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Article ; Online: Understanding the paradigm.

Okerberg, Carl / Adie, Sarah / Konerman, Matthew / Zimmerman, Chris

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

2024

Abstract: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author ... ...

Abstract	In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time.
Language	English
Publishing date	2024-03-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1224627-x
ISSN	1535-2900 ; 1079-2082
ISSN (online)	1535-2900
ISSN	1079-2082
DOI	10.1093/ajhp/zxae071
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Article ; Online: Redox biology in physiology and disease.

Zimmerman, Matthew C / Case, Adam J

Redox biology

2019 Volume 27, Page(s) 101267

MeSH term(s)	Biology/methods ; Biomarkers/metabolism ; Humans ; Oxidation-Reduction ; Oxidative Stress/physiology ; Reactive Oxygen Species/metabolism ; Signal Transduction/physiology
Chemical Substances	Biomarkers ; Reactive Oxygen Species
Language	English
Publishing date	2019-07-01
Publishing country	Netherlands
Document type	Editorial ; Research Support, N.I.H., Extramural
ISSN	2213-2317
ISSN (online)	2213-2317
DOI	10.1016/j.redox.2019.101267
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Article ; Online: Implementation of a clinical decision support alert to prevent use of intravenous β-blockers and nondihydropyridine calcium channel blockers in hospitalized patients with acute decompensated heart failure.

Okerberg, Carl / Adie, Sarah / Konerman, Matthew / Zimmerman, Chris

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

2023 Volume 80, Issue 9, Page(s) e119–e125

Abstract: Purpose: Intravenous (IV) β-blockers (BBs) and nondihydropyridine calcium channel blockers (NDCCBs) are harmful in patients with acute decompensated heart failure (ADHF), but they are commonly used for rate control in atrial fibrillation (AF). This ... ...

Abstract	Purpose: Intravenous (IV) β-blockers (BBs) and nondihydropyridine calcium channel blockers (NDCCBs) are harmful in patients with acute decompensated heart failure (ADHF), but they are commonly used for rate control in atrial fibrillation (AF). This study evaluated the implementation of a clinical decision support (CDS) alert in the electronic health record (EHR) to prevent the use of these agents for AF in patients with ADHF, as well as results from the alert's continuous quality improvement. Methods: This was a single-center, retrospective, quasi-experimental pre/post analysis of hospitalized adult patients with an ejection fraction of less than 40% documented during their encounter. Groups corresponding to encounters before and after introduction of the alert were compared, and the first version of the alert was compared to its second version that was refined by iterative design. Results: For all patient hospital encounters, the rate of IV BB and NDCCB orders decreased in the period after alert implementation from 16.2% to 12% (P < 0.001). The alert's override rate decreased from 83.8% for the first version to 70.1% after iterative design (P = 0.015). Conclusion: This study demonstrates that a CDS alert can be used in the EHR to reduce the use of potentially harmful IV BBs and NDCCBs in patients with ADHF for rate control. User compliance with the alert was improved by applying human factors design principles and iterative design during continuous quality improvement.
MeSH term(s)	Adult ; Humans ; Calcium Channel Blockers/therapeutic use ; Decision Support Systems, Clinical ; Retrospective Studies ; Adrenergic beta-Antagonists/therapeutic use ; Heart Failure/drug therapy ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy
Chemical Substances	Calcium Channel Blockers ; Adrenergic beta-Antagonists
Language	English
Publishing date	2023-02-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1224627-x
ISSN	1535-2900 ; 1079-2082
ISSN (online)	1535-2900
ISSN	1079-2082
DOI	10.1093/ajhp/zxad036
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Article ; Online: Mobility and bioaccessibility of arsenic (As) bound to titanium dioxide (TiO

Zimmerman, Amanda Jo / Garcia Gutierrez, Danira / Shaghaghi, Negar / Sharma, Aakriti / Deonarine, Amrika / Landrot, Gautier / Weindorf, David C / Siebecker, Matthew G

Environmental pollution (Barking, Essex : 1987)

2023 Volume 326, Page(s) 121468

Abstract: This work systematically describes arsenic mobility and potential bioaccessibility of arsenic-enriched titanium dioxide water treatment residuals ( ... ...

Abstract	This work systematically describes arsenic mobility and potential bioaccessibility of arsenic-enriched titanium dioxide water treatment residuals (TiO
MeSH term(s)	Arsenic/chemistry ; Titanium/chemistry ; Adsorption ; Water Purification/methods ; X-Ray Absorption Spectroscopy
Chemical Substances	Arsenic (N712M78A8G) ; titanium dioxide (15FIX9V2JP) ; Titanium (D1JT611TNE)
Language	English
Publishing date	2023-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2023.121468
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Zs.A 2599: Show issues

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Article: Hydrogen Peroxide Scavenging Restores N-Type Calcium Channels in Cardiac Vagal Postganglionic Neurons and Mitigates Myocardial Infarction-Evoked Ventricular Arrhythmias in Type 2 Diabetes Mellitus.

Zhang, Dongze / Tu, Huiyin / Hu, Wenfeng / Duan, Bin / Zimmerman, Matthew C / Li, Yu-Long

Frontiers in cardiovascular medicine

2022 Volume 9, Page(s) 871852

Abstract: Objective: Withdrawal of cardiac vagal activity is associated with ventricular arrhythmia-related high mortality in patients with type 2 diabetes mellitus (T2DM). Our recent study found that reduced cell excitability of cardiac vagal postganglionic (CVP) ...

Abstract	Objective: Withdrawal of cardiac vagal activity is associated with ventricular arrhythmia-related high mortality in patients with type 2 diabetes mellitus (T2DM). Our recent study found that reduced cell excitability of cardiac vagal postganglionic (CVP) neurons is involved in cardiac vagal dysfunction and further exacerbates myocardial infarction (MI)-evoked ventricular arrhythmias and mortality in T2DM. However, the mechanisms responsible for T2DM-impaired cell excitability of CVP neurons remain unclear. This study tested if and how elevation of hydrogen peroxide (H Methods and results: Rat T2DM was induced by a high-fat diet plus streptozotocin injection. Local Conclusions: We concluded that endogenous H
Language	English
Publishing date	2022-04-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.871852
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Article ; Online: Anatomic total shoulder arthroplasty with a nonspherical humeral head and inlay glenoid: 90-day complication profile in the inpatient versus outpatient setting.

Posner, Andrew D / Kuna, Michael C / Carroll, Jeremy D / Perloff, Eric M / Anderson, Matthew J / Hutchinson, Ian D / Zimmerman, Joseph P

Clinics in shoulder and elbow

2023 Volume 26, Issue 4, Page(s) 380–389

Abstract: Background: Total shoulder arthroplasty (TSA) with a nonspherical humeral head component and inlay glenoid is a successful bone-preserving treatment for glenohumeral arthritis. This study aimed to describe the 90-day complication profile of TSA with ... ...

Abstract	Background: Total shoulder arthroplasty (TSA) with a nonspherical humeral head component and inlay glenoid is a successful bone-preserving treatment for glenohumeral arthritis. This study aimed to describe the 90-day complication profile of TSA with this prosthesis and compare major and minor complication and readmission rates between inpatient- and outpatient-procedure patients. Methods: A retrospective review was performed of a consecutive cohort of patients undergoing TSA with a nonspherical humeral head and inlay glenoid in the inpatient and outpatient settings by a single surgeon between 2017 and 2022. Age, sex, body mass index, American Society of Anesthesiologists (ASA) score, Charlson Comorbidity Index (CCI), and 90-day complication and readmission rates were compared between inpatient and outpatient groups. Results: One hundred eighteen TSAs in 111 patients were identified. Mean age was 64.9 years (range, 39-90) and 65% of patients were male. Ninety-four (80%) and 24 (20%) patients underwent outpatient and inpatient procedures, respectively. Four complications (3.4%) were recorded: axillary nerve stretch injury, isolated ipsilateral arm deep venous thrombosis (DVT), ipsilateral arm DVT with pulmonary embolism requiring readmission, and gastrointestinal bleed requiring readmission. There were no reoperations or other complications. Outpatients were younger with lower ASA and CCI scores than inpatients; however, there was no difference in complications (1/24 vs. 3/94, P=1.00) or readmissions (1/24 vs. 1/94, P=0.37) between these two groups. Conclusions: TSA with a nonspherical humeral head and inlay glenoid can be performed safely in both inpatient and outpatient settings. Rates of early complications and readmissions were low with no difference according to surgical setting. Level of evidence: IV.
Language	English
Publishing date	2023-11-01
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3031244-9
ISSN	2288-8721 ; 2383-8337
ISSN (online)	2288-8721
ISSN	2383-8337
DOI	10.5397/cise.2023.00479
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Article ; Online: Effectiveness of fit testing versus fit checking for healthcare workers respiratory protective equipment: A systematic review.

Goko, Charlotte / Forster, Elizabeth / Mason, Matthew / Zimmerman, Peta-Anne

International journal of nursing sciences

2023 Volume 10, Issue 4, Page(s) 568–578

Abstract: Objectives: Respiratory protection is critical in healthcare to minimise the risk of airborne infections for healthcare workers (HCWs). It emphasizes the use of proper fitting of particulate filter respirators and equivalent respiratory protective ... ...

Abstract	Objectives: Respiratory protection is critical in healthcare to minimise the risk of airborne infections for healthcare workers (HCWs). It emphasizes the use of proper fitting of particulate filter respirators and equivalent respiratory protective equipment (RPE) to ensure a good facial seal. The systematic review aimed to compare the effectiveness of fit testing and fit checking for HCWs' respiratory protective equipment. Methods: A systematic review of the literature exploring RPE for HCWs to determine the effectiveness of fit-testing versus fit-checking from January 2003 to April 2022 was identified using CINAHL Complete via EBSCO Host, Cochrane Library, EMBASE, PubMed, and MEDLINE via Ovid electronic databases, and grey literature. The study protocol was registered with PROSPERO (registration number: CRD42020213968). Results: Of the 561 articles identified in the search, 25 articles (22 quantitative studies and three guidelines) were included in this review. Overall, these studies suggest fit-testing as a method that is more effective, widely adopted, and reliable in assessing the effectiveness of RPE; however, a respiratory program should include both fit-testing and fit-checking to maximise effectiveness of the RPE. The COVID-19 epidemic highlighted a lack of knowledge among HCWs regarding fit-checking and fit-testing, and relevant education increased the effectiveness of respiratory equipment protection. Conclusion: It is imperative that both fit-testing and fit-checking is implemented in order to ensure HCW safety. It is recommended to integrate education, fit-testing and fit-checking into a comprehensive respiratory protective program run by trained fit-testers. There is also a need for practical testing methods that incorporate the clinical environment.
Language	English
Publishing date	2023-09-20
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2800296-9
ISSN	2352-0132 ; 2352-0132
ISSN (online)	2352-0132
ISSN	2352-0132
DOI	10.1016/j.ijnss.2023.09.011
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Article ; Online: Perturbation of the insomnia WDR90 GWAS locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, PIG-Q.

Sonti, Shilpa / Littleton, Sheridan H / Pahl, Matthew C / Zimmerman, Amber J / Chesi, Alessandra / Palermo, Justin / Lasconi, Chiara / Brown, Elizabeth B / Pippin, James A / Wells, Andrew D / Doldur-Balli, Fusun / Pack, Allan I / Gehrman, Phillip R / Keene, Alex C / Grant, Struan F A

Sleep

2024

Abstract: Although genome wide association studies (GWAS) have identified loci for sleep-related traits, they do not directly uncover the underlying causal variants and corresponding effector genes. The majority of such variants reside in non-coding regions and ... ...

Abstract	Although genome wide association studies (GWAS) have identified loci for sleep-related traits, they do not directly uncover the underlying causal variants and corresponding effector genes. The majority of such variants reside in non-coding regions and are therefore presumed to impact cis-regulatory elements. Our previously reported 'variant-to-gene mapping' effort in human induced pluripotent stem cell (iPSC)-derived neural progenitor cells (NPCs), combined with validation in both Drosophila and zebrafish, implicated PIG-Q as a functionally relevant gene at the insomnia 'WDR90' GWAS locus. However, importantly that effort did not characterize the corresponding underlying causal variant. Specifically, our previous 3D genomic datasets nominated a shortlist of three neighboring single nucleotide polymorphisms (SNPs) in strong linkage disequilibrium within an intronic enhancer region of WDR90 that contacted the open PIG-Q promoter. We sought to investigate the influence of these SNPs collectively and then individually on PIG-Q modulation to pinpoint the causal "regulatory" variant. Starting with gross level perturbation, deletion of the entire region in NPCs via CRISPR-Cas9 editing and subsequent RNA sequencing revealed expression changes in specific PIG-Q transcripts. Results from individual luciferase reporter assays for each SNP in iPSCs revealed that the region with the rs3752495 risk allele induced a ~2.5-fold increase in luciferase expression. Importantly, rs3752495 also exhibited an allele specific effect, with the risk allele increasing the luciferase expression by ~2-fold versus the non-risk allele. In conclusion, our variant-to-function approach and in vitro validation implicates rs3752495 as a causal insomnia variant embedded within WDR90 while modulating the expression of the distally located PIG-Q.
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	424441-2
ISSN	1550-9109 ; 0161-8105
ISSN (online)	1550-9109
ISSN	0161-8105
DOI	10.1093/sleep/zsae085
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Zs.A 1475: Show issues

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Article ; Online: Oxidative stress in early pregnancy and the risk of preeclampsia.

Ahmad, Iman M / Zimmerman, Matthew C / Moore, Tiffany A

Pregnancy hypertension

2019 Volume 18, Page(s) 99–102

Abstract: Introduction: Preeclampsia (PE), one of the most serious complications of pregnancy, is characterized by endothelial dysfunction and hypertension. The pathophysiology of the disease is still unknown; however, evidence suggests that placental and ... ...

Abstract	Introduction: Preeclampsia (PE), one of the most serious complications of pregnancy, is characterized by endothelial dysfunction and hypertension. The pathophysiology of the disease is still unknown; however, evidence suggests that placental and maternal oxidative stress promote the disease process. Several studies have assessed levels of oxidative stress during pregnancy, but after diagnosis of PE. However, few studies have examined oxidative stress before PE diagnosis. Thus, the present work was aimed to gain further insight into the role of oxidative stress prior to diagnosis of PE (i.e. 12-20 weeks of gestation) and to further understand and predict PE incidence. Methods: Blood levels of superoxide (O Results: CAT activity, GSH, and Total glutathione (TGSH) were significantly lower with All PE pregnant groups, whereas O Conclusion: CAT is the only antioxidant as shown in our study to be related to the severity of the disease and may be a promising predictor for PE. Further studies are warranted to investigate the use of CAT as a novel therapeutic for PE.
MeSH term(s)	Adult ; Case-Control Studies ; Female ; Glutathione/blood ; Humans ; Longitudinal Studies ; Oxidative Stress ; Pre-Eclampsia/blood ; Pre-Eclampsia/diagnosis ; Pre-Eclampsia/physiopathology ; Pregnancy ; Pregnancy Trimester, First ; Pregnancy Trimester, Second ; Prenatal Diagnosis ; Prospective Studies ; Superoxide Dismutase/blood
Chemical Substances	Superoxide Dismutase (EC 1.15.1.1) ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2019-10-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2584464-7
ISSN	2210-7797 ; 2210-7789
ISSN (online)	2210-7797
ISSN	2210-7789
DOI	10.1016/j.preghy.2019.09.014
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Article ; Online: Mobility and bioaccessibility of arsenic (As) bound to titanium dioxide (TiO2) water treatment residuals (WTRs)

Zimmerman, Amanda Jo / Garcia Gutierrez, Danira / Shaghaghi, Negar / Sharma, Aakriti / Deonarine, Amrika / Landrot, Gautier / Weindorf, David C. / Siebecker, Matthew G.

Environmental Pollution. 2023 June, v. 326 p.121468-

2023

Abstract: This work systematically describes arsenic mobility and potential bioaccessibility of arsenic-enriched titanium dioxide water treatment residuals (TiO₂ WTRs) by employing a suite of wet chemical experiments and spectroscopic measurements. Specifically, ... ...

Abstract	This work systematically describes arsenic mobility and potential bioaccessibility of arsenic-enriched titanium dioxide water treatment residuals (TiO₂ WTRs) by employing a suite of wet chemical experiments and spectroscopic measurements. Specifically, Environmental Protection Agency (EPA) digestion method 3051a indicated <3% of total arsenic in the solid phase was released, and arsenic assessed by EPA method 1340 for bioaccessibility was below detection limits. A novel finding is while the arsenic appeared to be stable under highly acidic digestion conditions, it is in fact highly mobile when exposed to simple phosphate solutions. On average, 55% of arsenic was extracted from all samples during a 50-day replenishment study. This was equivalent to 169 mg kg⁻¹ arsenic released from the solid phase. Macroscopic desorption experiments indicated arsenic likely formed inner-sphere bonds with the TiO₂ particles present in the samples. This was confirmed with X-ray absorption spectroscopy (XAS), where an interatomic distance of 3.32 Å and a coordination number (CN) of 1.79 titanium atoms were determined. This translates to a configuration of arsenic on TiO₂ surfaces as a bidentate binuclear inner-sphere complex. Thus, both macroscopic and spectroscopic data are in agreement. During incubation experiments, arsenic(V) was actively reduced to arsenic(III); the amount of arsenic(III) in solution varied from 8 to 38% of total dissolved arsenic. Lastly, elevated concentrations and mobility of vanadium in these systems merit further investigation. The high mobility of arsenic and its potential for reduction when reintroduced into the environment, particularly in agriculturally important areas, presents an important risk when waste products are not properly managed.
Keywords	X-ray absorption spectroscopy ; arsenic ; bioavailability ; desorption ; digestion ; environmental protection ; phosphates ; pollution ; risk ; spectral analysis ; titanium ; titanium dioxide ; vanadium ; water treatment ; Mobility ; Speciation ; Drinking water
Language	English
Dates of publication	2023-06
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2023.121468
Database	NAL-Catalogue (AGRICOLA)

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