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  1. Article ; Online: Efficacy of atomoxetine plus oxybutynin in the treatment of obstructive sleep apnea with moderate pharyngeal collapsibility.

    Schweitzer, Paula K / Maynard, James P / Wylie, Paul E / Emsellem, Helene A / Sands, Scott A

    Sleep & breathing = Schlaf & Atmung

    2022  Volume 27, Issue 2, Page(s) 495–503

    Abstract: Purpose: Preliminary studies have shown a significant decrease in severity of obstructive sleep apnea (OSA) with the use of a combination of atomoxetine and oxybutynin, with patients having moderate pharyngeal collapsibility during sleep more likely to ... ...

    Abstract Purpose: Preliminary studies have shown a significant decrease in severity of obstructive sleep apnea (OSA) with the use of a combination of atomoxetine and oxybutynin, with patients having moderate pharyngeal collapsibility during sleep more likely to respond. This study evaluated the efficacy and safety of AD036 (atomoxetine 80 mg and oxybutynin 5 mg) in the treatment of OSA.
    Methods: This trial was a phase 2, randomized, placebo-controlled crossover study comparing AD036, atomoxetine 80 mg alone, and placebo during three home sleep studies, each separated by about 1 week. The trial included patients with OSA and moderate pharyngeal collapsibility as defined by a higher proportion of hypopneas to apneas and mild oxygen desaturation.
    Results: Of 62 patients who were randomized, 60 were included in efficacy analyses. The apnea-hypopnea index (AHI) from a median (interquartile range) of 14.2 (5.4 to 22.3) events/h on placebo to 6.2 (2.8 to 13.6) with AD036 and 4.8 (1.4 to 11.6) with atomoxetine alone (p < .0001). Both drugs also decreased the oxygen desaturation index (ODI) and the hypoxic burden (p < .0001). AD036, but not atomoxetine alone, reduced the respiratory arousal index and improved ventilation at the respiratory arousal threshold (greater V
    Conclusion: AD036 significantly improved OSA severity in patients with moderate pharyngeal collapsibility. Atomoxetine may account for the majority of improvement in OSA severity, while the addition of oxybutynin may mitigate the disruptive effect of atomoxetine on sleep and further improve ventilation.
    Trial registration: Clinical trial registered with www.
    Clinicaltrials: gov (NCT04445688).
    MeSH term(s) Humans ; Atomoxetine Hydrochloride/pharmacology ; Atomoxetine Hydrochloride/therapeutic use ; Cross-Over Studies ; Sleep Apnea, Obstructive ; Sleep
    Chemical Substances Atomoxetine Hydrochloride (57WVB6I2W0) ; oxybutynin (K9P6MC7092)
    Language English
    Publishing date 2022-05-13
    Publishing country Germany
    Document type Randomized Controlled Trial ; Clinical Trial, Phase II ; Journal Article
    ZDB-ID 1500381-4
    ISSN 1522-1709 ; 1520-9512
    ISSN (online) 1522-1709
    ISSN 1520-9512
    DOI 10.1007/s11325-022-02634-x
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  2. Article: Finding a shadow in the dark: rediscovery of Fugler’s Shadow Snake (Emmochliophis fugleri Fritts & Smith, 1969) after 54 years, with comments on its conservation status, distribution, and the tribe Diaphorolepidini

    Maynard, Ross J. / Culebras, Jaime / Kohn, Sebastian / Guayasamin, Juan M. / Trageser, Scott J.

    Check list. 2021 Feb. 11, v. 17, no. 1

    2021  

    Abstract: Herein we report the second known record of Emmochliophis fugleri Fritts & Smith, 1969, present the first color images of the species, extend its known distribution and elevational range, provide the snout–vent and tail lengths of the holotype, and ... ...

    Abstract Herein we report the second known record of Emmochliophis fugleri Fritts & Smith, 1969, present the first color images of the species, extend its known distribution and elevational range, provide the snout–vent and tail lengths of the holotype, and demonstrate that the condition of fused prefrontals is an unreliable diagnostic character for the genus Diaphorolepis. Considering the rarity of this snake as well as the imminent threat that mining poses to the Río Manduriacu Reserve, we recommend a conservation status of Critically Endangered for E. fugleri.
    Keywords color ; conservation status ; holotypes ; snakes
    Language English
    Dates of publication 2021-0211
    Size p. 239-245.
    Publishing place Pensoft Publishers
    Document type Article
    ZDB-ID 2252867-2
    ISSN 1809-127X
    ISSN 1809-127X
    DOI 10.15560/17.1.239
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Informal field-based learning and work design.

    Wolfson, Mikhail A / Mathieu, John E / Tannenbaum, Scott I / Maynard, M Travis

    The Journal of applied psychology

    2019  Volume 104, Issue 10, Page(s) 1283–1295

    Abstract: U.S. organizations continue to invest most of their learning budgets in formal training and development programs despite estimates that the majority of learning in the workplace happens informally. In this study we focus on informal field-based learning ( ...

    Abstract U.S. organizations continue to invest most of their learning budgets in formal training and development programs despite estimates that the majority of learning in the workplace happens informally. In this study we focus on informal field-based learning (IFBL), which represents individuals engaging in self-directed, intentional, and field-based development of their knowledge and skills. We build on the informal learning literature to advance a cross-level model of individual and job-level characteristics as influences on IFBL and subsequent changes in job performance. We tested our model using a sample of 378 health care employees who occupied 47 different jobs. The results showed promotion-focused individuals more readily engaged in IFBL, as moderated by job time pressures. Moreover, engaging in IFBL behaviors positively related to performance improvements in jobs that require greater updating and use of relevant information, as well as in jobs with relatively low decision making and problem-solving requirements. Exploratory subdimensional analyses revealed some interesting countervailing relationships between the feedback-seeking and vicarious-learning elements of IFBL. Results are discussed in terms of contingency relationships associated with IFBL behaviors and different job types, as well as theoretical and practical implications. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
    MeSH term(s) Adult ; Employment ; Female ; Health Personnel ; Humans ; Learning ; Male ; Middle Aged ; Professional Competence ; Work Performance
    Language English
    Publishing date 2019-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219157-x
    ISSN 1939-1854 ; 0021-9010
    ISSN (online) 1939-1854
    ISSN 0021-9010
    DOI 10.1037/apl0000408
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  4. Article ; Online: Finding a shadow in the dark

    Ross J. Maynard / Jaime Culebras / Sebastian Kohn / Juan M. Guayasamin / Scott J. Trageser

    Check List, Vol 17, Iss 1, Pp 239-

    rediscovery of Fugler’s Shadow Snake (Emmochliophis fugleri Fritts & Smith, 1969) after 54 years, with comments on its conservation status, distribution, and the tribe Diaphorolepidini

    2021  Volume 245

    Abstract: Herein we report the second known record of Emmochliophis fugleri Fritts & Smith, 1969, present the first color images of the species, extend its known distribution and elevational range, provide the snout–vent and tail lengths of the holotype, and ... ...

    Abstract Herein we report the second known record of Emmochliophis fugleri Fritts & Smith, 1969, present the first color images of the species, extend its known distribution and elevational range, provide the snout–vent and tail lengths of the holotype, and demonstrate that the condition of fused prefrontals is an unreliable diagnostic character for the genus Diaphorolepis. Considering the rarity of this snake as well as the imminent threat that mining poses to the Río Manduriacu Reserve, we recommend a conservation status of Critically Endangered for E. fugleri.
    Keywords Critically Endangered ; Ecuador ; Imbabura ; Río Mand ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Pensoft Publishers
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Book: Robert M. Hutchins, Scott Buchanan, Donald N. Michael, Chalmers Sherwin, James Real, Lynn White, Jr., on science, scientists, and politics

    Hutchins, Robert Maynard

    (Occasional paper)

    1963  

    Institution Center for the Study of Democratic Institutions
    Series title Occasional paper
    Keywords Science/Philosophy.
    Language English
    Size 15 p.
    Publisher Fund for the Republic
    Publishing place New York
    Document type Book
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: A cross-level investigation of informal field-based learning and performance improvements.

    Wolfson, Mikhail A / Tannenbaum, Scott I / Mathieu, John E / Maynard, M Travis

    The Journal of applied psychology

    2018  Volume 103, Issue 1, Page(s) 14–36

    Abstract: Organizations often operate in complex and dynamic environments which place a premium on employees' ongoing learning and acquisition of new competencies. Additionally, the majority of learning in organizations does not take place in formal training ... ...

    Abstract Organizations often operate in complex and dynamic environments which place a premium on employees' ongoing learning and acquisition of new competencies. Additionally, the majority of learning in organizations does not take place in formal training settings, but we know relatively little about how informal field-based learning (IFBL) behaviors relate to changes in job performance. In this study, we first clarified the construct of IFBL as a subset of informal learning. Second, on the basis of this clarified construct definition, we developed a measure of IFBL behaviors and demonstrated its psychometric properties using (a) a sample of subject matter experts who made item content validity judgments and (b) both an Amazon Mechanical Turk sample (N = 400) and a sample of 1,707 healthcare employees. Third, we advanced a grounded theory of IFBL in healthcare, and related it to individuals' regulatory foci and contextual moderators of IFBL behaviors-job performance relationships using a cross-level design and lagged nonmethod bound measures. Specifically, using a sample of 407 healthcare workers from 49 hospital units, our results suggested that promotion-focused individuals, especially in well-staffed units, readily engage in IFBL behaviors. Additionally, we found that the IFBL-changes in job performance relationship was strengthened to the extent that individuals worked in units with relatively nonpunitive climates. Interestingly, staffing levels had a weakening moderating effect on the positive IFBL-performance improvements relationship. Detailed follow-up analyses revealed that the peculiar effect was attributable to differential relationships from IFBL subdimensions. Implications for future theory building, research, and practice are discussed. (PsycINFO Database Record
    MeSH term(s) Adult ; Employment/psychology ; Female ; Health Personnel ; Humans ; Learning ; Male ; Organizational Culture ; Work Performance
    Language English
    Publishing date 2018-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219157-x
    ISSN 1939-1854 ; 0021-9010
    ISSN (online) 1939-1854
    ISSN 0021-9010
    DOI 10.1037/apl0000267
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    Zs.A 1238: Show issues Location:
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  7. Article ; Online: Insuring nanotech requires effective risk communication.

    Murphy, Finbarr / Mullins, Martin / Hester, Karena / Gelwick, Allen / Scott-Fordsmand, Janeck J / Maynard, Trevor

    Nature nanotechnology

    2017  Volume 12, Issue 8, Page(s) 717–719

    Language English
    Publishing date 2017-08-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2254964-X
    ISSN 1748-3395 ; 1748-3387
    ISSN (online) 1748-3395
    ISSN 1748-3387
    DOI 10.1038/nnano.2017.162
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  8. Article ; Online: Structural Characterization and Modeling of a Respiratory Syncytial Virus Fusion Glycoprotein Nanoparticle Vaccine in Solution.

    Krueger, Susan / Curtis, Joseph E / Scott, Daniel R / Grishaev, Alexander / Glenn, Greg / Smith, Gale / Ellingsworth, Larry / Borisov, Oleg / Maynard, Ernest L

    Molecular pharmaceutics

    2020  Volume 18, Issue 1, Page(s) 359–376

    Abstract: The respiratory syncytial virus (RSV) fusion (F) protein/polysorbate 80 (PS80) nanoparticle vaccine is the most clinically advanced vaccine for maternal immunization and protection of newborns against RSV infection. It is composed of a near-full-length ... ...

    Abstract The respiratory syncytial virus (RSV) fusion (F) protein/polysorbate 80 (PS80) nanoparticle vaccine is the most clinically advanced vaccine for maternal immunization and protection of newborns against RSV infection. It is composed of a near-full-length RSV F glycoprotein, with an intact membrane domain, formulated into a stable nanoparticle with PS80 detergent. To understand the structural basis for the efficacy of the vaccine, a comprehensive study of its structure and hydrodynamic properties in solution was performed. Small-angle neutron scattering experiments indicate that the nanoparticle contains an average of 350 PS80 molecules, which form a cylindrical micellar core structure and five RSV F trimers that are arranged around the long axis of the PS80 core. All-atom models of full-length RSV F trimers were built from crystal structures of the soluble ectodomain and arranged around the long axis of the PS80 core, allowing for the generation of an ensemble of conformations that agree with small-angle neutron and X-ray scattering data as well as transmission electron microscopy (TEM) images. Furthermore, the hydrodynamic size of the RSV F nanoparticle was found to be modulated by the molar ratio of PS80 to protein, suggesting a mechanism for nanoparticle assembly involving addition of RSV F trimers to and growth along the long axis of the PS80 core. This study provides structural details of antigen presentation and conformation in the RSV F nanoparticle vaccine, helping to explain the induction of broad immunity and observed clinical efficacy. Small-angle scattering methods provide a general strategy to visualize surface glycoproteins from other pathogens and to structurally characterize nanoparticle vaccines.
    MeSH term(s) Antibodies, Neutralizing/chemistry ; Antibodies, Neutralizing/immunology ; Glycoproteins/chemistry ; Glycoproteins/immunology ; Nanoparticles/chemistry ; Respiratory Syncytial Virus Infections/immunology ; Respiratory Syncytial Virus Vaccines/chemistry ; Respiratory Syncytial Virus Vaccines/immunology ; Respiratory Syncytial Virus, Human/chemistry ; Respiratory Syncytial Virus, Human/immunology ; Vaccination/methods
    Chemical Substances Antibodies, Neutralizing ; Glycoproteins ; Respiratory Syncytial Virus Vaccines
    Language English
    Publishing date 2020-12-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.0c00986
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    Zs.A 6250: Show issues Location:
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  9. Article ; Online: Impact of center volume and the adoption of laparoscopic donor nephrectomy on outcomes in pediatric kidney transplantation.

    Burg, Jennifer M / Scott, David L / Roayaie, Kayvan / Maynard, Erin / Barry, John M / Enestvedt, C Kristian

    Pediatric transplantation

    2018  Volume 22, Issue 3, Page(s) e13121

    Abstract: Reports for pediatric kidney transplant recipients suggested better outcomes for ODN compared to LDN. Contemporary outcomes stratified by donor type and center volume have not been evaluated in a national dataset. UNOS data (2000-2014) were analyzed for ... ...

    Abstract Reports for pediatric kidney transplant recipients suggested better outcomes for ODN compared to LDN. Contemporary outcomes stratified by donor type and center volume have not been evaluated in a national dataset. UNOS data (2000-2014) were analyzed for pediatric living donor kidney transplant recipients. The primary outcome was GF; secondary outcomes were DGF, rejection, and patient survival. Live donor nephrectomies for pediatric recipients decreased 30% and transitioned from ODN to LDN. GF rates did not differ for ODN vs LDN (P = .24). GF was lowest at high volume centers (P < .01). Donor operative approach did not contribute to GF. LDN was associated with less rejection than ODN (OR 0.66, CI 0.5-0.87, P < .01). Analysis of the 0- to 5-yr recipient group showed no effect of ODN vs LDN on GF or rejection. For the contemporary era, there was no association between DGF and LDN in the 0- to 5-yr group (OR 1.12, CI 0.67-1.89, P = .67). Outcomes of kidney transplants in pediatric recipients following LDN have improved since its introduction and LDN should be the approach for live donor nephrectomy regardless of recipient age. The association between case volume and improved outcomes highlights future challenges in organ transplantation.
    MeSH term(s) Adolescent ; Adult ; Child ; Child, Preschool ; Female ; Graft Rejection ; Graft Survival ; Hospitals, High-Volume ; Hospitals, Low-Volume ; Humans ; Infant ; Infant, Newborn ; Kidney Transplantation/mortality ; Laparoscopy ; Male ; Nephrectomy/methods ; Outcome Assessment (Health Care) ; Survival Analysis
    Language English
    Publishing date 2018-02-02
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1390284-2
    ISSN 1399-3046 ; 1397-3142
    ISSN (online) 1399-3046
    ISSN 1397-3142
    DOI 10.1111/petr.13121
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    Zs.A 4947: Show issues Location:
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  10. Article ; Online: The development and validation of an Army team resilience measure.

    Tannenbaum, Scott / Mathieu, John / Levy, Jamie / Watson, Dale / Maynard, Travis / Beard, Rebecca / Salas, Eduardo / Boyle, Bridget / Cato, Colanda / Berry, Cassie / Blue, Shala

    Military psychology : the official journal of the Division of Military Psychology, American Psychological Association

    2022  Volume 36, Issue 1, Page(s) 83–95

    Abstract: Given the demanding nature of its mission, the collective units of the Army, not just individual Soldiers, need to be able to withstand and adapt to a wide range of challenges. Therefore, it is important to be able to effectively assess resilience at the ...

    Abstract Given the demanding nature of its mission, the collective units of the Army, not just individual Soldiers, need to be able to withstand and adapt to a wide range of challenges. Therefore, it is important to be able to effectively assess resilience at the team-level and to understand the factors that can enable or diminish it. This article describes the development of a construct valid and psychometrically-sound measure of team resilience - the Team Resilience Scale (TRS). A theoretical framework of team resilience and related constructs is introduced. We then summarize the procedures for developing the TRS and related constructs, providing evidence of the content validity of the TRS. Finally, we assess the psychometric soundness and construct validity of the TRS in two Army field studies. Our analyses support the convergent validity of items and indicate that the measure can be used to examine three first-order dimensions of resilience (i.e., physical, affective, and cognitive) or as a single overall resilience composite. Results show the TRS was positively related to team performance in both samples and it co-varied with stressors and team actions. Practical recommendations for use of the measure and suggestions for future research are offered.
    MeSH term(s) Humans ; Resilience, Psychological ; Military Personnel ; Physical Examination ; Psychometrics ; Sound
    Language English
    Publishing date 2022-05-03
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2021130-2
    ISSN 1532-7876 ; 0899-5605
    ISSN (online) 1532-7876
    ISSN 0899-5605
    DOI 10.1080/08995605.2022.2065154
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