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  1. Book ; Online ; E-Book: Trust in medicine

    Wolfensberger, Markus / Wrigley, Anthony

    its nature, justification, significance, and decline

    (Cambridge bioethics and law)

    2019  

    Author's details Markus Wolfensberger, Anthony Wrigley
    Series title Cambridge bioethics and law
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xvii, 249 Seiten)
    Publisher Cambridge University Press
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020273988
    ISBN 978-1-108-77058-3 ; 9781108487191 ; 1-108-77058-4 ; 110848719X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Modality and Counterfactuals: Understanding the Role and Context of Metaphysical Underpinnings for Harm, Benefit and Identity Claims Arising from Genome Editing and Genetic Modification.

    Wrigley, Anthony

    The American journal of bioethics : AJOB

    2022  Volume 22, Issue 9, Page(s) 52–54

    MeSH term(s) Gene Editing ; Germ Cells ; Humans
    Language English
    Publishing date 2022-08-30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2060433-6
    ISSN 1536-0075 ; 1526-5161
    ISSN (online) 1536-0075
    ISSN 1526-5161
    DOI 10.1080/15265161.2022.2105426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Hope and Exploitation in Commercial Provision of Assisted Reproductive Technologies.

    Wrigley, Anthony / Watts, Gabriel / Lipworth, Wendy / Newson, Ainsley J

    The Hastings Center report

    2023  Volume 53, Issue 5, Page(s) 30–41

    Abstract: Innovation is a key driver of care provision in assisted reproductive technologies (ART). ART providers offer a range of add-on interventions, aiming to augment standard in vitro fertilization protocols and improve the chances of a live birth. ... ...

    Abstract Innovation is a key driver of care provision in assisted reproductive technologies (ART). ART providers offer a range of add-on interventions, aiming to augment standard in vitro fertilization protocols and improve the chances of a live birth. Particularly in the context of commercial provision, an ever-increasing array of add-ons are marketed to ART patients, even when evidence to support them is equivocal. A defining feature of ART is hope-hope that a cycle will lead to a baby or that another test or intervention will make a difference. Yet such hope also leaves ART patients vulnerable in a variety of ways. This article argues that previous attempts to safeguard ART patients have neglected how the use of add-ons in commercial ART can exploit patients' hopes. Commercial providers of ART should provide add-ons only free of charge, under a suitable research protocol.
    MeSH term(s) Pregnancy ; Female ; Humans ; Reproductive Techniques, Assisted ; Fertilization in Vitro ; Live Birth
    Language English
    Publishing date 2023-11-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 194940-8
    ISSN 1552-146X ; 0093-0334
    ISSN (online) 1552-146X
    ISSN 0093-0334
    DOI 10.1002/hast.1513
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Technical Categories and Ethical Justifications: Why Cwik's Approach is the Wrong Way Around for Categorizing Germ-Line Gene Editing.

    Wrigley, Anthony / Newson, Ainsley J

    The American journal of bioethics : AJOB

    2020  Volume 20, Issue 8, Page(s) 27–29

    MeSH term(s) Gene Editing ; Germ Cells ; Morals
    Language English
    Publishing date 2020-08-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2060433-6
    ISSN 1536-0075 ; 1526-5161
    ISSN (online) 1536-0075
    ISSN 1526-5161
    DOI 10.1080/15265161.2020.1782525
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  5. Article ; Online: An Eliminativist Approach to Vulnerability.

    Wrigley, Anthony

    Bioethics

    2015  Volume 29, Issue 7, Page(s) 478–487

    Abstract: The concept of vulnerability has been subject to numerous different interpretations but accounts are still beset with significant problems as to their adequacy, such as their contentious application or the lack of genuine explanatory role for the concept. ...

    Abstract The concept of vulnerability has been subject to numerous different interpretations but accounts are still beset with significant problems as to their adequacy, such as their contentious application or the lack of genuine explanatory role for the concept. The constant failure to provide a compelling conceptual analysis and satisfactory definition leaves the concept open to an eliminativist move whereby we can question whether we need the concept at all. I highlight problems with various kinds of approach and explain why a satisfactory account of vulnerability is unlikely ever to be offered if we wish the concept to play a genuinely explanatory role in bioethical contexts. I outline why an eliminativist position should be taken with regard to this concept in light of these concerns but mitigate some of the severity of this position by arguing that we can still make sense of retaining our widespread use of the term by viewing it as nothing more than a useful pragmatic linguistic device that acts as a marker to draw attention to certain kinds of issue. These issues will be entirely governed by other, better understood ethical concepts and theories.
    MeSH term(s) Concept Formation ; Ethics, Research ; Human Experimentation/ethics ; Humans ; Moral Obligations ; Terminology as Topic ; Vulnerable Populations
    Language English
    Publishing date 2015-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 632984-6
    ISSN 1467-8519 ; 0269-9702
    ISSN (online) 1467-8519
    ISSN 0269-9702
    DOI 10.1111/bioe.12144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Ethics and end of life care: the Liverpool Care Pathway and the Neuberger Review.

    Wrigley, Anthony

    Journal of medical ethics

    2015  Volume 41, Issue 8, Page(s) 639–643

    Abstract: The Liverpool Care Pathway for the Dying has recently been the topic of substantial media interest and also been subject to the independent Neuberger Review. This review has identified clear failings in some areas of care and recommended the Liverpool ... ...

    Abstract The Liverpool Care Pathway for the Dying has recently been the topic of substantial media interest and also been subject to the independent Neuberger Review. This review has identified clear failings in some areas of care and recommended the Liverpool Care Pathway be phased out. I argue that while the evidence gathered of poor incidences of practice by the Review is of genuine concern for end of life care, the inferences drawn from this evidence are inconsistent with the causes for the concern. Seeking to end an approach that is widely seen as best practice and which can genuinely deliver high quality care because of negative impressions that have been formed from failing to implement it properly is not a good basis for radically overhauling our approach to end of life care. I conclude that improvements in training, communication and ethical decision-making, without the added demand to end the Liverpool Care Pathway, would have resulted in a genuine advance in end of life care.
    MeSH term(s) Communication ; Critical Pathways/ethics ; Critical Pathways/legislation & jurisprudence ; Decision Making ; Evidence-Based Medicine ; Humans ; Policy Making ; Quality Improvement ; Quality Indicators, Health Care ; Terminal Care/ethics ; Terminal Care/legislation & jurisprudence ; Terminology as Topic ; United Kingdom/epidemiology
    Language English
    Publishing date 2015-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 194927-5
    ISSN 1473-4257 ; 0306-6800
    ISSN (online) 1473-4257
    ISSN 0306-6800
    DOI 10.1136/medethics-2013-101780
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: An ethical defence of the Liverpool Care Pathway.

    Wrigley, Anthony

    Nursing times

    2014  Volume 110, Issue 40, Page(s) 20–21

    Abstract: Palliative care in the UK has been ranked as the best in the world. However, the Liverpool Care Pathway was criticised and phased out. This article looks at the LCP's aims, assesses the problems and how these should be tackled. Many of these problems ... ...

    Abstract Palliative care in the UK has been ranked as the best in the world. However, the Liverpool Care Pathway was criticised and phased out. This article looks at the LCP's aims, assesses the problems and how these should be tackled. Many of these problems stemmed not from the LCP itself, but its improper use. Better training on the pathway and on communication with patients and relatives could ensure it is used correctly.
    MeSH term(s) Critical Pathways ; England ; Health Priorities ; Terminal Care
    Language English
    Publishing date 2014-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 391202-4
    ISSN 0954-7762 ; 0029-6589
    ISSN 0954-7762 ; 0029-6589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Limitations on personhood arguments for abortion and 'after-birth abortion'.

    Wrigley, Anthony

    Journal of medical ethics

    2013  Volume 39, Issue 5, Page(s) e15–8

    Abstract: Two notable limitations exist on the use of personhood arguments in establishing moral status. Firstly, although the attribution of personhood may give us sufficient reason to grant something moral status, it is not a necessary condition. Secondly, even ... ...

    Abstract Two notable limitations exist on the use of personhood arguments in establishing moral status. Firstly, although the attribution of personhood may give us sufficient reason to grant something moral status, it is not a necessary condition. Secondly, even if a person is that which has the 'highest' moral status, this does not mean that any interests of a person are justifiable grounds to kill something that has a 'lower' moral status. Additional justification is needed to overcome a basic wrongness associated with killing something possessing moral status. There are clear arguments already available in this regard in the case of a foetus that are not available in the case of a newborn infant. Hence, there is scope to consistently hold that abortion may be permissible but that after-birth abortion may not be permissible.
    MeSH term(s) Abortion, Induced/ethics ; Adoption ; Beginning of Human Life/ethics ; Fetal Viability ; Humans ; Infanticide/ethics ; Moral Obligations ; Personhood ; Value of Life
    Language English
    Publishing date 2013-05
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 194927-5
    ISSN 1473-4257 ; 0306-6800
    ISSN (online) 1473-4257
    ISSN 0306-6800
    DOI 10.1136/medethics-2012-100958
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Is Mitochondrial Donation Germ-Line Gene Therapy? Classifications and Ethical Implications.

    Newson, Ainsley J / Wrigley, Anthony

    Bioethics

    2017  Volume 31, Issue 1, Page(s) 55–67

    Abstract: The classification of techniques used in mitochondrial donation, including their role as purported germ-line gene therapies, is far from clear. These techniques exhibit characteristics typical of a variety of classifications that have been used in both ... ...

    Abstract The classification of techniques used in mitochondrial donation, including their role as purported germ-line gene therapies, is far from clear. These techniques exhibit characteristics typical of a variety of classifications that have been used in both scientific and bioethics scholarship. This raises two connected questions, which we address in this paper: (i) how should we classify mitochondrial donation techniques?; and (ii) what ethical implications surround such a classification? First, we outline how methods of genetic intervention, such as germ-line gene therapy, are typically defined or classified. We then consider whether techniques of mitochondrial donation fit into these, whether they might do so with some refinement of these categories, or whether they require some other approach to classification. To answer the second question, we discuss the relationship between classification and several key ethical issues arising from mitochondrial donation. We conclude that the properties characteristic of mitochondrial inheritance mean that most mitochondrial donation techniques belong to a new sub-class of genetic modification, which we call 'conditionally inheritable genomic modification' (CIGM).
    Language English
    Publishing date 2017-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 632984-6
    ISSN 1467-8519 ; 0269-9702
    ISSN (online) 1467-8519
    ISSN 0269-9702
    DOI 10.1111/bioe.12312
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  10. Article ; Online: Ethical and legal issues in mitochondrial transfer.

    Newson, Ainsley J / Wilkinson, Stephen / Wrigley, Anthony

    EMBO molecular medicine

    2016  Volume 8, Issue 6, Page(s) 589–591

    MeSH term(s) Female ; Genetic Engineering/ethics ; Genetic Engineering/legislation & jurisprudence ; Humans ; Male ; Mitochondria/genetics ; Mitochondrial Diseases/genetics ; Mitochondrial Diseases/therapy ; Mitochondrial Replacement Therapy/ethics ; Mitochondrial Replacement Therapy/legislation & jurisprudence ; Reproduction/ethics ; Tissue Donors/ethics ; Tissue Donors/legislation & jurisprudence
    Language English
    Publishing date 2016-06-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2467145-9
    ISSN 1757-4684 ; 1757-4676
    ISSN (online) 1757-4684
    ISSN 1757-4676
    DOI 10.15252/emmm.201606281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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