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Article ; Online: Acute Kidney Injury, Microvascular Rarefaction, and Estimated Glomerular Filtration Rate in Kidney Transplant Recipients.

Doreille, Alice / Azzi, Féryel / Larivière-Beaudoin, Stéphanie / Karakeussian-Rimbaud, Annie / Trudel, Dominique / Hébert, Marie-Josée / Dieudé, Mélanie / Patey, Natacha / Cardinal, Héloïse

Clinical journal of the American Society of Nephrology : CJASN

2021 Volume 16, Issue 3, Page(s) 415–426

Abstract: Background and objectives: Animal studies suggest that microvascular rarefaction is a key factor in the acute kidney disease to CKD transition. Hence, delayed graft function appears as a unique human model of AKI to further explore the role of ... ...

Abstract	Background and objectives: Animal studies suggest that microvascular rarefaction is a key factor in the acute kidney disease to CKD transition. Hence, delayed graft function appears as a unique human model of AKI to further explore the role of microvascular rarefaction in kidney transplant recipients. Here, we assessed whether delayed graft function is associated with peritubular capillary loss and evaluated the association between this loss and long-term kidney graft function. Design, setting, participants, & measurements: This observational, retrospective cohort study included 61 participants who experienced delayed graft function and 130 who had immediate graft function. We used linear regression models to evaluate associations between delayed graft function and peritubular capillary density expressed as the percentage of efficient cortical area occupied by peritubular capillaries in pre- and post-transplant graft biopsies. eGFRs 1 and 3 years post-transplant were secondary outcomes. Results: Post-transplant biopsies were performed at a median of 113 days (interquartile range, 101-128) after transplantation. Peritubular capillary density went from 15.4% to 11.5% in patients with delayed graft function (median change, -3.7%; interquartile range, -6.6% to -0.8%) and from 19.7% to 15.1% in those with immediate graft function (median change, -4.5%; interquartile range, -8.0% to -0.8%). Although the unadjusted change in peritubular capillary density was similar between patients with and without delayed graft function, delayed graft function was associated with more peritubular capillary loss in the multivariable analysis (adjusted difference in change, -2.9%; 95% confidence interval, -4.0 to -1.8). Pretransplant peritubular capillary density and change in peritubular capillary density were associated with eGFR 1 and 3 years post-transplantation. Conclusions: Perioperative AKI is associated with lower density in peritubular capillaries before transplantation and with loss of peritubular capillaries following transplantation. Lower peritubular capillary density is linked to lower long-term eGFR.
MeSH term(s)	Acute Kidney Injury/physiopathology ; Adult ; Cohort Studies ; Female ; Glomerular Filtration Rate ; Humans ; Kidney Transplantation ; Male ; Microvascular Rarefaction/physiopathology ; Middle Aged ; Postoperative Complications/physiopathology ; Retrospective Studies
Language	English
Publishing date	2021-03-01
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2226665-3
ISSN	1555-905X ; 1555-9041
ISSN (online)	1555-905X
ISSN	1555-9041
DOI	10.2215/CJN.07270520
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Article ; Online: Endothelin uncouples gap junctions in sustentacular cells and olfactory ensheathing cells of the olfactory mucosa.

Le Bourhis, Mikaël / Rimbaud, Stéphanie / Grebert, Denise / Congar, Patrice / Meunier, Nicolas

The European journal of neuroscience

2014 Volume 40, Issue 6, Page(s) 2878–2887

Abstract: Several factors modulate the first step of odour detection in the rat olfactory mucosa (OM). Among others, vasoactive peptides such as endothelin might play multifaceted roles in the different OM cells. Like their counterparts in the central nervous ... ...

Abstract	Several factors modulate the first step of odour detection in the rat olfactory mucosa (OM). Among others, vasoactive peptides such as endothelin might play multifaceted roles in the different OM cells. Like their counterparts in the central nervous system, the olfactory sensory neurons are encompassed by different glial-like non-neuronal OM cells; sustentacular cells (SCs) surround their cell bodies, whereas olfactory ensheathing cells (OECs) wrap their axons. Whereas SCs maintain both the structural and ionic integrity of the OM, OECs assure protection, local blood flow control and guiding of olfactory sensory neuron axons toward the olfactory bulb. We previously showed that these non-neuronal OM cells are particularly responsive to endothelin in vitro. Here, we confirmed that the endothelin system is strongly expressed in the OM using in situ hybridization. We then further explored the effects of endothelin on SCs and OECs using electrophysiological recordings and calcium imaging approaches on both in vitro and ex vivo OM preparations. Endothelin induced both robust calcium signals and gap junction uncoupling in both types of cells. This latter effect was mimicked by carbenoxolone, a known gap junction uncoupling agent. However, although endothelin is known for its antiapoptotic effect in the OM, the uncoupling of gap junctions by carbenoxolone was not sufficient to limit the cellular death induced by serum deprivation in OM primary culture. The functional consequence of the endothelin 1-induced reduction of the gap junctional communication between OM non-neuronal cells thus remains to be elucidated.
MeSH term(s)	Animals ; Calcium/metabolism ; Carbenoxolone/pharmacology ; Cell Death/drug effects ; Cell Death/physiology ; Cells, Cultured ; Electric Stimulation ; Endothelins/metabolism ; Gap Junctions/drug effects ; Gap Junctions/physiology ; Immunohistochemistry ; In Situ Hybridization ; L-Lactate Dehydrogenase/metabolism ; Male ; Neuroglia/drug effects ; Neuroglia/physiology ; Olfactory Mucosa/drug effects ; Olfactory Mucosa/physiology ; Optical Imaging ; Patch-Clamp Techniques ; Rats, Wistar ; Sensory Receptor Cells/drug effects ; Sensory Receptor Cells/physiology ; Sensory System Agents/pharmacology ; Tissue Culture Techniques
Chemical Substances	Endothelins ; Sensory System Agents ; L-Lactate Dehydrogenase (EC 1.1.1.27) ; Carbenoxolone (MM6384NG73) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2014-09
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645180-9
ISSN	1460-9568 ; 0953-816X
ISSN (online)	1460-9568
ISSN	0953-816X
DOI	10.1111/ejn.12665
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Article: Mitochondrial biogenesis in cardiac pathophysiology.

Rimbaud, Stéphanie / Garnier, Anne / Ventura-Clapier, Renée

Pharmacological reports : PR

2009 Volume 61, Issue 1, Page(s) 131–138

Abstract: Cardiac performance depends on a fine balance between the work the heart has to perform to satisfy the needs of the body and the energy that it is able to produce. Thus, energy production by oxidative metabolism, the main energy source of the cardiac ... ...

Abstract	Cardiac performance depends on a fine balance between the work the heart has to perform to satisfy the needs of the body and the energy that it is able to produce. Thus, energy production by oxidative metabolism, the main energy source of the cardiac muscle, has to be strictly regulated to adapt to cardiac work. Mitochondrial biogenesis is the mechanism responsible for mitochondrial component synthesis and assembly. This process controls mitochondrial content and thus correlates with energy production that, in turn, sustains cardiac contractility. Mitochondrial biogenesis should be finely controlled to match cardiac growth and cardiac work. When the heart is subjected to an increase in work in response to physiological and pathological challenges, it adapts by increasing its mass and expressing a new genetic program. In response to physiological stimuli such as endurance training, mitochondrial biogenesis seems to follow a program involving increased cardiac mass. But in the context of pathological hypertrophy, the modifications of this mechanism remain unclear. What appears clear is that mitochondrial biogenesis is altered in heart failure, and the imbalance between cardiac work demand and energy production represents a major factor in the development of heart failure.
MeSH term(s)	Animals ; Cardiomegaly/physiopathology ; Energy Metabolism/physiology ; Gene Expression Regulation ; Heart Failure/physiopathology ; Humans ; Mitochondria, Heart/metabolism ; Mitochondrial Proteins/genetics ; Oxygen Consumption/physiology ; Transcription, Genetic
Chemical Substances	Mitochondrial Proteins
Language	English
Publishing date	2009-03-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2186248-5
ISSN	1734-1140
ISSN	1734-1140
DOI	10.1016/s1734-1140(09)70015-5
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Article: Early survival factor deprivation in the olfactory epithelium enhances activity-driven survival.

François, Adrien / Laziz, Iman / Rimbaud, Stéphanie / Grebert, Denise / Durieux, Didier / Pajot-Augy, Edith / Meunier, Nicolas

Frontiers in cellular neuroscience

2013 Volume 7, Page(s) 271

Abstract: The neuronal olfactory epithelium undergoes permanent renewal because of environmental aggression. This renewal is partly regulated by factors modulating the level of neuronal apoptosis. Among them, we had previously characterized endothelin as ... ...

Abstract	The neuronal olfactory epithelium undergoes permanent renewal because of environmental aggression. This renewal is partly regulated by factors modulating the level of neuronal apoptosis. Among them, we had previously characterized endothelin as neuroprotective. In this study, we explored the effect of cell survival factor deprivation in the olfactory epithelium by intranasal delivery of endothelin receptors antagonists to rat pups. This treatment induced an overall increase of apoptosis in the olfactory epithelium. The responses to odorants recorded by electroolfactogram were decreased in treated animal, a result consistent with a loss of olfactory sensory neurons (OSNs). However, the treated animal performed better in an olfactory orientation test based on maternal odor compared to non-treated littermates. This improved performance could be due to activity-dependent neuronal survival of OSNs in the context of increased apoptosis level. In order to demonstrate it, we odorized pups with octanal, a known ligand for the rI7 olfactory receptor (Olr226). We quantified the number of OSN expressing rI7 by RT-qPCR and whole mount in situ hybridization. While this number was reduced by the survival factor removal treatment, this reduction was abolished by the presence of its ligand. This improved survival was optimal for low concentration of odorant and was specific for rI7-expressing OSNs. Meanwhile, the number of rI7-expressing OSNs was not affected by the odorization in non-treated littermates; showing that the activity-dependant survival of OSNs did not affect the OSN population during the 10 days of odorization in control conditions. Overall, our study shows that when apoptosis is promoted in the olfactory mucosa, the activity-dependent neuronal plasticity allows faster tuning of the olfactory sensory neuron population toward detection of environmental odorants.
Language	English
Publishing date	2013-12-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452963-1
ISSN	1662-5102
ISSN	1662-5102
DOI	10.3389/fncel.2013.00271
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Article ; Online: Resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure.

Rimbaud, Stéphanie / Ruiz, Matthieu / Piquereau, Jérôme / Mateo, Philippe / Fortin, Dominique / Veksler, Vladimir / Garnier, Anne / Ventura-Clapier, Renée

PloS one

2011 Volume 6, Issue 10, Page(s) e26391

Abstract: Heart failure (HF) is characterized by contractile dysfunction associated with altered energy metabolism. This study was aimed at determining whether resveratrol, a polyphenol known to activate energy metabolism, could be beneficial as a metabolic ... ...

Abstract	Heart failure (HF) is characterized by contractile dysfunction associated with altered energy metabolism. This study was aimed at determining whether resveratrol, a polyphenol known to activate energy metabolism, could be beneficial as a metabolic therapy of HF. Survival, ventricular and vascular function as well as cardiac and skeletal muscle energy metabolism were assessed in a hypertensive model of HF, the Dahl salt-sensitive rat fed with a high-salt diet (HS-NT). Resveratrol (18 mg/kg/day; HS-RSV) was given for 8 weeks after hypertension and cardiac hypertrophy were established (which occurred 3 weeks after salt addition). Resveratrol treatment improved survival (64% in HS-RSV versus 15% in HS-NT, p<0.001), and prevented the 25% reduction in body weight in HS-NT (P<0.001). Moreover, RSV counteracted the development of cardiac dysfunction (fractional shortening -34% in HS-NT) as evaluated by echocardiography, which occurred without regression of hypertension or hypertrophy. Moreover, aortic endothelial dysfunction present in HS-NT was prevented in resveratrol-treated rats. Resveratrol treatment tended to preserve mitochondrial mass and biogenesis and completely protected mitochondrial fatty acid oxidation and PPARα (peroxisome proliferator-activated receptor α) expression. We conclude that resveratrol treatment exerts beneficial protective effects on survival, endothelium-dependent smooth muscle relaxation and cardiac contractile and mitochondrial function, suggesting that resveratrol or metabolic activators could be a relevant therapy in hypertension-induced HF.
MeSH term(s)	Animals ; Body Weight/drug effects ; Disease Models, Animal ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/pathology ; Energy Metabolism/drug effects ; Heart/drug effects ; Heart/physiopathology ; Heart Failure/etiology ; Heart Failure/metabolism ; Heart Failure/pathology ; Heart Failure/physiopathology ; Hemodynamics/drug effects ; Hypertension/complications ; Male ; Mitochondria/drug effects ; Mitochondria/metabolism ; Rats ; Rats, Inbred Dahl ; Resveratrol ; Signal Transduction/drug effects ; Stilbenes/pharmacology ; Survival Analysis
Chemical Substances	Stilbenes ; Resveratrol (Q369O8926L)
Language	English
Publishing date	2011-10-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0026391
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Article ; Online: FAT/CD36 is located on the outer mitochondrial membrane, upstream of long-chain acyl-CoA synthetase, and regulates palmitate oxidation.

Smith, Brennan K / Jain, Swati S / Rimbaud, Stéphanie / Dam, Aaron / Quadrilatero, Joe / Ventura-Clapier, Renée / Bonen, Arend / Holloway, Graham P

The Biochemical journal

2011 Volume 437, Issue 1, Page(s) 125–134

Abstract: FAT/CD36 (fatty acid translocase/Cluster of Differentiation 36), a plasma membrane fatty-acid transport protein, has been found on mitochondrial membranes; however, it remains unclear where FAT/CD36 resides on this organelle or its functional role within ...

Abstract	FAT/CD36 (fatty acid translocase/Cluster of Differentiation 36), a plasma membrane fatty-acid transport protein, has been found on mitochondrial membranes; however, it remains unclear where FAT/CD36 resides on this organelle or its functional role within mitochondria. In the present study, we demonstrate, using several different approaches, that in skeletal muscle FAT/CD36 resides on the OMM (outer mitochondrial membrane). To determine the functional role of mitochondrial FAT/CD36 in this tissue, we determined oxygen consumption rates in permeabilized muscle fibres in WT (wild-type) and FAT/CD36-KO (knockout) mice using a variety of substrates. Despite comparable muscle mitochondrial content, as assessed by unaltered mtDNA (mitochondrial DNA), citrate synthase, β-hydroxyacyl-CoA dehydrogenase, cytochrome c oxidase complex IV and respiratory capacities [maximal OXPHOS (oxidative phosphorylation) respiration] in WT and KO mice, palmitate-supported respiration was 34% lower in KO animals. In contrast, palmitoyl-CoA-supported respiration was unchanged. These results indicate that FAT/CD36 is key for palmitate-supported respiration. Therefore we propose a working model of mitochondrial fatty-acid transport, in which FAT/CD36 is positioned on the OMM, upstream of long-chain acyl-CoA synthetase, thereby contributing to the regulation of mitochondrial fatty-acid transport. We further support this model by providing evidence that FAT/CD36 is not located in mitochondrial contact sites, and therefore does not directly interact with carnitine palmitoyltransferase-I as original proposed.
MeSH term(s)	Acyl Coenzyme A/metabolism ; Animals ; CD36 Antigens/analysis ; CD36 Antigens/genetics ; CD36 Antigens/metabolism ; Coenzyme A Ligases/metabolism ; Mice ; Mice, Knockout ; Microscopy, Electron, Transmission ; Mitochondrial Membranes/metabolism ; Muscle, Skeletal/metabolism ; Oxidation-Reduction ; Palmitates/metabolism ; Rats
Chemical Substances	Acyl Coenzyme A ; CD36 Antigens ; Palmitates ; Coenzyme A Ligases (EC 6.2.1.-)
Language	English
Publishing date	2011-07-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2969-5
ISSN	1470-8728 ; 0006-2936 ; 0306-3275 ; 0264-6021
ISSN (online)	1470-8728
ISSN	0006-2936 ; 0306-3275 ; 0264-6021
DOI	10.1042/BJ20101861
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Article ; Online: Catecholamine-induced cardiac mitochondrial dysfunction and mPTP opening: protective effect of curcumin.

Izem-Meziane, Malika / Djerdjouri, Bahia / Rimbaud, Stephanie / Caffin, Fanny / Fortin, Dominique / Garnier, Anne / Veksler, Vladimir / Joubert, Frederic / Ventura-Clapier, Renee

American journal of physiology. Heart and circulatory physiology

2011 Volume 302, Issue 3, Page(s) H665–74

Abstract: The present study was designed to characterize the mitochondrial dysfunction induced by catecholamines and to investigate whether curcumin, a natural antioxidant, induces cardioprotective effects against catecholamine-induced cardiotoxicity by preserving ...

Abstract	The present study was designed to characterize the mitochondrial dysfunction induced by catecholamines and to investigate whether curcumin, a natural antioxidant, induces cardioprotective effects against catecholamine-induced cardiotoxicity by preserving mitochondrial function. Because mitochondria play a central role in ischemia and oxidative stress, we hypothesized that mitochondrial dysfunction is involved in catecholamine toxicity and in the potential protective effects of curcumin. Male Wistar rats received subcutaneous injection of 150 mg·kg(-1)·day(-1) isoprenaline (ISO) for two consecutive days with or without pretreatment with 60 mg·kg(-1)·day(-1) curcumin. Twenty four hours after, cardiac tissues were examined for apoptosis and oxidative stress. Expression of proteins involved in mitochondrial biogenesis and function were measured by real-time RT-PCR. Isolated mitochondria and permeabilized cardiac fibers were used for swelling and mitochondrial function experiments, respectively. Mitochondrial morphology and permeability transition pore (mPTP) opening were assessed by fluorescence in isolated cardiomyocytes. ISO treatment induced cell damage, oxidative stress, and apoptosis that were prevented by curcumin. Moreover, mitochondria seem to play an important role in these effects as respiration and mitochondrial swelling were increased following ISO treatment, these effects being again prevented by curcumin. Importantly, curcumin completely prevented the ISO-induced increase in mPTP calcium susceptibility in isolated cardiomyocytes without affecting mitochondrial biogenesis and mitochondrial network dynamic. The results unravel the importance of mitochondrial dysfunction in isoprenaline-induced cardiotoxicity as well as a new cardioprotective effect of curcumin through prevention of mitochondrial damage and mPTP opening.
MeSH term(s)	Adrenergic beta-Agonists/toxicity ; Animals ; Apoptosis/drug effects ; Cardiomegaly/chemically induced ; Cardiomegaly/drug therapy ; Cardiomegaly/metabolism ; Cardiotonic Agents/pharmacology ; Catecholamines/metabolism ; Curcumin/pharmacology ; Disease Models, Animal ; Drug Interactions ; Enzyme Inhibitors/pharmacology ; Isoproterenol/toxicity ; Male ; Mitochondrial Diseases/chemically induced ; Mitochondrial Diseases/drug therapy ; Mitochondrial Diseases/metabolism ; Mitochondrial Membrane Transport Proteins/metabolism ; Myocarditis/chemically induced ; Myocarditis/drug therapy ; Myocarditis/metabolism ; Oxidative Stress/drug effects ; Rats ; Rats, Wistar
Chemical Substances	Adrenergic beta-Agonists ; Cardiotonic Agents ; Catecholamines ; Enzyme Inhibitors ; Mitochondrial Membrane Transport Proteins ; mitochondrial permeability transition pore ; Curcumin (IT942ZTH98) ; Isoproterenol (L628TT009W)
Language	English
Publishing date	2011-11-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00467.2011
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Article ; Online: Resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure.

Stéphanie Rimbaud / Matthieu Ruiz / Jérôme Piquereau / Philippe Mateo / Dominique Fortin / Vladimir Veksler / Anne Garnier / Renée Ventura-Clapier

PLoS ONE, Vol 6, Iss 10, p e

2011 Volume 26391

Abstract	Heart failure (HF) is characterized by contractile dysfunction associated with altered energy metabolism. This study was aimed at determining whether resveratrol, a polyphenol known to activate energy metabolism, could be beneficial as a metabolic therapy of HF. Survival, ventricular and vascular function as well as cardiac and skeletal muscle energy metabolism were assessed in a hypertensive model of HF, the Dahl salt-sensitive rat fed with a high-salt diet (HS-NT). Resveratrol (18 mg/kg/day; HS-RSV) was given for 8 weeks after hypertension and cardiac hypertrophy were established (which occurred 3 weeks after salt addition). Resveratrol treatment improved survival (64% in HS-RSV versus 15% in HS-NT, p<0.001), and prevented the 25% reduction in body weight in HS-NT (P<0.001). Moreover, RSV counteracted the development of cardiac dysfunction (fractional shortening -34% in HS-NT) as evaluated by echocardiography, which occurred without regression of hypertension or hypertrophy. Moreover, aortic endothelial dysfunction present in HS-NT was prevented in resveratrol-treated rats. Resveratrol treatment tended to preserve mitochondrial mass and biogenesis and completely protected mitochondrial fatty acid oxidation and PPARα (peroxisome proliferator-activated receptor α) expression. We conclude that resveratrol treatment exerts beneficial protective effects on survival, endothelium-dependent smooth muscle relaxation and cardiac contractile and mitochondrial function, suggesting that resveratrol or metabolic activators could be a relevant therapy in hypertension-induced HF.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2011-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity.

Lantier, Louise / Fentz, Joachim / Mounier, Rémi / Leclerc, Jocelyne / Treebak, Jonas T / Pehmøller, Christian / Sanz, Nieves / Sakakibara, Iori / Saint-Amand, Emmanuelle / Rimbaud, Stéphanie / Maire, Pascal / Marette, André / Ventura-Clapier, Renée / Ferry, Arnaud / Wojtaszewski, Jørgen F P / Foretz, Marc / Viollet, Benoit

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2014 Volume 28, Issue 7, Page(s) 3211–3224

Abstract: ... Sakakibara, I., Saint-Amand, E., Rimbaud, S., Maire, P., Marette, A., Ventura-Clapier, R., Ferry ...

Abstract	AMP-activated protein kinase (AMPK) is a sensor of cellular energy status that plays a central role in skeletal muscle metabolism. We used skeletal muscle-specific AMPKα1α2 double-knockout (mdKO) mice to provide direct genetic evidence of the physiological importance of AMPK in regulating muscle exercise capacity, mitochondrial function, and contraction-stimulated glucose uptake. Exercise performance was significantly reduced in the mdKO mice, with a reduction in maximal force production and fatigue resistance. An increase in the proportion of myofibers with centralized nuclei was noted, as well as an elevated expression of interleukin 6 (IL-6) mRNA, possibly consistent with mild skeletal muscle injury. Notably, we found that AMPKα1 and AMPKα2 isoforms are dispensable for contraction-induced skeletal muscle glucose transport, except for male soleus muscle. However, the lack of skeletal muscle AMPK diminished maximal ADP-stimulated mitochondrial respiration, showing an impairment at complex I. This effect was not accompanied by changes in mitochondrial number, indicating that AMPK regulates muscle metabolic adaptation through the regulation of muscle mitochondrial oxidative capacity and mitochondrial substrate utilization but not baseline mitochondrial muscle content. Together, these results demonstrate that skeletal muscle AMPK has an unexpected role in the regulation of mitochondrial oxidative phosphorylation that contributes to the energy demands of the exercising muscle.-Lantier, L., Fentz, J., Mounier, R., Leclerc, J., Treebak, J. T., Pehmøller, C., Sanz, N., Sakakibara, I., Saint-Amand, E., Rimbaud, S., Maire, P., Marette, A., Ventura-Clapier, R., Ferry, A., Wojtaszewski, J. F. P., Foretz, M., Viollet, B. AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity.
MeSH term(s)	AMP-Activated Protein Kinases/metabolism ; Animals ; Glucose/metabolism ; Interleukin-6/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mitochondria/metabolism ; Muscle Contraction/physiology ; Muscle Fatigue/physiology ; Muscle Fibers, Skeletal/metabolism ; Oxidation-Reduction ; Phosphorylation/physiology ; Physical Conditioning, Animal ; Physical Endurance/physiology
Chemical Substances	Interleukin-6 ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2014-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.14-250449
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Zs.A 2266: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Early survival factor deprivation in the olfactory epithelium enhances activity-survival driven survival

François, Adrien / Laziz, Iman / Rimbaud, STEPHANIE / Grebert, Denise / Durieux, Didier / Pajot-Augy, Edith / Meunier, Nicolas

Frontiers in cellular neuroscience (7), 9 p.. (2013)

Abstract	The neuronal olfactory epithelium undergoes permanent renewal because of environmental aggression. This renewal is partly regulated by factors modulating the level of neuronal apoptosis. Among them, we had previously characterized endothelin as neuroprotective. In this study, we explored the effect of cell survival factor deprivation in the olfactory epithelium by intranasal delivery of endothelin receptors antagonists to rat pups. This treatment induced an overall increase of apoptosis in the olfactory epithelium. The responses to odorants recorded by electroolfactogram were decreased in treated animal, a result consistent with a loss of olfactory sensory neurons (OSNs). However, the treated animal performed better in an olfactory orientation test based on maternal odor compared to non-treated littermates. This improved performance could be due to activity-dependent neuronal survival of OSNs in the context of increased apoptosis level. In order to demonstrate it, we odorized pups with octanal, a known ligand for the rI7 olfactory receptor (Olr226). We quantified the number of OSN expressing rI7 by RT-qPCR and whole mount in situ hybridization. While this number was reduced by the survival factor removal treatment, this reduction was abolished by the presence of its ligand. This improved survival was optimal for low concentration of odorant and was specific for rI7-expressing OSNs. Meanwhile, the number of rI7-expressing OSNs was not affected by the odorization in non-treated littermates; showing that the activity-dependant survival of OSNs did not affect the OSN population during the 10 days of odorization in control conditions. Overall, our study shows that when apoptosis is promoted in the olfactory mucosa, the activity-dependent neuronal plasticity allows faster tuning of the olfactory sensory neuron population toward detection of environmental odorants.
Language	English
Document type	Article
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

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In stock of ZB MED Cologne/Königswinter

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Inter-library loan at ZB MED