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  1. Book ; Online ; E-Book: Practical oncologic molecular pathology

    Ding, Yi / Zhang, Linsheng

    frequently asked questions

    (Practical anatomic pathology)

    2021  

    Author's details Yi Ding, Linsheng Zhang, editors
    Series title Practical anatomic pathology
    MeSH term(s) Neoplasms/diagnosis ; Pathology, Molecular ; Medical Oncology/methods
    Keywords Pathology ; Oncology ; Pathology, Molecular ; Cancer/Molecular diagnosis
    Subject code 616.994075
    Language English
    Dates of publication 2021-2021
    Size 1 online resource (446 pages) :, illustrations (some color)
    Publisher Springer
    Publishing place Cham, Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-73227-4 ; 3-030-73226-6 ; 978-3-030-73227-1 ; 978-3-030-73226-4
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Molecular Genetic Profile of Myelofibrosis: Implications in the Diagnosis, Prognosis, and Treatment Advancements.

    Verma, Tanvi / Papadantonakis, Nikolaos / Peker Barclift, Deniz / Zhang, Linsheng

    Cancers

    2024  Volume 16, Issue 3

    Abstract: Myelofibrosis (MF) is an essential element of primary myelofibrosis, whereas secondary MF may develop in the advanced stages of other myeloid neoplasms, especially polycythemia vera and essential thrombocythemia. Over the last two decades, advances in ... ...

    Abstract Myelofibrosis (MF) is an essential element of primary myelofibrosis, whereas secondary MF may develop in the advanced stages of other myeloid neoplasms, especially polycythemia vera and essential thrombocythemia. Over the last two decades, advances in molecular diagnostic techniques, particularly the integration of next-generation sequencing in clinical laboratories, have revolutionized the diagnosis, classification, and clinical decision making of myelofibrosis. Driver mutations involving
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16030514
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Study on pyroptosis-related genes Casp8, Gsdmd and Trem2 in mice with cerebral infarction.

    Liang, Shunli / Xu, Linsheng / Xin, Xilin / Zhang, Rongbo / Wu, You

    PeerJ

    2024  Volume 12, Page(s) e16818

    Abstract: Objective: Cerebral infarction is the main cause of death in patients with cerebrovascular diseases. Our research aimed to screen and validate pyroptosis-related genes in cerebral infarction for the targeted therapy of cerebral infarction.: Methods ... ...

    Abstract Objective: Cerebral infarction is the main cause of death in patients with cerebrovascular diseases. Our research aimed to screen and validate pyroptosis-related genes in cerebral infarction for the targeted therapy of cerebral infarction.
    Methods and results: A total of 1,517 differentially expressed genes (DEGs) were obtained by DESeq2 software analysis. Gene set enrichment analysis results indicated that genes of middle cerebral artery occlusion (MCAO) mice aged 3 months and 18 months were enriched in pyroptosis, respectively. Differentially expressed pyroptosis-related genes (including Aim2, Casp8, Gsdmd, Naip2, Naip5, Naip6 and Trem2) were obtained through intersection of DEGs and genes from pyroptosis Gene Ontology Term (GO:0070269), and they were up-regulated in the brain tissues of MCAO mice in GSE137482. In addition, Casp8, Gsdmd, and Trem2 were verified to be significantly up-regulated in MCAO mice in GSE93376. The evaluation of neurologic function and triphenyltetrazolium chloride staining showed that the MCAO mouse models were successfully constructed. Meanwhile, the expressions of TNF-
    Conclusions: Casp8, Gsdmd and Trem2 can regulate pyroptosis, thus affecting cerebral infarction.
    MeSH term(s) Animals ; Humans ; Mice ; Disease Models, Animal ; Infarction, Middle Cerebral Artery/genetics ; Membrane Glycoproteins/genetics ; Neuronal Apoptosis-Inhibitory Protein ; Pyroptosis/physiology ; Receptors, Immunologic
    Chemical Substances Membrane Glycoproteins ; Naip5 protein, mouse ; Neuronal Apoptosis-Inhibitory Protein ; Receptors, Immunologic ; Trem2 protein, mouse ; Casp8 protein, mouse (EC 3.4.22.-) ; Gsdmd protein, mouse
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359 ; 2167-8359
    ISSN (online) 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.16818
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Heterologous overexpression of Tawzy1-2 gene encoding an SK

    Wang, Xiaoyu / Liu, Hao / Li, Yuwei / Zhang, Linsheng / Wang, Bo

    Planta

    2024  Volume 259, Issue 2, Page(s) 39

    Abstract: Main conclusion: The nuclear localized TaWZY1-2 helps plants resist abiotic stress by preserving the cell's ability to remove reactive oxygen species and decrease lipid oxidation under such conditions. In light of the unpredictable environmental ... ...

    Abstract Main conclusion: The nuclear localized TaWZY1-2 helps plants resist abiotic stress by preserving the cell's ability to remove reactive oxygen species and decrease lipid oxidation under such conditions. In light of the unpredictable environmental conditions in which food crops grow, precise strategies must be developed by crops to effectively cope with abiotic stress and minimize damage over their lifespan. A key component in this endeavor is the group II of late embryogenesis abundant (LEA) proteins, known as dehydrins, which play crucial roles in enhancing the tolerance of plants to abiotic stress. Tawzy1-2 is a dehydrin-encoding gene which is constitutively expressed in various tissues of wheat. However, the biological function of TaWZY1-2 is not yet fully understood. In this study, TaWZY1-2 was isolated and identified in the wheat genome, and its functional role in conferring tolerance to abiotic stresses was detected in both prokaryotic and eukaryotic cells. Results showed that TaWZY1-2 is a nuclear localized hydrophilic protein that accumulates in response to multiple stresses. Escherichia coli cells expressing TaWZY1-2 showed enhanced tolerance to multiple stress conditions. Overexpression of TaWZY1-2 in Nicotiania benthamiana improved growth, germination and survival rate of the transgenic plants exposed to four kinds of abiotic stress conditions. Our results show that Tawzy1-2 transgenic plants exhibit improved capability in clearing reactive oxygen species and reducing lipid degradation, thereby enhancing their resistance to abiotic stress. This demonstrates a significant role of TaWZY1-2 in mitigating abiotic stress-induced damage. Consequently, these findings not only establish a basis for future investigation into the functional mechanism of TaWZY1-2 but also contribute to the expansion of functional diversity within the dehydrin protein family. Moreover, they identify potential candidate genes for crop optimization.
    MeSH term(s) Crops, Agricultural ; Escherichia coli ; Lipids ; Nuclear Proteins ; Plants, Genetically Modified ; Reactive Oxygen Species ; Stress, Physiological ; Nicotiana
    Chemical Substances Lipids ; Nuclear Proteins ; Reactive Oxygen Species
    Language English
    Publishing date 2024-01-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 208909-9
    ISSN 1432-2048 ; 0032-0935 ; 1866-2749
    ISSN (online) 1432-2048
    ISSN 0032-0935 ; 1866-2749
    DOI 10.1007/s00425-023-04328-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 46/303: Show issues

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  5. Article ; Online: Using propensity score matching models to assess the protection effectiveness in Pudacuo national Park, China

    Zhang Xiaoyao / Zhong Linsheng / Zhang Haizhou

    Ecological Indicators, Vol 150, Iss , Pp 110222- (2023)

    2023  

    Abstract: Scientific monitoring and assessment of ecosystem services (ESs) in national parks is an important path to strengthen the management and protection of national parks. In this study, we constructed a test scheme for the ESs protection effectiveness based ... ...

    Abstract Scientific monitoring and assessment of ecosystem services (ESs) in national parks is an important path to strengthen the management and protection of national parks. In this study, we constructed a test scheme for the ESs protection effectiveness based on the InVEST model and the Propensity score matching model (PSM). Based on this scheme, we best-matched three groups of pairs inside and outside the national park, and analyzed the magnitude and significance of differences in ESs protection between the best-matched groups by t-test, and then assessed whether the establishment of Pudacuo National Park had a protective effect on ESs. The results show that: Except for soil conservation, all ESs within Pudacuo National Park and its external 0–10 km range were higher than those in the 10–20 km area outside the national park. Moreover, the ESs within the national park and its external 0–10 km showed the same increase and decrease, and the difference between the two was small. This indicates that the existence of Pudacuo National Park effectively protects ESs and also has a positive spillover effect on its outer 0–10 km range. In addition, this study found that the soil conservation protection effect of Pudacuo National Park was slightly deficient. It exhibits weaker soil conservation than areas outside the national park. It is recommended to further strengthen the investment in soil conservation services and develop relevant measures to curb soil erosion according to local conditions.
    Keywords Protection effectiveness ; Ecosystem Services ; Propensity score matching model ; Pudacuo National Park ; Ecology ; QH540-549.5
    Subject code 710
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Syk regulates the haemocyte autophagy through inducing the mRNA expressions of autophagy-related genes and the cleavage of

    Yao, Hongsheng / Sun, Jiejie / Zhang, Tong / Wang, Lingling / Song, Linsheng

    Fish and shellfish immunology reports

    2023  Volume 4, Page(s) 100085

    Abstract: Spleen tyrosine kinase (Syk) is reported to be involved in activating the autophagy. Recently, a homologue of Syk was identified from Pacific ... ...

    Abstract Spleen tyrosine kinase (Syk) is reported to be involved in activating the autophagy. Recently, a homologue of Syk was identified from Pacific oyster
    Language English
    Publishing date 2023-01-16
    Publishing country England
    Document type Journal Article
    ISSN 2667-0119
    ISSN (online) 2667-0119
    DOI 10.1016/j.fsirep.2023.100085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A Rare Lipoma of Tongue in a 4-Year-Old Child: A Case Report With Literature Review.

    Yang, Yong / Zuo, Hailiang / Ding, Meiyun / Ma, Fujiang / Zhao, Linsheng / Zhang, Jiancheng

    Ear, nose, & throat journal

    2024  , Page(s) 1455613241237083

    Abstract: Lipoma of the tongue is a rare benign tumor that accounts for approximately 1% to 5% of all oral cavity tumors while 0.3% of tumors are of the tongue. Notably, it is rarer in children. In this article, we report the case of a 4-year-old girl with lipomas ...

    Abstract Lipoma of the tongue is a rare benign tumor that accounts for approximately 1% to 5% of all oral cavity tumors while 0.3% of tumors are of the tongue. Notably, it is rarer in children. In this article, we report the case of a 4-year-old girl with lipomas of the tongue. The lipomas were found at age 1 year by her parents, located on the tip, ventro, and dorsum of the tongue, and presenting with a trend to increase gradually. At the time of presentation to the hospital at age 4 years, the articulatory function of the patient was partially affected, and surgical excision was performed. The surgery was uneventful, and no evidence of recurrence was noted at 3 month follow-up.
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 750153-5
    ISSN 1942-7522 ; 0145-5613
    ISSN (online) 1942-7522
    ISSN 0145-5613
    DOI 10.1177/01455613241237083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 107: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Measurable (Minimal) Residual Disease in Myelodysplastic Neoplasms (MDS): Current State and Perspectives.

    Zhang, Linsheng / Deeb, George / Deeb, Kristin K / Vale, Colin / Peker Barclift, Deniz / Papadantonakis, Nikolaos

    Cancers

    2024  Volume 16, Issue 8

    Abstract: Myelodysplastic Neoplasms (MDS) have been traditionally studied through the assessment of blood counts, cytogenetics, and morphology. In recent years, the introduction of molecular assays has improved our ability to diagnose MDS. The role of Measurable ( ... ...

    Abstract Myelodysplastic Neoplasms (MDS) have been traditionally studied through the assessment of blood counts, cytogenetics, and morphology. In recent years, the introduction of molecular assays has improved our ability to diagnose MDS. The role of Measurable (minimal) Residual Disease (MRD) in MDS is evolving, and molecular and flow cytometry techniques have been used in several studies. In this review, we will highlight the evolving concept of MRD in MDS, outline the various techniques utilized, and provide an overview of the studies reporting MRD and the correlation with outcomes.
    Language English
    Publishing date 2024-04-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16081503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Correction to: Characterization of wheat Wrab18 gene promoter and expression analysis under abiotic stress.

    Wang, Xiaoyu / Liu, Hao / Yu, Zhengyang / Zhu, Weining / Zhang, Linsheng / Wang, Bo

    Molecular biology reports

    2023  Volume 50, Issue 12, Page(s) 10681–10685

    Language English
    Publishing date 2023-11-03
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-023-08783-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: The Immunoprotection of

    Jia, Jianlei / Zhao, Meng / Ma, Kairu / Zhang, Hongjian / Gui, Linsheng / Sun, Huzhi / Ren, Huiying / Okabayashi, Tamaki / Zhao, Jing

    Veterinary sciences

    2023  Volume 10, Issue 3

    Abstract: ... ...

    Abstract OmpH
    Language English
    Publishing date 2023-03-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2768971-2
    ISSN 2306-7381 ; 2306-7381
    ISSN (online) 2306-7381
    ISSN 2306-7381
    DOI 10.3390/vetsci10030221
    Database MEDical Literature Analysis and Retrieval System OnLINE

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