavo / Sánchez-Alcázar, José A

Orphanet journal of rare diseases

2017 Volume 12, Issue 1, Page(s) 23

Abstract: Background: Gaucher disease (GD) is caused by mutations in the GBA1 gene which encodes lysosomal β-glucocerebrosidase (GCase). In GD, partial or complete loss of GCase activity causes the accumulation of the glycolipids glucosylceramide (GlcCer) and ... ...

Abstract	Background: Gaucher disease (GD) is caused by mutations in the GBA1 gene which encodes lysosomal β-glucocerebrosidase (GCase). In GD, partial or complete loss of GCase activity causes the accumulation of the glycolipids glucosylceramide (GlcCer) and glucosylsphingosine in the lysosomes of macrophages. In this manuscript, we investigated the effects of glycolipids accumulation on lysosomal and mitochondrial function, inflammasome activation and efferocytosis capacity in a THP-1 macrophage model of Gaucher disease. In addition, the beneficial effects of coenzyme Q Results: Chemically-induced Gaucher macrophages showed impaired autophagy flux associated with mitochondrial dysfunction and increased oxidative stress, inflammasome activation and impaired efferocytosis. All abnormalities were partially restored by supplementation with CoQ. Conclusion: These data suggest that targeting mitochondria function and oxidative stress by CoQ can ameliorate the pathological phenotype of Gaucher cells. Chemically-induced Gaucher macrophages provide cellular models that can be used to investigate disease pathogenesis and explore new therapeutics for GD.
Language	English
Publishing date	2017-02-06
Publishing country	England
Document type	Journal Article
ISSN	1750-1172
ISSN (online)	1750-1172
DOI	10.1186/s13023-017-0574-8
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